NO20074188L - Prosess for fremstilling av montelukast og mellomprodukter for det - Google Patents

Prosess for fremstilling av montelukast og mellomprodukter for det

Info

Publication number
NO20074188L
NO20074188L NO20074188A NO20074188A NO20074188L NO 20074188 L NO20074188 L NO 20074188L NO 20074188 A NO20074188 A NO 20074188A NO 20074188 A NO20074188 A NO 20074188A NO 20074188 L NO20074188 L NO 20074188L
Authority
NO
Norway
Prior art keywords
montelukast
intermediates
manufacturing
compound
formula
Prior art date
Application number
NO20074188A
Other languages
English (en)
Norwegian (no)
Inventor
Arjanne Overeem
Lambertus Thijs
Petr Benovsky
Jakub Castulik
Jie Zhu
Petr Bartos
Radomir Skoumal
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of NO20074188L publication Critical patent/NO20074188L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/75—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20074188A 2005-11-18 2007-08-15 Prosess for fremstilling av montelukast og mellomprodukter for det NO20074188L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73775205P 2005-11-18 2005-11-18
US79442906P 2006-04-24 2006-04-24
US82438206P 2006-09-01 2006-09-01
PCT/EP2006/011127 WO2007057225A2 (fr) 2005-11-18 2006-11-20 Procede de preparation de montelukast et produits intermediaires utilises pour la preparation

Publications (1)

Publication Number Publication Date
NO20074188L true NO20074188L (no) 2008-08-13

Family

ID=37685804

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074188A NO20074188L (no) 2005-11-18 2007-08-15 Prosess for fremstilling av montelukast og mellomprodukter for det

Country Status (12)

