NO20072739L - Stabiliserte ramiprilsammensetninger og fremgangsmater for fremstilling - Google Patents

Stabiliserte ramiprilsammensetninger og fremgangsmater for fremstilling

Info

Publication number: NO20072739L
Authority: NO; Norway
Prior art keywords: methods; ramipril; preparation; stabilized; preparations
Prior art date: 2004-11-05

Application number

NO20072739A

Other languages

English (en)

Norwegian (no)

Inventor

Edward Wilson

Kevin H Sills

M Jolly

Martin W Beasley

David P Hause

Original Assignee

King Pharmaceuticals Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-05

Filing date

2007-05-30

Publication date

2007-07-24

2007-05-30 Application filed by King Pharmaceuticals Res & Dev filed Critical King Pharmaceuticals Res & Dev

2007-07-24 Publication of NO20072739L publication Critical patent/NO20072739L/no

Links

HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 title abstract 4
229960003401 ramipril Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
238000000354 decomposition reaction Methods 0.000 abstract 1
239000007857 degradation product Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
KOVMAAYRBJCASY-JBDAPHQKSA-N ramipril diketopiperazine Chemical compound C([C@@H](C(=O)OCC)N1C([C@@H]2C[C@@H]3CCC[C@@H]3N2C(=O)[C@@H]1C)=O)CC1=CC=CC=C1 KOVMAAYRBJCASY-JBDAPHQKSA-N 0.000 abstract 1
KEDYTOTWMPBSLG-HILJTLORSA-N ramiprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)C(O)=O)CC1=CC=CC=C1 KEDYTOTWMPBSLG-HILJTLORSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Manufacturing Of Micro-Capsules (AREA)

NO20072739A 2004-11-05 2007-05-30 Stabiliserte ramiprilsammensetninger og fremgangsmater for fremstilling NO20072739L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US62527004P	2004-11-05	2004-11-05
PCT/US2005/040430 WO2006052968A2 (fr)	2004-11-05	2005-11-07	Composition de ramipril stabilisee et procedes de fabrication

Publications (1)

Publication Number	Publication Date
NO20072739L true NO20072739L (no)	2007-07-24

Family

ID=36319833

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20072739A NO20072739L (no)	2004-11-05	2007-05-30	Stabiliserte ramiprilsammensetninger og fremgangsmater for fremstilling
NO20072741A NO20072741L (no)	2004-11-05	2007-05-30	Stabiliserte, individuelt belagte ramiprilpartikler, sammensetninger og fremgangsmater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20072741A NO20072741L (no)	2004-11-05	2007-05-30	Stabiliserte, individuelt belagte ramiprilpartikler, sammensetninger og fremgangsmater

Country Status (14)

Country	Link
US (2)	US20060134213A1 (fr)
EP (2)	EP1817007A2 (fr)
JP (2)	JP2008519063A (fr)
KR (2)	KR20070085754A (fr)
CN (2)	CN101098679A (fr)
AU (2)	AU2005301989A1 (fr)
BR (2)	BRPI0517662A (fr)
CA (2)	CA2586547A1 (fr)
IL (2)	IL183018A0 (fr)
MX (2)	MX2007005377A (fr)
NO (2)	NO20072739L (fr)
RU (2)	RU2007120817A (fr)
WO (2)	WO2006050533A2 (fr)
ZA (2)	ZA200704767B (fr)

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RU2479310C2 (ru) *	2011-02-09	2013-04-20	Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН")	Фармацевтическая композиция для лечения артериальной гипертензии и застойной сердечной недостаточности и способ ее получения
CN102139109A (zh) *	2011-03-30	2011-08-03	上海蓝药实业有限公司	一种质量稳定的血管紧张素转化酶抑制剂的制剂组合物
WO2013032002A1 (fr) *	2011-08-31	2013-03-07	株式会社奈良機械製作所	Dispositif pouvant être utilisé pour la modification de la surface de particules solides et procédé de modification de la surface de particules solides
US20150094345A1 (en) *	2012-02-17	2015-04-02	Egis Gyogyszergyar Zrt.	Pharmaceutical formulation having improved stability
CN113842362A (zh)	2012-11-14	2021-12-28	格雷斯公司	含有生物活性材料与无序无机氧化物的组合物
HUP1300496A2 (hu) *	2013-08-16	2015-03-02	Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag	Stabil kombinációs gyógyszerkészítmény
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JP2004534812A (ja) *	2001-06-22	2004-11-18	ファイザー・プロダクツ・インク	薬物および中性ポリマーの分散物の医薬組成物
CA2450748A1 (fr) *	2001-06-22	2003-01-03	Pfizer Products Inc.	Compositions pharmaceutiques contenant des ensembles polymere et medicament
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WO2004064809A1 (fr) *	2003-01-22	2004-08-05	Sandoz Ag	Composition pharmaceutique solide comprenant du ramipril
WO2005002548A1 (fr) *	2003-06-26	2005-01-13	Teva Pharmaceutical Industries Ltd.	Composition pharmaceutique stable de derives de l'acide 2-aza-bicyclo[3.3.0]-octane-3-carboxylique
KR20070085754A (ko) *	2004-11-05	2007-08-27	킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨	안정화된 라미프릴 조성물 및 제조 방법
GB0518129D0 (en) *	2005-09-06	2005-10-12	Arrow Int Ltd	Ramipril formulation

