NO20063383L - Krystall av salt av 4-(3-klor-4(cyklopropylaminokarbonyl)aminofenoksy)-7-metoksy-6-kinolinkarboksamid eller av solvat derav og fremgangsmater for fremstilling av disse - Google Patents

Krystall av salt av 4-(3-klor-4(cyklopropylaminokarbonyl)aminofenoksy)-7-metoksy-6-kinolinkarboksamid eller av solvat derav og fremgangsmater for fremstilling av disse

Info

Publication number
NO20063383L
NO20063383L NO20063383A NO20063383A NO20063383L NO 20063383 L NO20063383 L NO 20063383L NO 20063383 A NO20063383 A NO 20063383A NO 20063383 A NO20063383 A NO 20063383A NO 20063383 L NO20063383 L NO 20063383L
Authority
NO
Norway
Prior art keywords
cyclopropylaminocarbonyl
aminophenoxy
solvate
chloro
methoxy
Prior art date
Application number
NO20063383A
Other languages
English (en)
Other versions
NO339110B1 (no
Inventor
Tomohiro Matsushima
Taiju Nakamura
Kazuhiro Yoshizawa
Atsushi Kamada
Yusuke Ayata
Naoko Suzuki
Itaru Arimoto
Takahisa Sakaguchi
Masaharu Gotoda
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34736366&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20063383(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO20063383L publication Critical patent/NO20063383L/no
Publication of NO339110B1 publication Critical patent/NO339110B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Krystaller av hydrokloridet, hydrobromidet, p-toluensulfo-natet, sulfatet, metansulfonatet eller etansulfonatet av 4-(3-klor-4-(cyklopropylaminokarbonyl)aminofenoksy)-7-metoksy-6-kinolinkarboksamid eller krystaller av et solvat av hvilken som helst av disse.
NO20063383A 2003-12-25 2006-07-21 Krystall av salt av 4-(3-klor-4-(cyklopropylaminokarbonyl)aminofenoksy)-7-metoksy-6-kinolinkarboksamid eller av solvat derav og fremgangsmåter for fremstilling av disse NO339110B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003430939 2003-12-25
PCT/JP2004/019223 WO2005063713A1 (ja) 2003-12-25 2004-12-22 ４−（３−クロロ−４−（シクロプロピルアミノカルボニル）アミノフェノキシ）−７−メトキシ−６−キノリンカルボキサミドの塩またはその溶媒和物の結晶およびそれらの製造方法

Publications (2)

Publication Number Publication Date
NO20063383L true NO20063383L (no) 2006-09-25
NO339110B1 NO339110B1 (no) 2016-11-14

Family

ID=34736366

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063383A NO339110B1 (no) 2003-12-25 2006-07-21 Krystall av salt av 4-(3-klor-4-(cyklopropylaminokarbonyl)aminofenoksy)-7-metoksy-6-kinolinkarboksamid eller av solvat derav og fremgangsmåter for fremstilling av disse

Country Status (28)

