NO20063794L - Tetrahydroisoquinolin- og tetrahydrobenzazepin-derivater som IGF-1R-inhibitorer - Google Patents

Tetrahydroisoquinolin- og tetrahydrobenzazepin-derivater som IGF-1R-inhibitorer

Info

Publication number: NO20063794L
Authority: NO; Norway
Prior art keywords: igf; tetrahydroisoquinoline; inhibitors; tetrahydrobenzazepine derivatives; tetrahydrobenzazepine
Prior art date: 2004-03-12

Application number

NO20063794A

Other languages

English (en)

Norwegian (no)

Inventor

Jan Gunzinger

Kurt Leander

Original Assignee

Analytecon Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-12

Filing date

2006-08-24

Publication date

2006-12-12

2006-08-24 Application filed by Analytecon Sa filed Critical Analytecon Sa

2006-12-12 Publication of NO20063794L publication Critical patent/NO20063794L/no

Links

UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 title 2
MZBVNYACSSGXID-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-1-benzazepine Chemical class N1CCCCC2=CC=CC=C21 MZBVNYACSSGXID-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
102000038455 IGF Type 1 Receptor Human genes 0.000 abstract 1
108010031794 IGF Type 1 Receptor Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20063794A 2004-03-12 2006-08-24 Tetrahydroisoquinolin- og tetrahydrobenzazepin-derivater som IGF-1R-inhibitorer NO20063794L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/CH2004/000147 WO2005087743A1 (en)	2004-03-12	2004-03-12	Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives as igf-1r inhibitors

Publications (1)

Publication Number	Publication Date
NO20063794L true NO20063794L (no)	2006-12-12

Family

ID=34957074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20063794A NO20063794L (no)	2004-03-12	2006-08-24	Tetrahydroisoquinolin- og tetrahydrobenzazepin-derivater som IGF-1R-inhibitorer

Country Status (21)

Country	Link
US (1)	US7875631B2 (pt)
EP (1)	EP1732898B1 (pt)
JP (1)	JP2007528877A (pt)
CN (1)	CN100590118C (pt)
AR (1)	AR049323A1 (pt)
AT (1)	ATE384700T1 (pt)
AU (1)	AU2004317166B2 (pt)
BR (1)	BRPI0418462A (pt)
CA (1)	CA2555745C (pt)
DE (1)	DE602004011578T2 (pt)
DK (1)	DK1732898T3 (pt)
EA (1)	EA200601687A1 (pt)
ES (1)	ES2299825T3 (pt)
IL (1)	IL177307A (pt)
NO (1)	NO20063794L (pt)
PL (1)	PL1732898T3 (pt)
PT (1)	PT1732898E (pt)
SI (1)	SI1732898T1 (pt)
TW (1)	TW200530213A (pt)
WO (1)	WO2005087743A1 (pt)
ZA (1)	ZA200607198B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE505457T1 (de) *	2005-09-09	2011-04-15	Analytecon Sa	Isochinoline als igf-1r-inhibitoren
AU2006288847A1 (en) *	2005-09-09	2007-03-15	Analytecon Sa	Isoquinolines derivatives as IGF-1R inhibitors
WO2009073203A1 (en)	2007-12-04	2009-06-11	Amgen Inc.	Trp-m8 receptor ligands and their use in treatments
EP2544672A1 (en)	2010-03-09	2013-01-16	OSI Pharmaceuticals, LLC	Combination anti-cancer therapy
CN102958914B (zh) *	2010-07-05	2015-05-27	埃科特莱茵药品有限公司	1-苯基取代的杂环衍生物及其作为前列腺素d2受体调节剂的用途
MX2013008833A (es)	2011-02-02	2013-12-06	Amgen Inc	Metodos y composiciones relacionadas con la inhibicion de receptor del factor de crecimiento similar a la insulina 1 (igf-1r).
WO2013071056A2 (en)	2011-11-11	2013-05-16	Duke University	Combination drug therapy for the treatment of solid tumors
TW201331179A (zh)	2011-12-21	2013-08-01	Actelion Pharmaceuticals Ltd	雜環衍生物及其作為前列腺素ｄ２受體調節劑之用途
CA2876808A1 (en)	2012-07-05	2014-01-09	Actelion Pharmaceuticals Ltd	1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
US8980259B2 (en)	2012-07-20	2015-03-17	Novartis Ag	Combination therapy
CN104672136B (zh) *	2013-11-30	2017-01-25	沈阳药科大学	1‑取代菲基‑n‑烷基(酰基)‑6,7‑二甲氧基‑1,2,3,4‑四氢异喹啉衍生物及其制备方法和用途
WO2017129763A1 (en)	2016-01-28	2017-08-03	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer
CN112500345B (zh) *	2020-12-18	2022-06-21	西安石油大学	α-氰基季碳取代四氢异喹啉化合物的合成方法
WO2024067463A1 (zh) *	2022-09-27	2024-04-04	苏州阿尔脉生物科技有限公司	苯并[7]环烯类衍生物、包含其的药物组合物及其医药用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4349472A (en)	1979-04-27	1982-09-14	Schering Corporation	(S)-8(1-Adamantanecarbonyloxy)-7-chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
PH25651A (en) *	1986-05-21	1991-08-21	Duphar Int Res	New di, tetrahydroisoquinoline derivatives
WO1990002119A1 (fr) *	1988-08-18	1990-03-08	Banyu Pharmaceutical Co., Ltd.	Derives de 1,2,3,4-tetrahydro-isoquinoline
WO2000035455A1 (en) *	1998-12-15	2000-06-22	Telik, Inc.	Heteroaryl-aryl ureas as igf-1 receptor antagonists
EP1113007A1 (en) *	1999-12-24	2001-07-04	Pfizer Inc.	Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
WO2002046164A1 (en) *	2000-12-07	2002-06-13	Astrazeneca Ab	Therapeutic compounds
SE0102168D0 (sv)	2001-06-19	2001-06-19	Karolinska Innovations Ab	New use and new compounds
SE0104140D0 (sv) *	2001-12-07	2001-12-07	Astrazeneca Ab	Novel Compounds
GB0212303D0 (en)	2002-05-28	2002-07-10	Isis Innovation	Molecular targetting of IGF-1 receptor

