NO20063324L - 3-cyano-kinolinderivater med antiproliferativ aktivitet - Google Patents

3-cyano-kinolinderivater med antiproliferativ aktivitet

Info

Publication number
NO20063324L
NO20063324L NO20063324A NO20063324A NO20063324L NO 20063324 L NO20063324 L NO 20063324L NO 20063324 A NO20063324 A NO 20063324A NO 20063324 A NO20063324 A NO 20063324A NO 20063324 L NO20063324 L NO 20063324L
Authority
NO
Norway
Prior art keywords
antiproliferative activity
cyanoquinoline derivatives
compounds
formula
cyanoquinoline
Prior art date
Application number
NO20063324A
Other languages
English (en)
Other versions
NO337622B1 (no
Inventor
Eddy Jean Edgard Freyne
Werner Constant Johan Embrechts
Kristof Van Emelen
Peter Jacobus Johan Buijnsters
Timothy Pietro Suren Perera
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34684508&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20063324(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20063324L publication Critical patent/NO20063324L/no
Publication of NO337622B1 publication Critical patent/NO337622B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Den foreliggende oppfinnelse vedrører forbindelsene med formel N-oksidformene, de farmasøytisk akseptable addisjonssalter og de stereokjemisk isomere former derav. Forbindelsene med formel (I) hemmer tyrosinkinase-enzymer.
NO20063324A 2003-12-18 2006-07-18 3-cyano-kinolinderivater med antiproliferativ aktivitet NO337622B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP03/51059 2003-12-18
PCT/EP2004/053497 WO2005058318A1 (en) 2003-12-18 2004-12-15 3-cyano-quinoline derivatives with antiproliferative activity

Publications (2)

Publication Number Publication Date
NO20063324L true NO20063324L (no) 2006-07-18
NO337622B1 NO337622B1 (no) 2016-05-09

Family

ID=34684508

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063324A NO337622B1 (no) 2003-12-18 2006-07-18 3-cyano-kinolinderivater med antiproliferativ aktivitet

Country Status (22)

