NO982503L - FremgangsmÕte ved fremstilling av dioksoazabicykloheksaner - Google Patents
FremgangsmÕte ved fremstilling av dioksoazabicykloheksanerInfo
- Publication number
- NO982503L NO982503L NO982503A NO982503A NO982503L NO 982503 L NO982503 L NO 982503L NO 982503 A NO982503 A NO 982503A NO 982503 A NO982503 A NO 982503A NO 982503 L NO982503 L NO 982503L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compound
- organic solvent
- base
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- HGCBTXNRSHFSOF-UHFFFAOYSA-N 1-cyclohexylpiperidine-2,3-dione Chemical class O=C1C(=O)CCCN1C1CCCCC1 HGCBTXNRSHFSOF-UHFFFAOYSA-N 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 abstract 1
- 229910000024 caesium carbonate Inorganic materials 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 239000011698 potassium fluoride Substances 0.000 abstract 1
- 235000003270 potassium fluoride Nutrition 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 abstract 1
- 235000019801 trisodium phosphate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Fremgangsmåte ved fremstilling av en forbindelse med formel (I), hvor R betyr CVCs-alkyl, C3-C6-cykloalkyl eller benzyl, og hvor fenyldelen av benzylgruppen valg- fritt kan være substituert med en eller flere substitu- enter som hver uavhengig velges fra halogen, nitrogen, Ci-Cj-alkyl, Ci-C^alkoksy, amino og trifluormetyl, omfattende å tilsette en oppløsning som inneholder en forbindelse med formel (II), et halogerinitrometan og et organisk oppløsningsmiddel utvalgt fra aceton, dimetyl- formamid, dimetylacetamid, acetonitril, dimetylsulf- oksid, N-metylpyrrolidinon og dimetoksyetan. I formel (II), hvor R har den ovennevnte betydning, til en blan- ding omfattende en base og et organisk oppløsningsmid- del, idet det organiske oppløsningsmiddel er som beskrevet ovenfor, og basen velges fra kaliumkarbonat, natriumkarbonat, cesiumkarbonat, trinatriumfosfat og kaliumfluorid, således at det dannes en forbindelse med formel (I), idet et eventuelt overskudd av base fjernes fra reaksjonsblandingen før produktet (I) isoleres.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9524466.1A GB9524466D0 (en) | 1995-11-30 | 1995-11-30 | Process |
| PCT/EP1996/004782 WO1997019921A1 (en) | 1995-11-30 | 1996-10-31 | Process for preparing dioxoazabicyclohexanes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO982503L true NO982503L (no) | 1998-06-02 |
| NO982503D0 NO982503D0 (no) | 1998-06-02 |
Family
ID=10784676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO982503A NO982503D0 (no) | 1995-11-30 | 1998-06-02 | FremgangsmÕte ved fremstilling av dioksoazabicykloheksaner |
Country Status (40)
| Country | Link |
|---|---|
| EP (1) | EP0863874B1 (no) |
| JP (1) | JP2000507919A (no) |
| KR (1) | KR100286157B1 (no) |
| CN (1) | CN1203588A (no) |
| AP (1) | AP746A (no) |
| AR (1) | AR004766A1 (no) |
| AT (1) | ATE198325T1 (no) |
| AU (1) | AU707221B2 (no) |
| BG (1) | BG102484A (no) |
| BR (1) | BR9611833A (no) |
| CA (1) | CA2231590A1 (no) |
| CO (1) | CO4480102A1 (no) |
| CZ (1) | CZ162298A3 (no) |
| DE (1) | DE69611380T2 (no) |
| DK (1) | DK0863874T3 (no) |
| ES (1) | ES2152571T3 (no) |
| GB (1) | GB9524466D0 (no) |
| GR (1) | GR3035341T3 (no) |
| HR (1) | HRP960555A2 (no) |
| HU (1) | HUP9903571A3 (no) |
| IL (1) | IL123561A0 (no) |
| IS (1) | IS4707A (no) |
| MA (1) | MA24015A1 (no) |
| MX (1) | MX9804311A (no) |
| MY (1) | MY132595A (no) |
| NO (1) | NO982503D0 (no) |
| NZ (1) | NZ321968A (no) |
| OA (1) | OA10692A (no) |
| PE (1) | PE24898A1 (no) |
| PL (1) | PL326978A1 (no) |
| PT (1) | PT863874E (no) |
| RU (1) | RU2156238C2 (no) |
| SK (1) | SK70798A3 (no) |
| TN (1) | TNSN96145A1 (no) |
| TR (1) | TR199800957T2 (no) |
| TW (1) | TW401397B (no) |
| UY (1) | UY24379A1 (no) |
