NO20072570L - Framgangsmate for framstilling av organisk fluor forbindelser i alkoholholdige losningsmidler. - Google Patents

Framgangsmate for framstilling av organisk fluor forbindelser i alkoholholdige losningsmidler.

Info

Publication number
NO20072570L
NO20072570L NO20072570A NO20072570A NO20072570L NO 20072570 L NO20072570 L NO 20072570L NO 20072570 A NO20072570 A NO 20072570A NO 20072570 A NO20072570 A NO 20072570A NO 20072570 L NO20072570 L NO 20072570L
Authority
NO
Norway
Prior art keywords
organic fluorine
fluorine
preparation
present
containing compounds
Prior art date
Application number
NO20072570A
Other languages
English (en)
Other versions
NO345018B1 (no
Inventor
Dae Hyuk Moon
Dae Yoon Chi
Dong Wook Kim
Seung Jun Oh
Jin-Sook Ryu
Original Assignee
Asan Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asan Foundation filed Critical Asan Foundation
Publication of NO20072570L publication Critical patent/NO20072570L/no
Publication of NO345018B1 publication Critical patent/NO345018B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/02—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of hydrogen atoms by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/007—Preparation of halogenated hydrocarbons from carbon or from carbides and halogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/15—Preparation of halogenated hydrocarbons by replacement by halogens with oxygen as auxiliary reagent, e.g. oxychlorination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/30—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reactions not involving the formation of esterified sulfo groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår en framgangsmåte for framstilling av organiske fluorholdige forbindelser som inneholder radioaktiv isotop fluor-18. Mer spesifikt angår foreliggende oppfinnelse en framgangsmåte for framstilling av en organisk fluorholdig forbindelse ved å reagere fluorsalt som inneholder en radioaktiv isotop fluor-18 med alkylhalid eller alkylsulfonat i nærvær av alkohol med kjemisk formel (I), hvor R1, R2 og R3 er hydrogen eller C1 ~ C18 alkyl-gruppe, som løsningsmiddel for å oppnå et høyt utbytte av organisk fluorholdig forbindelse. Syntesereaksjonen i samsvar med foreliggende oppfinnelse kan utføres under milde forhold for å gi et høyt utbytte av de organiske fluorholdige forbindelsene og reaksjonstiden er redusert, og den er dermed egnet for masseproduksjonen av de organiske fluorholdige forbindelsene. (I)
NO20072570A 2004-12-15 2007-05-21 Framgangsmåte for framstilling av organofluorforbindelser i alkoholholdige løsningsmidler. NO345018B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20040106553 2004-12-15
KR1020050084411A KR100789847B1 (ko) 2004-12-15 2005-09-10 알코올 용매하에서 유기플루오로 화합물의 제조방법
PCT/KR2005/004228 WO2006065038A1 (en) 2004-12-15 2005-12-09 Method for preparation of organofluoro compounds in alcohol solvents

Publications (2)

Publication Number Publication Date
NO20072570L true NO20072570L (no) 2007-09-04
NO345018B1 NO345018B1 (no) 2020-08-24

Family

ID=36588062

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072570A NO345018B1 (no) 2004-12-15 2007-05-21 Framgangsmåte for framstilling av organofluorforbindelser i alkoholholdige løsningsmidler.

Country Status (13)

