NO20070686L - 17-Desmetylrapamucin og analoger av det, framgangsmater for framstilling av disse, og bruk av disse som immunosupressanter, antikreft-forbindelser, soppdrepende forbindelser, osv - Google Patents

17-Desmetylrapamucin og analoger av det, framgangsmater for framstilling av disse, og bruk av disse som immunosupressanter, antikreft-forbindelser, soppdrepende forbindelser, osv

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Publication number
NO20070686L
NO20070686L NO20070686A NO20070686A NO20070686L NO 20070686 L NO20070686 L NO 20070686L NO 20070686 A NO20070686 A NO 20070686A NO 20070686 A NO20070686 A NO 20070686A NO 20070686 L NO20070686 L NO 20070686L
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NO
Norway
Prior art keywords
compounds
analogs
diseases
processes
desmethylrapamucine
Prior art date
Application number
NO20070686A
Other languages
English (en)
Norwegian (no)
Inventor
Matthew Alan Gregory
Christine Janet Martin
Original Assignee
Biotica Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of NO20070686L publication Critical patent/NO20070686L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20070686A 2004-08-11 2007-02-06 17-Desmetylrapamucin og analoger av det, framgangsmater for framstilling av disse, og bruk av disse som immunosupressanter, antikreft-forbindelser, soppdrepende forbindelser, osv NO20070686L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0417852.1A GB0417852D0 (en) 2004-08-11 2004-08-11 Production of polyketides and other natural products
PCT/GB2005/003158 WO2006016167A2 (en) 2004-08-11 2005-08-11 17-desmethylrapamycin and analogues thereof, methods for their roduction and their use as immunosupressants, anticancer agents, antifungal agents, etc.

Publications (1)

Publication Number Publication Date
NO20070686L true NO20070686L (no) 2007-04-25

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NO20070686A NO20070686L (no) 2004-08-11 2007-02-06 17-Desmetylrapamucin og analoger av det, framgangsmater for framstilling av disse, og bruk av disse som immunosupressanter, antikreft-forbindelser, soppdrepende forbindelser, osv

Country Status (19)

