NO20072355L - Cupredoxinderiverte transportmidler og metoder for fremstilling av disse - Google Patents

Cupredoxinderiverte transportmidler og metoder for fremstilling av disse

Info

Publication number
NO20072355L
NO20072355L NO20072355A NO20072355A NO20072355L NO 20072355 L NO20072355 L NO 20072355L NO 20072355 A NO20072355 A NO 20072355A NO 20072355 A NO20072355 A NO 20072355A NO 20072355 L NO20072355 L NO 20072355L
Authority
NO
Norway
Prior art keywords
methods
cupredoxin
preparation
transport agents
derived transport
Prior art date
Application number
NO20072355A
Other languages
English (en)
Inventor
Ananda Chakrabarty
Tapas Das Gupta
Tohru Yamada
Arsenio Fialho
Original Assignee
Arsenio Fialho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arsenio Fialho filed Critical Arsenio Fialho
Publication of NO20072355L publication Critical patent/NO20072355L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13Tumour cells, irrespective of tissue of origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/14Peptides, e.g. proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasonic imaging preparations
    • A61K49/221Echographic preparations; Ultrasonic imaging preparations characterised by the targeting agent or modifying agent linked to the acoustically-active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

Foreliggende oppfinnelse angir fremgangsmåter og materialer for levering av en cargoforbindelse inn i en cancercelle. Leveringen av cargoforbindelsen gjennomføres ved anvendelse av protein transduksjonsdoméne derivert fra cupredoxiner. Oppfinnelsen angir også fremgangsmåter for å behandle cancer og cancerdiagnostisering.
NO20072355A 2004-10-07 2007-05-07 Cupredoxinderiverte transportmidler og metoder for fremstilling av disse NO20072355L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61678204P 2004-10-07 2004-10-07
US68050005P 2005-05-13 2005-05-13
US70029705P 2005-07-19 2005-07-19
PCT/US2005/035758 WO2006088508A2 (en) 2004-10-07 2005-10-06 Cupredoxin derived transport agents and methods of use thereof

Publications (1)

Publication Number Publication Date
NO20072355L true NO20072355L (no) 2007-07-04

Family

ID=36916885

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072355A NO20072355L (no) 2004-10-07 2007-05-07 Cupredoxinderiverte transportmidler og metoder for fremstilling av disse

Country Status (17)

