PE20060739A1 - FORMAS CRISTALINAS DE 3-(1-HIDROXI-1-METIL-ETIL)-1-(4-METOXI-FENIL)-6-[4-(2-OXO-2H-PIRIDIN-1-IL)-FENIL]-1,4,5,6-TETRAHIDRO-PIRAZOLO[3,4-c]PIRIDIN-7-ONA COMO INHIBIDORES DEL FACTOR Xa - Google Patents

FORMAS CRISTALINAS DE 3-(1-HIDROXI-1-METIL-ETIL)-1-(4-METOXI-FENIL)-6-[4-(2-OXO-2H-PIRIDIN-1-IL)-FENIL]-1,4,5,6-TETRAHIDRO-PIRAZOLO[3,4-c]PIRIDIN-7-ONA COMO INHIBIDORES DEL FACTOR Xa

Info

Publication number: PE20060739A1
Authority: PE; Peru
Prior art keywords: pyridin; phenyl; crystalline forms; ona; pyrazolo
Prior art date: 2004-12-15

Application number

PE2005001450A

Other languages

English (en)

Spanish (es)

Inventor

Michael J Orwat

Mary F Malley

Roxana Schlam

Bing-Shiou Yang

Victor W Rosso

Steven R Fabian

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-15

Filing date

2005-12-14

Publication date

2006-08-16

2005-12-14 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2006-08-16 Publication of PE20060739A1 publication Critical patent/PE20060739A1/es

Links

108010074860 Factor Xa Proteins 0.000 title abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical class CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
GPKUICFDWYEPTK-UHFFFAOYSA-N methoxycyclohexatriene Chemical class COC1=CC=C=C[CH]1 GPKUICFDWYEPTK-UHFFFAOYSA-N 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
JTXMVXSTHSMVQF-UHFFFAOYSA-N 2-acetyloxyethyl acetate Chemical compound CC(=O)OCCOC(C)=O JTXMVXSTHSMVQF-UHFFFAOYSA-N 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000009424 thromboembolic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PE2005001450A 2004-12-15 2005-12-14 FORMAS CRISTALINAS DE 3-(1-HIDROXI-1-METIL-ETIL)-1-(4-METOXI-FENIL)-6-[4-(2-OXO-2H-PIRIDIN-1-IL)-FENIL]-1,4,5,6-TETRAHIDRO-PIRAZOLO[3,4-c]PIRIDIN-7-ONA COMO INHIBIDORES DEL FACTOR Xa PE20060739A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63638704P	2004-12-15	2004-12-15
US73798505P	2005-11-18	2005-11-18

Publications (1)

Publication Number	Publication Date
PE20060739A1 true PE20060739A1 (es)	2006-08-16

Family

ID=36384503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PE2005001450A PE20060739A1 (es)	2004-12-15	2005-12-14	FORMAS CRISTALINAS DE 3-(1-HIDROXI-1-METIL-ETIL)-1-(4-METOXI-FENIL)-6-[4-(2-OXO-2H-PIRIDIN-1-IL)-FENIL]-1,4,5,6-TETRAHIDRO-PIRAZOLO[3,4-c]PIRIDIN-7-ONA COMO INHIBIDORES DEL FACTOR Xa

Country Status (15)

