NO20072046L - Halogensubstituerte benzodiazepinderivater - Google Patents

Halogensubstituerte benzodiazepinderivater

Info

Publication number
NO20072046L
NO20072046L NO20072046A NO20072046A NO20072046L NO 20072046 L NO20072046 L NO 20072046L NO 20072046 A NO20072046 A NO 20072046A NO 20072046 A NO20072046 A NO 20072046A NO 20072046 L NO20072046 L NO 20072046L
Authority
NO
Norway
Prior art keywords
halogen
benzodiazepine derivatives
substituted benzodiazepine
substituted
triazolo
Prior art date
Application number
NO20072046A
Other languages
English (en)
Inventor
Andrew William Thomas
Henner Knust
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35735152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20072046(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20072046L publication Critical patent/NO20072046L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Oppfinnelsen angår halogensubstituerte imidazo[1,5-a][1,2,4]triazolo[1,5d][1,4]benzodiazepinderivater med formel (I) og deres farmasøytisk akseptable syreaddisjonssalter. Forbindelsene kan anvendes for behandling av kognitiv stimulering, kognitive lidelser, angst, Alzheimers sykdom og schizofreni.
NO20072046A 2004-10-20 2007-04-20 Halogensubstituerte benzodiazepinderivater NO20072046L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04105167 2004-10-20
PCT/EP2005/010907 WO2006045429A1 (en) 2004-10-20 2005-10-11 Halogen substituted benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
NO20072046L true NO20072046L (no) 2007-04-26

Family

ID=35735152

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072046A NO20072046L (no) 2004-10-20 2007-04-20 Halogensubstituerte benzodiazepinderivater

Country Status (17)

Country Link
US (1) US7507728B2 (no)
EP (1) EP1807432A1 (no)
JP (1) JP4751398B2 (no)
KR (1) KR100915469B1 (no)
CN (1) CN101084220B (no)
AR (1) AR051333A1 (no)
AU (1) AU2005299031B2 (no)
BR (1) BRPI0516244A (no)
CA (1) CA2584757C (no)
IL (1) IL182697A (no)
MX (1) MX2007004640A (no)
NO (1) NO20072046L (no)
NZ (1) NZ554556A (no)
RU (1) RU2007114763A (no)
TW (1) TWI304404B (no)
WO (1) WO2006045429A1 (no)
ZA (1) ZA200703244B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0617204A2 (pt) * 2005-10-11 2011-07-19 Hoffmann La Roche derivados de imidazo benzodiazepina
EP2457569A1 (en) 2010-11-05 2012-05-30 F. Hoffmann-La Roche AG Use of active pharmaceutical compounds for the treatment of central nervous system conditions
MX341471B (es) 2010-11-05 2016-08-22 Hoffmann La Roche Uso de compuestos farmaceuticos activos para el tratamiento de estados patologicos del sistema nervioso central.
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
NZ760341A (en) * 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX392119B (es) 2015-06-19 2025-03-11 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
SG11202001240XA (en) * 2017-09-07 2020-03-30 Eisai R&D Man Co Ltd Pentacyclic compound
CN112601749B (zh) 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
EA202191966A1 (ru) 2019-03-05 2021-12-08 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Пентациклическое гетероциклическое соединение
BR112021015979A2 (pt) 2019-03-05 2021-10-05 Eisai R&D Management Co., Ltd. Sal de composto pentacíclico e cristal do mesmo

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL49161A (en) * 1975-08-07 1982-04-30 Sparamedica Ag Imidazo(1,5-a)(1,4)-diazepine derivatives,their manufacture and pharmaceutical compositions containing them
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
IL74070A (en) 1984-01-19 1988-12-30 Hoffmann La Roche Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
US4897392A (en) * 1989-07-03 1990-01-30 Hoechst-Roussel Pharmaceuticals, Inc. 4H-indolo(1,2-d)(1,2,4)triazolo(4,3-A)(1,4)benzodiazepines
TW201311B (no) * 1991-06-17 1993-03-01 Hoffmann La Roche
JPH078869A (ja) * 1993-06-29 1995-01-13 Mitsubishi Chem Corp 粉粒体のコーティング方法
TWI239333B (en) * 2000-11-16 2005-09-11 Hoffmann La Roche Benzodiazepine derivatives as GABA A receptor modulators
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives

Also Published As

Publication number Publication date
MX2007004640A (es) 2007-06-08
AR051333A1 (es) 2007-01-03
CA2584757C (en) 2012-07-03
AU2005299031B2 (en) 2011-11-10
IL182697A0 (en) 2007-09-20
CN101084220B (zh) 2010-12-15
WO2006045429A1 (en) 2006-05-04
KR100915469B1 (ko) 2009-09-03
NZ554556A (en) 2009-11-27
CA2584757A1 (en) 2006-05-04
US7507728B2 (en) 2009-03-24
JP4751398B2 (ja) 2011-08-17
ZA200703244B (en) 2008-08-27
KR20070085398A (ko) 2007-08-27
IL182697A (en) 2012-02-29
BRPI0516244A (pt) 2008-08-26
AU2005299031A1 (en) 2006-05-04
TWI304404B (en) 2008-12-21
CN101084220A (zh) 2007-12-05
JP2008517010A (ja) 2008-05-22
US20060084801A1 (en) 2006-04-20
EP1807432A1 (en) 2007-07-18
TW200630371A (en) 2006-09-01
RU2007114763A (ru) 2008-11-27

Similar Documents

Publication Publication Date Title
NO20072046L (no) Halogensubstituerte benzodiazepinderivater
NO20071967L (no) Imidazo-benzodiazepinderivater
MX2010004819A (es) Derivados de [1h-pirazolo[3,4-b]piridin-4-il]-fenilo o piridin-2-ilo como proteina cinasa c-theta.
DE602004007239D1 (de) 4-AMINOTHIENOÄ2,3-dÜ PYRIMIDIN -6-CARBONITRIL-DERIVATIVE ZUR VERWENDUNG ALS PDE7 INHIBITOREN
EA201171306A1 (ru) ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-α]ПИРИДИНА, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ β-СЕКРЕТАЗЫ
ZA200704476B (en) Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
AP1860A (en) Aryl fused azapolycyclic compounds.
WO2007040438A3 (en) Novel imidazo [4,5 -b] pyridine derivatives as inhibitors of glycogen synthase kinase 3 for use in the treatment of dementia and neurodegenerative disorders
TNSN06226A1 (en) Pyrazolo[1,5-a]pyrimidin-7-yl-amine derivatives for use in the treatment of protein kinase dependent diseases
NO20056030L (no) Nye pyridopyraziner og anvendelse derav som kinaseinhibitorer
NO20081523L (no) Fremstilling og anvendelse av tetrahydropyrrolo(3,2-C)Pyridin-4-on-derivater for behandling av fedme, psykiatriske og neurologiske forstyrrelser
NO20056032L (no) Nye pyridopyraziner og anvendelse derav som kinasemodulatorer
CY1107204T1 (el) Πιπεραζινοβενζοθειαζολια ως ουσιες για την θεραπευτικη αντιμετωπιση εγκεφαλικων ισχαιμικων διαταραχων ή διαταραχων του κνς
ATE428711T1 (de) Substituierte 1h-pyrroloä3,2-b, 3,2-c und 2,3- cüpyridin-2-carbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i- epsilon
MXPA05013628A (es) Pirazolo[3,4-b]piridin-6-onas como inhibidores de gsk-3.
ATE402707T1 (de) Imidazoä1,5aütriazoloä1,5dübenzodiazepin- derivative zur behandlung kognitiver störungen
BR0010693A (pt) Derivados azaindol para tratamento de depressão
DE60108626D1 (de) Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b] pyridinen als cyclin-abhängige kinase-hemmer
ATE389655T1 (de) Pyrimidinderivate
ATE444069T1 (de) Chinolin-derivate zur behandlung von mglur5- rezeptor-vermittelten erkrankungen
WO2009064836A3 (en) Kynurenine-aminotransferase inhibitors
DE60111553D1 (de) Hexahydropyrazino[1'2':1,6]-pyrido[3,4-b]indole-1,4-dion-derivate zur behandlung von cardiovaskulären erkrankungen und erektionsstörungen
WO2006056873A3 (en) Therapeutic pyrazolo[3,4-b] pyridines and indazoles
IL184439A0 (en) 2,5-disubstituted phenyl methanone derivatives as glycine transporter 1
TW200514779A (en) Imidazole derivatives III

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application