Country Link
US (2) US7847092B2 (no)
EP (1) EP1824805B1 (no)
JP (1) JP4981683B2 (no)
KR (1) KR100789847B1 (no)
CN (1) CN101094824B (no)
AU (1) AU2005317370B8 (no)
CA (1) CA2590014C (no)
IL (1) IL183548A (no)
NO (1) NO345018B1 (no)
NZ (1) NZ555538A (no)
RU (1) RU2357947C2 (no)
UA (1) UA83324C2 (no)
WO (1) WO2006065038A1 (no)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
SG194363A1 (en) * 2004-12-17 2013-11-29 Univ Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
EP2017359A3 (en) 2007-06-11 2009-08-05 Trasis S.A. Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step
KR101009712B1 (ko) * 2007-02-22 2011-01-19 재단법인 아산사회복지재단 양성자성 용매와 이에 녹는 염들을 이용한 음이온 교환고분자 지지체로부터의 플루오린-18 플루오라이드 용리와이를 이용한 플루오린-18의 표지방법
EP2062630A1 (en) 2007-11-20 2009-05-27 Trasis S.A. Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium by the use of strong organic bases
AU2009220244B2 (en) 2008-02-29 2014-10-09 Lantheus Medical Imaging, Inc. Contrast agents for applications including perfusion imaging
KR100891700B1 (ko) * 2008-04-22 2009-04-03 한국원자력연구원 방사선을 이용한 플루오로알킬 화합물의 제조방법
GB0812923D0 (en) * 2008-07-15 2008-08-20 Isis Innovation Preparation of flourine-labelled compounds
KR101602992B1 (ko) 2009-04-15 2016-03-11 랜티우스 메디컬 이메징, 인크. 아스코르브산을 사용한 방사성 약제 조성물의 안정화
CA2767475A1 (en) * 2009-07-10 2011-01-13 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
CN104211620B (zh) * 2009-08-07 2016-05-25 和光纯药工业株式会社 双季铵盐的制造法和其中间体
GB0922023D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Preparation of n-monofluoroalkyl compounds
CN102858752B (zh) 2010-02-08 2018-10-16 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
WO2011127345A1 (en) 2010-04-08 2011-10-13 Siemens Medical Solutions Usa, Inc. Synthesis of 18f-labeled tracers in hydrous organic solvents
EP2569071B1 (en) 2010-05-10 2015-07-08 Technische Universität München Method for the direct elution of reactive [18f]fluoride from an anion exchange resin in an organic medium suitable for radiolabelling without any evaporation step by the use of alkalimetal and alkaline earth metal cryptates
AU2011260420A1 (en) 2010-06-04 2013-01-10 Piramal Imaging Sa Method for production of F-18 labeled amyloid beta ligand
SG185782A1 (en) 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
EA201201647A1 (ru) * 2010-06-04 2013-05-30 Пирамаль Имэджинг Са Способ получения f-18 меченных лигандов бета-амилоида
DE102010036356A1 (de) * 2010-07-12 2012-01-12 Abx Advanced Biochemical Compounds Gmbh Vorrichtung zur Synthese radioaktiv markierter Verbindungen
CN103442738A (zh) 2010-09-09 2013-12-11 皮拉马影像股份公司 快速制备用于亲核[18f]氟化的适当[18f]氟化物的方法
KR101269588B1 (ko) 2010-10-13 2013-06-05 (주)퓨쳐켐 Ｆｐ―ｃｉｔ 전구체로서의 아제티디늄 염, 이의 선택적 제조방법 및 ｆｐ―ｃｉｔ의 합성
WO2012081880A2 (ko) 2010-12-14 2012-06-21 서강대학교산학협력단 18f 방사성의약품 제조를 위한 고체 지지체에 연결된 전구체 화합물, 이의 제조방법 및 응용
WO2012157900A2 (ko) * 2011-05-13 2012-11-22 서강대학교산학협력단 18f-표지 pet 방사성의약품의 전구체 및 그 제조방법
GB201117785D0 (en) * 2011-10-14 2011-11-30 Ge Healthcare Ltd Improved radiosynthesis method
GB201117786D0 (en) * 2011-10-14 2011-11-30 Ge Healthcare Ltd Eluent vial
US20140243533A1 (en) 2011-10-19 2014-08-28 Piramal Imaging Sa Method for production of f-18 labeled a-beta ligands
GB201120586D0 (en) * 2011-11-30 2012-01-11 Ge Healthcare Ltd Solid phase extraction neutralisation
KR101326000B1 (ko) * 2012-01-30 2013-11-07 재단법인 아산사회복지재단 수소이온 농도가 조절된 플루오린-18의 용리액 제조 및 이를 이용한 플루오린-18의 표지방법
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
CN104109111B (zh) * 2013-04-22 2019-02-12 江苏豪森药业集团有限公司 托西酸贝格列汀及其中间体的制备方法
PL3049378T3 (pl) * 2013-09-25 2019-06-28 SpecGx LLC Wytwarzanie radiojodowanego 3-fluoropropylo-nor-beta-CIT
WO2015063692A1 (en) * 2013-10-31 2015-05-07 Sabic Global Technologies B.V. Process for making axially fluorinated-phthalocyanines and their use in photovoltaic applications
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
DK3216780T5 (da) 2014-11-07 2021-03-15 Asan Found Fremgangsmåde til fremstilling af organisk fluorid-alifatisk forbindelse og fremgangsmåde til oprensning af organisk fluorid-alifatisk forbindelse
BE1023674B1 (fr) * 2015-12-11 2017-06-12 Out And Out Chemistry Sprl Actionneur rotatif a positionnement multiple controle par un fluide
KR20170076933A (ko) * 2015-12-24 2017-07-05 (의료)길의료재단 불소-18 동위원소를 함유하는 방사성 화합물의 제조방법
ES2929277T3 (es) * 2016-11-08 2022-11-28 Univ California Métodos para la síntesis multidosis de [F-18]FDDNP para contextos clínicos
KR101842989B1 (ko) * 2018-01-02 2018-03-28 (주)퓨쳐켐 카보닐기를 갖는 알코올 용매를 이용한 플루오르화 화합물의 제조방법
KR102063498B1 (ko) 2019-06-25 2020-01-08 (주)퓨쳐켐 불포화 탄화수소기를 갖는 알코올 용매를 이용한 플루오로 화합물의 제조방법
CN115160308A (zh) * 2022-08-08 2022-10-11 江苏华益科技有限公司 一种18f-fpcit的自动化合成方法
EP4559890A1 (en) 2023-11-27 2025-05-28 Trasis S.A. Stabilized method for 18f-labeling
WO2025114063A1 (en) 2023-11-27 2025-06-05 Trasis S.A. Stabilized method for 18f-labeling
BE1031675B1 (fr) * 2023-11-27 2025-01-08 Trasis S A Methode stabilisée pour le marquage au 18f

