BR0010693A - Derivados azaindol para tratamento de depressão - Google Patents

Derivados azaindol para tratamento de depressão

Info

Publication number
BR0010693A
BR0010693A BR0010693-3A BR0010693A BR0010693A BR 0010693 A BR0010693 A BR 0010693A BR 0010693 A BR0010693 A BR 0010693A BR 0010693 A BR0010693 A BR 0010693A
Authority
BR
Brazil
Prior art keywords
treating depression
azaindole derivatives
depression
affected
ring
Prior art date
Application number
BR0010693-3A
Other languages
English (en)
Inventor
Richard Eric Mewshaw
Kristin Lynne Meagher
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of BR0010693A publication Critical patent/BR0010693A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: "DERIVADOS AZAINDOL PARA TRATAMENTO DE DEPRESSãO". Compostos úteis no tratamento de doenças afetadas por desordens dos sistemas neurológicos afetados - serotonina, tais como depressão e ansiedade, são providos tendo a fórmula (1) onde: R~ 1~ e R~ 2~ formam um anel carbocíclico ou heterocíclico de 5 a 7 átomos, onde o dito anel pode ser saturado ou insaturado; e X é independentemente hidrogênio, ciano, carbamoíla, halogênio ou alcóxi; ou seus sais farmaceuticamente aceitáveis.
BR0010693-3A 1999-04-22 2000-04-20 Derivados azaindol para tratamento de depressão BR0010693A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29673699A 1999-04-22 1999-04-22
PCT/US2000/010628 WO2000064898A1 (en) 1999-04-22 2000-04-20 Azaindole derivatives for the treatment of depression

Publications (1)

Publication Number Publication Date
BR0010693A true BR0010693A (pt) 2002-02-05

Family

ID=23143341

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010693-3A BR0010693A (pt) 1999-04-22 2000-04-20 Derivados azaindol para tratamento de depressão

Country Status (8)

Country Link
EP (1) EP1171439A1 (pt)
JP (1) JP2002543079A (pt)
CN (1) CN1348451A (pt)
AR (1) AR028475A1 (pt)
AU (1) AU4364400A (pt)
BR (1) BR0010693A (pt)
CA (1) CA2367681A1 (pt)
WO (1) WO2000064898A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1490365B1 (en) * 2002-03-28 2010-02-10 Eisai R&D Management Co., Ltd. Azaindoles as inhibitors of c-jun n-terminal kinases
JP5138938B2 (ja) 2003-12-19 2013-02-06 プレキシコン インコーポレーテッド Ｒｅｔ調節剤の開発のための化合物および方法
ES2331144T3 (es) 2004-11-26 2009-12-22 Janssen Pharmaceutica Nv Derivados de isoxazolina-indol con actividad antipsicotica y ansiolitica mejorada.
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
CA2738573C (en) 2009-04-03 2013-02-19 F. Hoffmann-La Roche Ag Compositions of propane-1 sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide and uses thereof
GEP20207129B (en) 2009-06-17 2020-07-10 Vertex Pharma Inhibitors of influenza viruses replication
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
PE20141360A1 (es) 2011-02-07 2014-10-13 Plexxikon Inc Compuestos y metodos para la modulacion de quinasas e indicaciones para los mismos.
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
PT3068776T (pt) 2013-11-13 2019-08-26 Vertex Pharma Inibidores da replicação de vírus da gripe
HUE038820T2 (hu) 2013-11-13 2018-11-28 Vertex Pharma Eljárás influenzavírusok replikációjának inhibitorai elõállítására
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
JP2002543079A (ja) 2002-12-17
EP1171439A1 (en) 2002-01-16
CA2367681A1 (en) 2000-11-02
AR028475A1 (es) 2003-05-14
AU4364400A (en) 2000-11-10
WO2000064898A1 (en) 2000-11-02
CN1348451A (zh) 2002-05-08

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired
B25D Requested change of name of applicant approved