Country Link
US (1) US7612208B2 (no)
EP (2) EP2567955A3 (no)
JP (2) JP4648835B2 (no)
KR (3) KR100804566B1 (no)
CN (4) CN101337933B (no)
AU (1) AU2004309217B2 (no)
BR (1) BRPI0418200A (no)
CA (1) CA2543650C (no)
CY (1) CY1116312T1 (no)
DK (1) DK1698623T3 (no)
ES (1) ES2540852T3 (no)
HR (1) HRP20150694T1 (no)
HU (1) HUE025742T2 (no)
IL (1) IL175933A (no)
LT (1) LTC1698623I2 (no)
ME (1) ME02184B (no)
MX (1) MXPA06007256A (no)
MY (1) MY139232A (no)
NO (1) NO339110B1 (no)
NZ (1) NZ547518A (no)
PL (1) PL1698623T3 (no)
PT (1) PT1698623E (no)
RS (1) RS54033B1 (no)
RU (1) RU2328489C3 (no)
SI (1) SI1698623T1 (no)
TW (1) TW200528432A (no)
WO (1) WO2005063713A1 (no)
ZA (1) ZA200605226B (no)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100600550B1 (ko) 2000-10-20 2006-07-13 에자이 가부시키가이샤 질소 함유 방향환 유도체
US20030181488A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
EP1604665B1 (en) * 2003-03-10 2011-05-11 Eisai R&D Management Co., Ltd. C-kit kinase inhibitor
JP4303726B2 (ja) 2003-11-11 2009-07-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウレア誘導体およびその製造方法
HUE025742T2 (hu) 2003-12-25 2016-04-28 Eisai R&D Man Co Ltd 4-(3-klór-4-(ciklopropilamino-karbonil)aminofenoxi)-7-metoxi-6-kinolin-karboxamid vagy szolvátja sójának kristálya és eljárás elõállításukra
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006030941A1 (ja) 2004-09-13 2006-03-23 Eisai R & D Management Co., Ltd. スルホンアミド含有化合物の血管新生阻害物質との併用
US8969379B2 (en) * 2004-09-17 2015-03-03 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
KR100951607B1 (ko) * 2005-06-23 2010-04-09 에자이 알앤드디 매니지먼트 가부시키가이샤 4-(3-클로로-4-(시클로프로필아미노카르보닐)아미노페녹시)-7-메톡시-6-퀴놀린카르복사미드의 비정질 염 및 그 제조방법
US7550483B2 (en) * 2005-06-23 2009-06-23 Eisai R&D Management Co., Ltd. Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same
JP5066446B2 (ja) * 2005-08-01 2012-11-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を予測する方法
JP4989476B2 (ja) 2005-08-02 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害物質の効果を検定する方法
CN102716490A (zh) * 2005-09-01 2012-10-10 卫材R&D管理有限公司 药物组合物的崩解性的改善方法
KR101353763B1 (ko) 2005-11-07 2014-01-21 에자이 알앤드디 매니지먼트 가부시키가이샤 혈관 신생 저해 물질과 ｃ―ｋｉｔ 키나아제 저해 물질의병용
US20090247576A1 (en) * 2005-11-22 2009-10-01 Eisai R & D Management Co., Ltd. Anti-tumor agent for multiple myeloma
CN104706637A (zh) * 2006-05-18 2015-06-17 卫材R&D管理有限公司 针对甲状腺癌的抗肿瘤剂
US20090203693A1 (en) * 2006-06-29 2009-08-13 Eisai R & D Management Co., Ltd. Therapeutic agent for liver fibrosis
JP5368096B2 (ja) 2006-08-28 2013-12-18 エーザイ・アール・アンド・ディー・マネジメント株式会社 未分化型胃癌に対する抗腫瘍剤
EP2116246A1 (en) 2007-01-19 2009-11-11 Eisai R&D Management Co., Ltd. Composition for treatment of pancreatic cancer
WO2008093855A1 (ja) 2007-01-29 2008-08-07 Eisai R & D Management Co., Ltd. 未分化型胃癌治療用組成物
CA2704000C (en) 2007-11-09 2016-12-13 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
WO2009096377A1 (ja) 2008-01-29 2009-08-06 Eisai R & D Management Co., Ltd. 血管阻害物質とタキサンとの併用
TW201920110A (zh) 2009-01-16 2019-06-01 美商艾克塞里克斯公司 包含n-(4-{[6,7-雙(甲氧基)喹啉-4-基]氧基}苯基)-n'-(4-氟苯基)環丙烷-1,1-二甲醯胺之蘋果酸鹽之醫藥組合物及其用途
CA2771403C (en) * 2009-08-19 2015-02-24 Eisai R&D Management Co. Ltd. Quinoline derivative-containing pharmaceutical composition
CN102958523B (zh) * 2010-06-25 2014-11-19 卫材R&D管理有限公司 使用具有激酶抑制作用的组合的抗肿瘤剂
WO2012009722A1 (en) * 2010-07-16 2012-01-19 Exelixis, Inc. C-met modulator pharmaceutical compositions
TW201309650A (zh) 2011-02-10 2013-03-01 艾克塞里克斯公司 製造喹啉化合物之方法及包含該化合物之醫藥組合物
AU2012246490B2 (en) 2011-04-18 2016-08-04 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
JPWO2014098176A1 (ja) * 2012-12-21 2017-01-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体のアモルファス及びその製造方法
CA2912219C (en) 2013-05-14 2021-11-16 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN105338977B (zh) 2013-06-26 2018-10-16 卫材R&D管理有限公司 艾日布林和乐伐替尼作为治疗癌症的联合疗法的用途
EP3187491A4 (en) 2014-08-28 2018-08-01 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
CA2960044A1 (en) 2014-09-03 2016-03-10 Pharmacyclics Llc Novel salts of 3-[(dimethylamino)methyl]-n-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide, related crystalline forms, method for preparing the same and pharmaceutical compositions containing the same
US20180028662A1 (en) 2015-02-25 2018-02-01 Eisai R&D Management Co., Ltd. Method for Suppressing Bitterness of Quinoline Derivative
KR20240064733A (ko) 2015-03-04 2024-05-13 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN106660965A (zh) * 2015-03-27 2017-05-10 江苏恒瑞医药股份有限公司 乐伐替尼的对甲苯磺酸盐、其结晶形式及制备方法
CN107848979A (zh) * 2015-05-21 2018-03-27 苏州晶云药物科技有限公司 乐伐替尼甲磺酸盐的新晶型及其制备方法
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
CN108135894B (zh) 2015-08-20 2021-02-19 卫材R&D管理有限公司 肿瘤治疗剂
KR20180129795A (ko) * 2016-04-15 2018-12-05 에자이 알앤드디 매니지먼트 가부시키가이샤 렌바티닙 및 에베롤리무스를 사용한 신세포 암종의 치료
CN107305202B (zh) * 2016-04-22 2020-04-17 北京睿创康泰医药研究院有限公司 分析甲磺酸乐伐替尼及其制剂杂质的hplc方法及杂质作参比标准的用途
CZ2016240A3 (cs) * 2016-04-27 2017-11-08 Zentiva, K.S. Soli lenvatinibu
CN105801481A (zh) * 2016-05-20 2016-07-27 湖南欧亚生物有限公司 一种乐伐替尼的合成方法
WO2017221215A1 (en) * 2016-06-23 2017-12-28 Sun Pharmaceutical Industries Limited Salts of lenvatinib
WO2017221214A1 (en) * 2016-06-23 2017-12-28 Sun Pharmaceutical Industries Limited Crystalline forms of salts of lenvatinib
EP3299360A1 (en) * 2016-09-21 2018-03-28 INDENA S.p.A. Crystal forms of lenvatinib
CN106632033A (zh) * 2016-10-28 2017-05-10 北京万全德众医药生物技术有限公司 乐伐替尼的一种制备方法
CN110248660A (zh) * 2016-12-29 2019-09-17 雷迪博士实验室有限公司 甲磺酸乐伐替尼的固态形式
CN110072528B (zh) 2017-02-08 2022-04-26 卫材R&D管理有限公司 治疗肿瘤的药物组合物
WO2018157411A1 (zh) * 2017-02-28 2018-09-07 深圳市塔吉瑞生物医药有限公司 取代的含氮芳环化合物及其应用
HUE069392T2 (hu) 2017-04-04 2025-03-28 Synthon Bv Lenvatinib-mezilátot tartalmazó gyógyszerkészítmény
AR111469A1 (es) 2017-04-21 2019-07-17 Yuhan Corp Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma
CN110494423B (zh) * 2017-04-25 2022-04-26 苏州科睿思制药有限公司 乐伐替尼甲磺酸盐的新晶型及其制备方法
WO2018212202A1 (en) 2017-05-16 2018-11-22 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
US11236050B2 (en) 2017-12-09 2022-02-01 Msn Laboratories Private Limited, R&D Center Polymorphs of 4-[3-chloro-4-(n′-cyclopropyl ureido)phenoxy] -7-methoxyquinoline-6-carboxamide, its salts and process for the preparation thereof
CN109988112A (zh) * 2017-12-29 2019-07-09 四川科伦药物研究院有限公司 仑伐替尼甲磺酸盐的晶型及其制备方法
KR20250073570A (ko) 2018-01-10 2025-05-27 에자이 알앤드디 매니지먼트 가부시키가이샤 간세포성 암종의 치료를 위한 조합 요법
WO2019222075A1 (en) 2018-05-14 2019-11-21 Merck Sharp And Dohme Corp. Biomarkers for a combination therapy comprising lenvatinib and a pd-1 antagonist
WO2019228485A1 (zh) * 2018-06-01 2019-12-05 成都苑东生物制药股份有限公司 一种甲磺酸乐伐替尼新晶型及其制备方法
CN110845408A (zh) * 2018-08-20 2020-02-28 润佳（苏州）医药科技有限公司 同位素富集的乐伐替尼
CN110862346A (zh) * 2018-08-28 2020-03-06 上海博志研新药物技术有限公司 乐伐替尼甲磺酸盐醋酸合物晶型、制备方法及其应用
EP3620453A1 (en) 2018-09-07 2020-03-11 Indena S.p.A. New crystal form of lenvatinib
PT3632436T (pt) * 2018-10-04 2022-07-22 Synthon Bv Composição farmacêutica compreendendo sais de lenvatinib
EP3860605B9 (en) * 2018-10-04 2024-07-03 Synthon B.V. Pharmaceutical composition comprising lenvatinib besylate
JP7431226B2 (ja) 2018-10-05 2024-02-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ及びエベロリムスを含む併用療法のためのバイオマーカー
JP7564097B2 (ja) 2018-10-05 2024-10-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 ソラフェニブ化合物を含む療法のためのバイオマーカー
CN111689897B (zh) * 2019-03-13 2024-02-06 齐鲁制药有限公司 一种高纯度甲磺酸乐伐替尼晶型c的制备方法
CN109867626A (zh) * 2019-04-18 2019-06-11 安礼特（上海）医药科技有限公司 一种甲磺酸仑伐替尼多晶型物及其制备方法
CN110229103A (zh) * 2019-06-27 2019-09-13 尚科生物医药（上海）有限公司 一种乐伐替尼甲磺酸盐晶型b的制备方法
CN110256341A (zh) * 2019-06-27 2019-09-20 尚科生物医药（上海）有限公司 一种乐伐替尼甲磺酸盐晶型c的制备方法
CN112174886A (zh) * 2019-07-02 2021-01-05 成都苑东生物制药股份有限公司 一种甲磺酸乐伐替尼晶型x的制备方法
EP4008730A4 (en) 2019-08-02 2023-09-06 Akeso Pharmaceuticals, Inc. BISPECIFIC ANTI-CTLA4-ANTI-PD-1 ANTIBODY AND ITS USES
BR112022002028A2 (pt) 2019-08-02 2022-04-12 Cttq Akeso Shanghai Biomed Tech Co Ltd Anticorpo anti-pd-1 e uso farmacêutico do mesmo
CN110563644A (zh) * 2019-10-30 2019-12-13 北京赛思源生物医药技术有限公司 一种仑伐替尼甲磺酸盐的新晶型
CN112851580A (zh) 2019-11-12 2021-05-28 深圳博澜医药有限责任公司 乐伐替尼甲磺酸盐的晶型及其方法
CN111233762B (zh) * 2020-02-20 2021-12-28 天津理工大学 一种乐伐替尼与对羟基苯甲酸共晶及其制备方法
WO2021213453A1 (zh) * 2020-04-24 2021-10-28 成都苑东生物制药股份有限公司 一种甲磺酸仑伐替尼晶型xi及其制备方法
JP7750884B2 (ja) 2020-06-22 2025-10-07 メルク・シャープ・アンド・ドーム・エルエルシー ＨＩＦ－２α阻害剤とレンバチニブの組み合わせを使用して、癌またはフォンヒッペル・リンダウ病を処置するための方法
CN113999173A (zh) * 2020-07-28 2022-02-01 药源药物化学（上海）有限公司 一种高纯度结晶的制备方法
CN111793027B (zh) * 2020-08-07 2021-12-03 天津理工大学 一种乐伐替尼与苯甲酸的共晶及其制备方法
CN116410133B (zh) * 2021-12-29 2026-07-03 重庆医药工业研究院有限责任公司 一种氟伐替尼氢溴酸盐及其制备方法
CN115710225B (zh) * 2022-12-08 2025-05-23 郑州德迈药业有限公司 一种仑伐替尼甲磺酸盐的制备方法
US20260138954A1 (en) 2025-08-18 2026-05-21 Synthon B.V. Amorphous solid form and pharmaceutical compositions of lenvatinib besylate

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339136C (en) 1987-07-01 1997-07-29 Sailesh Amilal Varia Amorphous form of aztreonam
JP2517424Y2 (ja) 1987-07-30 1996-11-20 株式会社 ナブコ ポンプ装置
RU2256654C2 (ru) * 1999-01-22 2005-07-20 Кирин Бир Кабусики Кайся Хинолиновые и хиназолиновые производные
JP2001131071A (ja) 1999-10-29 2001-05-15 Meiji Seika Kaisha Ltd 非晶質および非晶質を含有する医薬組成物
KR100600550B1 (ko) * 2000-10-20 2006-07-13 에자이 가부시키가이샤 질소 함유 방향환 유도체
GB0119467D0 (en) 2001-08-09 2001-10-03 Smithkline Beecham Plc Novel compound
WO2004039782A1 (ja) 2002-10-29 2004-05-13 Kirin Beer Kabushiki Kaisha Ｆｌｔ３自己リン酸化を阻害するキノリン誘導体およびキナゾリン誘導体並びにそれらを含有する医薬組成物
EP1604665B1 (en) 2003-03-10 2011-05-11 Eisai R&D Management Co., Ltd. C-kit kinase inhibitor
US20070117842A1 (en) * 2003-04-22 2007-05-24 Itaru Arimoto Polymorph of 4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6- quinolinecarboxamide and a process for the preparation of the same
JP4303726B2 (ja) 2003-11-11 2009-07-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ウレア誘導体およびその製造方法
HUE025742T2 (hu) 2003-12-25 2016-04-28 Eisai R&D Man Co Ltd 4-(3-klór-4-(ciklopropilamino-karbonil)aminofenoxi)-7-metoxi-6-kinolin-karboxamid vagy szolvátja sójának kristálya és eljárás elõállításukra
US8969379B2 (en) * 2004-09-17 2015-03-03 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
US7550483B2 (en) * 2005-06-23 2009-06-23 Eisai R&D Management Co., Ltd. Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same

Also Published As

Publication number Publication date
EP1698623A1 (en) 2006-09-06
BRPI0418200A (pt) 2007-04-17
US7612208B2 (en) 2009-11-03
KR100839554B1 (ko) 2008-06-20
WO2005063713A1 (ja) 2005-07-14
NO339110B1 (no) 2016-11-14
CN101337933A (zh) 2009-01-07
CN100569753C (zh) 2009-12-16
TW200528432A (en) 2005-09-01
EP1698623B1 (en) 2015-04-15
LTPA2015039I1 (lt) 2015-11-25
JP4648835B2 (ja) 2011-03-09
ME02184B (me) 2016-02-20
MXPA06007256A (es) 2006-08-23
US20070078159A1 (en) 2007-04-05
RU2328489C2 (ru) 2008-07-10
EP2567955A2 (en) 2013-03-13
MY139232A (en) 2009-09-30
RU2006126977A (ru) 2008-01-27
DK1698623T3 (da) 2015-06-15
NZ547518A (en) 2009-06-26
KR20070107185A (ko) 2007-11-06
HK1102027A1 (en) 2007-11-02
PL1698623T3 (pl) 2015-08-31
HUE025742T2 (hu) 2016-04-28
PT1698623E (pt) 2015-06-29
CN101337932B (zh) 2011-06-08
CN101337933B (zh) 2011-03-02
TWI331996B (no) 2010-10-21
ZA200605226B (en) 2007-04-25
CY1116312T1 (el) 2017-02-08
SI1698623T1 (sl) 2015-07-31
CN101337931A (zh) 2009-01-07
JPWO2005063713A1 (ja) 2007-12-20
RU2328489C3 (ru) 2018-06-01
KR20080028511A (ko) 2008-03-31
CA2543650A1 (en) 2005-07-14
AU2004309217A1 (en) 2005-07-14
IL175933A0 (en) 2006-10-05
KR20060113759A (ko) 2006-11-02
CA2543650C (en) 2010-10-26
JP2010280713A (ja) 2010-12-16
LTC1698623I2 (lt) 2017-04-10
HRP20150694T1 (xx) 2015-08-14
CN101337931B (zh) 2010-09-29
CN1890220A (zh) 2007-01-03
EP2567955A3 (en) 2013-03-27
KR100870681B1 (ko) 2008-11-26
ES2540852T3 (es) 2015-07-14
IL175933A (en) 2010-12-30
AU2004309217B2 (en) 2008-11-06
RS54033B1 (sr) 2015-10-30
HK1094200A1 (en) 2007-03-23
CN101337932A (zh) 2009-01-07
EP1698623A4 (en) 2009-05-13
KR100804566B1 (ko) 2008-02-20

Similar Documents

Publication Publication Date Title
CY1116312T1 (el) Κρυσταλλος αλατος 4-(3-χλωρο-4-(κυκλοπροπυλ αμινοκαρβονυλ)αμινο-φαινοξυ)-7-μεθοξυ-6-κινολινοκαρβοξαμιδιου ή διαλυτωματος αυτου και διεργασιες για την παρασκευη αυτων
DK1564210T3 (da) 4-Oxoquinolinforbindelser og anvendelse deraf som HIV-integraseinhibitorer
DK1542668T3 (da) Formulering af aripiprazolkompleks og fremgangsmåde
ATE483463T1 (de) Pyridonsulfonamide und pyridonsulfamide als mek- hemmer
DK1656370T3 (da) Heterocykliske biarylforbindelser og fremgangsmåder til fremstilling og anvendelse af samme
NO20042147L (no) Heterocykliske forbindelser og fremgangsmater for anvendelse derav
NO20050476L (no) Kinolinderivater og deres anvendelse som mykobakterielle inhibitorer
NO20061396L (no) Nye heterocykliske forbindelser som HSP90-inhibitorer
IL190137A0 (en) Crystals of laquinimod sodium, and process for the manufacture thereof
DK1480955T3 (da) O-cyclopropyl-carboxanilider og deres anvendelse som fungicider
NO20053356L (no) Aminindazolderivater og anvendelse derav som kinaseinhibitorer.
DK1711184T3 (da) (3-Oxo-3,4-dihydro-quinoxalin-2-yl-amino)-benzamid-derivater og beslægtede forbindelser som glycogenphosphorylaseinhibitorer til behandling af diabetes og fedme
BRPI0516905A (pt) processo para a preparação de um derivado n-[2-(2-piridinil)etil]carboxamida e compostos
NO20040356L (no) Indaneddiksyrederivater og deres andvendelse som farmasoytiske midler, intermediater og fremgangsmate for fremstilling.
DK1651644T3 (da) Substituerede derivater af thiazol-benzoisothiazoldioxid, fremgangsmåde deraf og deres anvendelse
NO20051674D0 (no) Framgangsmate og anordning for maling av tilstanden i stalstrukturer
DK1720848T3 (da) Derivater af alkylpiperazin- og alkylhomopiperazincarboxylater, fremgangsmåde til fremstilling heraf og anvendelse heraf som inhibitorer af enzymet FAAH
DE60216278D1 (de) Polyoxyalkylen-ammoniumsalze und ihre verwendung als antistatika
NO20054876D0 (no) Substituerte 4-fenyltetrahydroisokinoliner, fremgangsmate for fremstilling derav, deres anvendelse som medikament og medikament inneholdende slike forbindelser
EA200501226A1 (ru) Новая кристаллическая модификация негидратированного боскалида
NO20043580D0 (no) Quinazolinonderivater og deres bruk som CB agonister
IL213615A0 (en) N-(5-substituted-2-nitrophenyl)amine derivatives and methods for the preparation of 6-substituted-1-methyl-1-h-benzimidazole derivatives utilizing the same
NO20035328D0 (no) Nye forbindelser og preparater som katepsinhibitorer
DK1841737T3 (da) Derivater af N-(heteroaryl)-1H-indol-2-carboxamider og anvendelse deraf som vanilloid-TRPV1-receptor-ligander
NO20031928D0 (no) Nye krystall- og solvatformer av ondansetronhydroklorid og fremgangmsmåterfor fremstilling av disse