NO20063549L - (3-okso-3,4-dihydro-quinoksalin-2-yl-amino)-Benzamidderivater og relatert forbindelse som glykogenfosforylaseinhibitorer for behandling av diabetes og fedme - Google Patents
(3-okso-3,4-dihydro-quinoksalin-2-yl-amino)-Benzamidderivater og relatert forbindelse som glykogenfosforylaseinhibitorer for behandling av diabetes og fedmeInfo
- Publication number
- NO20063549L NO20063549L NO20063549A NO20063549A NO20063549L NO 20063549 L NO20063549 L NO 20063549L NO 20063549 A NO20063549 A NO 20063549A NO 20063549 A NO20063549 A NO 20063549A NO 20063549 L NO20063549 L NO 20063549L
- Authority
- NO
- Norway
- Prior art keywords
- obesity
- diabetes
- treatment
- glycogen phosphorylase
- dihydroquinoxalin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000007390 Glycogen Phosphorylase Human genes 0.000 title abstract 2
- 108010046163 Glycogen Phosphorylase Proteins 0.000 title abstract 2
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- VKTAXRVXRXQVOY-UHFFFAOYSA-N 2-[(3-oxo-4h-quinoxalin-2-yl)amino]benzamide Chemical class NC(=O)C1=CC=CC=C1NC1=NC2=CC=CC=C2NC1=O VKTAXRVXRXQVOY-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- FFRYUAVNPBUEIC-UHFFFAOYSA-N quinoxalin-2-ol Chemical class C1=CC=CC2=NC(O)=CN=C21 FFRYUAVNPBUEIC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det beskrives farmasøytisk aktive kinoksalinoner med formel (I), samt preparater inneholdende disse og metoder for fremstilling og anvendelse av forbindelsene. I formel (I) er R1 H, C1-6-alkyl eller halo; R2 er H eller halo; R3 er H, C1-6-alkyl; X er N eller CH; Y er en kovalent binding, -NHCO- eller -CONH-; Z er fenyl eller en 5- eller 6-leddet heterosyklyl med mellom 1 og 2 heteroatomer uavhengig valgt blant N, O og S; og n er 0, 1 eller 2; eller et farmasøytisk akseptabelt salt, en ester, et amid, et hydrat eller et solvat derav. Videre beskrives forbindelsenes anvendelse som glykogenfosforylaseinhibitorer for behandling av diabetes og obesitet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53453404P | 2004-01-06 | 2004-01-06 | |
| PCT/US2004/043409 WO2005067932A1 (en) | 2004-01-06 | 2004-12-22 | (3-oxo-3, 4-dihydro-quinoxalin-2-yl-amino) -benzamide derivatives and related compound as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20063549L true NO20063549L (no) | 2006-09-12 |
Family
ID=34794290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20063549A NO20063549L (no) | 2004-01-06 | 2006-08-04 | (3-okso-3,4-dihydro-quinoksalin-2-yl-amino)-Benzamidderivater og relatert forbindelse som glykogenfosforylaseinhibitorer for behandling av diabetes og fedme |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20050148586A1 (no) |
| EP (1) | EP1711184B1 (no) |
| JP (1) | JP2007517800A (no) |
| KR (1) | KR20060130159A (no) |
| CN (1) | CN1901917A (no) |
| AR (1) | AR047085A1 (no) |
| AT (1) | ATE367161T1 (no) |
| AU (1) | AU2004313246A1 (no) |
| BR (1) | BRPI0418368A (no) |
| CA (1) | CA2551639A1 (no) |
| CO (1) | CO5700757A2 (no) |
| CR (1) | CR8505A (no) |
| CY (1) | CY1106881T1 (no) |
| DE (1) | DE602004007693T2 (no) |
| DK (1) | DK1711184T3 (no) |
| EA (1) | EA200601287A1 (no) |
| ES (1) | ES2290782T3 (no) |
| HR (1) | HRP20070430T3 (no) |
| IL (1) | IL176648A0 (no) |
| MX (1) | MXPA06007715A (no) |
| NO (1) | NO20063549L (no) |
| PL (1) | PL1711184T3 (no) |
| PT (1) | PT1711184E (no) |
| SI (1) | SI1711184T1 (no) |
| TW (1) | TW200533360A (no) |
| WO (1) | WO2005067932A1 (no) |
| ZA (1) | ZA200606530B (no) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009509988A (ja) | 2005-09-29 | 2009-03-12 | サノフィ−アベンティス | フェニル−及びピリジニル−１，２，４−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| WO2009109341A1 (en) | 2008-03-05 | 2009-09-11 | Merck Patent Gmbh | Pyridopyrazinones derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
| HUE027811T2 (en) * | 2008-03-05 | 2016-11-28 | Merck Patent Gmbh | Quinoxalinone derivatives as stimulators of insulin secretion, methods for their preparation and their use in the treatment of diabetes |