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE710129C (de) * 1936-12-24 1941-09-04 Dr Alfred Gnuechtel Verfahren zur Herstellung fluorierter aliphatischer Kohlenwasserstoffe
US2980670A (en) 1959-11-02 1961-04-18 Pfizer & Co C Fluorinated corticosteroids
DE68922353T2 (de) * 1988-08-26 1996-01-18 Asahi Glass Co Ltd Kernfluorierte aromatische Carboxylate und ihre Herstellungsverfahren.
JPH05301844A (ja) * 1992-04-22 1993-11-16 Idemitsu Kosan Co Ltd ２−フルオロイソ酪酸エステルの製造方法
WO1995009844A1 (en) * 1993-10-04 1995-04-13 Board Of Regents, The University Of Texas System Rapid synthesis and use of 18f-fluoromisonidazole and analogs
CA2340394A1 (en) * 1998-08-20 2000-03-02 Jorge R. Barrio Methods for labeling .beta.-amyloid plaques and neurofibrillary tangles
RU2165266C1 (ru) * 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
DE10104250A1 (de) * 2001-01-31 2002-08-14 Deutsches Krebsforsch Markierungsfähige Verbindungen zur einfachen Synthese von 3'-[18F]Fluor-3'-deoxythymidin und Verfahren zu deren Herstellung
GB0115927D0 (en) * 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
KR100441153B1 (ko) * 2002-03-14 2004-07-21 주식회사 씨트리 유기 불소화합물의 제조방법
WO2006078384A2 (en) * 2004-12-17 2006-07-27 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use

