BRPI0508220A - derivados de pirazol heteroarila fundidos - Google Patents

derivados de pirazol heteroarila fundidos

Info

Publication number
BRPI0508220A
BRPI0508220A BRPI0508220-0A BRPI0508220A BRPI0508220A BR PI0508220 A BRPI0508220 A BR PI0508220A BR PI0508220 A BRPI0508220 A BR PI0508220A BR PI0508220 A BRPI0508220 A BR PI0508220A
Authority
BR
Brazil
Prior art keywords
pyrazole derivatives
fused heteroaryl
heteroaryl pyrazole
formula
compounds
Prior art date
Application number
BRPI0508220-0A
Other languages
English (en)
Inventor
Nidhi Arora
Roland Joseph Billedeau
Nolan James Dewdney
Tobias Gabriel
David Michael Goldstein
Kristen Lynn Mccaleb
Michael Soth
Teresa Alejandra Trejo-Martin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0508220A publication Critical patent/BRPI0508220A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Rheumatology (AREA)
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  • Endocrinology (AREA)
  • Hematology (AREA)
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  • Dermatology (AREA)
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  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)

Abstract

DERIVADOS DE PIRAZOL HETEROARILA FUNDIDOS. Compostos da fórmula (I): onde A, B, X, Y, Z, k, R¬1¬ , R¬2¬ , e R¬3¬ são aqueles definidos aqui e composições compreendendo os mesmo. A presente invenção também provê métodos para preparação de compostos da fórmula (I) e uso dos mesmos no tratamento de distúrbios mediados por p38 em um paciente.
BRPI0508220-0A 2004-02-27 2005-02-22 derivados de pirazol heteroarila fundidos BRPI0508220A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54864204P 2004-02-27 2004-02-27
PCT/EP2005/001815 WO2005085248A1 (en) 2004-02-27 2005-02-22 Heteroaryl-fused pyrazolo derivatives

Publications (1)

Publication Number Publication Date
BRPI0508220A true BRPI0508220A (pt) 2007-07-17

Family

ID=34919387

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0508220-0A BRPI0508220A (pt) 2004-02-27 2005-02-22 derivados de pirazol heteroarila fundidos

Country Status (16)

Country Link
US (1) US7452880B2 (pt)
EP (1) EP1720878A1 (pt)
JP (1) JP2007523936A (pt)
KR (1) KR100844864B1 (pt)
CN (1) CN1934111A (pt)
AR (1) AR048069A1 (pt)
AU (1) AU2005219517A1 (pt)
BR (1) BRPI0508220A (pt)
CA (1) CA2558109A1 (pt)
IL (1) IL177259A0 (pt)
MX (1) MXPA06009462A (pt)
NO (1) NO20064000L (pt)
RU (1) RU2006134021A (pt)
TW (1) TW200533671A (pt)
WO (1) WO2005085248A1 (pt)
ZA (1) ZA200606615B (pt)

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US7452880B2 (en) 2008-11-18
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