NO20074770L - Polyoksyalkylenderivat - Google Patents

Polyoksyalkylenderivat

Info

Publication number
NO20074770L
NO20074770L NO20074770A NO20074770A NO20074770L NO 20074770 L NO20074770 L NO 20074770L NO 20074770 A NO20074770 A NO 20074770A NO 20074770 A NO20074770 A NO 20074770A NO 20074770 L NO20074770 L NO 20074770L
Authority
NO
Norway
Prior art keywords
polyoxyalkylene
reacting
symbol
disclosure
following formula
Prior art date
Application number
NO20074770A
Other languages
English (en)
Inventor
Kenji Sakanoue
Kenichiro Nakamoto
Yuji Yamamoto
Hiroki Yoshioka
Original Assignee
Nof Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nof Corp filed Critical Nof Corp
Publication of NO20074770L publication Critical patent/NO20074770L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Et nytt polyoksyalkylenderivat representert ved den følgende formelen (1), hvor hvert symbol er som definert i redegjørelsen, som har en funksjonell gruppe i stand til å reagere med ulike fysiologisk aktive substanser i henhold til objektet er tilveiebrakt.
NO20074770A 2005-02-18 2007-09-18 Polyoksyalkylenderivat NO20074770L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005041523 2005-02-18
PCT/JP2006/303359 WO2006088248A1 (ja) 2005-02-18 2006-02-17 ポリオキシアルキレン誘導体

Publications (1)

Publication Number Publication Date
NO20074770L true NO20074770L (no) 2007-11-15

Family

ID=36916633

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074770A NO20074770L (no) 2005-02-18 2007-09-18 Polyoksyalkylenderivat

Country Status (5)

Country Link
US (1) US8012488B2 (no)
EP (1) EP1857462B9 (no)
JP (1) JP4877225B2 (no)
NO (1) NO20074770L (no)
WO (1) WO2006088248A1 (no)

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WO2007140282A1 (en) * 2006-05-24 2007-12-06 Peg Biosciences Peg linker compounds and biologically active conjugates thereof
MX2009002855A (es) * 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales.
US9828597B2 (en) 2006-11-22 2017-11-28 Toyota Motor Engineering & Manufacturing North America, Inc. Biofunctional materials
WO2008112289A2 (en) 2007-03-12 2008-09-18 Nektar Therapeutics Oligomer-protease inhibitor conjugates
US8796009B2 (en) 2010-06-21 2014-08-05 Toyota Motor Engineering & Manufacturing North America, Inc. Clearcoat containing thermolysin-like protease from Bacillus stearothermophilus for cleaning of insect body stains
US9388370B2 (en) 2010-06-21 2016-07-12 Toyota Motor Engineering & Manufacturing North America, Inc. Thermolysin-like protease for cleaning insect body stains
US10988714B2 (en) 2010-06-21 2021-04-27 Regents Of The University Of Minnesota Methods of facilitating removal of a fingerprint from a substrate or a coating
US11015149B2 (en) 2010-06-21 2021-05-25 Toyota Motor Corporation Methods of facilitating removal of a fingerprint
US9121016B2 (en) 2011-09-09 2015-09-01 Toyota Motor Engineering & Manufacturing North America, Inc. Coatings containing polymer modified enzyme for stable self-cleaning of organic stains
US10040761B2 (en) * 2010-06-25 2018-08-07 Nof Corporation Branched hetero polyethylene glycol and intermediate
JP5825507B2 (ja) * 2010-06-25 2015-12-02 日油株式会社 分岐型ヘテロポリエチレングリコール
PT3057585T (pt) 2013-10-15 2020-10-21 Seagen Inc Fármaco-ligadores peguilados para farmacocinética melhorada de conjugados de fármaco-ligando
US11229708B2 (en) 2015-12-04 2022-01-25 Seagen Inc. Conjugates of quaternized tubulysin compounds
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
EP3433278A4 (en) 2016-03-25 2019-11-06 Seattle Genetics, Inc. METHOD FOR THE PRODUCTION OF PEGYLATED ACTIVE LINKERS AND INTERMEDIATE PRODUCTS THEREOF
US11135307B2 (en) 2016-11-23 2021-10-05 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
JP7527787B2 (ja) 2017-03-24 2024-08-05 シージェン インコーポレイテッド グルクロニド薬物－リンカーの調製のためのプロセスおよびその中間体
BR112020008540A2 (pt) * 2017-11-06 2020-10-06 Hanmi Fine Chemical Co., Ltd. derivado de polietilenoglicol e método de preparação deste
EP3778628A4 (en) * 2018-03-29 2021-11-24 NOF Corporation DEGRADABLE POLYETHYLENE GLYCOL CONJUGATE
EP3778705B1 (en) * 2018-03-29 2024-08-07 NOF Corporation Degradable polyethylene glycol derivative
EP3950776A4 (en) 2019-03-29 2023-01-04 NOF Corporation BRANCHED AND DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE
CN113646323A (zh) 2019-03-29 2021-11-12 日油株式会社 分支型分解性聚乙二醇键合物
US12448488B2 (en) 2019-04-15 2025-10-21 Nof Corporation Conjugate of bio-related substance and block polymer, and block polymer derivative for obtaining said conjugate
CN114450324B (zh) * 2019-09-26 2024-02-27 日油株式会社 具有肽连接子的异双官能单分散聚乙二醇
CA3156055A1 (en) 2019-09-26 2021-04-01 Nof Corporation ASYMETRICALLY BRANCHED POLYETHYLENE GLYCOL DERIVATIVE, DEGRADABLE
CA3156038A1 (en) 2019-09-26 2021-04-01 Nof Corporation DEGRADABLE MULTI-BRANCHED POLYETHYLENE GLYCOL DERIVATIVE
CA3164940A1 (en) * 2019-12-27 2021-07-01 Nof Corporation Method for purifying branched polyethylene glycol

