NO20072666L - Krystallinske former av en faktor Xa-inhibitor - Google Patents

Krystallinske former av en faktor Xa-inhibitor

Info

Publication number: NO20072666L
Authority: NO; Norway
Prior art keywords: crystal forms; inhibitor; factor; crystalline forms; pyridin
Prior art date: 2004-12-15

Application number

NO20072666A

Other languages

English (en)

Norwegian (no)

Inventor

Mary F Malley

Michael J Orwat

Roxana F Schlam

Steven R Fabian

Bing-Shiou Yang

Victor W Rosso

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-15

Filing date

2007-05-25

Publication date

2007-09-07

2007-05-25 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2007-09-07 Publication of NO20072666L publication Critical patent/NO20072666L/no

Links

229940123583 Factor Xa inhibitor Drugs 0.000 title 1
239000013078 crystal Substances 0.000 abstract 4
238000000034 method Methods 0.000 abstract 2
CIILSCBHHPSNEY-UHFFFAOYSA-N 3-(2-hydroxypropan-2-yl)-1-(4-methoxyphenyl)-6-[4-(2-oxopyridin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridin-7-one Chemical compound C1=CC(OC)=CC=C1N1C(C(=O)N(CC2)C=3C=CC(=CC=3)N3C(C=CC=C3)=O)=C2C(C(C)(C)O)=N1 CIILSCBHHPSNEY-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
230000009424 thromboembolic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20072666A 2004-12-15 2007-05-25 Krystallinske former av en faktor Xa-inhibitor NO20072666L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US63638704P	2004-12-15	2004-12-15
US73798505P	2005-11-18	2005-11-18
PCT/US2005/045158 WO2006065853A2 (en)	2004-12-15	2005-12-14	Crystalline forms of a factor xa inhibitor

Publications (1)

Publication Number	Publication Date
NO20072666L true NO20072666L (no)	2007-09-07

Family

ID=36384503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20072666A NO20072666L (no)	2004-12-15	2007-05-25	Krystallinske former av en faktor Xa-inhibitor

Country Status (15)

Country	Link
US (2)	US7371864B2 (2)
EP (1)	EP1828187A2 (2)
JP (1)	JP2008524228A (2)
KR (1)	KR20070087606A (2)
AR (1)	AR053990A1 (2)
AU (1)	AU2005317158A1 (2)
BR (1)	BRPI0519331A2 (2)
CA (1)	CA2589886A1 (2)
IL (1)	IL183825A0 (2)
MX (1)	MX2007006919A (2)
NO (1)	NO20072666L (2)
PE (1)	PE20060739A1 (2)
RU (1)	RU2007126770A (2)
TW (1)	TW200634011A (2)
WO (1)	WO2006065853A2 (2)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5588970B2 (ja)	2008-05-27	2014-09-10	ダコ・デンマーク・エー／エス	ハイブリダイゼーション組成物及び方法
US9303287B2 (en) *	2009-02-26	2016-04-05	Dako Denmark A/S	Compositions and methods for RNA hybridization applications
US10662465B2 (en)	2011-09-30	2020-05-26	Agilent Technologies, Inc.	Hybridization compositions and methods using formamide
US11118226B2 (en)	2011-10-21	2021-09-14	Agilent Technologies, Inc.	Hybridization compositions and methods
UY38438A (es)	2018-11-02	2020-05-29	Biocryst Pharm Inc	Sales cristalinas de un inhibidor de calicreína plasmática

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI320039B (en)	2001-09-21	2010-02-01		Lactam-containing compounds and derivatives thereof as factor xa inhibitors
CN104744461A (zh) *	2001-09-21	2015-07-01	百时美施贵宝公司	含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
US7304157B2 (en) *	2004-09-28	2007-12-04	Bristol-Myers Squibb Company	Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US20060069260A1 (en) *	2004-09-28	2006-03-30	Huiping Zhang	Preparation of N-aryl pyridones
US20060069085A1 (en) *	2004-09-28	2006-03-30	Rulin Zhao	Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US7388096B2 (en)	2004-09-28	2008-06-17	Bristol-Myers Squibb Company	Crystalline forms of a factor Xa inhibitor

2005
- 2005-12-14 BR BRPI0519331-1A patent/BRPI0519331A2/pt not_active IP Right Cessation
- 2005-12-14 WO PCT/US2005/045158 patent/WO2006065853A2/en not_active Ceased
- 2005-12-14 RU RU2007126770/04A patent/RU2007126770A/ru not_active Application Discontinuation
- 2005-12-14 PE PE2005001450A patent/PE20060739A1/es not_active Application Discontinuation
- 2005-12-14 AU AU2005317158A patent/AU2005317158A1/en not_active Abandoned
- 2005-12-14 KR KR1020077013364A patent/KR20070087606A/ko not_active Withdrawn
- 2005-12-14 US US11/302,692 patent/US7371864B2/en active Active
- 2005-12-14 MX MX2007006919A patent/MX2007006919A/es active IP Right Grant
- 2005-12-14 JP JP2007546841A patent/JP2008524228A/ja active Pending
- 2005-12-14 CA CA002589886A patent/CA2589886A1/en not_active Abandoned
- 2005-12-14 AR ARP050105253A patent/AR053990A1/es unknown
- 2005-12-14 EP EP05853961A patent/EP1828187A2/en not_active Withdrawn
- 2005-12-14 TW TW094144289A patent/TW200634011A/zh unknown
2007
- 2007-05-25 NO NO20072666A patent/NO20072666L/no unknown
- 2007-06-10 IL IL183825A patent/IL183825A0/en unknown
2008
- 2008-04-09 US US12/099,906 patent/US20080188517A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL183825A0 (en)	2007-09-20
KR20070087606A (ko)	2007-08-28
AU2005317158A1 (en)	2006-06-22
BRPI0519331A2 (pt)	2009-01-20
US20080188517A1 (en)	2008-08-07
JP2008524228A (ja)	2008-07-10
WO2006065853A3 (en)	2006-08-24
AR053990A1 (es)	2007-05-30
US7371864B2 (en)	2008-05-13
MX2007006919A (es)	2007-06-26
TW200634011A (en)	2006-10-01
US20060148846A1 (en)	2006-07-06
PE20060739A1 (es)	2006-08-16
RU2007126770A (ru)	2009-01-27
EP1828187A2 (en)	2007-09-05
WO2006065853A2 (en)	2006-06-22
CA2589886A1 (en)	2006-06-22

Publication	Publication Date	Title
NO20084912L (no)	2009-02-03	Bisykliske derivater som CETP-inhibitorer
NO20061454L (no)	2006-07-06	Compounds having CRTH2 antagonist activity
NO20071702L (no)	2007-05-25	Fremgangsmate for fremstilling av 4,5-dihydro-pyrazolo[3,4-C]pyrid-oner
NO20062561L (no)	2006-09-08	Kinoliner nyttige for behandling av kardiovaskulaere sykdommer
NO20071549L (no)	2007-05-15	Nye benzofuserte heteroalrylsulfamidderivater, anvendelige som anti-krampemidler
WO2007143434A3 (en)	2008-07-03	Indazole and isoindole derivatives as glucokinase activating agents
NO20085373L (no)	2005-11-29	P38 inhibitorer, deres fremstilling og anvendelse
NO20043531L (no)	2004-10-25	Indazolforbindelser som er nyttige som proteinkinaseinhibitorer
NO20082026L (no)	2008-06-25	Deazapuriner som er nyttige som inhibitorer for Janus-kinaser
WO2006123088A3 (en)	2007-06-28	4- (thiazol-2-ylthioalkyl) -pyrazoles and their use as herbicides
WO2008060476A3 (en)	2008-12-24	Nitrogen-containing heterocyclic compounds and methods of use thereof
NO20083246L (no)	2008-09-11	Nye benzimidazolderivater som vanilloid-reseptor 1 (VRL) inhibitorer
WO2006005609A3 (de)	2006-03-16	Substituierte oxindol-derivate und diese enthaltende arzneimittel
NO20082112L (no)	2008-06-23	3-Amino-2-arylpropylazaindoler og deres anvendelse
WO2006034093A3 (en)	2006-07-13	3- (2-acylamino-1-hydroxyethyl)- morpholine derivatives and their use as bace inhibitors
NO20072666L (no)	2007-09-07	Krystallinske former av en faktor Xa-inhibitor
NO20035571L (no)	2004-02-16	N-formyl hydroksylaminforbindelser som PDF-inhibitorer
NO20080033L (no)	2008-01-03	Kinolinderivater som NK3-antagonister
WO2005065018A3 (en)	2005-10-20	Crystalline forms of (6r) -l-erythro-tetrahydrobiopterin dihydrochloride
WO2005089511A3 (en)	2007-02-22	Novel pharmaceutical forms, and methods of making and using the same
NO20042861L (no)	2001-11-22	N-(3-butyn-1-yl)-N-hydroksyurea
NO20063576L (no)	2006-10-06	1,3-dioksanederivativer og analoge forbindelser for behandling av fedme og diabetes
WO2003087062A3 (en)	2003-11-20	4-(heterocyclyl)-benzenesulfoximine compounds for the treatment of inflammation
AU2003238475A1 (en)	2004-01-19	2-(phenyl)-2h-pyrazole-3-carboxylic acid-n-4-(thioxo-heterocyclyl)-phenyl-amide derivatives and corresponding imino-heterocyclyl derivatives and relates compounds for use as inhibitors of the coagulation factors xa and/or viia for treating thromboses
WO2004072029A3 (en)	2004-12-16	Pyrazolopyridazines useful as inhibitors of protein kinases