Country	Link
US (2)	US7371864B2 (2)
EP (1)	EP1828187A2 (2)
JP (1)	JP2008524228A (2)
KR (1)	KR20070087606A (2)
AR (1)	AR053990A1 (2)
AU (1)	AU2005317158A1 (2)
BR (1)	BRPI0519331A2 (2)
CA (1)	CA2589886A1 (2)
IL (1)	IL183825A0 (2)
MX (1)	MX2007006919A (2)
NO (1)	NO20072666L (2)
PE (1)	PE20060739A1 (2)
RU (1)	RU2007126770A (2)
TW (1)	TW200634011A (2)
WO (1)	WO2006065853A2 (2)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5588970B2 (ja)	2008-05-27	2014-09-10	ダコ・デンマーク・エー／エス	ハイブリダイゼーション組成物及び方法
US9303287B2 (en) *	2009-02-26	2016-04-05	Dako Denmark A/S	Compositions and methods for RNA hybridization applications
US10662465B2 (en)	2011-09-30	2020-05-26	Agilent Technologies, Inc.	Hybridization compositions and methods using formamide
US11118226B2 (en)	2011-10-21	2021-09-14	Agilent Technologies, Inc.	Hybridization compositions and methods
UY38438A (es)	2018-11-02	2020-05-29	Biocryst Pharm Inc	Sales cristalinas de un inhibidor de calicreína plasmática

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI320039B (en)	2001-09-21	2010-02-01		Lactam-containing compounds and derivatives thereof as factor xa inhibitors
CN104744461A (zh) *	2001-09-21	2015-07-01	百时美施贵宝公司	含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
US7304157B2 (en) *	2004-09-28	2007-12-04	Bristol-Myers Squibb Company	Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US20060069260A1 (en) *	2004-09-28	2006-03-30	Huiping Zhang	Preparation of N-aryl pyridones
US20060069085A1 (en) *	2004-09-28	2006-03-30	Rulin Zhao	Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
US7388096B2 (en)	2004-09-28	2008-06-17	Bristol-Myers Squibb Company	Crystalline forms of a factor Xa inhibitor

2005
- 2005-12-14 BR BRPI0519331-1A patent/BRPI0519331A2/pt not_active IP Right Cessation
- 2005-12-14 WO PCT/US2005/045158 patent/WO2006065853A2/en not_active Ceased
- 2005-12-14 RU RU2007126770/04A patent/RU2007126770A/ru not_active Application Discontinuation
- 2005-12-14 PE PE2005001450A patent/PE20060739A1/es not_active Application Discontinuation
- 2005-12-14 AU AU2005317158A patent/AU2005317158A1/en not_active Abandoned
- 2005-12-14 KR KR1020077013364A patent/KR20070087606A/ko not_active Withdrawn
- 2005-12-14 US US11/302,692 patent/US7371864B2/en active Active
- 2005-12-14 MX MX2007006919A patent/MX2007006919A/es active IP Right Grant
- 2005-12-14 JP JP2007546841A patent/JP2008524228A/ja active Pending
- 2005-12-14 CA CA002589886A patent/CA2589886A1/en not_active Abandoned
- 2005-12-14 AR ARP050105253A patent/AR053990A1/es unknown
- 2005-12-14 EP EP05853961A patent/EP1828187A2/en not_active Withdrawn
- 2005-12-14 TW TW094144289A patent/TW200634011A/zh unknown
2007
- 2007-05-25 NO NO20072666A patent/NO20072666L/no unknown
- 2007-06-10 IL IL183825A patent/IL183825A0/en unknown
2008
- 2008-04-09 US US12/099,906 patent/US20080188517A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL183825A0 (en)	2007-09-20
KR20070087606A (ko)	2007-08-28
AU2005317158A1 (en)	2006-06-22
BRPI0519331A2 (pt)	2009-01-20
US20080188517A1 (en)	2008-08-07
JP2008524228A (ja)	2008-07-10
WO2006065853A3 (en)	2006-08-24
AR053990A1 (es)	2007-05-30
US7371864B2 (en)	2008-05-13
MX2007006919A (es)	2007-06-26
TW200634011A (en)	2006-10-01
US20060148846A1 (en)	2006-07-06
RU2007126770A (ru)	2009-01-27
EP1828187A2 (en)	2007-09-05
NO20072666L (no)	2007-09-07
WO2006065853A2 (en)	2006-06-22
CA2589886A1 (en)	2006-06-22

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Legal Events

Date	Code	Title	Description
2008-03-24	FC	Refusal