NO20064000L - Heteroarylkoblede pyrazoloderivater - Google Patents
Heteroarylkoblede pyrazoloderivaterInfo
- Publication number
- NO20064000L NO20064000L NO20064000A NO20064000A NO20064000L NO 20064000 L NO20064000 L NO 20064000L NO 20064000 A NO20064000 A NO 20064000A NO 20064000 A NO20064000 A NO 20064000A NO 20064000 L NO20064000 L NO 20064000L
- Authority
- NO
- Norway
- Prior art keywords
- heteroeryl
- linked
- pyrazolo derivatives
- pyrazolo
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
Abstract
Forbindelser med formel I hvor A, B, X, Y, Z, k, R1, R2 og R3 er de definert her og preparater omfattende disse. Foreliggende oppfinnelse tilveiebringer også metoder for fremstilling av forbindelser med formel I og anvendelse av dem ved behandling av p38 medierte lidelser hos en pasient.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54864204P | 2004-02-27 | 2004-02-27 | |
| PCT/EP2005/001815 WO2005085248A1 (en) | 2004-02-27 | 2005-02-22 | Heteroaryl-fused pyrazolo derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20064000L true NO20064000L (no) | 2006-09-22 |
Family
ID=34919387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20064000A NO20064000L (no) | 2004-02-27 | 2006-09-06 | Heteroarylkoblede pyrazoloderivater |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7452880B2 (no) |
| EP (1) | EP1720878A1 (no) |
| JP (1) | JP2007523936A (no) |
| KR (1) | KR100844864B1 (no) |
| CN (1) | CN1934111A (no) |
| AR (1) | AR048069A1 (no) |
| AU (1) | AU2005219517A1 (no) |
| BR (1) | BRPI0508220A (no) |
| CA (1) | CA2558109A1 (no) |
| IL (1) | IL177259A0 (no) |
| MX (1) | MXPA06009462A (no) |
| NO (1) | NO20064000L (no) |
| RU (1) | RU2006134021A (no) |
| TW (1) | TW200533671A (no) |
| WO (1) | WO2005085248A1 (no) |
| ZA (1) | ZA200606615B (no) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028480A2 (en) * | 2003-09-03 | 2005-03-31 | Neurogen Corporation | 5-aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds |
| KR100844864B1 (ko) | 2004-02-27 | 2008-07-09 | 에프. 호프만-라 로슈 아게 | 헤테로아릴-융합 피라졸로 유도체 |
| JP2007523938A (ja) * | 2004-02-27 | 2007-08-23 | エフ.ホフマン−ラ ロシュ アーゲー | ピラゾールの縮合誘導体 |
| US7405220B2 (en) * | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| ZA200704888B (en) * | 2004-11-22 | 2009-02-25 | Vertex Pharma | Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases |
| GB0427604D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| KR101011956B1 (ko) * | 2005-08-25 | 2011-01-31 | 에프. 호프만-라 로슈 아게 | P38 mαp 키나아제 저해제 및 이의 사용 방법 |
| BRPI0615270A2 (pt) * | 2005-08-25 | 2009-08-04 | Hoffmann La Roche | pirazol fundido como inibidores de p38 map cinase |
| DE102006029074A1 (de) * | 2006-06-22 | 2007-12-27 | Friedrich-Schiller-Universität Jena | 4-Amino-3-arylamino-6-arylpyrazolo[3,4-d]pyrimidin-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung als antivirale Wirkstoffe |
| TW200831085A (en) * | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| CN101558072A (zh) | 2006-12-19 | 2009-10-14 | 霍夫曼-拉罗奇有限公司 | 吡唑并[3,4-d]嘧啶p38map激酶抑制剂 |
| WO2008104473A2 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Pyrazolopyriidine derivatives and their use as kinase inhibitors |
| WO2008112695A2 (en) * | 2007-03-12 | 2008-09-18 | Irm Llc | Pyrazolo [3,4-d] pyrimidines and 1, 2, 5, 6-tetraaza- as- indacenes as protein kinase inhibitors for cancer treatment |
| GB2467670B (en) | 2007-10-04 | 2012-08-01 | Intellikine Inc | Chemical entities and therapeutic uses thereof |
| US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
| JP5547099B2 (ja) | 2008-03-14 | 2014-07-09 | インテリカイン, エルエルシー | キナーゼ阻害剤および使用方法 |
| US8119637B2 (en) | 2008-06-10 | 2012-02-21 | Plexxikon Inc. | Substituted pyrrolo[2,3-b]pyrazines and methods for kinase modulation, and indications therefor |
| AU2009268611B2 (en) | 2008-07-08 | 2015-04-09 | Intellikine, Llc | Kinase inhibitors and methods of use |
| US8220787B2 (en) * | 2008-09-19 | 2012-07-17 | Panasonic Corporation | Part mounting device |
| US8476282B2 (en) | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