Country Link
US (1) US7803808B2 (pt)
EP (2) EP2029611A2 (pt)
JP (1) JP2008509895A (pt)
KR (1) KR20070052784A (pt)
CN (2) CN101056880A (pt)
AU (1) AU2005270989B2 (pt)
BR (1) BRPI0514236A (pt)
CA (1) CA2575582A1 (pt)
CR (1) CR8990A (pt)
EC (1) ECSP077303A (pt)
GB (1) GB0417852D0 (pt)
IL (1) IL181171A0 (pt)
MX (1) MX2007001809A (pt)
NO (1) NO20070686L (pt)
NZ (1) NZ553074A (pt)
RU (2) RU2430922C2 (pt)
UA (1) UA95895C2 (pt)
WO (1) WO2006016167A2 (pt)
ZA (1) ZA200701622B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504994D0 (en) 2005-03-11 2005-04-20 Biotica Tech Ltd Novel compounds
WO2006095173A2 (en) * 2005-03-11 2006-09-14 Biotica Technology Limited Medical uses of 39-desmethoxyrapamycin and analogues thereof
NZ561647A (en) * 2005-03-11 2011-01-28 Biotica Tech Ltd Medical uses of 39-desmethoxyrapamycin and analogues thereof
GB0609963D0 (en) * 2006-05-19 2006-06-28 Biotica Tech Ltd Novel compounds
WO2007144876A1 (en) * 2006-06-12 2007-12-21 Ramot At Tel-Aviv University Ltd. Methods for treating cancer
US8063075B2 (en) 2008-06-10 2011-11-22 Hoffmann-La Roche Inc. Pyrrolidine ether derivatives as NK3 receptor antagonists
US9250237B2 (en) 2010-11-30 2016-02-02 The Johns Hopkins University Hybrid cyclic libraries and screens thereof
GB201122305D0 (en) 2011-12-23 2012-02-01 Biotica Tech Ltd Novel compound
WO2014100742A2 (en) 2012-12-21 2014-06-26 The Regents Of The University Of California Modulation of expression of acyltransferases to modify hydroxycinnamic acid content
GB201312318D0 (en) 2013-07-09 2013-08-21 Isomerase Therapeutics Ltd Novel methods and compounds
US11708391B2 (en) 2016-02-04 2023-07-25 The Johns Hopkins University Rapaglutins, novel inhibitors of GLUT and use thereof
JP6891183B2 (ja) * 2016-02-04 2021-06-18 ザ・ジョンズ・ホプキンス・ユニバーシティ ラパフシン・ライブラリの合成と組成物
MX380313B (es) 2016-02-04 2025-03-12 Univ Johns Hopkins Rapadocinas, inhibidores de transportador 1 de nucleósido equilibrador y usos de los mismos.
US11066416B2 (en) 2016-02-04 2021-07-20 The Johns Hopkins University Rapafucin derivative compounds and methods of use thereof
JP2020507632A (ja) * 2017-02-10 2020-03-12 マウント タム セラピューティクス, インコーポレイテッドMount Tam Therapeutics, Inc. ラパマイシン類似体
CN108456213B (zh) * 2017-02-22 2021-01-15 浙江九洲药业股份有限公司 一种3-氟-4-羟基环己烷羧酸酯的制备方法
CN107629994B (zh) * 2017-10-25 2021-11-02 中国科学院上海有机化学研究所 一种构建fk520高产工程菌株的方法和吸水链霉菌高产菌株
WO2020076738A2 (en) * 2018-10-12 2020-04-16 Bellicum Pharmaceuticals, Inc Protein-binding compounds
CN109467579B (zh) * 2018-11-01 2021-10-15 海南大学 一种具有免疫抑制活性的pks i型聚酮类化合物及其制备方法和应用
CN110627702B (zh) * 2019-10-18 2022-11-15 福建师范大学 聚酮化合物及其制备方法和用途
EP3854349A1 (en) 2020-01-23 2021-07-28 Kardiozis SAS Endoprosthesis and method of manufacturing an endoprosthesis
EP3854350A1 (en) 2020-01-23 2021-07-28 Kardiozis SAS Endoprosthesis and method of manufacturing an endoprosthesis
EP3854348A1 (en) 2020-01-23 2021-07-28 Kardiozis SAS Endoprosthesis and method of attaching a fiber to a surface
CN115125179B (zh) * 2021-03-26 2023-10-27 上海医药工业研究院 产雷帕霉素的基因工程菌及其应用
US20230104503A1 (en) * 2021-06-25 2023-04-06 The Regents Of The University Of California Small molecule compounds
KR102774027B1 (ko) * 2021-12-09 2025-02-27 국립낙동강생물자원관 항암, 항적조 및 항염증 활성을 가지는 민물해면 분리 마이크로모노스포라 속 ms-62 균주 및 이의 용도
CN118324775B (zh) * 2024-03-01 2025-03-21 中山大学附属第五医院 一种聚酮化合物及其在制备抗肺纤维化的药物中的应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US3993479A (en) 1975-08-04 1976-11-23 Olin Corporation Copper base alloy
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447223A (en) 1982-04-16 1984-05-08 Cct Associates Medicament implant applicator
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US5109112A (en) 1989-01-19 1992-04-28 Merck & Co., Inc. FK-506 cytosolic binding protein
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5023262A (en) 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
US5221670A (en) 1990-09-19 1993-06-22 American Home Products Corporation Rapamycin esters
US5138051A (en) 1991-08-07 1992-08-11 American Home Products Corporation Rapamycin analogs as immunosuppressants and antifungals
