ATE427104T1 - Butylphthalid-enthaltende weichgelkapsel und prozess ihrer herstellung - Google Patents

Butylphthalid-enthaltende weichgelkapsel und prozess ihrer herstellung

Info

Publication number
ATE427104T1
ATE427104T1 AT04802425T AT04802425T ATE427104T1 AT E427104 T1 ATE427104 T1 AT E427104T1 AT 04802425 T AT04802425 T AT 04802425T AT 04802425 T AT04802425 T AT 04802425T AT E427104 T1 ATE427104 T1 AT E427104T1
Authority
AT
Austria
Prior art keywords
butylphthalide
capsule
soft capsule
production
soft gel
Prior art date
Application number
AT04802425T
Other languages
English (en)
Inventor
Jianqing Li
Min Bai
Wenmin Guo
Surui Chen
Liyun Liu
Guirong Zhou
Original Assignee
Cspc Zhongqi Pharmaceutical Te
Cspc Nbp Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cspc Zhongqi Pharmaceutical Te, Cspc Nbp Pharmaceutical Co Ltd filed Critical Cspc Zhongqi Pharmaceutical Te
Application granted granted Critical
Publication of ATE427104T1 publication Critical patent/ATE427104T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Formation And Processing Of Food Products (AREA)
AT04802425T 2003-12-05 2004-12-03 Butylphthalid-enthaltende weichgelkapsel und prozess ihrer herstellung ATE427104T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB2003101193361A CN1257711C (zh) 2003-12-05 2003-12-05 丁苯酞软胶囊及其制备工艺

Publications (1)

Publication Number Publication Date
ATE427104T1 true ATE427104T1 (de) 2009-04-15

Family

ID=34638049

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04802425T ATE427104T1 (de) 2003-12-05 2004-12-03 Butylphthalid-enthaltende weichgelkapsel und prozess ihrer herstellung

Country Status (14)

Country Link
US (4) US20080020034A1 (de)
EP (1) EP1702612B1 (de)
JP (1) JP4634394B2 (de)
KR (1) KR100761437B1 (de)
CN (1) CN1257711C (de)
AT (1) ATE427104T1 (de)
AU (1) AU2004294254B2 (de)
BR (1) BRPI0417339C8 (de)
CA (1) CA2549498C (de)
DE (1) DE602004020381D1 (de)
MX (1) MXPA06006401A (de)
NO (1) NO338520B1 (de)
RU (1) RU2322976C1 (de)
WO (1) WO2005053658A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100471494C (zh) * 2005-12-24 2009-03-25 石药集团中奇制药技术（石家庄）有限公司 丁苯酞滴丸及制备方法
RU2420291C3 (ru) * 2006-01-24 2020-07-21 Р-Тек Уено, Лтд. Состав в мягкой желатиновой капсуле
CN101342152B (zh) * 2007-07-10 2010-10-13 石药集团中奇制药技术（石家庄）有限公司 丁苯酞片及其制备方法
US8726005B2 (en) 2009-12-10 2014-05-13 George Mason Intellectual Properties, Inc. Website matching based on network traffic
CN102058560B (zh) * 2010-12-30 2013-07-24 张家界茅岩莓有限公司 一种二氢杨梅素软胶囊及制备方法
CN102178643B (zh) * 2011-04-29 2014-05-14 石药集团恩必普药业有限公司 一种丁苯酞或其衍生物的微乳透皮凝胶剂及其制备方法
CN103169685B (zh) * 2011-12-23 2018-03-06 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞控释制剂及其制备方法
CN107648222A (zh) * 2012-06-06 2018-02-02 石药集团中奇制药技术（石家庄）有限公司 一种丁苯酞药物活性组合物及其制备方法
CN102716103B (zh) * 2012-07-02 2013-12-18 西安力邦制药有限公司 2,2′,6,6′-四异丙基-4,4′-二联苯酚软胶囊制剂及其制备方法
CN109939102B (zh) * 2013-06-13 2022-05-17 石药集团中奇制药技术（石家庄）有限公司 一种包含丁苯酞和冰片的药物组合物及其应用
CN106606498A (zh) * 2016-07-25 2017-05-03 山东诚创医药技术开发有限公司 一种丁苯酞软胶囊
CN106580959B (zh) * 2017-01-10 2019-04-23 山东省立医院 一种缓解急性缺血性脑卒中的丁苯酞尼群地平软胶囊
CN109432042B (zh) * 2018-12-24 2022-04-22 石药集团恩必普药业有限公司 一种软胶囊囊壳及其制备方法
CN112336700B (zh) * 2019-08-08 2023-12-01 河北菲尼斯生物技术有限公司 一种稳定的含丁苯酞药物及其制备方法
CN114073694B (zh) * 2020-08-14 2024-03-12 北京科莱博医药开发有限责任公司 丁苯酞制剂及其制备方法
KR102294072B1 (ko) 2020-11-19 2021-08-26 (주)알피바이오 식물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 식물성 츄어블 연질캡슐
KR102523186B1 (ko) 2020-11-19 2023-04-18 (주)알피바이오 동물성 츄어블 연질캡슐용 조성물 및 이를 통해 형성된 동물성 츄어블 연질캡슐
CN113975242A (zh) * 2021-10-14 2022-01-28 山东诚创蓝海医药科技有限公司 一种提高口服生物利用度的丁苯酞软胶囊
KR102909778B1 (ko) * 2022-08-17 2026-01-07 김미숙 초임계 유체 잣 추출물을 함유한 잣오일 캡슐 제조방법 및 그 방법에 의해 제조되는 잣오일 캡슐
CN115453014B (zh) * 2022-10-28 2024-04-19 成都施贝康生物医药科技有限公司 一种丁苯酞及其有关物质的检测方法
CN115469039B (zh) * 2022-10-28 2024-04-26 成都施贝康生物医药科技有限公司 一种丁苯酞及其有关物质检测方法
WO2025127804A1 (ko) * 2023-12-15 2025-06-19 한국 한의학 연구원 부틸프탈라이드 또는 이의 허용 가능한 염을 유효성분으로 포함하는 노화에 의한 난소 저반응군의 예방, 개선 또는 치료용 조성물

