NO20073068L - Stereoisomere anrikete 3-aminokarbonylbisykloheptenpyrimidindiaminforindelser og deres anvendelse - Google Patents

Stereoisomere anrikete 3-aminokarbonylbisykloheptenpyrimidindiaminforindelser og deres anvendelse

Info

Publication number
NO20073068L
NO20073068L NO20073068A NO20073068A NO20073068L NO 20073068 L NO20073068 L NO 20073068L NO 20073068 A NO20073068 A NO 20073068A NO 20073068 A NO20073068 A NO 20073068A NO 20073068 L NO20073068 L NO 20073068L
Authority
NO
Norway
Prior art keywords
compounds
aminocarbonylbicycloheptenpyrimidinediamine
stereoisomeric
enriched
stereoisomeric enriched
Prior art date
Application number
NO20073068A
Other languages
English (en)
Inventor
Rajinder Singh
Ankush Argade
Hui Li
Original Assignee
Rigel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of NO20073068L publication Critical patent/NO20073068L/no

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer stereoisomerer og stereoisomere blandinger av 3-aminokarbonyl-bicykloheptan-2,4-pyrimidindiaminforbindelser som har antiproliferativ aktivitet, sammensetningene omfatter forbindelsene og fremgangsmåtene for å anvende forbindelsene til å hemme cellulær proliferering og til å behandle prohfereringssykdommer slik som tumorigene cancere.
NO20073068A 2004-11-15 2007-06-15 Stereoisomere anrikete 3-aminokarbonylbisykloheptenpyrimidindiaminforindelser og deres anvendelse NO20073068L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62819904P 2004-11-15 2004-11-15
PCT/US2005/041359 WO2006055561A2 (en) 2004-11-15 2005-11-15 Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses

Publications (1)

Publication Number Publication Date
NO20073068L true NO20073068L (no) 2007-06-15

Family

ID=35516756

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073068A NO20073068L (no) 2004-11-15 2007-06-15 Stereoisomere anrikete 3-aminokarbonylbisykloheptenpyrimidindiaminforindelser og deres anvendelse

Country Status (26)

Country Link
US (4) US7863286B2 (no)
EP (1) EP1824489B1 (no)
JP (1) JP4812770B2 (no)
KR (1) KR101335917B1 (no)
CN (1) CN101171012B (no)
AT (1) ATE494280T1 (no)
AU (1) AU2005307849B2 (no)
BR (1) BRPI0516795A (no)
CA (1) CA2580150C (no)
CY (1) CY1112743T1 (no)
DE (2) DE102005054092A1 (no)
DK (1) DK1824489T3 (no)
ES (2) ES2296477B2 (no)
FR (1) FR2877944A1 (no)
GB (1) GB2420559B (no)
IL (1) IL181923A (no)
IT (1) ITMI20052171A1 (no)
MX (1) MX2007005807A (no)
NO (1) NO20073068L (no)
NZ (1) NZ554419A (no)
PL (1) PL1824489T3 (no)
RU (1) RU2416604C2 (no)
SI (1) SI1824489T1 (no)
UA (1) UA88660C2 (no)
WO (1) WO2006055561A2 (no)
ZA (1) ZA200702180B (no)

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MX2007005807A (es) 2007-10-18
GB2420559B (en) 2008-08-06
US8030483B2 (en) 2011-10-04
IL181923A (en) 2012-03-29
DK1824489T3 (da) 2011-04-26
CN101171012A (zh) 2008-04-30
WO2006055561A3 (en) 2008-05-22
EP1824489B1 (en) 2011-01-05
US8101627B2 (en) 2012-01-24
IL181923A0 (en) 2007-07-04
AU2005307849A1 (en) 2006-05-26
DE102005054092A1 (de) 2006-07-06
DE602005025803D1 (de) 2011-02-17
CA2580150C (en) 2013-10-22
CY1112743T1 (el) 2016-02-10
RU2416604C2 (ru) 2011-04-20
US20070179140A1 (en) 2007-08-02
US20090176981A1 (en) 2009-07-09
KR20070085571A (ko) 2007-08-27
US20080051412A1 (en) 2008-02-28
CN101171012B (zh) 2013-04-17
US7863286B2 (en) 2011-01-04
US20090137589A1 (en) 2009-05-28
ZA200702180B (en) 2008-09-25
ITMI20052171A1 (it) 2006-05-16
AU2005307849B2 (en) 2012-11-15
WO2006055561A2 (en) 2006-05-26
UA88660C2 (ru) 2009-11-10
JP4812770B2 (ja) 2011-11-09
NZ554419A (en) 2010-09-30
HK1114338A1 (en) 2008-10-31
ATE494280T1 (de) 2011-01-15
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US8044054B2 (en) 2011-10-25
CA2580150A1 (en) 2006-05-26
KR101335917B1 (ko) 2013-12-03
ES2359416T3 (es) 2011-05-23
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FR2877944A1 (fr) 2006-05-19
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GB2420559A (en) 2006-05-31
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