Country Link
US (5) US7786138B2 (fr)
EP (3) EP1948610A2 (fr)
JP (1) JP2009515922A (fr)
AR (3) AR057909A1 (fr)
AT (1) ATE497493T1 (fr)
AU (3) AU2006314729A1 (fr)
CA (3) CA2598093A1 (fr)
DE (1) DE602006019979D1 (fr)
IL (1) IL185129A0 (fr)
NO (1) NO20074188L (fr)
PT (1) PT1954679E (fr)
WO (3) WO2007057225A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080146809A1 (en) * 2004-11-19 2008-06-19 Matrix Laboratories Ltd Process for the Preparation of Novel Amorphous Montelukast Sodium
EP1904448B1 (fr) 2005-07-05 2011-02-02 Teva Pharmaceutical Industries, Ltd. Purification du montélukast
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.
EP2014650A1 (fr) * 2007-07-13 2009-01-14 Lonza Ag Procédé et intermédiaire pour la préparation d'un intermédiaire dans la préparation de montelukast
ES2320077B1 (es) 2007-07-31 2010-02-26 Moehs Iberica, S.L. Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo.
EP2276739A1 (fr) * 2008-04-25 2011-01-26 Synthon B.V. Procédé pour préparer des intermédiaires de montélukast
EP2552892A1 (fr) 2010-03-31 2013-02-06 KRKA, D.D., Novo Mesto Synthèse efficace pour la préparation de montélukast et nouvelle forme cristalline d'intermédiaires dans celle-ci
US10842770B2 (en) 2010-05-03 2020-11-24 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
TWI450275B (zh) * 2010-05-19 2014-08-21 Wistron Corp 可提升寫入保護之記憶體系統及相關方法
US8471030B2 (en) 2010-12-06 2013-06-25 Orochem Technologies Inc. Purification of montelukast using simulated moving bed
EP2502910A1 (fr) 2011-03-15 2012-09-26 Laboratorios Lesvi, S.L. Sel de camphre sulfonique d'un intermédiaire clef du Montélukast
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000836A1 (fr) * 1985-08-06 1987-02-12 Boehringer Biochemia Robin S.P.A. 1,4-dihydropyridines pharmaceutiquement actives a substitution 2-thiomethyle
CA2038178A1 (fr) 1990-04-05 1991-10-06 Carl C. Greco Alcoxyalcoxydes de niobium et methode de formation
US5856322A (en) 1990-10-12 1999-01-05 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
DK0480717T3 (da) 1990-10-12 1999-02-08 Merck Frosst Canada Inc Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister
US5565473A (en) 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
EP0480716A1 (fr) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Acides hydroxyalkylquinoliniques saturés comme antagonistes de leukotriène
US5266568A (en) * 1990-10-12 1993-11-30 Merck Frosst Canada, Inc. Hydroxyalkylquinoline ether acids as leukotriene antagonists
IE920499A1 (en) * 1991-02-21 1992-08-26 Merck Frosst Canada Inc Quinoline-containing ketoacids as leukotriene antagonists
US5270324A (en) 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
TW448160B (en) 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
GB9423511D0 (en) 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5523477A (en) 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5869673A (en) 1997-02-28 1999-02-09 Merck & Co., Inc. Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
CN1420113A (zh) 2001-11-16 2003-05-28 北京上地新世纪生物医药研究所 孟鲁司特钠的制备方法及其制备中间体
CN1171873C (zh) * 2001-12-26 2004-10-20 北京上地新世纪生物医药研究所 一种孟鲁司特钠的制备方法及其制备中间体
US20050107612A1 (en) * 2002-12-30 2005-05-19 Dr. Reddy's Laboratories Limited Process for preparation of montelukast and its salts
US20040265375A1 (en) 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
US7553853B2 (en) 2003-10-10 2009-06-30 Synthon Bv Solid-state montelukast
KR20060117356A (ko) * 2004-01-30 2006-11-16 테바 파마슈티컬 인더스트리즈 리미티드 몬테루카스트 유리산 다형체
US7189853B2 (en) * 2004-04-15 2007-03-13 Dr. Reddy's Laboratories Limited Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
US7829716B2 (en) * 2004-04-30 2010-11-09 Synthon Pharmaceuticals, Inc. Process for making montelukast and intermediates therefor
US20090143590A1 (en) * 2004-07-19 2009-06-04 Matrix Laboratories Ltd. Process for the Preparation of Montelukast and its Salts
ITMI20050247A1 (it) * 2005-02-18 2006-08-19 Chemi Spa Processo per la preparazione di montelukast
AR057909A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico.

Also Published As

Publication number Publication date
US7601741B2 (en) 2009-10-13
DE602006019979D1 (de) 2011-03-17
EP1954679B1 (fr) 2011-02-02
WO2007057227A1 (fr) 2007-05-24
US20070135643A1 (en) 2007-06-14
US20090093636A1 (en) 2009-04-09
AR057909A1 (es) 2007-12-26
US20070135642A1 (en) 2007-06-14
CA2629834A1 (fr) 2007-05-24
AU2006314728A1 (en) 2007-05-24
AR056815A1 (es) 2007-10-24
US20070135480A1 (en) 2007-06-14
IL185129A0 (en) 2007-12-03
AU2006314729A1 (en) 2007-05-24
US7786138B2 (en) 2010-08-31
AU2006314726A1 (en) 2007-05-24
US7476748B2 (en) 2009-01-13
WO2007057225A3 (fr) 2007-07-26
JP2009515922A (ja) 2009-04-16
WO2007057228A1 (fr) 2007-05-24
US20100099879A1 (en) 2010-04-22
ATE497493T1 (de) 2011-02-15
WO2007057225A2 (fr) 2007-05-24
EP1960362A1 (fr) 2008-08-27
EP1948610A2 (fr) 2008-07-30
AR057908A1 (es) 2007-12-26
EP1954679A1 (fr) 2008-08-13
CA2629840A1 (fr) 2007-05-24
PT1954679E (pt) 2011-05-05
CA2598093A1 (fr) 2007-05-24

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application