Also Published As

Publication number Publication date
JP4981683B2 (ja) 2012-07-25
EP1824805B1 (en) 2020-02-12
NZ555538A (en) 2010-10-29
KR100789847B1 (ko) 2007-12-28
AU2005317370B8 (en) 2008-12-11
AU2005317370A1 (en) 2007-06-14
IL183548A0 (en) 2007-09-20
EP1824805A4 (en) 2010-01-06
AU2005317370B2 (en) 2006-06-22
RU2357947C2 (ru) 2009-06-10
CN101094824B (zh) 2011-07-27
US20080171863A1 (en) 2008-07-17
HK1108683A1 (en) 2008-05-16
US7847092B2 (en) 2010-12-07
JP2008524205A (ja) 2008-07-10
KR20060067808A (ko) 2006-06-20
RU2007126814A (ru) 2009-01-27
EP1824805A1 (en) 2007-08-29
CA2590014A1 (en) 2006-06-22
WO2006065038A1 (en) 2006-06-22
NO345018B1 (no) 2020-08-24
CN101094824A (zh) 2007-12-26
UA83324C2 (ru) 2008-06-25
CA2590014C (en) 2010-05-25
IL183548A (en) 2011-04-28
US20100113763A1 (en) 2010-05-06

Similar Documents

Publication Publication Date Title
NO20072570L (no) Framgangsmate for framstilling av organisk fluor forbindelser i alkoholholdige losningsmidler.
Milcent et al. The main and recent syntheses of the N-CF3 motif
FR2962731A1 (fr) Procede de preparation de derives d&#39;amino-benzoyl-benzofurane
RU2007143164A (ru) Тайгециклин и способы получения 9-нитроминоциклина
NO341560B1 (no) Fluorineringsframgangsmåter, nye forbindelser, samt radiofarmasøytiske sett og kassetter
IL260303A (en) Process for the preparation of 3,1,1-trioxo-2,1-benzothiazole-6-carboxamide
CN111217796B (zh) 一类螺环-二吡咯甲烷/二吡咯甲川化合物及其制备方法和应用
CN111217842B (zh) 一类螺环-二吡咯甲烷硼配合物/二吡咯甲川硼配合物及其制备方法和应用
CN111848423B (zh) 3-氧代环丁基氨基甲酸叔丁酯的制备方法
Kolleth et al. Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process
Sarabia et al. A highly efficient methodology of asymmetric epoxidation based on a novel chiral sulfur ylide
US9156758B2 (en) Perfluoroalkylation of carbonyl compounds
MXPA02012398A (es) Proceso para la preparacion de derivados de quinolina.
Gong et al. Novel chiral bifunctional l-thiazoline-amide derivatives: Design and application in the direct enantioselective aldol reactions
US7186860B2 (en) Process for the preparation of 2-[(diphenylmethyl) thio] acetamide
JP6894608B2 (ja) 新規な環状尿素誘導体−三臭化水素酸塩
KR100743617B1 (ko) 고광학순도를 갖는 키랄 3-히드록시 피롤리딘 및 그유도체를 제조하는 방법
Song et al. The synthesis of N-Trifluoromethyl hydroxylamine from (trifluoromethyl) trimethylsilane
CN106187843B (zh) 一种制备(s)-4-氨基-5-巯基戊酸的方法
CN110669021B (zh) 一种3-芳基-4,5-二氢异噁唑-5-基甲基磺酸酯以及类似物的合成方法
NO982503L (no) FremgangsmÕte ved fremstilling av dioksoazabicykloheksaner
CN109574778A (zh) 一种布瓦西坦及其中间体的制备方法
Zhou et al. A Convenient synthesis of trifluoroacetamides from sodium trifluoroacetate and amines
WO2011041529A2 (en) Tri-2-naphthylamines
ES2279093T3 (es) Procedimiento para preparar derivados imidazolicos y sus sales.