| PL2285786T3 (pl) * | 2008-06-16 | 2014-01-31 | Merck Patent Gmbh | Pochodne chinoksalinodionowe |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| KR102919209B1 (ko) | 2018-08-10 | 2026-01-28 | 다이아핀 테라퓨틱스, 엘엘씨 | 트리-펩타이드 그리고 대사, 심장혈관 및 염증성 장애의 치료 |
| CN109793739A (zh) * | 2019-01-14 | 2019-05-24 | 北京理工大学 | 一种喹喔啉酮衍生物的结构、制备方法及用途 |
| CN112480109B (zh) * | 2020-11-16 | 2022-04-01 | 浙江大学 | 吡啶并[2,3-b]吡嗪-3(4H)-酮类衍生物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008864A1 (en) * | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| WO1995009159A1 (en) * | 1993-09-28 | 1995-04-06 | Otsuka Pharmaceutical Company, Limited | Quinoxaline derivative as antidiabetic agent |
| SE9800836D0 (sv) * | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| JP2002534512A (ja) * | 1999-01-15 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 非ペプチドｇｌｐ−１アゴニスト |
| IL148903A0 (en) * | 1999-09-30 | 2002-09-12 | Neurogen Corp | Certain alkylene diamine-substituted heterocycles |
-
2004
- 2004-12-22 PL PL04815480T patent/PL1711184T3/pl unknown
- 2004-12-22 MX MXPA06007715A patent/MXPA06007715A/es not_active Application Discontinuation
- 2004-12-22 DE DE602004007693T patent/DE602004007693T2/de not_active Expired - Fee Related
- 2004-12-22 KR KR1020067015598A patent/KR20060130159A/ko not_active Withdrawn
- 2004-12-22 BR BRPI0418368-1A patent/BRPI0418368A/pt not_active Application Discontinuation
- 2004-12-22 JP JP2006547399A patent/JP2007517800A/ja not_active Withdrawn
- 2004-12-22 SI SI200430449T patent/SI1711184T1/sl unknown
- 2004-12-22 AU AU2004313246A patent/AU2004313246A1/en not_active Abandoned
- 2004-12-22 ES ES04815480T patent/ES2290782T3/es not_active Expired - Lifetime
- 2004-12-22 WO PCT/US2004/043409 patent/WO2005067932A1/en not_active Ceased
- 2004-12-22 PT PT04815480T patent/PT1711184E/pt unknown
- 2004-12-22 US US11/019,505 patent/US20050148586A1/en not_active Abandoned
- 2004-12-22 EP EP04815480A patent/EP1711184B1/en not_active Expired - Lifetime
- 2004-12-22 EA EA200601287A patent/EA200601287A1/ru unknown
- 2004-12-22 HR HR20070430T patent/HRP20070430T3/xx unknown
- 2004-12-22 CA CA002551639A patent/CA2551639A1/en not_active Abandoned
- 2004-12-22 CN CNA2004800399887A patent/CN1901917A/zh active Pending
- 2004-12-22 DK DK04815480T patent/DK1711184T3/da active
- 2004-12-22 AT AT04815480T patent/ATE367161T1/de not_active IP Right Cessation
-
2005
- 2005-01-05 TW TW094100198A patent/TW200533360A/zh unknown
- 2005-01-05 AR ARP050100030A patent/AR047085A1/es not_active Application Discontinuation
-
2006
- 2006-06-29 IL IL176648A patent/IL176648A0/en unknown
- 2006-07-05 CR CR8505A patent/CR8505A/es not_active Application Discontinuation
- 2006-07-14 CO CO06068718A patent/CO5700757A2/es not_active Application Discontinuation
- 2006-08-04 NO NO20063549A patent/NO20063549L/no not_active Application Discontinuation
- 2006-08-04 ZA ZA200606530A patent/ZA200606530B/en unknown
-
2007
- 2007-09-19 CY CY20071101214T patent/CY1106881T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1901917A (zh) | 2007-01-24 |
| PL1711184T3 (pl) | 2007-12-31 |
| ES2290782T3 (es) | 2008-02-16 |
| SI1711184T1 (sl) | 2007-12-31 |
| CO5700757A2 (es) | 2006-11-30 |
| HRP20070430T3 (en) | 2007-11-30 |
| JP2007517800A (ja) | 2007-07-05 |
| CA2551639A1 (en) | 2005-07-28 |
| WO2005067932A1 (en) | 2005-07-28 |
| ZA200606530B (en) | 2008-02-27 |
| DE602004007693D1 (de) | 2007-08-30 |
| TW200533360A (en) | 2005-10-16 |
| ATE367161T1 (de) | 2007-08-15 |
| EA200601287A1 (ru) | 2006-10-27 |
| DK1711184T3 (da) | 2007-11-05 |
| DE602004007693T2 (de) | 2008-06-05 |
| CR8505A (es) | 2008-09-09 |
| IL176648A0 (en) | 2006-10-31 |
| CY1106881T1 (el) | 2012-09-26 |
| BRPI0418368A (pt) | 2007-05-15 |
| EP1711184A1 (en) | 2006-10-18 |
| MXPA06007715A (es) | 2007-01-26 |
| AU2004313246A1 (en) | 2005-07-28 |
| US20050148586A1 (en) | 2005-07-07 |
| AR047085A1 (es) | 2006-01-04 |
| KR20060130159A (ko) | 2006-12-18 |
| PT1711184E (pt) | 2007-09-24 |
| EP1711184B1 (en) | 2007-07-18 |
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