NO20072288L - Sulfonamid pert-substituerte bicykler for okklusly arteriesykdom - Google Patents
Sulfonamid pert-substituerte bicykler for okklusly arteriesykdomInfo
- Publication number
- NO20072288L NO20072288L NO20072288A NO20072288A NO20072288L NO 20072288 L NO20072288 L NO 20072288L NO 20072288 A NO20072288 A NO 20072288A NO 20072288 A NO20072288 A NO 20072288A NO 20072288 L NO20072288 L NO 20072288L
- Authority
- NO
- Norway
- Prior art keywords
- sulfonamide
- occlusly
- pert
- artery disease
- substituted
- Prior art date
Links
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 200000000007 Arterial disease Diseases 0.000 title 1
- 208000028922 artery disease Diseases 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 Acyl sulfonamide Chemical class 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- C—CHEMISTRY; METALLURGY
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Surgery (AREA)
Abstract
Det er beskrevet acylsulfonamid, peri-substituerte, fusjonerte bicykliske ring-forbindelser som er nyttige for behandling eller profylakse av en prostaglandinformidlet sykdom eller lidelse. Forbindelsene er av generell formel (I). Et representativt eksempel er formel (II):
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61817204P | 2004-10-12 | 2004-10-12 | |
| PCT/US2005/023009 WO2006044000A1 (en) | 2004-10-12 | 2005-06-27 | Sulfonamide pert-substituted bicyclics for occlusive artery disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20072288L true NO20072288L (no) | 2007-06-25 |
Family
ID=35229642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20072288A NO20072288L (no) | 2004-10-12 | 2007-05-02 | Sulfonamid pert-substituerte bicykler for okklusly arteriesykdom |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7598397B2 (no) |
| EP (1) | EP1812388B1 (no) |
| JP (1) | JP2008515971A (no) |
| KR (1) | KR20070091607A (no) |
| CN (1) | CN101142184A (no) |
| AT (1) | ATE499344T1 (no) |
| AU (1) | AU2005296305A1 (no) |
| BR (1) | BRPI0516003A (no) |
| CA (1) | CA2583667A1 (no) |
| DE (1) | DE602005026553D1 (no) |
| IL (1) | IL182488A0 (no) |
| MX (1) | MX2007004525A (no) |
| NO (1) | NO20072288L (no) |
| NZ (1) | NZ554491A (no) |
| RU (1) | RU2403240C2 (no) |
| WO (1) | WO2006044000A1 (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2580730C (en) * | 2003-09-25 | 2015-01-13 | Cenomed, Inc. | Tetrahydroindolone derivatives for treatment of neurological conditions |
| KR20070091607A (ko) * | 2004-10-12 | 2007-09-11 | 디코드 제네틱스, 아이엔씨. | 폐쇄성 동맥 질환용의 설폰아미드 주변 치환된바이사이클릭 화합물 |
| RU2007115522A (ru) * | 2004-10-12 | 2008-10-27 | Декод Дженетикс Ехф (Is) | Пери-замещенные бициклические карбоновые кислоты для лечения окклюзионного заболевания артерий |
| TW200740435A (en) * | 2005-08-10 | 2007-11-01 | Takeda Pharmaceuticals Co | Therapeutic agent for diabetes |
| WO2007137040A2 (en) * | 2006-05-16 | 2007-11-29 | Decode Genetics Ehf | 7-(acryloyl) indole compositions and methods for making and using same |
| EP2027117A2 (en) * | 2006-05-16 | 2009-02-25 | Decode Genetics EHF | Process for preparing 7-(acryloyl)-indoles |