2005
- 2005-11-07 KR KR1020077012627A patent/KR20070085754A/ko not_active Withdrawn
- 2005-11-07 CA CA002586547A patent/CA2586547A1/fr not_active Abandoned
- 2005-11-07 AU AU2005301989A patent/AU2005301989A1/en not_active Abandoned
- 2005-11-07 US US11/269,388 patent/US20060134213A1/en not_active Abandoned
- 2005-11-07 EP EP05851434A patent/EP1817007A2/fr not_active Withdrawn
- 2005-11-07 CN CNA2005800460767A patent/CN101098679A/zh active Pending
- 2005-11-07 EP EP05826288A patent/EP1824451A2/fr not_active Withdrawn
- 2005-11-07 ZA ZA200704767A patent/ZA200704767B/xx unknown
- 2005-11-07 US US11/269,387 patent/US20060159742A1/en not_active Abandoned
- 2005-11-07 RU RU2007120817/15A patent/RU2007120817A/ru not_active Application Discontinuation
- 2005-11-07 KR KR1020077012632A patent/KR20070085759A/ko not_active Withdrawn
- 2005-11-07 CN CNA2005800460678A patent/CN101098681A/zh active Pending
- 2005-11-07 WO PCT/US2005/040429 patent/WO2006050533A2/fr not_active Ceased
- 2005-11-07 ZA ZA200704768A patent/ZA200704768B/xx unknown
- 2005-11-07 BR BRPI0517662-0A patent/BRPI0517662A/pt not_active Application Discontinuation
- 2005-11-07 RU RU2007120821/15A patent/RU2007120821A/ru not_active Application Discontinuation
- 2005-11-07 BR BRPI0517663-8A patent/BRPI0517663A/pt not_active Application Discontinuation
- 2005-11-07 CA CA002586760A patent/CA2586760A1/fr not_active Abandoned
- 2005-11-07 JP JP2007540170A patent/JP2008519063A/ja active Pending
- 2005-11-07 MX MX2007005377A patent/MX2007005377A/es not_active Application Discontinuation
- 2005-11-07 MX MX2007005373A patent/MX2007005373A/es not_active Application Discontinuation
- 2005-11-07 WO PCT/US2005/040430 patent/WO2006052968A2/fr not_active Ceased
- 2005-11-07 AU AU2005304664A patent/AU2005304664A1/en not_active Abandoned
- 2005-11-07 JP JP2007540169A patent/JP2008519062A/ja active Pending
2007
- 2007-05-06 IL IL183018A patent/IL183018A0/en unknown
- 2007-05-06 IL IL183017A patent/IL183017A0/en unknown
- 2007-05-30 NO NO20072739A patent/NO20072739L/no not_active Application Discontinuation
- 2007-05-30 NO NO20072741A patent/NO20072741L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20070085759A (ko)	2007-08-27
KR20070085754A (ko)	2007-08-27
WO2006050533A3 (fr)	2006-09-14
WO2006050533A2 (fr)	2006-05-11
JP2008519063A (ja)	2008-06-05
EP1824451A2 (fr)	2007-08-29
CA2586760A1 (fr)	2006-05-18
JP2008519062A (ja)	2008-06-05
US20060159742A1 (en)	2006-07-20
CN101098681A (zh)	2008-01-02
WO2006052968A3 (fr)	2006-10-12
WO2006052968A2 (fr)	2006-05-18
CA2586547A1 (fr)	2006-05-11
RU2007120821A (ru)	2008-12-10
NO20072741L (no)	2007-08-03
ZA200704768B (en)	2008-08-27
BRPI0517663A (pt)	2008-10-14
IL183017A0 (en)	2007-09-20
US20060134213A1 (en)	2006-06-22
AU2005304664A1 (en)	2006-05-18
RU2007120817A (ru)	2008-12-10
EP1817007A2 (fr)	2007-08-15
MX2007005377A (es)	2008-01-11
ZA200704767B (en)	2008-08-27
AU2005301989A1 (en)	2006-05-11
IL183018A0 (en)	2007-09-20
CN101098679A (zh)	2008-01-02
MX2007005373A (es)	2007-08-14
BRPI0517662A (pt)	2008-10-14

Legal Events

Date	Code	Title	Description
2009-06-29	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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