2004
- 2004-03-12 EP EP04719900A patent/EP1732898B1/en not_active Expired - Lifetime
- 2004-03-12 DK DK04719900T patent/DK1732898T3/da active
- 2004-03-12 PT PT04719900T patent/PT1732898E/pt unknown
- 2004-03-12 ES ES04719900T patent/ES2299825T3/es not_active Expired - Lifetime
- 2004-03-12 US US10/591,174 patent/US7875631B2/en not_active Expired - Fee Related
- 2004-03-12 JP JP2007502162A patent/JP2007528877A/ja active Pending
- 2004-03-12 WO PCT/CH2004/000147 patent/WO2005087743A1/en not_active Ceased
- 2004-03-12 BR BRPI0418462-9A patent/BRPI0418462A/pt not_active IP Right Cessation
- 2004-03-12 PL PL04719900T patent/PL1732898T3/pl unknown
- 2004-03-12 CN CN200480042030A patent/CN100590118C/zh not_active Expired - Fee Related
- 2004-03-12 AU AU2004317166A patent/AU2004317166B2/en not_active Ceased
- 2004-03-12 DE DE602004011578T patent/DE602004011578T2/de not_active Expired - Lifetime
- 2004-03-12 AT AT04719900T patent/ATE384700T1/de active
- 2004-03-12 EA EA200601687A patent/EA200601687A1/ru unknown
- 2004-03-12 CA CA2555745A patent/CA2555745C/en not_active Expired - Fee Related
- 2004-03-12 SI SI200430684T patent/SI1732898T1/sl unknown
2005
- 2005-02-25 TW TW094105813A patent/TW200530213A/zh unknown
- 2005-03-10 AR ARP050100920A patent/AR049323A1/es not_active Application Discontinuation
2006
- 2006-08-06 IL IL177307A patent/IL177307A/en not_active IP Right Cessation
- 2006-08-24 NO NO20063794A patent/NO20063794L/no not_active Application Discontinuation
- 2006-08-29 ZA ZA2006/07198A patent/ZA200607198B/en unknown