CA2102116A1 (en) 1991-05-31 1992-12-01 Gary R. Schulte Use of rapamycin prodrugs as immunosuppressant agents
US5763590A (en) 1991-10-11 1998-06-09 Vertex Pharmaceuticals, Inc. Isolation of an Mr 52,000 FK506 binding protein and molecular cloning of a corresponding human cDNA
US5498597A (en) 1992-01-17 1996-03-12 Dana-Farber Cancer Institute, Inc. FKBP-13, an FK506-binding immunophilin
ZA935112B (en) 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
CA2106034A1 (en) 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
GB9221220D0 (en) 1992-10-09 1992-11-25 Sandoz Ag Organic componds
US5354845A (en) 1993-04-21 1994-10-11 Children's Research Institute FK-506 and rapamycin specific binding immunophilin
US5378836A (en) 1993-10-08 1995-01-03 American Home Products Corporation Rapamycin oximes and hydrazones
US5391730A (en) 1993-10-08 1995-02-21 American Home Products Corporation Phosphorylcarbamates of rapamycin and oxime derivatives thereof
US5373014A (en) 1993-10-08 1994-12-13 American Home Products Corporation Rapamycin oximes
SK78196A3 (en) 1993-12-17 1997-02-05 Sandoz Ag Rapamycin demethoxy-derivatives, preparation method thereof and pharmaceutical agent containing them
US5457182A (en) 1994-02-15 1995-10-10 Merck & Co., Inc. FK-506 cytosolic binding protein, FKBP12.6
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5563145A (en) 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
US5985890A (en) 1995-06-09 1999-11-16 Novartis Ag Rapamycin derivatives
US5780462A (en) 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
GB9710962D0 (en) * 1997-05-28 1997-07-23 Univ Cambridge Tech Polyketides and their synthesis
ES2244001T3 (es) 1996-07-05 2005-12-01 Biotica Technology Limited Eritromicinas y procedimiento para su preparacion.
PT956034E (pt) 1996-07-30 2002-12-31 Novartis Ag Composicoes farmaceuticas para o tratamento da rejeicao de transplantes estados inflamatorios ou auto-imunes compreendendo ciclosporina a e 40-o-(2-hidroxietil)-rapamicina
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
GB9814006D0 (en) 1998-06-29 1998-08-26 Biotica Tech Ltd Polyketides and their synthesis
GB9814622D0 (en) 1998-07-06 1998-09-02 Biotica Tech Ltd Polyketides,their preparation,and materials for use therein
CA2377918A1 (en) 1999-07-09 2001-01-18 Bruce G. Gold Compositions and methods for promoting nerve regeneration
ATE264863T1 (de) * 1999-08-24 2004-05-15 Ariad Gene Therapeutics Inc 28-epirapaloge
DE60033965T2 (de) * 1999-10-29 2008-01-10 Kosan Biosciences, Inc., Hayward Rapamycin analoge
AU4858801A (en) 2000-04-13 2001-10-30 Biotica Tech Ltd Hybrid glycosylated products and their production and use
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
GB0019986D0 (en) 2000-08-14 2000-10-04 Biotica Tech Ltd Polyketides and their synthesis
GB0125043D0 (en) 2001-10-17 2001-12-12 Biotica Tech Ltd Production, detection and use of transformant cells
GB0128680D0 (en) 2001-11-29 2002-01-23 Biotica Tech Ltd Hybrid glycosylated products and their production and use
IL163529A0 (en) 2002-02-19 2005-12-18 Dow Agrosciences Llc Novel spinosyn-producing polyketidesynthases
CA2492153C (en) * 2002-07-16 2012-05-08 Biotica Technology Limited Production of polyketide fkbp-ligand analogues

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US7803808B2 (en) 2010-09-28
ZA200701622B (en) 2008-06-25
AU2005270989A1 (en) 2006-02-16
RU2007108772A (ru) 2008-09-20
GB0417852D0 (en) 2004-09-15
AU2005270989B2 (en) 2012-04-05
UA95895C2 (ru) 2011-09-26
IL181171A0 (en) 2007-07-04
EP2471797A3 (en) 2012-10-17
MX2007001809A (es) 2007-10-08
KR20070052784A (ko) 2007-05-22
RU2430922C2 (ru) 2011-10-10
CR8990A (es) 2009-01-14
CN101056880A (zh) 2007-10-17
ECSP077303A (es) 2007-04-26
NZ553074A (en) 2011-01-28
EP2471797B1 (en) 2016-02-03
JP2008509895A (ja) 2008-04-03
US20090253732A1 (en) 2009-10-08
EP2471797A2 (en) 2012-07-04
WO2006016167A3 (en) 2006-04-13
BRPI0514236A (pt) 2008-06-03
EP2029611A2 (en) 2009-03-04
RU2009140290A (ru) 2011-05-10
CA2575582A1 (en) 2006-02-16
WO2006016167A2 (en) 2006-02-16
CN101805748A (zh) 2010-08-18

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