Country Link
US (5) US7691383B2 (no)
EP (1) EP1797114A4 (no)
JP (2) JP2008515428A (no)
KR (1) KR20070108128A (no)
CN (1) CN101437842A (no)
AP (1) AP2007003959A0 (no)
AU (1) AU2005327535A1 (no)
BR (1) BRPI0515850A (no)
CA (1) CA2582164A1 (no)
CR (1) CR9033A (no)
EA (1) EA200700813A1 (no)
IL (1) IL182202A0 (no)
NO (1) NO20072355L (no)
TN (1) TNSN07113A1 (no)
UA (1) UA97466C2 (no)
WO (1) WO2006088508A2 (no)
ZA (1) ZA200702855B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618939B2 (en) * 2001-02-15 2009-11-17 The Board Of Trustees Of The University Of Illinois Compositions and methods to prevent cancer with cupredoxins
US9096663B2 (en) * 2001-02-15 2015-08-04 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
US7381701B2 (en) 2001-02-15 2008-06-03 The Borad Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
US7556810B2 (en) 2005-07-19 2009-07-07 The Board Of Trustees Of The University Of Ilinois Compositions and methods to control angiogenesis with cupredoxins
US7491394B2 (en) 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
US7301010B2 (en) * 2001-02-15 2007-11-27 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating HIV infection with cupredoxin and cytochrome c
WO2005082912A1 (en) * 2004-02-23 2005-09-09 Dow Global Technologies Inc Aqueous-based adhesive for bonding low surface energy substrates
US20090208476A1 (en) * 2006-05-19 2009-08-20 Tapas Das Gupta Compositions and methods to concurrently treat or prevent multiple diseases with cupredoxins
US9434770B2 (en) * 2004-10-07 2016-09-06 Tapas K Das Gupta Modified cupredoxin derived peptides
US9968685B2 (en) * 2004-10-07 2018-05-15 Brad N. Taylor Methods to treat cancer with cupredoxins
AP2007003959A0 (en) 2004-10-07 2007-04-30 Ananda Chakrabarty Cupredoxin derived transport agents and methods ofuse thereof
US10675326B2 (en) 2004-10-07 2020-06-09 The Board Of Trustees Of The University Of Illinois Compositions comprising cupredoxins for treating cancer
US8158574B2 (en) * 2004-10-07 2012-04-17 Cdg Therapeutics, Inc. Compositions and methods to prevent cancer with cupredoxins
US9598470B2 (en) * 2004-10-07 2017-03-21 Craig W. Beattie Compositions and methods to prevent cancer by stabilizing P53 through non MDM2-mediated pathways
MX2008000994A (es) 2005-07-19 2008-03-19 Univ Illinois Agentes de transporte para cruzar la barrera hematoencefalica y hacia el interior de las celulas de cancer cerebral, y metodos para el uso de los mismos.
KR20080034905A (ko) * 2005-07-19 2008-04-22 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 쿠프레독신으로 혈관신생을 제어하는 조성물과 방법
US20100278937A1 (en) * 2005-10-06 2010-11-04 Das Gupta Tapas K Compositions and methods to prevent and/or treat cancer with pa-card
US10266868B2 (en) * 2006-05-19 2019-04-23 The Board Of Trustees Of The University Of Illinois Compositions for treating HIV infection with cupredoxin and cytochrome C
EP2061487A4 (en) 2006-09-11 2009-12-02 Univ Illinois MODIFIED CUPREDOXIN-DERIVED PEPTIDES AND METHOD FOR THEIR USE
SG174784A1 (en) * 2006-09-14 2011-10-28 Univ Illinois Compositions and methods to prevent cancer with cupredoxins
KR20090095626A (ko) 2006-12-04 2009-09-09 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 쿠프레독신과 CpG 리치 DNA를 이용한 조성물 및 암 치료 방법
WO2008086523A2 (en) * 2007-01-11 2008-07-17 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
AU2008212788A1 (en) 2007-02-08 2008-08-14 The Board Of Trustees Of The University Of Illinois Compositions and methods to prevent cancer with cupredoxins
BRPI0806029A2 (pt) * 2007-07-19 2009-11-10 Biosigma Sa plasmìdeos para transformação de bactérias do gênero aciditiobacillus spp. e método de transformação
EP2197903B9 (en) * 2007-09-04 2015-04-22 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity
WO2009078977A2 (en) * 2007-12-14 2009-06-25 Cdg Therapeutics Inc Compositions and methods to concurrently treat or prevent multiple diseases with cupredoxins
ES2936256T3 (es) * 2008-02-01 2023-03-15 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas
WO2010028246A2 (en) * 2008-09-05 2010-03-11 Id Biomedical Corporation Of Quebec Novel compositions and adjuvants
KR20120000062A (ko) * 2009-02-20 2012-01-03 씨디쥐 테라퓨틱스, 인크. Pa-card로 암을 예방 및/또는 치료하기 위한 조성물 및 방법
WO2011031892A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
WO2011031877A1 (en) 2009-09-09 2011-03-17 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
WO2011123795A1 (en) 2010-04-02 2011-10-06 Battelle Memorial Institute Methods for associating or dissociating guest materials with a metal organic framework, systems for associating or dissociating guest materials within a series of metal organic frameworks, and gas separation assemblies
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
EP2638057B1 (en) 2010-11-10 2019-03-06 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
US20150241963A1 (en) * 2014-02-11 2015-08-27 Osterhout Group, Inc. Eye imaging in head worn computing
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
WO2016176573A1 (en) 2015-04-30 2016-11-03 Board Of Regents, The University Of Texas System Antibacterial polypeptide libraries and methods for screening the same
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
WO2025217401A1 (en) * 2024-04-10 2025-10-16 The Regents Of The University Of Colorado, A Body Corporate A peptide inhibitor of the eya and pp2a-b55a interaction useful for myc-driven cancer therapy

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827934A (en) 1988-03-08 1998-10-27 The University Of Wyoming Cytotoxic diphtheria toxin fragments
US5972899A (en) 1996-01-25 1999-10-26 New York University Apoptosis induced by Shigella IpaB
JP3715745B2 (ja) * 1997-06-17 2005-11-16 ジーイー横河メディカルシステム株式会社 超音波撮像装置
EP1144605B1 (en) 1999-01-26 2009-12-16 University College London Dimethylarginine dimethylaminohydrolases
US6800437B1 (en) * 1999-08-06 2004-10-05 Tibotec Bvba Method of monitoring a biological system by labeling with an apo metal binding protein
US20020164703A1 (en) 2000-12-21 2002-11-07 Krzysztof Pawlowski Card-domain containing polypeptides, encoding nucleic acids, and methods of use
US7338766B2 (en) * 2001-02-15 2008-03-04 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating malaria with cupredoxin and cytochrome
CA2664797A1 (en) * 2001-02-15 2002-10-03 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
US7491394B2 (en) 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
US6708054B2 (en) * 2001-04-12 2004-03-16 Koninklijke Philips Electronics, N.V. MR-based real-time radiation therapy oncology simulator
JP4091318B2 (ja) * 2002-03-04 2008-05-28 ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー X線ct装置
GB0211295D0 (en) 2002-05-16 2002-06-26 Univ London Treatment of pain
WO2003097095A1 (en) 2002-05-20 2003-11-27 Chemstop Pty Ltd Process for the preparation and activation of substances and a means of producing same
WO2004046177A2 (en) 2002-11-15 2004-06-03 Chiron Srl Unexpected surface proteins in neisseria meningitidis
AP2007003959A0 (en) 2004-10-07 2007-04-30 Ananda Chakrabarty Cupredoxin derived transport agents and methods ofuse thereof
US7322469B2 (en) 2005-02-17 2008-01-29 International Paper Company Container for recording media
CA2608512A1 (en) 2005-05-20 2007-02-15 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
EP2061487A4 (en) 2006-09-11 2009-12-02 Univ Illinois MODIFIED CUPREDOXIN-DERIVED PEPTIDES AND METHOD FOR THEIR USE
SG174784A1 (en) 2006-09-14 2011-10-28 Univ Illinois Compositions and methods to prevent cancer with cupredoxins
KR20090095626A (ko) * 2006-12-04 2009-09-09 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 쿠프레독신과 CpG 리치 DNA를 이용한 조성물 및 암 치료 방법
AU2008212788A1 (en) * 2007-02-08 2008-08-14 The Board Of Trustees Of The University Of Illinois Compositions and methods to prevent cancer with cupredoxins
WO2009078977A2 (en) 2007-12-14 2009-06-25 Cdg Therapeutics Inc Compositions and methods to concurrently treat or prevent multiple diseases with cupredoxins