Country Link
US (4) US7655642B2 (no)
EP (1) EP1696914B1 (no)
JP (1) JP4892353B2 (no)
KR (1) KR101158440B1 (no)
CN (1) CN1893944B (no)
AR (1) AR047060A1 (no)
AT (1) ATE446750T1 (no)
AU (1) AU2004298784B2 (no)
BR (1) BRPI0417609B8 (no)
CA (1) CA2549728C (no)
DE (1) DE602004023876D1 (no)
EA (1) EA200601176A1 (no)
ES (1) ES2335216T3 (no)
IL (1) IL176358A (no)
MX (1) MXPA06007018A (no)
NO (1) NO337622B1 (no)
NZ (1) NZ547795A (no)
SG (1) SG151288A1 (no)
TW (2) TWI389890B (no)
UA (1) UA83880C2 (no)
WO (1) WO2005058318A1 (no)
ZA (1) ZA200604971B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200601176A1 (ru) 2003-12-18 2006-10-27 Янссен Фармацевтика Н.В. 3-цианохинолиновые производные с антипролиферативной активностью
AU2004298448B2 (en) * 2003-12-18 2010-09-09 Janssen Pharmaceutica N.V. Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents
JO3088B1 (ar) * 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف
MY169441A (en) 2004-12-08 2019-04-11 Janssen Pharmaceutica Nv 2,4, (4,6) pyrimidine derivatives
NI200700147A (es) 2004-12-08 2019-05-10 Janssen Pharmaceutica Nv Derivados de quinazolina inhibidores de cinasas dirigidos a multip
US10517876B2 (en) 2005-11-16 2019-12-31 Cti Biopharma Corp. Oxygen linked pyrimidine derivatives
CN101360751B (zh) 2005-11-16 2011-09-14 S*Bio私人有限公司 氧连接的嘧啶衍生物
CA2654583C (en) 2006-07-13 2015-11-24 Janssen Pharmaceutica N.V. Mtki quinazoline derivatives
EP2123627B1 (en) * 2007-01-19 2013-11-20 Ube Industries, Ltd. Process for producing aromatic amine having aralkyloxy or heteroaralkyloxy group
EP2170827B1 (en) * 2007-06-21 2013-08-14 Janssen Pharmaceutica, N.V. Indolin-2-ones and aza-indolin-2-ones
AU2008281849B2 (en) 2007-07-27 2013-11-28 Janssen Pharmaceutica Nv Pyrrolopyrimidines
CN102127087B (zh) * 2011-01-21 2012-07-04 江苏先声药物研究有限公司 喹唑啉衍生物
MA39822A (fr) 2014-04-03 2018-02-06 Janssen Pharmaceutica Nv Dérivés de pyrimidine bicycle
MA39823A (fr) 2014-04-03 2018-01-09 Janssen Pharmaceutica Nv Dérivés de pyridine macrocyclique
US20190112317A1 (en) 2015-10-05 2019-04-18 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028613A (en) 1990-02-16 1991-07-02 Repligen Corporation Novel pyrroloquinoline alkaloids and methods of use
UA73073C2 (uk) * 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
CZ303899B6 (cs) * 1998-09-29 2013-06-19 Wyeth Holdings Corporation Substituovaný 3-kyanochinolin, zpusob jeho prípravy a farmaceutická kompozice s jeho obsahem
US6288082B1 (en) 1998-09-29 2001-09-11 American Cyanamid Company Substituted 3-cyanoquinolines
NZ536114A (en) * 2002-03-30 2007-11-30 Boehringer Ingelheim Pharma 4-(N-phenylamino)-quinazolines / quinolines as tyrosine kinase inhibitors
JO2785B1 (en) 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives
EA200601176A1 (ru) * 2003-12-18 2006-10-27 Янссен Фармацевтика Н.В. 3-цианохинолиновые производные с антипролиферативной активностью

Also Published As

Publication number Publication date
JP2007514711A (ja) 2007-06-07
UA83880C2 (en) 2008-08-26
CA2549728A1 (en) 2005-06-30
DE602004023876D1 (de) 2009-12-10
US9040511B2 (en) 2015-05-26
NO337622B1 (no) 2016-05-09
EP1696914A1 (en) 2006-09-06
AU2004298784A1 (en) 2005-06-30
IL176358A0 (en) 2006-10-05
US20140256948A1 (en) 2014-09-11
AR047060A1 (es) 2006-01-04
CN1893944A (zh) 2007-01-10
NZ547795A (en) 2009-07-31
AU2004298784B2 (en) 2011-06-09
US9365517B2 (en) 2016-06-14
BRPI0417609A (pt) 2007-04-10
TW201132628A (en) 2011-10-01
US8778920B2 (en) 2014-07-15
US7655642B2 (en) 2010-02-02
KR20070005560A (ko) 2007-01-10
SG151288A1 (en) 2009-04-30
TW200530187A (en) 2005-09-16
TWI389890B (zh) 2013-03-21
ES2335216T3 (es) 2010-03-23
US20080139601A1 (en) 2008-06-12
TWI374879B (en) 2012-10-21
JP4892353B2 (ja) 2012-03-07
BRPI0417609B1 (pt) 2019-02-19
US20130197022A1 (en) 2013-08-01
CN1893944B (zh) 2011-07-06
KR101158440B1 (ko) 2012-07-06
EP1696914B1 (en) 2009-10-28
EA200601176A1 (ru) 2006-10-27
ZA200604971B (en) 2009-05-27
ATE446750T1 (de) 2009-11-15
IL176358A (en) 2010-06-16
BRPI0417609B8 (pt) 2021-05-25
HK1095742A1 (en) 2007-05-18
US20100069424A1 (en) 2010-03-18
WO2005058318A1 (en) 2005-06-30
MXPA06007018A (es) 2006-08-31
CA2549728C (en) 2015-07-21

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