NO20074071L - Hydrazinometyl, hydrozonometyl og 5-leddete heterocykliske forbindelser som virker som MTOR inhibitorer og anvendelse derav som anti-cancer midler - Google Patents

Hydrazinometyl, hydrozonometyl og 5-leddete heterocykliske forbindelser som virker som MTOR inhibitorer og anvendelse derav som anti-cancer midler

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Publication number
NO20074071L
NO20074071L NO20074071A NO20074071A NO20074071L NO 20074071 L NO20074071 L NO 20074071L NO 20074071 A NO20074071 A NO 20074071A NO 20074071 A NO20074071 A NO 20074071A NO 20074071 L NO20074071 L NO 20074071L
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cambridge
group
cb40wg
cambridgeshire
science park
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NO20074071A
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English (en)
Inventor
Xiao-Ling Fan Cockcroft
Sylvie Gomez
Keith Allan Menear
Marc Geoffrey Hummersone
Graeme Caameron Murray Smith
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Kudos Pharm Ltd
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Publication date
Priority claimed from GBGB0503962.3A external-priority patent/GB0503962D0/en
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of NO20074071L publication Critical patent/NO20074071L/no

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    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • C07D471/04—Ortho-condensed systems

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  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelser med formel I:. A-B-C (I) og isomerer, salter, solvater, kjemisk beskyttede former og prodrugs derav hvor: B er valgt fra gruppen som består av:hvor Rer H eller Me; eller B er en divalent, heterocyklisk C-rest som inneholder ett eller to ring-heteroatomer; A er:og Rer uavhengig valgt fra halogen,og R, hvor R° er H eller Me og Rer H eller CiA alkyl;er valgt fra N og CR, hvor Rer valgt fra H, OR, CHOH, C0H, NHS0Me og NHCOMe;Roger uavhengig valgt fra H, halogen og OR; ellerog Rkan sammen med karbonatomene de er bundet til, ellerog Rkan sammen med karbonatomene de er bundet til, danne en heterocyklisk eller heteroaromatisk C.-ring som inneholder minst ett ring-nitrogenatom;og dersom X ikke er N, så er 1, 2 eller 3 av Rtil Rikke H; C er:. hvor X er valgt fra N og CH, Y er valgt fra N og CH og Z er valgt fra N og CR;. Rer valgt fra H, halogen og en eventuelt substituert, N-holdig, heterocyklisk C.-gruppe; Rer en gruppe valgt fra:. hvor gruppen kan være "selected" med én eller to C_alkylgrupper eller en karboksygruppe;. RerH; eller når X og Y er N, så kanog R(når Z er CR) sammen med karbonatomene de er bundet til, danne en kondensert, aromatisk C-ring valgt fra gruppen som består av:. Oppfinner:. Sylvie Gomez, c/o Kudos Pharmaceuticals Ltd, 327 Cambridge Science Park, Milton Road,. CB40WG CAMBRIDGE, CAMBRIDGESHIRE, GB. Keith Allan Menear, c/o Kudos Pharmaceuticals Ltd, 327 Cambridge Science Park, Milton Road,. CB40WG CAMBRIDGE, CAMBRIDGESHIRE, GB. Marc Geoffrey Hummersone, c/o Kudos Pharmaceuticals Ltd, 327 Cambridge Science Park, Milton Road,. CB40WG CAMBRIDGE, CAMBRIDGESHIRE, GB. Graeme Caameron Murray Smith, c/o Kudos Pharmaceuticals Ltd, 327 Cambridge Science Park, Milton Road,. CB40WG CAMBRIDGE, CAMBRIDGESHIRE, GB
NO20074071A 2005-02-25 2007-08-07 Hydrazinometyl, hydrozonometyl og 5-leddete heterocykliske forbindelser som virker som MTOR inhibitorer og anvendelse derav som anti-cancer midler NO20074071L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65619305P 2005-02-25 2005-02-25
GBGB0503962.3A GB0503962D0 (en) 2005-02-25 2005-02-25 Compounds
PCT/GB2006/000668 WO2006090167A2 (en) 2005-02-25 2006-02-24 Hydrazinomethyl, hydr zonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents

Publications (1)

Publication Number Publication Date
NO20074071L true NO20074071L (no) 2007-09-17

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NO20074071A NO20074071L (no) 2005-02-25 2007-08-07 Hydrazinometyl, hydrozonometyl og 5-leddete heterocykliske forbindelser som virker som MTOR inhibitorer og anvendelse derav som anti-cancer midler

Country Status (10)

Country Link
US (1) US20100130473A1 (no)
EP (1) EP1877388A2 (no)
JP (1) JP2008531537A (no)
KR (1) KR20070108916A (no)
AU (1) AU2006217742A1 (no)
CA (1) CA2599320A1 (no)
IL (1) IL184900A0 (no)
MX (1) MX2007010404A (no)
NO (1) NO20074071L (no)
WO (1) WO2006090167A2 (no)

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