NO20070114L - Fremstilling av makromolekylaere konjugater ved firekomponent kondensasjonsreaksjon - Google Patents

Fremstilling av makromolekylaere konjugater ved firekomponent kondensasjonsreaksjon

Info

Publication number
NO20070114L
NO20070114L NO20070114A NO20070114A NO20070114L NO 20070114 L NO20070114 L NO 20070114L NO 20070114 A NO20070114 A NO 20070114A NO 20070114 A NO20070114 A NO 20070114A NO 20070114 L NO20070114 L NO 20070114L
Authority
NO
Norway
Prior art keywords
conjugates
condensation reaction
preparation
component condensation
macromolecular conjugates
Prior art date
Application number
NO20070114A
Other languages
English (en)
Inventor
Samuel Zalipsky
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of NO20070114L publication Critical patent/NO20070114L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyethers (AREA)

Abstract

Polymere biomolekylkonjugater er fremstilt, generelt på en setespesifikk eller selektiv måte, ved en firekomponents kondensasjonsreaksjon. Fremgangsmåten kan anvendes for fremstilling av konjugater som har to polymere molekyler tilfestet ved et enkelt sete på et biomolekyl. Konjugatene er typisk vaimløselige og har fordelaktige farmakologiske egenskaper, slik som redusert immunogenisitet og økt sirkulasjonstid.
NO20070114A 2004-06-08 2007-01-08 Fremstilling av makromolekylaere konjugater ved firekomponent kondensasjonsreaksjon NO20070114L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57819904P 2004-06-08 2004-06-08
PCT/US2005/020138 WO2005123140A2 (en) 2004-06-08 2005-06-08 Preparation of macromolecular conjugates by four-component condensation reaction

Publications (1)

Publication Number Publication Date
NO20070114L true NO20070114L (no) 2007-01-08

Family

ID=35355954

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070114A NO20070114L (no) 2004-06-08 2007-01-08 Fremstilling av makromolekylaere konjugater ved firekomponent kondensasjonsreaksjon

Country Status (12)

Country Link
US (1) US7476725B2 (no)
EP (1) EP1761282A2 (no)
JP (1) JP2008502788A (no)
KR (1) KR20070027621A (no)
CN (1) CN1997401A (no)
AU (1) AU2005253979A1 (no)
CA (1) CA2568388A1 (no)
IL (1) IL179303A0 (no)
MX (1) MXPA06014307A (no)
NO (1) NO20070114L (no)
WO (1) WO2005123140A2 (no)
ZA (1) ZA200609930B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505853A (ja) 2004-04-13 2008-02-28 クインテセンス バイオサイエンシーズ インコーポレーティッド 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体
US20090306349A1 (en) * 2006-03-31 2009-12-10 Rampak Corp Binding partners with immunoglobulin domains modified to have extended half-life
EP2089052A4 (en) * 2006-05-24 2011-02-16 Peg Biosciences POLYETHYLENE GLYCOL-BASED LINK COMPOUNDS AND BIOLOGICALLY ACTIVE CONJUGATES BASED ON SAID COMPOUNDS
US8840882B2 (en) 2006-06-23 2014-09-23 Quintessence Biosciences, Inc. Modified ribonucleases
BRPI0713963A2 (pt) * 2006-07-07 2012-11-27 Novo Nordisk Healthcare Ag conjugados de proteìna e métodos para sua preparação
WO2008010991A2 (en) 2006-07-17 2008-01-24 Quintessence Biosciences, Inc. Methods and compositions for the treatment of cancer
WO2009048909A1 (en) * 2007-10-08 2009-04-16 Quintessence Biosciences, Inc. Compositions and methods for ribonuclease-based therapies
KR100967833B1 (ko) * 2008-05-20 2010-07-05 아이디비켐(주) 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법
BRPI0920743A2 (pt) 2008-10-01 2016-09-20 Quintessence Biosciences Inc ribonucleases terapeuticas
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
WO2012171020A1 (en) * 2011-06-10 2012-12-13 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
JP5841768B2 (ja) * 2011-08-05 2016-01-13 花王株式会社 脂肪蓄積抑制剤