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0437563T3 (da) 1989-08-07 1995-05-29 Debio Rech Pharma Sa Bioligiske aktive lægemiddelpolymerderivater
JPH0421636A (ja) * 1990-05-17 1992-01-24 Ajinomoto Co Inc 肝機能改善剤
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
DK1007082T3 (da) * 1997-01-15 2007-02-19 Phoenix Pharmacologics Inc Modificeret tumor nekrose faktor
IL122933A (en) * 1998-01-14 2005-03-20 Efrat Biopolymers Ltd Polymeric carrier for delivery of a bioactive molecule
PT1075282E (pt) * 1998-04-28 2005-09-30 Applied Research Systems Conjugados analogos de peg-lhrh
WO2001046220A2 (en) * 1999-12-22 2001-06-28 Polymun Scientific Immunbiologische Forschung Gmbh Bioactive oligopeptides
CA2436623C (en) 2001-01-30 2011-08-02 Kyowa Hakko Kogyo Co., Ltd. Branched polyalkylene glycols
JP4123856B2 (ja) * 2001-07-31 2008-07-23 日油株式会社 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法
JP4412461B2 (ja) * 2002-11-20 2010-02-10 日油株式会社 修飾された生体関連物質、その製造方法および中間体
ATE444984T1 (de) * 2002-12-31 2009-10-15 Nektar Therapeutics Al Corp Hydrolysestabile maleimidendgruppen-enthaltende polymere
JP2006025766A (ja) * 2004-07-21 2006-02-02 Nof Corp 細胞表面オプソニン化剤

Also Published As

Publication number Publication date
JP4877225B2 (ja) 2012-02-15
WO2006088248A1 (ja) 2006-08-24
EP1857462A4 (en) 2009-06-24
US20090023859A1 (en) 2009-01-22
EP1857462A1 (en) 2007-11-21
JPWO2006088248A1 (ja) 2008-07-17
US8012488B2 (en) 2011-09-06
EP1857462B9 (en) 2013-02-13
EP1857462B1 (en) 2011-12-07

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