NO20072684L - Konjugater med anti-inflammatorisk aktivitet - Google Patents

Konjugater med anti-inflammatorisk aktivitet

Info

Publication number
NO20072684L
NO20072684L NO20072684A NO20072684A NO20072684L NO 20072684 L NO20072684 L NO 20072684L NO 20072684 A NO20072684 A NO 20072684A NO 20072684 A NO20072684 A NO 20072684A NO 20072684 L NO20072684 L NO 20072684L
Authority
NO
Norway
Prior art keywords
inflammatory activity
steroid
xiii
nonsteroidal
substructure
Prior art date
Application number
NO20072684A
Other languages
English (en)
Inventor
Mladen Mercep
Milan Mesic
Linda Tomaskovic
Stribor Markovic
Visnja Poljak
Gordana Sijan
Selvira Selmani
Original Assignee
Glaxosmithkline Zagreb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Zagreb filed Critical Glaxosmithkline Zagreb
Publication of NO20072684L publication Critical patent/NO20072684L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det foreliggende oppfinnelsen vedrører nye forbindelser representert ved formel 1: hvor m representerer en makrolid subenhet av substrukturen VIII: L representerer kjeden i substrukturen IX eller XIII: -X1-(CH2)m-Q-(CH2)n-X2- IX -X1-(CH2)m-V-(CH2)p-Q-(CH2)n-X2- XIII Z representerer steroidet eller den ikke-steroide subenheten som er utledet fra steroide eller ikke-steroide (NSAID) medikamenter med antiinflammatorisk aktivitet. Den foreliggende oppfinnelsen vedrører også farmasøytisk akseptable salter og oppløsninger av slike tillagede forbindelser, til prosess og intermediater for deres tillaging, så vel som den forbedrede terapeutiske virkningen og anvendelsen i behandlingen av inflammatoriske sykdommer og tilstander hos mennesker og dyr.
NO20072684A 2004-10-27 2007-05-25 Konjugater med anti-inflammatorisk aktivitet NO20072684L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62315404P 2004-10-27 2004-10-27
PCT/IB2005/003213 WO2006046123A2 (en) 2004-10-27 2005-10-27 Conjugates with anti-inflammatory activity

Publications (1)

Publication Number Publication Date
NO20072684L true NO20072684L (no) 2007-07-11

Family

ID=36097295

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072684A NO20072684L (no) 2004-10-27 2007-05-25 Konjugater med anti-inflammatorisk aktivitet

Country Status (17)

Country Link
US (1) US20090048221A1 (no)
EP (2) EP1805202B1 (no)
JP (1) JP2008517993A (no)
KR (1) KR20070083811A (no)
CN (1) CN101090908A (no)
AT (1) ATE453658T1 (no)
AU (1) AU2005298312A1 (no)
BR (1) BRPI0517024A (no)
CA (1) CA2585711A1 (no)
DE (1) DE602005018672D1 (no)
ES (1) ES2337915T3 (no)
IL (1) IL182694A0 (no)
MX (1) MX2007005073A (no)
NO (1) NO20072684L (no)
RU (1) RU2007119577A (no)
WO (1) WO2006046123A2 (no)
ZA (1) ZA200702579B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2337915T3 (es) * 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
FR2909876A1 (fr) * 2006-12-19 2008-06-20 Galderma Res & Dev S N C Snc Utilisation du nepafenac ou ses derives pour le traitement de desordres dermatologiques
CN101708338B (zh) * 2008-12-26 2014-06-04 中国人民解放军军事医学科学院放射与辐射医学研究所 含甾体结构的前药及其高度分散制剂
KR101245078B1 (ko) * 2010-11-11 2013-03-18 부산대학교 산학협력단 대장 선택성 셀레콕시브 전구체 화합물 및 이를 유효성분으로 함유하는 대장성 질환 치료 또는 예방용 약학조성물
AU2014252462A1 (en) 2013-04-10 2015-10-01 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
CN111148750A (zh) 2017-04-20 2020-05-12 来兴泰德基金会 作为抗癌剂的包含鏻离子的阿奇霉素衍生物
JP2020517748A (ja) 2017-04-20 2020-06-18 ライジング タイド ファウンデーション 抗がん剤としてホスホニウムイオンを含むアジスロマイシン誘導体
CN111601618A (zh) * 2018-09-14 2020-08-28 江阴贝瑞森制药有限公司 孟鲁司特与肽的新缀合物
CN111170959A (zh) * 2019-12-30 2020-05-19 南开大学 一种大环内酯化合物的晶型及其制备方法与用途
CN112521398B (zh) * 2020-07-30 2022-03-15 上海交通大学医学院附属仁济医院 一种海绵共附生菌来源开环重排甾体化合物及其制备方法与应用

Family Cites Families (22)

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ES2032831T5 (es) 1986-08-19 2001-02-16 Genentech Inc Dispositivo y dispersion para suministro intrapulmonar de factores de crecimiento polipeptidos y citoquinas.
EP0283055B1 (en) 1987-09-03 1990-08-29 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. 10-dihydro-10-deoxo-11-azaerythronolide-a-compounds, methods and intermediates for the manufacture thereof and their use in pharmaceuticals and in the manufacture thereof
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
ES2107806T3 (es) 1992-12-24 1997-12-01 Rhone Poulenc Rorer Ltd Nuevos esteroides.
KR970704456A (ko) 1994-08-12 1997-09-06 우에하라 아끼라 인터류킨 5 생성 억제제(Interleukin 5 Production Inhibitor)
EP0771564A4 (en) 1994-08-12 1998-05-06 Taisho Pharmaceutical Co Ltd Interleukin-5 production inhibitor
DE19616573C2 (de) 1996-04-25 1999-03-04 Pari Gmbh Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase
JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
EP1126838A4 (en) 1998-10-30 2005-02-16 Nitromed Inc NITROSIS AND NITROSYAL NON-STEROID ANTI-INFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
HRP20000310A2 (en) 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors
FI110835B (fi) 2000-07-11 2003-03-31 Radiolinja Ab Menetelmä palvelunumeropuhelun tarjoamiseksi matkaviestintilaajalle ennalta määrätyllä taksalla
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
AU2003219770B2 (en) * 2002-02-15 2008-10-09 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
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RU2330858C2 (ru) 2002-07-08 2008-08-10 Глаксомитклайн Истраживацки Центар Загреб Д.О.О. Новые соединения, составы и способы лечения воспалительных заболеваний и состояний
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ES2337915T3 (es) * 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.

Also Published As

Publication number Publication date
BRPI0517024A (pt) 2008-03-25
US20090048221A1 (en) 2009-02-19
JP2008517993A (ja) 2008-05-29
EP1805202B1 (en) 2009-12-30
ZA200702579B (en) 2008-08-27
RU2007119577A (ru) 2008-12-10
WO2006046123A2 (en) 2006-05-04
AU2005298312A1 (en) 2006-05-04
MX2007005073A (es) 2007-06-25
EP2196469A1 (en) 2010-06-16
ES2337915T3 (es) 2010-04-30
CN101090908A (zh) 2007-12-19
ATE453658T1 (de) 2010-01-15
WO2006046123A3 (en) 2006-07-06
DE602005018672D1 (de) 2010-02-11
EP1805202A2 (en) 2007-07-11
IL182694A0 (en) 2007-09-20
KR20070083811A (ko) 2007-08-24
CA2585711A1 (en) 2006-05-04

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