| US7705035B2 (en) * | 2006-06-12 | 2010-04-27 | Merck Frosst Canada Ltd. | Indoline amide derivatives as EP4 receptor ligands |
| US20100069380A1 (en) * | 2006-09-22 | 2010-03-18 | Soongyu Choi | Heterocyclic inhibitors of bacterial peptidyl trna hydrolase and uses thereof |
| CN101679246A (zh) | 2007-03-30 | 2010-03-24 | 盐野义制药株式会社 | 新型吡咯啉酮衍生物以及包含其的药物组合物 |
| WO2009062134A1 (en) * | 2007-11-09 | 2009-05-14 | Cenomed Biosciences, Llc | Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds |
| US20090264443A1 (en) * | 2008-04-18 | 2009-10-22 | David Helton | Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds |
| WO2010059244A2 (en) * | 2008-11-21 | 2010-05-27 | Iroko Pharmaceuticals, Llc | Method for reducing thrombocytopenia and thrombocytopenia-associated mortality |
| AR086411A1 (es) * | 2011-05-20 | 2013-12-11 | Nippon Soda Co | Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria |
| JP5841361B2 (ja) * | 2011-06-29 | 2016-01-13 | 壽製薬株式会社 | 三環性化合物及びそれを含有する医薬組成物 |
| WO2014005274A1 (zh) * | 2012-07-03 | 2014-01-09 | 海南卫康制药(潜山)有限公司 | 多取代的8-氮杂环【3.2.1】辛烷化合物 |
| CA3002144C (en) | 2015-10-16 | 2024-01-23 | Eisai R&D Management Co., Ltd. | Ep4 antagonists |
| WO2020008317A1 (en) * | 2018-07-03 | 2020-01-09 | Janssen Pharmaceutica Nv | Acylsufonamide compounds useful as ep3 receptor antagonists |
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| WO2024206284A2 (en) * | 2023-03-27 | 2024-10-03 | Rutgers, The State University Of New Jersey | Therapeutic compounds |
| CN119100992B (zh) * | 2023-06-02 | 2025-09-16 | 帕潘纳(北京)科技有限公司 | 一种特戈拉赞中间体及其衍生物的制备方法 |
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| JPS5030632B2 (no) * | 1971-11-29 | 1975-10-02 | ||
| DK151884C (da) | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
| GB8927981D0 (en) * | 1989-12-11 | 1990-02-14 | Ici Plc | Carbamoyl derivative |
| US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| US5239083A (en) * | 1991-03-11 | 1993-08-24 | Kyowa Hakko Kogyo Co., Ltd. | Indole derivatives which inhibit steroid 5α reductase |
| GB9122590D0 (en) * | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
| JPH06297860A (ja) * | 1993-04-14 | 1994-10-25 | New Oji Paper Co Ltd | 感熱記録体 |
| GB9412719D0 (en) | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
| AU3578495A (en) * | 1994-09-30 | 1996-04-26 | Nippon Chemiphar Co. Ltd. | Quinoline derivative |
| WO1997005091A1 (en) * | 1995-07-26 | 1997-02-13 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives and drugs comprising the same as active ingredients |
| EP0882718B1 (en) | 1995-12-28 | 2005-08-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| JP2000503984A (ja) | 1996-01-22 | 2000-04-04 | 藤沢薬品工業株式会社 | チアゾリルベンゾフラン誘導体およびその医薬組成物 |
| JP4373497B2 (ja) * | 1996-06-19 | 2009-11-25 | ローン−プーラン・ロレ・リミテツド | 置換されたアザビシクロ化合物、ならびにtnfおよびサイクリックampホスホジエステラーゼ産生の阻害剤としてのそれらの使用 |
| ZA984040B (en) | 1997-05-15 | 1998-11-20 | Ono Pharmaceutical Co | Benzenesulfonamide compounds |
| RU2199532C2 (ru) * | 1997-06-27 | 2003-02-27 | Фудзисава Фармасьютикал Ко., Лтд. | Сульфонамидное соединение |
| JP3256513B2 (ja) * | 1998-02-11 | 2002-02-12 | ファイザー製薬株式会社 | ベンゾイミダゾールシクロオキシゲナーゼ−2阻害剤 |
| US6242493B1 (en) | 1998-03-13 | 2001-06-05 | Merck Frosst Canada & Co. | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment |
| CA2347365A1 (en) * | 1998-10-23 | 2000-05-04 | Merck Frosst Canada & Co. | Combination product comprising an e-type prostaglandin ligand and a cox-2 selective inhibitor and methods of use |
| US6348032B1 (en) | 1998-11-23 | 2002-02-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with benzimidazole derivatives |
| JP4929472B2 (ja) * | 2000-08-22 | 2012-05-09 | 小野薬品工業株式会社 | カルボン酸誘導体、それらの製造方法およびそれらを有効成分として含有する薬剤 |
| TWI314457B (no) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| NZ531153A (en) | 2001-08-09 | 2005-10-28 | Ono Pharmaceutical Co | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
| KR20070091607A (ko) * | 2004-10-12 | 2007-09-11 | 디코드 제네틱스, 아이엔씨. | 폐쇄성 동맥 질환용의 설폰아미드 주변 치환된바이사이클릭 화합물 |
| WO2007137040A2 (en) | 2006-05-16 | 2007-11-29 | Decode Genetics Ehf | 7-(acryloyl) indole compositions and methods for making and using same |
-
2005
- 2005-06-27 KR KR1020077010837A patent/KR20070091607A/ko not_active Ceased
- 2005-06-27 CN CNA2005800426037A patent/CN101142184A/zh active Pending
- 2005-06-27 AU AU2005296305A patent/AU2005296305A1/en not_active Abandoned
- 2005-06-27 AT AT05769472T patent/ATE499344T1/de not_active IP Right Cessation
- 2005-06-27 WO PCT/US2005/023009 patent/WO2006044000A1/en not_active Ceased
- 2005-06-27 EP EP05769472A patent/EP1812388B1/en not_active Expired - Lifetime
- 2005-06-27 NZ NZ554491A patent/NZ554491A/en not_active IP Right Cessation
- 2005-06-27 DE DE602005026553T patent/DE602005026553D1/de not_active Expired - Lifetime
- 2005-06-27 JP JP2007536680A patent/JP2008515971A/ja active Pending
- 2005-06-27 CA CA002583667A patent/CA2583667A1/en not_active Abandoned
- 2005-06-27 RU RU2007115410/04A patent/RU2403240C2/ru not_active IP Right Cessation
- 2005-06-27 BR BRPI0516003-0A patent/BRPI0516003A/pt not_active IP Right Cessation
- 2005-06-27 US US11/169,161 patent/US7598397B2/en not_active Expired - Fee Related
- 2005-06-27 MX MX2007004525A patent/MX2007004525A/es active IP Right Grant
-
2007
- 2007-04-11 IL IL182488A patent/IL182488A0/en unknown
- 2007-05-02 NO NO20072288A patent/NO20072288L/no not_active Application Discontinuation
-
2009
- 2009-08-03 US US12/534,390 patent/US20090291948A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL182488A0 (en) | 2007-09-20 |
| AU2005296305A1 (en) | 2006-04-27 |
| MX2007004525A (es) | 2007-09-19 |
| US20060079520A1 (en) | 2006-04-13 |
| RU2007115410A (ru) | 2008-11-10 |
| US7598397B2 (en) | 2009-10-06 |
| ATE499344T1 (de) | 2011-03-15 |
| DE602005026553D1 (de) | 2011-04-07 |
| JP2008515971A (ja) | 2008-05-15 |
| CA2583667A1 (en) | 2006-04-27 |
| RU2403240C2 (ru) | 2010-11-10 |
| US20090291948A1 (en) | 2009-11-26 |
| EP1812388A1 (en) | 2007-08-01 |
| CN101142184A (zh) | 2008-03-12 |
| BRPI0516003A (pt) | 2008-04-29 |
| KR20070091607A (ko) | 2007-09-11 |
| NZ554491A (en) | 2009-07-31 |
| WO2006044000A1 (en) | 2006-04-27 |
| EP1812388B1 (en) | 2011-02-23 |
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