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en) * 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US5103556A (en) * 1988-05-05 1992-04-14 Circon Corporation Method of manufacturing an electrohydraulic probe
US4902502A (en) * 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
ES2136595T5 (es) 1989-04-19 2004-04-01 Enzon, Inc. Carbonatos activos de oxidos de polialquileno para la modificacion de polipeptidos.
DK0400472T3 (da) 1989-05-27 1996-05-13 Sumitomo Pharma Fremgangsmåde til fremstilling af polyethylenglycolderivater og modificeret protein
JP3202744B2 (ja) * 1989-05-27 2001-08-27 住友製薬株式会社 ポリエチレングリコール誘導体を含有する蛋白質修飾試薬
US5286637A (en) * 1989-08-07 1994-02-15 Debiopharm, S.A. Biologically active drug polymer derivatives and method for preparing same
JPH06506217A (ja) 1991-03-18 1994-07-14 エンゾン，インコーポレーテッド ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
US5395619A (en) * 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US5932462A (en) * 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
EP0964702B1 (en) * 1996-08-02 2006-10-04 Ortho-McNeil Pharmaceutical, Inc. Polypeptides having a single covalently bound n-terminal water-soluble polymer
DE19636538A1 (de) * 1996-09-09 1998-03-12 Bayer Ag Substituierte Aminosäurederivate
HU226867B1 (en) * 1997-05-14 2009-12-28 Morphochem Ag Method for producing polymers having nucleo-bases as side-groups
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
JP2000146971A (ja) * 1998-11-10 2000-05-26 Nisshinbo Ind Inc 生物学的活性物質の固定化用担体
EP1006767B1 (en) * 1998-11-30 2006-06-07 Omron Corporation Electronic component comprising a control unit with a battery holder including a battery reverse insertion prevention means
SE519326C2 (sv) 1999-11-22 2003-02-11 Astrazeneca Ab Funktionaliserade polymera reagens innefattande en syralabil isonitrildel samt förfarande för dess framställning
WO2001093914A2 (en) * 2000-06-08 2001-12-13 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
DE10150077B4 (de) * 2001-10-10 2004-07-29 Morphochem Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung polymergebundener Isonitrile
DE10162134A1 (de) * 2001-12-18 2003-07-10 Morphochem Ag Ag Fuer Kombinat Harzgebundene Isonitrile
DE10326303A1 (de) * 2003-06-11 2004-12-30 Celares Gmbh Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung
JP2005146068A (ja) * 2003-11-13 2005-06-09 Japan Science & Technology Agency アルコキシアセチル基を構成するカルボン酸修飾されたモノメチルエーテルポリエチレングリコールポリマーの利用、前記ポリマーからの誘導体化合物類

Also Published As

Publication number Publication date
US20050287113A1 (en) 2005-12-29
WO2005123140A3 (en) 2006-08-03
AU2005253979A1 (en) 2005-12-29
IL179303A0 (en) 2007-03-08
EP1761282A2 (en) 2007-03-14
MXPA06014307A (es) 2007-03-12
WO2005123140A2 (en) 2005-12-29
CA2568388A1 (en) 2005-12-29
CN1997401A (zh) 2007-07-11
US7476725B2 (en) 2009-01-13
KR20070027621A (ko) 2007-03-09
ZA200609930B (en) 2009-01-28
JP2008502788A (ja) 2008-01-31

Similar Documents

Publication Publication Date Title
NO20070114L (no) Fremstilling av makromolekylaere konjugater ved firekomponent kondensasjonsreaksjon
DK2213678T3 (da) Fremgangsmåde til fremstilling af opløst lignin, saccharidråmateriale og monosaccharidråmateriale såvel som opløst lignin
EP2415820A3 (en) Method of changing the molecular structure of biomass
NO20075756L (no) Fremstilling av enzymbestandig stivelse ved ekstrudering
WO2007000343A3 (en) Process for manufacturing vaccines
DK1940918T3 (da) Dimercaptanterminerede polythioetherpolymerer og fremgangsmåder til at fremstille og anvende samme
BRPI1015952B8 (pt) Método de introdução de uma nuclease sequência-específica (ssn) em uma célula vegetal
NO20064631L (no) Konjugater av hydroksyalkylstivelse og et protein fremstilt ved reduktiv aminering
SE0401270D0 (sv) Method for amplifying specific nucleic acids in parallel
BRPI0413323B8 (pt) método para a preparação de uma vacina meningocócica conjugada ao toxóide tetânico em volumes comerciais
BRPI0813913A2 (pt) Molécula de ácido nucleico, sequência de ácido nucleico recombinante, célula hospedeira, métodos para produzir fsh humano recombinante, e para produzir a célula hospedeira, e, uso de uma sequência de ácido nucleico.
NO20064068L (no) Svellbare partikler
AR053827A1 (es) Composiciones de tigeciclina y metodos de preparacion
NO20083198L (no) Totrinns kur polyimidoligomerer
EP1654302A4 (en) THERMOSTATIC POLY (ORGANOPHOSPHAZENE), METHOD OF MANUFACTURING THEREOF AND INJECTABLE HEAT-SENSITIVE POLYPHOSPHAZENHYDROGELES THEREWITH
NO20080062L (no) Fremgangsmate for pavisning av mikroorganisme og kit for pavisning av mikroorganisme
FR2920775B1 (fr) Nouveaux composes diaminophenothiazine, leur procede de preparation et leurs utilisations.
UA103597C2 (xx) Тразодон та гідрохлорид тразодону в очищеній формі$тразодон и гидрохлорид тразодона в очищенной форме
NO20062275L (no) Fremgangsmate for a modifisere stivelse og stivelsesderivater
MX2008015689A (es) Inulina de agave altamente soluble en agua, producto que contiene inulina de agave, producto originado de inulina de agave, subproducto y el metodo para la produccion de las mismas.
BRPI0818432A2 (pt) Bactéria fermentativa capaz de fermentar glicose, manose e xilose simultaneamente, e, processo para produzir etanol
WO2006101387A3 (en) Method for interfering with blood coagulation by modulating cross-beta structures fibril formation
FR2919205B1 (fr) Membranes zeolithique supportees de type structural fau, leur procede de preparation et leurs applications.
EP2576670A4 (en) MECHANICALLY STABILIZED POLYAZOLE
IS8943A (is) Aðferð við framleiðslu á metanoli og afurðum þess eingöngu úr innihaldi jarðvarma og með orku hans.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application