NO20073287L - 2,5 og 2,6-disubstituerte benzazol-analoger som proteinkinaseinhibitorer - Google Patents

2,5 og 2,6-disubstituerte benzazol-analoger som proteinkinaseinhibitorer

Info

Publication number
NO20073287L
NO20073287L NO20073287A NO20073287A NO20073287L NO 20073287 L NO20073287 L NO 20073287L NO 20073287 A NO20073287 A NO 20073287A NO 20073287 A NO20073287 A NO 20073287A NO 20073287 L NO20073287 L NO 20073287L
Authority
NO
Norway
Prior art keywords
benzazole
disubstituted
analogs
protein kinase
kinase inhibitors
Prior art date
Application number
NO20073287A
Other languages
English (en)
Inventor
Thomas Herz
Rolf Krauss
Michael Kubbutat
Martin Lang
Christophe Schachtele
Stefan Tasler
Frank Totzke
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of NO20073287L publication Critical patent/NO20073287L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser av generelle formler (I), (Ia) og (II) og salter og fysiologisk funksjonelle derivater derav, hvori substituentene -Y er bundet til 5- eller 6-stillingen av benzazolet.
NO20073287A 2004-12-27 2007-06-27 2,5 og 2,6-disubstituerte benzazol-analoger som proteinkinaseinhibitorer NO20073287L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04030819A EP1674466A1 (en) 2004-12-27 2004-12-27 2,5- and 2,6-disubstituted benzazole analogues useful as protein kinase inhibitors
PCT/EP2005/013922 WO2006069740A1 (en) 2004-12-27 2005-12-22 2, 5 and 2, 6-disubstituted benzazole analogues useful as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20073287L true NO20073287L (no) 2007-09-25

Family

ID=34928006

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073287A NO20073287L (no) 2004-12-27 2007-06-27 2,5 og 2,6-disubstituerte benzazol-analoger som proteinkinaseinhibitorer

Country Status (15)

Country Link
EP (2) EP1674466A1 (no)
JP (1) JP5302540B2 (no)
CN (1) CN101090899B (no)
AU (1) AU2005321517B2 (no)
BR (1) BRPI0519479A2 (no)
CA (1) CA2592509C (no)
EA (1) EA013863B1 (no)
IL (1) IL184266A (no)
MX (1) MX2007007897A (no)
NO (1) NO20073287L (no)
NZ (1) NZ555303A (no)
SG (1) SG178717A1 (no)
UA (1) UA92730C2 (no)
WO (1) WO2006069740A1 (no)
ZA (1) ZA200704313B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1674467A1 (en) * 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
ES2452349T3 (es) 2007-05-21 2014-04-01 Novartis Ag Inhibidores de CSF-1R, composiciones, y métodos de uso
FR2922550B1 (fr) * 2007-10-19 2009-11-27 Sanofi Aventis Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet
FR2933981A1 (fr) * 2008-07-18 2010-01-22 Sanofi Aventis NOUVEAUX DERIVES IMIDAZO°1,2-a!PYRIDINE, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET
FR2933982A1 (fr) * 2008-07-18 2010-01-22 Sanofi Aventis Nouveaux derives imidazo°1,2-a!pyrimidine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
FR2933980B1 (fr) * 2008-07-18 2011-07-29 Sanofi Aventis Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
WO2010010435A2 (en) * 2008-07-22 2010-01-28 Glenmark Pharmaceutical S.A. Fused oxazole and thiazole derivatives as trpms modulators
WO2011033094A1 (en) 2009-09-18 2011-03-24 4Sc Ag Schedule of administration of benzazole derivatives in the treatment of leukemias
KR20180099933A (ko) 2010-11-19 2018-09-05 리간드 파마슈티칼스 인코포레이티드 복소환 아민 및 이의 용도
WO2013174735A1 (en) 2012-05-21 2013-11-28 Bayer Pharma Aktiengesellschaft Substituted benzothienopyrimidines
TW201412740A (zh) * 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
US10807983B2 (en) 2015-03-16 2020-10-20 Ligand Pharmaceuticals, Inc. Imidazo-fused heterocycles and uses thereof
KR102719387B1 (ko) * 2017-01-26 2024-10-21 한미약품 주식회사 이미다조피리다진 화합물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9900752D0 (en) * 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
AU2002232439A1 (en) * 2000-11-29 2002-06-11 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
AU2003220970A1 (en) * 2002-03-01 2003-09-16 Smithkline Beecham Corporation Diamino-pyrimidines and their use as angiogenesis inhibitors
NZ535985A (en) * 2002-03-29 2007-04-27 Chiron Corp Substituted benzazoles and use thereof as RAF kinase inhibitors
US7531553B2 (en) * 2003-03-21 2009-05-12 Amgen Inc. Heterocyclic compounds and methods of use
PT2213661E (pt) * 2003-09-26 2011-12-15 Exelixis Inc Moduladores de c-met e métodos de uso
WO2005073224A2 (en) * 2004-01-23 2005-08-11 Amgen Inc Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer

Also Published As

Publication number Publication date
EP1674466A1 (en) 2006-06-28
EP1833823A1 (en) 2007-09-19
SG178717A1 (en) 2012-03-29
CN101090899B (zh) 2015-09-09
IL184266A0 (en) 2007-10-31
CA2592509A1 (en) 2006-07-06
EA200700997A1 (ru) 2007-12-28
AU2005321517B2 (en) 2011-09-29
CA2592509C (en) 2015-02-17
MX2007007897A (es) 2008-01-11
IL184266A (en) 2013-04-30
EA013863B1 (ru) 2010-08-30
WO2006069740A1 (en) 2006-07-06
ZA200704313B (en) 2008-11-26
AU2005321517A1 (en) 2006-07-06
JP5302540B2 (ja) 2013-10-02
JP2008525361A (ja) 2008-07-17
NZ555303A (en) 2010-01-29
CN101090899A (zh) 2007-12-19
BRPI0519479A2 (pt) 2009-02-03
UA92730C2 (ru) 2010-12-10

Similar Documents

Publication Publication Date Title
NO20073287L (no) 2,5 og 2,6-disubstituerte benzazol-analoger som proteinkinaseinhibitorer
NO20066055L (no) Pyridinderivater
NO20082090L (no) Pyridopyrimidinoninhibitorer av P13K alfa
NO20070336L (no) Indolderivater som histamin-reseptorantagonister
NO20075082L (no) Pyridin-3-karboksamidderivater som CB1-inversagonister
NO20070249L (no) Pyrrazolo-pyrimidin derivater
NO20080391L (no) Pyrazolbaserte LXR modulatorer
NO20050007L (no) 1-Heterosyklylalkyl-3-sulfonylazaindol eller -azaindazolderivater som 5-hydroksytryptamin-6 ligander
NO20070224L (no) 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
NO20072963L (no) 5-substituerte kinolin- og isokinolinderivater, fremgangsmate for deres fremstilling og deres anvendelse som betennelseshemmere
NO20071137L (no) Nye piperidinderivater for behandling av depresjon
NO20084489L (no) Azolopyrimidiner som inhibitorer av cannabinoid 1 aktivitet
NO20064976L (no) Azanidoler som er nyttige som inhibitorer av rock og andre proteinkinaser
NO20076460L (no) Nye fluorenderivater, sammensetninger inneholdende nevnte derivater og anvendelse derav
DK1483265T3 (da) Purinderivater som kinaseinhibitorer
NO20085099L (no) Puritonderivativer som HM74A agonister
NO20050014L (no) 1-Heterosyklylalkyl-3-sulfonylindol eller -indazolderivater som 5-hydroksytryptamin-6 ligander
NO20085257L (no) Purinonderivater som HM74a-agonister
PL1899329T3 (pl) Pirymidyno-podstawione pochodne benzimidazolu jako inhibitory kinaz białkowych
CO5590895A2 (es) Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos
NO20062020L (no) 1-amino-2-oksysubstituerte tetrahydronaftalenderivater, fremgangsmate for fremstilling derav, og deres anvendelse som antiflogistika
NO20082096L (no) Azaindol-2-karboksamidderivativer
NO20076060L (no) Piperidin-4-yl-amidderivater og deres anvendelse som SST-reseptor subtype 5-antagonister
NO20082939L (no) Sykloheksyl piperasinyl metanon derivater og anvendelse av disse som histamin H3 reseptor modulatorer
NO20075406L (no) Pyrimidindionerivater som prokineticin-2-reseprorantagonister

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application