NO20071524L - Fremgangsmate for enantioselektiv fremstilling av sulfoksid-derivater - Google Patents

Fremgangsmate for enantioselektiv fremstilling av sulfoksid-derivater

Info

Publication number
NO20071524L
NO20071524L NO20071524A NO20071524A NO20071524L NO 20071524 L NO20071524 L NO 20071524L NO 20071524 A NO20071524 A NO 20071524A NO 20071524 A NO20071524 A NO 20071524A NO 20071524 L NO20071524 L NO 20071524L
Authority
NO
Norway
Prior art keywords
preparation
sulfoxide derivatives
enantioselective
enantioselective preparation
sulfoxide
Prior art date
Application number
NO20071524A
Other languages
English (en)
Inventor
Avraham Cohen
Suzy Charbit
Frederic Martinet
Francois Schutze
Patricia Gizecki
Original Assignee
Sidem Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sidem Pharma Sa filed Critical Sidem Pharma Sa
Publication of NO20071524L publication Critical patent/NO20071524L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C07D213/34—Sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Foreliggende oppfinnelse omhandler enantioselektiv fremstilling av sulfoksidderivater eller deres salter. Fremgangsmåten består i å utføre en enantioselektiv oksidasjon av et svovel med generell formel A-CH2-S-B hvori A er en pyridinylring substituert på forskjellig måte og B en heterosyklisk rest som omfatter en imidazopyridinyl ring, ved anvendelse av et oksidasjonsmiddel i nærvær av en titan(IV)-basert katalysator og en kiral ligand som består av en syklisk beta- eller gamma-aminoalkohol, i et organisk løsemiddel, fulgt hvis nødvendig av saltdannelse med en base. Oppfinnelsen er egnet for fremstilling av sulfoksider som er nyttige i terapeutiske midler.
NO20071524A 2004-10-05 2007-03-23 Fremgangsmate for enantioselektiv fremstilling av sulfoksid-derivater NO20071524L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0410483A FR2876101B1 (fr) 2004-10-05 2004-10-05 Procede de preparation enantioselective de derives de sulfoxydes
PCT/FR2005/002447 WO2006037894A1 (fr) 2004-10-05 2005-10-05 Procede de preparation enantioselective de derives de sulfoxydes.

Publications (1)

Publication Number Publication Date
NO20071524L true NO20071524L (no) 2007-04-27

Family

ID=34949706

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071524A NO20071524L (no) 2004-10-05 2007-03-23 Fremgangsmate for enantioselektiv fremstilling av sulfoksid-derivater

Country Status (21)

Country Link
US (1) US7528251B2 (no)
EP (1) EP1802620B1 (no)
JP (1) JP5213444B2 (no)
KR (1) KR101258744B1 (no)
CN (1) CN101035787B (no)
AT (1) ATE417848T1 (no)
AU (1) AU2005291156B2 (no)
BR (1) BRPI0516465A (no)
CA (1) CA2580446C (no)
DE (1) DE602005011840D1 (no)
DK (1) DK1802620T3 (no)
ES (1) ES2319804T3 (no)
FR (1) FR2876101B1 (no)
IL (1) IL181831A (no)
MX (1) MX2007003953A (no)
NO (1) NO20071524L (no)
NZ (1) NZ553841A (no)
PL (1) PL1802620T3 (no)
RU (1) RU2380357C2 (no)
WO (1) WO2006037894A1 (no)
ZA (1) ZA200702273B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101012141B (zh) * 2007-02-02 2012-05-23 沈阳药科大学 手性亚砜类化合物的制备方法
FR2925899B1 (fr) * 2007-12-27 2012-12-21 Sidem Pharma Sa Procede de preparation enantioselective de sulfoxydes.
ES2525535T3 (es) * 2009-07-16 2014-12-26 Bayer Intellectual Property Gmbh Procedimiento para la preparación de derivados de 3-triazolil-sulfóxido quirales
RU2448954C1 (ru) * 2010-10-18 2012-04-27 Учреждение Российской академии наук Институт катализа им. Г.К. Борескова Сибирского отделения РАН Способ получения сульфоксидов

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
AR030284A1 (es) * 2000-06-08 2003-08-20 Merck & Co Inc Proceso para la sintesis de (2r, 2-alfa-r,3a) -2-[1-(3,5-bis(trifluorometil) fenil) etoxi]-3-(4-fluorofenil)-1,4-oxazina; dicho compuesto y sus formas polimorficas
AU2003262375A1 (en) * 2002-04-22 2003-11-03 Sun Pharmaceutical Industries Limited Optically active substituted pyridinylmethyl-sulphinyl-benzimidazole and salts
CN1453278A (zh) * 2002-04-23 2003-11-05 中国人民解放军军事医学科学院放射医学研究所 一种拉唑类化合物及其制备方法与应用
FR2848555B1 (fr) * 2002-12-16 2006-07-28 Negma Gild Enantiomere(-)du tenatoprazole et son application en therapeutique
CN100558726C (zh) * 2003-02-24 2009-11-11 田边三菱制药株式会社 泰妥拉唑的对映体及其在治疗中的应用

Also Published As

Publication number Publication date
EP1802620B1 (fr) 2008-12-17
DK1802620T3 (da) 2009-04-06
ES2319804T3 (es) 2009-05-12
BRPI0516465A (pt) 2008-09-09
ZA200702273B (en) 2008-06-25
FR2876101B1 (fr) 2007-03-02
KR20070102660A (ko) 2007-10-19
DE602005011840D1 (de) 2009-01-29
MX2007003953A (es) 2007-06-14
JP5213444B2 (ja) 2013-06-19
WO2006037894A1 (fr) 2006-04-13
IL181831A (en) 2011-04-28
EP1802620A1 (fr) 2007-07-04
CN101035787B (zh) 2013-03-27
NZ553841A (en) 2010-09-30
RU2007116816A (ru) 2008-11-20
AU2005291156A1 (en) 2006-04-13
AU2005291156B2 (en) 2011-12-22
KR101258744B1 (ko) 2013-04-29
US7528251B2 (en) 2009-05-05
US20070299261A1 (en) 2007-12-27
RU2380357C2 (ru) 2010-01-27
JP2008515860A (ja) 2008-05-15
IL181831A0 (en) 2007-07-04
ATE417848T1 (de) 2009-01-15
CA2580446A1 (fr) 2006-04-13
CN101035787A (zh) 2007-09-12
PL1802620T3 (pl) 2009-07-31
FR2876101A1 (fr) 2006-04-07
CA2580446C (fr) 2013-05-21

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