Also Published As

Publication number	Publication date
TW200530213A (en)	2005-09-16
PL1732898T3 (pl)	2008-06-30
CN1922147A (zh)	2007-02-28
US20070129399A1 (en)	2007-06-07
DE602004011578T2 (de)	2009-02-19
BRPI0418462A (pt)	2007-06-05
DK1732898T3 (da)	2008-05-13
PT1732898E (pt)	2008-04-07
ES2299825T3 (es)	2008-06-01
EA200601687A1 (ru)	2007-04-27
AU2004317166A1 (en)	2005-09-22
AR049323A1 (es)	2006-07-19
CN100590118C (zh)	2010-02-17
JP2007528877A (ja)	2007-10-18
IL177307A (en)	2011-09-27
EP1732898B1 (en)	2008-01-23
AU2004317166B2 (en)	2010-11-11
EP1732898A1 (en)	2006-12-20
IL177307A0 (en)	2006-12-10
WO2005087743A1 (en)	2005-09-22
CA2555745A1 (en)	2005-09-22
ZA200607198B (en)	2008-04-30
US7875631B2 (en)	2011-01-25
SI1732898T1 (sl)	2008-06-30
DE602004011578D1 (de)	2008-03-13
ATE384700T1 (de)	2008-02-15
CA2555745C (en)	2011-05-31

Legal Events

Date	Code	Title	Description
2016-01-18	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20063794L (no)	2006-12-12	Tetrahydroisoquinolin- og tetrahydrobenzazepin-derivater som IGF-1R-inhibitorer
CY1109722T1 (el)	2014-04-09	Ενδιαμεσες ενωσεις για την παρασκευη της trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,73oxepino[4,5-c]pyrrole
EP2862859A3 (en)	2015-05-06	Compounds, compositions and methods
WO2007090141A3 (en)	2007-11-15	Pyrrolo [2, 3, b] pyridine derivatives useful as raf kinase inhibitors
NO20072608L (no)	2007-06-21	Biaryloksymetylarenkarboksylsyrer
AU2003226572A1 (en)	2003-11-17	Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors
WO2004096798A3 (fr)	2006-01-26	Derives de 2-acylamino-4-phenylthiazole, leur preparation et leur application en therapeutique
ATE508747T1 (de)	2011-05-15	C-kit kinase-hemmer
WO2003076398A3 (en)	2004-02-26	Pyrrole-2, 5-dione derivatives and their use as gsk-3 inhibitors
WO2002096905A8 (en)	2005-07-28	Thiazole compounds useful as inhibitors of protein kinases
WO2007048064A3 (en)	2007-06-21	Amino-pyrimidines as casein kinase ii (ck2) modulators
WO2006011050A3 (en)	2006-10-05	Pyridine derivatives
WO2004064730A3 (en)	2005-03-24	Compounds, compositions and methods
NO20051103L (no)	2005-04-08	Indol-3-karboksamider som Glukokinase-(GK)-Aktivatorer
WO2004043367A3 (en)	2004-10-14	Fused heterocyclic compounds and use thereof
MX2009003821A (es)	2009-05-25	Compuestos de n-aril pirazol para usarse contra la diabetes.
WO2004063151A3 (en)	2004-12-09	Novel tyrosine kinase inhibitors
WO2003095398A3 (en)	2004-09-16	Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
WO2003018059A3 (de)	2003-11-13	Kombinationspräparate von arylsubstituierten propanolaminderivaten mit weiteren wirkstoffen und deren verwendung
WO2007007042A8 (en)	2008-09-12	Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes
WO2002085906A3 (en)	2002-12-19	Phthalazinones derivatives useful as pde4/7 inhibitors
WO2006061417A3 (en)	2006-08-03	Macrocyclic quinazole derivatives and their use as mtki
BRPI0407841A (pt)	2006-11-14	inibidores heterocìclicos de quinase
WO2004043362A3 (en)	2004-08-12	Acyl guanidine compounds and use thereof
WO2006008545A3 (en)	2006-03-30	Thiazole and isothiazole derivatives as protein kinase inhibitors