NO20075071L - Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005 - Google Patents
Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005Info
- Publication number
- NO20075071L NO20075071L NO20075071A NO20075071A NO20075071L NO 20075071 L NO20075071 L NO 20075071L NO 20075071 A NO20075071 A NO 20075071A NO 20075071 A NO20075071 A NO 20075071A NO 20075071 L NO20075071 L NO 20075071L
- Authority
- NO
- Norway
- Prior art keywords
- dibenzo
- piperazinyl
- thiazepine
- derivate
- substituted
- Prior art date
Links
- -1 11- (4-Substituted-1-Piperazinyl) Dibenzo [b, f] [1,4] Thiazepine Chemical class 0.000 title abstract 2
- 239000010936 titanium Substances 0.000 abstract 3
- JLOAJISUHPIQOX-UHFFFAOYSA-N Norquetiapine Chemical class C1CNCCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 JLOAJISUHPIQOX-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 2
- 150000004703 alkoxides Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229910052719 titanium Inorganic materials 0.000 abstract 2
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001090 anti-dopaminergic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
En fremgangsmåte for fremstilling av et ll-(4-substituert-l-piperazinyl)dibenzo[b,fJ[l,4]tiazepinderivat, av generell Formel I, hvor A er hydrogen eller en. -(CH)2-OH gruppe eller en -(CH)2-0-(CH)2-OH gruppe, eller et salt derav, omfattende et trinn i hvilket 10H-dibenzo[b,fJ[l,4]tiazepin-l 1-on blir reagert med et piperazinderivat i tilstedeværelsen av et titaniumalkoksid av generell formel Ti(OR), hvor R er en rett eller forgrenet alkylgruppe som har fra ett til åtte karbonatomer for å oppnå nevnte Formel I derivat eller et salt derav. Hvor A er -(CH)2-0-(CH)2-OH, så er piperazinderivatet 1 -(2-(2-hydroksyetoksy)etyl)piperazin og. 1 l-(4-substituert-l-piperazinyl)dibenzo[b,fJ[l,4]tiazepinet er quetiapin, (1 l-(4-(2-(2-hydroksyetoksy)etyl)-l-piperazinyl)dibenzo[b,fJ[l,4]tiazepin). Prosessen kan omfatte et tilleggstrinn av å reagere quetiapinet med fumarsyre for å oppnå quetiapinhemifumarat.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200500513A ES2234447B1 (es) | 2005-03-07 | 2005-03-07 | Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina. |
| PCT/EP2005/014055 WO2006094549A1 (en) | 2005-03-07 | 2005-12-21 | A PROCESS FOR THE PREPARATION OF AN 11-(4-SUBSTITUTED-I-PIPERAZINYL)DIBENZO[b,f][1,4]THIAZEPINE DERIVATIVE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20075071L true NO20075071L (no) | 2007-11-28 |
Family
ID=34707636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075071A NO20075071L (no) | 2005-03-07 | 2007-10-08 | Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7902355B2 (no) |
| EP (1) | EP1856073B1 (no) |
| AT (1) | ATE467624T1 (no) |
| DE (1) | DE602005021256D1 (no) |
| DK (1) | DK1856073T3 (no) |
| ES (1) | ES2234447B1 (no) |
| NO (1) | NO20075071L (no) |
| PT (1) | PT1856073E (no) |
| WO (1) | WO2006094549A1 (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7687622B2 (en) | 2005-04-14 | 2010-03-30 | Teva Pharmaceutical Industries, Ltd | Process for preparing quetiapine fumarate |
| CZ300451B6 (cs) * | 2006-07-03 | 2009-05-20 | Farmak, A. S. | Zpusob prípravy solí 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolu (quetiapinu) a jejich cištení |
| JP2011510960A (ja) * | 2008-01-31 | 2011-04-07 | フェルミオン オサケ ユキチュア | ケチアピンの製造方法 |
| WO2010100623A1 (en) | 2009-03-04 | 2010-09-10 | Ranbaxy Laboratories Limited | Process for the preparation of quetiapine fumarate |
| CN101891707B (zh) * | 2010-07-29 | 2012-10-17 | 浙江海正药业股份有限公司 | 喹硫平或其可药用盐的制备方法 |
| CN103664822B (zh) * | 2012-09-18 | 2015-07-15 | 四川大学华西医院 | 一种可用作麻醉剂的化合物 |
| CN104803947A (zh) * | 2015-03-12 | 2015-07-29 | 常州康丽制药有限公司 | 11-(1-哌嗪基)二苯并[b,f][1,4]硫氮杂*富马酸盐的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607684D0 (en) * | 1986-03-27 | 1986-04-30 | Ici America Inc | Thiazepine compounds |
| GB8705574D0 (en) * | 1987-03-10 | 1987-04-15 | Ici Plc | Preparation of thiazepine compound |
| GB9716161D0 (en) * | 1997-08-01 | 1997-10-08 | Zeneca Ltd | Process |
| HU227039B1 (en) * | 2000-01-25 | 2010-05-28 | Egis Gyogyszergyar Nyilvanosan | New process for the production of quetiapine and intermediates therefor |
| CN1777594A (zh) * | 2003-02-22 | 2006-05-24 | 特瓦制药工业有限公司 | 喹迪平及其可药用盐的合成 |
-
2005
- 2005-03-07 ES ES200500513A patent/ES2234447B1/es not_active Expired - Fee Related
- 2005-12-21 EP EP05850361A patent/EP1856073B1/en not_active Expired - Lifetime
- 2005-12-21 WO PCT/EP2005/014055 patent/WO2006094549A1/en not_active Ceased
- 2005-12-21 PT PT05850361T patent/PT1856073E/pt unknown
- 2005-12-21 DK DK05850361.6T patent/DK1856073T3/da active
- 2005-12-21 AT AT05850361T patent/ATE467624T1/de active
- 2005-12-21 DE DE602005021256T patent/DE602005021256D1/de not_active Expired - Lifetime
- 2005-12-21 US US11/817,884 patent/US7902355B2/en not_active Expired - Fee Related
-
2007
- 2007-10-08 NO NO20075071A patent/NO20075071L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1856073A1 (en) | 2007-11-21 |
| ES2234447B1 (es) | 2006-03-01 |
| ES2234447A1 (es) | 2005-06-16 |
| PT1856073E (pt) | 2010-07-06 |
| US7902355B2 (en) | 2011-03-08 |
| EP1856073B1 (en) | 2010-05-12 |
| WO2006094549A1 (en) | 2006-09-14 |
| DK1856073T3 (da) | 2010-08-23 |
| US20080171869A1 (en) | 2008-07-17 |
| DE602005021256D1 (de) | 2010-06-24 |
| ATE467624T1 (de) | 2010-05-15 |
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| FC2A | Withdrawal, rejection or dismissal of laid open patent application |