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US3927195A (en) * 1974-01-31 1975-12-16 Lilly Industries Ltd Production of capsules
NL7510104A (nl) * 1975-08-27 1977-03-01 Akzo Nv Werkwijze ter bereiding van een oraal werkzaam farmaceutisch preparaat.
US4366145A (en) * 1981-06-24 1982-12-28 Sandoz, Inc. Soft gelatin capsule with a liquid ergot alkaloid center fill solution and method of preparation
AU552068B2 (en) * 1981-09-21 1986-05-22 Asama Chemical Co. Ltd. Preservation of edible oils
FR2608456B1 (fr) * 1986-12-18 1993-06-18 Mero Rousselot Satia Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention
JPH01199958A (ja) * 1987-07-23 1989-08-11 Tsumura & Co 新規なフタリド誘導体およびその製造方法
WO1995000157A1 (en) 1993-06-25 1995-01-05 Mobius Consultancy Pty. Ltd. Therapeutic agent
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
AUPO990397A0 (en) * 1997-10-22 1997-11-13 R.P. Scherer Holdings Pty Ltd Clear solutions of herbal extracts
CN1086942C (zh) * 1998-12-18 2002-07-03 中国医学科学院药物研究所 丁基苯酞在制备抗血栓形成及抗血小板聚集药物中的应用
US6800329B2 (en) * 1999-02-12 2004-10-05 Lts Lohmann Therapie-Systeme Ag Method for producing film-type dosage
US6193999B1 (en) * 1999-03-01 2001-02-27 Banner Pharmacaps, Inc. Gum acacia substituted soft gelatin capsules
CN1102397C (zh) * 2000-03-01 2003-03-05 山东绿叶制药股份有限公司 当归油软胶囊及其制备工艺
CN1375288A (zh) * 2002-05-13 2002-10-23 周桂荣 一种治疗脑血管疾病的药物组合物
CA2494157C (en) * 2002-08-21 2010-10-12 Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof

Also Published As

Publication number Publication date
KR20060105013A (ko) 2006-10-09
CA2549498A1 (en) 2005-06-16
NO20062895L (no) 2006-09-04
CN1257711C (zh) 2006-05-31
WO2005053658A1 (en) 2005-06-16
DE602004020381D1 (de) 2009-05-14
US20080020034A1 (en) 2008-01-24
US20120052117A1 (en) 2012-03-01
US20070134316A1 (en) 2007-06-14
BRPI0417339A (pt) 2007-02-21
AU2004294254A1 (en) 2005-06-16
BRPI0417339C1 (pt) 2021-05-25
EP1702612A4 (de) 2006-12-20
BRPI0417339B8 (pt) 2020-06-02
JP2007513097A (ja) 2007-05-24
EP1702612B1 (de) 2009-04-01
RU2322976C1 (ru) 2008-04-27
JP4634394B2 (ja) 2011-02-16
US20080305163A1 (en) 2008-12-11
US8609137B2 (en) 2013-12-17
BRPI0417339B1 (pt) 2017-12-19
MXPA06006401A (es) 2007-11-13
HK1090302A1 (en) 2006-12-22
CA2549498C (en) 2011-07-12
RU2006122207A (ru) 2008-01-10
WO2005053658A8 (en) 2005-10-13
CN1623542A (zh) 2005-06-08
EP1702612A1 (de) 2006-09-20
AU2004294254B2 (en) 2008-02-07
BRPI0417339C8 (pt) 2022-02-01
NO338520B1 (no) 2016-08-29
KR100761437B1 (ko) 2007-10-04

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties