NO20063477L - Optisk aktive, heteroaromatiske β-hydroksyestere, fremgangsmater for deres fremstilling fra β-ketoestere, og fremgangsmater for fremstilling av disse β-ketoestere - Google Patents

Optisk aktive, heteroaromatiske β-hydroksyestere, fremgangsmater for deres fremstilling fra β-ketoestere, og fremgangsmater for fremstilling av disse β-ketoestere

Info

Publication number
NO20063477L
NO20063477L NO20063477A NO20063477A NO20063477L NO 20063477 L NO20063477 L NO 20063477L NO 20063477 A NO20063477 A NO 20063477A NO 20063477 A NO20063477 A NO 20063477A NO 20063477 L NO20063477 L NO 20063477L
Authority
NO
Norway
Prior art keywords
processes
ketoesters
preparation
heteroaromatic
optically active
Prior art date
Application number
NO20063477A
Other languages
English (en)
Inventor
Johannes Platzek
Werner Skuballa
Bernd Buchmann
Ludwig Zorn
Orlin Petrov
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20063477L publication Critical patent/NO20063477L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Foreliggende oppfinnelse gjelder optisk aktive, heteroaromatiske (-hydroksyestere med formel (I): som er anvendbare i syntesen av epo-tilonderivater til (-ketoestere med formel (IV): som anvendes for fremstilling av disse intermediatene ved hjelp av en asymmetrisk hydrogenering med en kiral metall-katalysator eller en mikrobiologisk eller enzymatisk reduksjon, så vel som fremgangsmåter for fremstilling av dem (I), hvor: A er en bisyklisk, hetero-aromatisk rest med formel (A): hvor "heteroaromatisk" står for en heteroaromatisk ring med fem eller seks medlemmer og opptil to heteroatomer utvalgt blant oksygen, nitrogen og svovel, som om ønskelig er substituert
NO20063477A 2003-12-31 2006-07-28 Optisk aktive, heteroaromatiske β-hydroksyestere, fremgangsmater for deres fremstilling fra β-ketoestere, og fremgangsmater for fremstilling av disse β-ketoestere NO20063477L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10361794A DE10361794B3 (de) 2003-12-31 2003-12-31 Optisch aktive heteroaromatische ß-Hydroxy-Ester und Verfahren zu deren Herstellung sowie deren Verwendung als Zwischenprodukte bei der Epothilon-Totalsynthese
PCT/EP2004/014753 WO2005064006A1 (en) 2003-12-31 2004-12-21 OPTICALLY ACTIVE, HETEROAROMATIC β-HYDROXY ESTERS, PROCESSES FOR THEIR PREPARATION FROM β-KETO ESTERS AND PROCESSES FOR THE PREPARATION OF THESE β-KETO ESTERS

Publications (1)

Publication Number Publication Date
NO20063477L true NO20063477L (no) 2006-08-23

Family

ID=34716267

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063477A NO20063477L (no) 2003-12-31 2006-07-28 Optisk aktive, heteroaromatiske β-hydroksyestere, fremgangsmater for deres fremstilling fra β-ketoestere, og fremgangsmater for fremstilling av disse β-ketoestere

Country Status (16)

Country Link
EP (1) EP2113031A1 (no)
JP (1) JP2007516999A (no)
KR (1) KR20070029641A (no)
CN (1) CN100510098C (no)
AU (1) AU2004309076A1 (no)
BR (1) BRPI0418254A (no)
CA (1) CA2546981A1 (no)
CR (1) CR8492A (no)
DE (1) DE10361794B3 (no)
EC (1) ECSP066740A (no)
IL (1) IL175908A0 (no)
MX (1) MXPA06007564A (no)
NO (1) NO20063477L (no)
RU (1) RU2006127553A (no)
WO (1) WO2005064006A1 (no)
ZA (1) ZA200606293B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104328152A (zh) * 2014-10-13 2015-02-04 青岛科技大学 一种产朊酵母催化生产亚环己基烯醇的方法
CN108118004B (zh) * 2017-12-15 2021-06-25 北京工商大学 一株喜仙人掌毕赤酵母在水果采后病害防治中的应用
CN111689982B (zh) * 2019-03-15 2023-04-07 博瑞生物医药（苏州）股份有限公司 艾日布林中间体及其制备方法
CN110283733B (zh) * 2019-06-20 2020-10-27 浙江工业大学 土星轮头酵母zjph1807及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012884A1 (en) * 1995-10-04 1997-04-10 Fmc Corporation Herbicidal 6-heterocyclic indazole derivatives
US5942644A (en) * 1997-05-27 1999-08-24 Biocatalytics, Inc. Precursors for the production of chiral vicinal aminoalcohols
US6211412B1 (en) * 1999-03-29 2001-04-03 The University Of Kansas Synthesis of epothilones
PE20010116A1 (es) * 1999-04-30 2001-02-15 Schering Ag Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion
JP2001213874A (ja) * 1999-07-22 2001-08-07 Mercian Corp イソクマリン誘導体の製造およびそのための中間体
DE10041470A1 (de) * 2000-08-18 2002-02-28 Schering Ag 12,13-Cyclopropyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
WO2003029195A1 (en) * 2001-09-28 2003-04-10 Sumika Fine Chemicals Co., Ltd. Intermediates for epothilone derivative and process for producing these
JP4432315B2 (ja) * 2002-03-19 2010-03-17 三菱化学株式会社 光学活性３−ヒドロキシ−３−（２’−チエニル）プロピオン酸エステル誘導体の製造方法

Also Published As

Publication number Publication date
BRPI0418254A (pt) 2007-04-17
AU2004309076A1 (en) 2005-07-14
IL175908A0 (en) 2006-10-05
CN1902322A (zh) 2007-01-24
ECSP066740A (es) 2006-10-31
RU2006127553A (ru) 2008-02-10
CN100510098C (zh) 2009-07-08
HK1097000A1 (en) 2007-06-15
MXPA06007564A (es) 2006-12-14
CA2546981A1 (en) 2005-07-14
WO2005064006A1 (en) 2005-07-14
CR8492A (es) 2007-03-08
DE10361794B3 (de) 2005-10-06
EP2113031A1 (en) 2009-11-04
ZA200606293B (en) 2009-08-26
JP2007516999A (ja) 2007-06-28
KR20070029641A (ko) 2007-03-14

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