NO20065609L - Piperazinderivater av alkyloksindoler. - Google Patents

Piperazinderivater av alkyloksindoler.

Info

Publication number
NO20065609L
NO20065609L NO20065609A NO20065609A NO20065609L NO 20065609 L NO20065609 L NO 20065609L NO 20065609 A NO20065609 A NO 20065609A NO 20065609 A NO20065609 A NO 20065609A NO 20065609 L NO20065609 L NO 20065609L
Authority
NO
Norway
Prior art keywords
alkyloxindoles
piperazine derivatives
derivatives
prophylaxis
therapy
Prior art date
Application number
NO20065609A
Other languages
English (en)
Inventor
Jozsef Barkoczy
Tibor Mezei
Gyula Simig
Balazs Volk
Dezsofi Rita Kapillerne
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of NO20065609L publication Critical patent/NO20065609L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Det tilveiebringes nye indol-2-onderivater med Formel (I). Forbindelsene har en gunstig aktivitetsprofil for profylakse og terapi av forstyrrelser i sentralnervesystemet eller det kardiovaskulære system.
NO20065609A 2004-05-11 2006-12-05 Piperazinderivater av alkyloksindoler. NO20065609L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0400953A HUP0400953A3 (en) 2004-05-11 2004-05-11 Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
PCT/HU2005/000050 WO2005108364A1 (en) 2004-05-11 2005-05-11 Piperazine derivatives of alkyl oxindoles

Publications (1)

Publication Number Publication Date
NO20065609L true NO20065609L (no) 2007-02-05

Family

ID=89982207

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065609A NO20065609L (no) 2004-05-11 2006-12-05 Piperazinderivater av alkyloksindoler.

Country Status (27)

Country Link
US (1) US7910591B2 (no)
EP (1) EP1751105B1 (no)
JP (1) JP2007537227A (no)
CN (1) CN101010296B (no)
AT (1) ATE412633T1 (no)
AU (1) AU2005240843B2 (no)
BG (1) BG109769A (no)
CA (1) CA2566096A1 (no)
CZ (1) CZ2006779A3 (no)
DE (1) DE602005010693D1 (no)
DK (1) DK1751105T3 (no)
EA (1) EA010789B1 (no)
ES (1) ES2319795T3 (no)
HR (1) HRP20060420A2 (no)
HU (1) HUP0400953A3 (no)
IL (1) IL179028A (no)
MX (1) MXPA06013068A (no)
NO (1) NO20065609L (no)
NZ (1) NZ551545A (no)
PL (2) PL1751105T3 (no)
PT (1) PT1751105E (no)
RS (1) RS20060621A (no)
SI (1) SI1751105T1 (no)
SK (1) SK51102006A3 (no)
UA (1) UA84927C2 (no)
WO (1) WO2005108364A1 (no)
ZA (1) ZA200610345B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use
CN104163813B (zh) * 2013-05-16 2017-02-01 广东东阳光药业有限公司 取代的吲哚化合物及其使用方法和用途
WO2016192657A1 (en) 2015-06-03 2016-12-08 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
MX173362B (es) * 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
FR2635104B1 (fr) 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
WO1998008816A1 (en) 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Oxindole derivatives and psychotropic drugs
HUP0400953A3 (en) * 2004-05-11 2008-02-28 Egis Gyogyszergyar Nyilvanosan Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use

Also Published As

Publication number Publication date
WO2005108364A1 (en) 2005-11-17
CN101010296B (zh) 2011-08-17
IL179028A (en) 2011-08-31
HRP20060420A2 (en) 2007-04-30
BG109769A (bg) 2008-03-31
EP1751105B1 (en) 2008-10-29
EA010789B1 (ru) 2008-10-30
PL1751105T3 (pl) 2009-07-31
PT1751105E (pt) 2009-02-10
ES2319795T3 (es) 2009-05-12
DK1751105T3 (da) 2009-03-09
MXPA06013068A (es) 2007-05-04
EP1751105A1 (en) 2007-02-14
RS20060621A (sr) 2008-09-29
HUP0400953A2 (en) 2007-09-28
UA84927C2 (en) 2008-12-10
US20080161323A1 (en) 2008-07-03
JP2007537227A (ja) 2007-12-20
AU2005240843A1 (en) 2005-11-17
CA2566096A1 (en) 2005-11-17
NZ551545A (en) 2010-07-30
SK51102006A3 (sk) 2007-05-03
PL381615A1 (pl) 2007-06-11
IL179028A0 (en) 2007-03-08
CZ2006779A3 (cs) 2007-03-07
CN101010296A (zh) 2007-08-01
DE602005010693D1 (de) 2008-12-11
SI1751105T1 (sl) 2009-06-30
AU2005240843B2 (en) 2012-02-02
US7910591B2 (en) 2011-03-22
ZA200610345B (en) 2008-05-28
EA200602084A1 (ru) 2007-04-27
ATE412633T1 (de) 2008-11-15
HUP0400953A3 (en) 2008-02-28
HU0400953D0 (en) 2004-07-28

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