| WO2010111527A1 (en) * | 2009-03-26 | 2010-09-30 | Plexxikon, Inc. | Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use |
| MY162604A (en) | 2009-08-17 | 2017-06-30 | Intellikine Llc | Heterocyclic compounds and uses thereof |
| US20120232062A1 (en) * | 2009-10-20 | 2012-09-13 | Eiger Biopharmaceuticals, Inc. | Azaindazoles to treat flaviviridae virus infection |
| AU2011209649A1 (en) * | 2010-01-27 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
| AU2011337041B2 (en) | 2010-12-02 | 2015-05-14 | Eli Lilly And Company | 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
| JP6130305B2 (ja) | 2011-02-23 | 2017-05-17 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| EA025496B1 (ru) * | 2011-05-17 | 2016-12-30 | Принсипиа Биофарма Инк. | Ингибиторы тирозинкиназы |
| TW201341367A (zh) | 2012-03-16 | 2013-10-16 | Axikin Pharmaceuticals Inc | 3,5-二胺基吡唑激酶抑制劑 |
| LT3495367T (lt) | 2012-06-13 | 2021-02-25 | Incyte Holdings Corporation | Pakeistieji tricikliniai junginiai, kaip fgfr inhibitoriai |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| WO2014153509A1 (en) | 2013-03-22 | 2014-09-25 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase |
| LT2986610T (lt) | 2013-04-19 | 2018-04-10 | Incyte Holdings Corporation | Bicikliniai heterociklai, kaip fgfr inhibitoriai |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CN105622613B (zh) * | 2014-11-14 | 2019-03-12 | 安礼特(上海)医药科技有限公司 | 一种合成伊鲁替尼的方法 |
| HUE049801T2 (hu) | 2014-12-23 | 2020-10-28 | Sma Therapeutics Inc | 3,5-diaminopirazol kináz inhibitorok |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| SG11201706287PA (en) | 2015-02-20 | 2017-09-28 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| JP7044375B2 (ja) * | 2016-05-31 | 2022-03-30 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | Ptpn11の複素環式阻害剤 |
| AR109595A1 (es) | 2016-09-09 | 2018-12-26 | Incyte Corp | Compuestos de pirazolopirimidina y usos de estos como inhibidores de hpk1 |
| IL292977A (en) | 2016-09-09 | 2022-07-01 | Incyte Corp | Pyrazolopyridine derivatives as modulators of hpk1 and their use in cancer therapy |
| US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| US10280164B2 (en) | 2016-09-09 | 2019-05-07 | Incyte Corporation | Pyrazolopyridone compounds and uses thereof |
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| CN108570052A (zh) * | 2017-03-13 | 2018-09-25 | 中国科学院上海药物研究所 | 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用 |
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2005
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- 2005-02-22 EP EP05715442A patent/EP1720878A1/en not_active Withdrawn
- 2005-02-22 MX MXPA06009462A patent/MXPA06009462A/es not_active Application Discontinuation
- 2005-02-22 CA CA002558109A patent/CA2558109A1/en not_active Abandoned
- 2005-02-22 AU AU2005219517A patent/AU2005219517A1/en not_active Abandoned
- 2005-02-22 CN CNA2005800063457A patent/CN1934111A/zh active Pending
- 2005-02-22 RU RU2006134021/04A patent/RU2006134021A/ru unknown
- 2005-02-22 WO PCT/EP2005/001815 patent/WO2005085248A1/en not_active Ceased
- 2005-02-22 JP JP2007500126A patent/JP2007523936A/ja active Pending
- 2005-02-22 BR BRPI0508220-0A patent/BRPI0508220A/pt not_active IP Right Cessation
- 2005-02-23 TW TW094105458A patent/TW200533671A/zh unknown
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- 2006-08-08 ZA ZA200606615A patent/ZA200606615B/xx unknown
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| US7452880B2 (en) | 2008-11-18 |
| AU2005219517A1 (en) | 2005-09-15 |
| MXPA06009462A (es) | 2007-03-15 |
| IL177259A0 (en) | 2006-12-10 |
| KR20060117359A (ko) | 2006-11-16 |
| CN1934111A (zh) | 2007-03-21 |
| AR048069A1 (es) | 2006-03-29 |
| CA2558109A1 (en) | 2005-09-15 |
| WO2005085248A1 (en) | 2005-09-15 |
| KR100844864B1 (ko) | 2008-07-09 |
| US20050203091A1 (en) | 2005-09-15 |
| ZA200606615B (en) | 2008-02-27 |
| BRPI0508220A (pt) | 2007-07-17 |
| TW200533671A (en) | 2005-10-16 |
| EP1720878A1 (en) | 2006-11-15 |
| JP2007523936A (ja) | 2007-08-23 |
| RU2006134021A (ru) | 2008-04-10 |
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