Also Published As

Publication number Publication date
EA200700813A1 (ru) 2008-10-30
US10239920B2 (en) 2019-03-26
UA97466C2 (ru) 2012-02-27
US9161989B2 (en) 2015-10-20
US20060149037A1 (en) 2006-07-06
CN101437842A (zh) 2009-05-20
US20140037554A1 (en) 2014-02-06
WO2006088508A3 (en) 2008-12-24
ZA200702855B (en) 2008-10-29
JP2008515428A (ja) 2008-05-15
TNSN07113A1 (en) 2008-06-02
US8206685B2 (en) 2012-06-26
KR20070108128A (ko) 2007-11-08
US20100209355A1 (en) 2010-08-19
WO2006088508A2 (en) 2006-08-24
US7691383B2 (en) 2010-04-06
CR9033A (es) 2010-04-08
EP1797114A4 (en) 2009-07-15
CA2582164A1 (en) 2006-08-24
US8530635B2 (en) 2013-09-10
EP1797114A2 (en) 2007-06-20
AP2007003959A0 (en) 2007-04-30
BRPI0515850A (pt) 2008-08-12
US20160031947A1 (en) 2016-02-04
US20130011338A1 (en) 2013-01-10
IL182202A0 (en) 2007-07-24
JP2014204720A (ja) 2014-10-30
AU2005327535A1 (en) 2006-08-24

Similar Documents

Publication Publication Date Title
TNSN07113A1 (en) Cupredoxin derived transport agents and methods of use thereof
NO20063569L (no) M-CSF-spesifikt monoklonalt antistoff og anvendelse derav
ATE549359T1 (de) Antikörper gegen den insulinähnlichen wachstumsfaktor i-rezeptor und deren verwendungen
MY145058A (en) Prlr-specific antibody and uses thereof
HRP20181459T1 (hr) Humanizirani antagonisti anti-beta7 i njihove uporabe
IL214325A (en) Antibody against cmet, a drug that includes and uses it
NO20083397L (no) Anti-EphB4-antistoffer og fremgangsmater for anvendelse av disse
NO20076003L (no) TGF-beta 1 spesifikke antistoffer
TNSN07264A1 (en) Organic compounds
AU2007292902A8 (en) Compositions and methods for enhancing transport through mucus
DE602005026556D1 (de) Zusammensetzung zur proteasomhemmung
MX2009012838A (es) Composicion de un primer anticuerpo monoclonal no marcado que se aglutina a un antigeno tumoral y a un segundo anticuerpo monoclonal de reaccion no cruzada marcado con un marcador fluorescsente del infrarrojo proximo.
TW200732349A (en) Anti-OX40L antibodies and methods using same
NO20090047L (no) Anti-DLL4-antistoffer og fremgangsmater for anvendelse av disse
SG170793A1 (en) Anti-mn antibodies and methods of using same
EA201170590A1 (ru) Ингибиторы рецептора фактора роста фибробластов-3 (fgfr-3) и способы лечения
WO2006038208A3 (en) Agents capable of downregulating an msf-a - dependent hif-1α and use thereof in cancer treatment
MX2009001341A (es) Anticuerpos especificos de ephb3 y usos de los mismos.
NO20083593L (no) Anti-EphrinB2-antistoffer og fremgangsmater for anvendelse av disse
ZA200802075B (en) MEK inhibitors and methods of their use
UA88638C2 (ru) Бета-карболины, полезные для лечения воспалительного заболевания
WO2010099139A3 (en) Combination of an either an anti-igf-ir- antibody or an igf binding protein and a small molecule igf-ir kinease inhibitor
DE602005026962D1 (de) Arylcarboxamide und ihre verwendung als antitumormittel
ATE487721T1 (de) Triaza-benzoäeüazulenderivate zur behandlung von tumoren
WO2004044000A3 (en) Compounds and methods for modulating functions of classical cadherins

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application