| WO (1) | WO1997019921A1 (no) |
| YU (1) | YU63196A (no) |
| ZA (1) | ZA9610053B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1087617A (ja) * | 1996-07-09 | 1998-04-07 | Pfizer Inc | キノリン系抗生物質の合成に有用な中間体の製法 |
| HN1998000106A (es) | 1997-08-01 | 1999-01-08 | Pfizer Prod Inc | Composiciones parenterales de alatroflaxacino |
| US7019142B2 (en) | 1998-01-16 | 2006-03-28 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
| BR0215659A (pt) * | 2002-03-25 | 2005-01-25 | Council Scient Ind Res | Perfilamento de proteìnas de plantas hiper acìdicas |
| NL2000192C2 (nl) * | 2006-08-23 | 2008-02-26 | Veenvoort B V De | Stabiel bitumenschuim en de bereiding en het gebruik ervan. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256791A (en) * | 1992-03-02 | 1993-10-26 | Pfizer Inc. | Preparation of intermediates in the synthesis of quinoline antibiotics |
| CZ286896B6 (en) * | 1994-01-18 | 2000-07-12 | Pfizer | Process for preparing pharmaceutically acceptable salts of naphthyridone carboxylic acid and intermediates for this preparation |
-
1995
- 1995-11-30 GB GBGB9524466.1A patent/GB9524466D0/en active Pending
-
1996
- 1996-10-21 TW TW085112856A patent/TW401397B/zh not_active IP Right Cessation
- 1996-10-31 BR BR9611833A patent/BR9611833A/pt not_active Application Discontinuation
- 1996-10-31 KR KR1019980703892A patent/KR100286157B1/ko not_active Expired - Fee Related
- 1996-10-31 DK DK96938058T patent/DK0863874T3/da active
- 1996-10-31 SK SK707-98A patent/SK70798A3/sk unknown
- 1996-10-31 EP EP96938058A patent/EP0863874B1/en not_active Expired - Lifetime
- 1996-10-31 DE DE69611380T patent/DE69611380T2/de not_active Expired - Fee Related
- 1996-10-31 ES ES96938058T patent/ES2152571T3/es not_active Expired - Lifetime
- 1996-10-31 TR TR1998/00957T patent/TR199800957T2/xx unknown
- 1996-10-31 NZ NZ321968A patent/NZ321968A/xx unknown
- 1996-10-31 IL IL12356196A patent/IL123561A0/xx unknown
- 1996-10-31 AT AT96938058T patent/ATE198325T1/de not_active IP Right Cessation
- 1996-10-31 CN CN96198667A patent/CN1203588A/zh active Pending
- 1996-10-31 WO PCT/EP1996/004782 patent/WO1997019921A1/en not_active Ceased
- 1996-10-31 PL PL96326978A patent/PL326978A1/xx unknown
- 1996-10-31 AU AU75629/96A patent/AU707221B2/en not_active Ceased
- 1996-10-31 CA CA002231590A patent/CA2231590A1/en not_active Abandoned
- 1996-10-31 RU RU98112016/04A patent/RU2156238C2/ru active
- 1996-10-31 HU HU9903571A patent/HUP9903571A3/hu unknown
- 1996-10-31 JP JP9520100A patent/JP2000507919A/ja active Pending
- 1996-10-31 CZ CZ981622A patent/CZ162298A3/cs unknown
- 1996-10-31 PT PT96938058T patent/PT863874E/pt unknown
- 1996-11-21 HR HR9524466.1A patent/HRP960555A2/hr not_active Application Discontinuation
- 1996-11-27 PE PE1996000850A patent/PE24898A1/es not_active Application Discontinuation
- 1996-11-27 TN TNTNSN96145A patent/TNSN96145A1/fr unknown
- 1996-11-27 UY UY24379A patent/UY24379A1/es not_active IP Right Cessation
- 1996-11-27 MA MA24403A patent/MA24015A1/fr unknown
- 1996-11-27 AR ARP960105343A patent/AR004766A1/es unknown
- 1996-11-28 CO CO96062767A patent/CO4480102A1/es unknown
- 1996-11-28 AP APAP/P/1996/000885A patent/AP746A/en active
- 1996-11-28 YU YU63196A patent/YU63196A/sh unknown
- 1996-11-29 MY MYPI96005005A patent/MY132595A/en unknown
- 1996-11-29 ZA ZA9610053A patent/ZA9610053B/xx unknown
-
1998
- 1998-03-31 IS IS4707A patent/IS4707A/is unknown
- 1998-05-25 BG BG102484A patent/BG102484A/xx unknown
- 1998-05-29 OA OA9800068A patent/OA10692A/en unknown
- 1998-05-29 MX MX9804311A patent/MX9804311A/es unknown
- 1998-06-02 NO NO982503A patent/NO982503D0/no not_active Application Discontinuation
-
2001
- 2001-02-01 GR GR20010400166T patent/GR3035341T3/el not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |