NO20071873L - DNA-PK inhibotorer. - Google Patents
DNA-PK inhibotorer.Info
- Publication number
- NO20071873L NO20071873L NO20071873A NO20071873A NO20071873L NO 20071873 L NO20071873 L NO 20071873L NO 20071873 A NO20071873 A NO 20071873A NO 20071873 A NO20071873 A NO 20071873A NO 20071873 L NO20071873 L NO 20071873L
- Authority
- NO
- Norway
- Prior art keywords
- optionally substituted
- alkyl
- hydrogen
- aryl
- group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
En forbindelse med formel I: og isomerer, salter, solvater, kjemisk beskyttede former og prodrug derav, hvori: R1 og R2 er uavhengig valgt fra hydrogen, en eventuelt substituert C1-7 alkylgruppe,C3-20 heterocyklylgruppe eller C5-10 arylgruppe, eller kan sammen danne, som nitrogenet til hvilket de er bundet, en eventuelt substituert heterosyklisk ring som har 4-8 ringatomer;Q er -NH-C(=O)- eller -O-; Y er en eventuelt substituert C1-5 alkylengruppe; X er valgt fra SR3 eller NR4R5, hvori R3 eller R4 og R5 er uavhengig valgt fra hydrogen, eventuelt substituerte C1-7 alkyl, C5-20 aryl eller C3-20 heterocyklylgrupper, eller R4 og R5 kan sammen danne, sammen med nitrogenatomet til hvilket de er bundet, en eventuelt substituert heterosyklisk ring som har fra 4 til 8 ringatomer; hvis Q er -O-, er X ytterligere valgt fra -C(=O)-NR6R7, hvori R6 og R7er uavhengig valgt fra hydrogen, eventuelt substituert C1-7 alkyl, C5-20 aryl eller C3-20 heterocyklylgrupper eller R6 og R7 kan sammen danne, sammen med nitrogenatomet til hvilket de er bundet, en eventuelt substituert heterosyklisk ring som har fra 4-8 ringatomer; og hvis Q er -NH- C(=O)-, kan -Y-X- i tillegg være valgt fra C1-7 alkyl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61151504P | 2004-09-20 | 2004-09-20 | |
| PCT/GB2005/003621 WO2006032869A1 (en) | 2004-09-20 | 2005-09-20 | Dna-pk inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20071873L true NO20071873L (no) | 2007-06-15 |
Family
ID=35610093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20071873A NO20071873L (no) | 2004-09-20 | 2007-04-12 | DNA-PK inhibotorer. |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20070238731A1 (no) |
| EP (1) | EP1794151A1 (no) |
| JP (1) | JP2008513428A (no) |
| KR (1) | KR20070059156A (no) |
| CN (1) | CN101061111A (no) |
| AU (1) | AU2005286329A1 (no) |
| BR (1) | BRPI0515498A (no) |
| CA (1) | CA2580229A1 (no) |
| IL (1) | IL181969A0 (no) |
| MX (1) | MX2007003116A (no) |
| NO (1) | NO20071873L (no) |
| RU (1) | RU2408596C2 (no) |
| TW (1) | TW200616986A (no) |
| UA (1) | UA88329C2 (no) |
| WO (1) | WO2006032869A1 (no) |
| ZA (1) | ZA200703079B (no) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| CN1703200B (zh) | 2002-09-20 | 2012-02-29 | 奥尔制药公司 | 隔离亚单元和相关组合物及方法 |
| EP1654257B1 (en) | 2003-08-13 | 2010-03-17 | Kudos Pharmaceuticals Limited | Aminopyrones and their use as atm inhibitors |
| TW200616986A (en) * | 2004-09-20 | 2006-06-01 | Kudos Pharm Ltd | DNA-pk inhibitors |
| JP2008529995A (ja) * | 2005-02-09 | 2008-08-07 | クドス ファーマシューティカルズ リミテッド | Ａｔｍ阻害剤 |
| AR054438A1 (es) * | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | Inhibidores de adn -pk |
| EP1895997A2 (en) * | 2005-05-26 | 2008-03-12 | Kudos Pharmaceuticals Ltd | Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies |
| TW200745094A (en) * | 2005-08-31 | 2007-12-16 | Kudos Pharm Ltd | ATM inhibitor |
| SI2719378T1 (sl) | 2006-06-19 | 2016-11-30 | Alpharma Pharmaceuticals Llc | Farmacevtski sestavki |
| US20080233156A1 (en) * | 2006-10-11 | 2008-09-25 | Alpharma, Inc. | Pharmaceutical compositions |
| UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones | |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| CA2709905A1 (en) * | 2007-12-17 | 2009-06-25 | Alfred Liang | Abuse-resistant oxycodone composition |
| WO2009130469A1 (en) * | 2008-04-25 | 2009-10-29 | Kudos Pharmaceuticals Limited | Dna-pk inhibitors |
| WO2020257325A1 (en) | 2019-06-17 | 2020-12-24 | Vertex Pharmaceuticals Inc. | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
| AU2021400745A1 (en) | 2020-12-17 | 2023-07-20 | Vertex Pharmaceuticals Incorporated | Compositions and methods for editing beta-globin for treatment of hemaglobinopathies |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| IL326136A (en) | 2023-08-07 | 2026-03-01 | Revolution Medicines Inc | RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025181336A1 (en) | 2024-03-01 | 2025-09-04 | Cellectis Sa | Compositions and methods for hbb-editing in hspc |
| WO2025217307A1 (en) | 2024-04-09 | 2025-10-16 | Revolution Medicines, Inc. | Methods for predicting response to a ras(on) inhibitor and combination therapies |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
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| GB1303724A (no) | 1969-05-14 | 1973-01-17 | ||
| JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
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| US5703075A (en) * | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
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| US7049313B2 (en) * | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
| EP2174939A1 (en) | 2002-02-25 | 2010-04-14 | Kudos Pharmaceuticals Limited | Pyranones useful as ATM inhibitors |
| DE60335359D1 (de) * | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
| EP1654257B1 (en) * | 2003-08-13 | 2010-03-17 | Kudos Pharmaceuticals Limited | Aminopyrones and their use as atm inhibitors |
| TW200616986A (en) | 2004-09-20 | 2006-06-01 | Kudos Pharm Ltd | DNA-pk inhibitors |
| JP2008529995A (ja) * | 2005-02-09 | 2008-08-07 | クドス ファーマシューティカルズ リミテッド | Ａｔｍ阻害剤 |
| AR054438A1 (es) * | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | Inhibidores de adn -pk |
| UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones |
-
2005
- 2005-09-20 TW TW094132553A patent/TW200616986A/zh unknown
- 2005-09-20 US US11/575,606 patent/US20070238731A1/en not_active Abandoned
- 2005-09-20 WO PCT/GB2005/003621 patent/WO2006032869A1/en not_active Ceased
- 2005-09-20 CN CNA2005800395503A patent/CN101061111A/zh active Pending
- 2005-09-20 AU AU2005286329A patent/AU2005286329A1/en not_active Abandoned
- 2005-09-20 EP EP05784727A patent/EP1794151A1/en not_active Withdrawn
- 2005-09-20 RU RU2007110629/04A patent/RU2408596C2/ru not_active IP Right Cessation
- 2005-09-20 JP JP2007531838A patent/JP2008513428A/ja active Pending
- 2005-09-20 UA UAA200704427A patent/UA88329C2/ru unknown
- 2005-09-20 CA CA002580229A patent/CA2580229A1/en not_active Abandoned
- 2005-09-20 MX MX2007003116A patent/MX2007003116A/es not_active Application Discontinuation
- 2005-09-20 US US11/231,041 patent/US7402607B2/en not_active Expired - Fee Related
- 2005-09-20 BR BRPI0515498-7A patent/BRPI0515498A/pt not_active IP Right Cessation
- 2005-09-20 KR KR1020077008831A patent/KR20070059156A/ko not_active Ceased
-
2007
- 2007-03-15 IL IL181969A patent/IL181969A0/en unknown
- 2007-04-12 NO NO20071873A patent/NO20071873L/no not_active Application Discontinuation
- 2007-04-16 ZA ZA200703079A patent/ZA200703079B/xx unknown
-
2008
- 2008-06-05 US US12/133,837 patent/US7732483B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005286329A1 (en) | 2006-03-30 |
| EP1794151A1 (en) | 2007-06-13 |
| JP2008513428A (ja) | 2008-05-01 |
| KR20070059156A (ko) | 2007-06-11 |
| US20080242664A1 (en) | 2008-10-02 |
| RU2007110629A (ru) | 2008-10-27 |
| US7732483B2 (en) | 2010-06-08 |
| WO2006032869A1 (en) | 2006-03-30 |
| TW200616986A (en) | 2006-06-01 |
| IL181969A0 (en) | 2007-07-04 |
| ZA200703079B (en) | 2008-08-27 |
| RU2408596C2 (ru) | 2011-01-10 |
| US20070238731A1 (en) | 2007-10-11 |
| US20060106025A1 (en) | 2006-05-18 |
| UA88329C2 (en) | 2009-10-12 |
| BRPI0515498A (pt) | 2008-07-29 |
| CA2580229A1 (en) | 2006-03-30 |
| MX2007003116A (es) | 2007-07-16 |
| US7402607B2 (en) | 2008-07-22 |
| CN101061111A (zh) | 2007-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |