NO20075237L - Forbedret fremgangsmate for rensing av oerindorpril - Google Patents
Forbedret fremgangsmate for rensing av oerindorprilInfo
- Publication number
- NO20075237L NO20075237L NO20075237A NO20075237A NO20075237L NO 20075237 L NO20075237 L NO 20075237L NO 20075237 A NO20075237 A NO 20075237A NO 20075237 A NO20075237 A NO 20075237A NO 20075237 L NO20075237 L NO 20075237L
- Authority
- NO
- Norway
- Prior art keywords
- perindopril
- salt
- april
- indoor
- cleaning
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004140 cleaning Methods 0.000 title 1
- 229960002582 perindopril Drugs 0.000 abstract 5
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 abstract 4
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- -1 perindopril dicyclohexylamine salt Chemical class 0.000 abstract 1
- IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical class CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Et dicykloheksylamin salt av en forbindelse med formel I, nemlig perindopril, som har en røntgen pulver diffraksjon mønster med karakteristiske topper (20): 8,462, 10,624, 18,693, 9,424, 17,272, 14,177, 19,499, 20,765, 21,409, og 14,540. En fremgangsmåte for fremstilling av nevnte salt av perindopril og dens anvendelse i rensing av en uren perindopril og en fremgangsmåte for rensing av perindopril omfatter dannelse av dets salt med dicykloheksylamin. Foreliggende oppfinnelse angår også fremstilling av perindopril tert-butyl amin salt direkte fra perindopril dicykloheksylamin salt uten isolering av den frie basen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN275MU2005 | 2005-03-14 | ||
| PCT/IN2005/000189 WO2006097941A1 (en) | 2005-03-14 | 2005-06-09 | An improved process for the purification of perindopril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20075237L true NO20075237L (no) | 2007-10-12 |
Family
ID=35840279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075237A NO20075237L (no) | 2005-03-14 | 2007-10-12 | Forbedret fremgangsmate for rensing av oerindorpril |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7728151B2 (no) |
| EP (1) | EP1861367B1 (no) |
| AU (1) | AU2005329237B2 (no) |
| CA (1) | CA2601647C (no) |
| CY (1) | CY1109432T1 (no) |
| DE (1) | DE602005015492D1 (no) |
| DK (1) | DK1861367T3 (no) |
| EA (1) | EA012420B1 (no) |
| ES (1) | ES2329923T3 (no) |
| HR (1) | HRP20090548T1 (no) |
| NO (1) | NO20075237L (no) |
| NZ (1) | NZ561684A (no) |
| PL (1) | PL1861367T3 (no) |
| PT (1) | PT1861367E (no) |
| RS (1) | RS51147B (no) |
| SI (1) | SI1861367T1 (no) |
| WO (1) | WO2006097941A1 (no) |
| ZA (1) | ZA200708802B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008002066A (es) * | 2005-08-12 | 2008-04-16 | Sandoz Ag | Neuva forma cristalina de perindopril-erbumina. |
| SI22543A (sl) * | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
| GB0910692D0 (en) | 2009-06-20 | 2009-08-05 | Teva Pharma | Compound |
| ES2876292T3 (es) * | 2017-07-24 | 2021-11-12 | Interquim Sa | Procedimiento de preparación y purificación del antagonista de LFA-1 lifitegrast |
| CN114394969A (zh) * | 2021-12-22 | 2022-04-26 | 深圳市祥根生物医药有限公司 | 一种培哚普利杂质k的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
| FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
| WO2004075889A1 (en) * | 2003-02-28 | 2004-09-10 | Lupin Limited | Process for preparation of perindopril and salts thereof |
| US7445296B1 (en) * | 2006-07-24 | 2008-11-04 | Chosen Co., Ltd. | Bicycle hub having enhanced strength |
-
2005
- 2005-06-09 WO PCT/IN2005/000189 patent/WO2006097941A1/en not_active Ceased
- 2005-06-09 DK DK05799448T patent/DK1861367T3/da active
- 2005-06-09 EP EP05799448A patent/EP1861367B1/en not_active Expired - Lifetime
- 2005-06-09 NZ NZ561684A patent/NZ561684A/en not_active IP Right Cessation
- 2005-06-09 DE DE602005015492T patent/DE602005015492D1/de not_active Expired - Lifetime
- 2005-06-09 PT PT05799448T patent/PT1861367E/pt unknown
- 2005-06-09 ZA ZA200708802A patent/ZA200708802B/xx unknown
- 2005-06-09 SI SI200530795T patent/SI1861367T1/sl unknown
- 2005-06-09 HR HR20090548T patent/HRP20090548T1/hr unknown
- 2005-06-09 AU AU2005329237A patent/AU2005329237B2/en not_active Ceased
- 2005-06-09 US US11/886,382 patent/US7728151B2/en not_active Expired - Fee Related
- 2005-06-09 PL PL05799448T patent/PL1861367T3/pl unknown
- 2005-06-09 EA EA200701862A patent/EA012420B1/ru not_active IP Right Cessation
- 2005-06-09 RS RSP-2009/0430A patent/RS51147B/sr unknown
- 2005-06-09 CA CA2601647A patent/CA2601647C/en not_active Expired - Fee Related
- 2005-06-09 ES ES05799448T patent/ES2329923T3/es not_active Expired - Lifetime
-
2007
- 2007-10-12 NO NO20075237A patent/NO20075237L/no unknown
-
2009
- 2009-09-24 CY CY20091100999T patent/CY1109432T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RS51147B (sr) | 2010-10-31 |
| EP1861367B1 (en) | 2009-07-15 |
| HRP20090548T1 (hr) | 2009-11-30 |
| EP1861367A1 (en) | 2007-12-05 |
| DE602005015492D1 (de) | 2009-08-27 |
| ZA200708802B (en) | 2009-01-28 |
| PL1861367T3 (pl) | 2009-12-31 |
| ES2329923T3 (es) | 2009-12-02 |
| WO2006097941A1 (en) | 2006-09-21 |
| AU2005329237B2 (en) | 2011-09-01 |
| PT1861367E (pt) | 2009-10-08 |
| EA200701862A1 (ru) | 2008-02-28 |
| DK1861367T3 (da) | 2009-11-02 |
| AU2005329237A1 (en) | 2006-09-21 |
| CA2601647C (en) | 2013-07-30 |
| SI1861367T1 (sl) | 2009-12-31 |
| CY1109432T1 (el) | 2014-08-13 |
| NZ561684A (en) | 2009-10-30 |
| US20080139823A1 (en) | 2008-06-12 |
| CA2601647A1 (en) | 2006-09-21 |
| EA012420B1 (ru) | 2009-10-30 |
| US7728151B2 (en) | 2010-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CREP | Change of representative |
Representative=s name: OSLO PATENTKONTOR AS, POSTBOKS 7007 MAJORSTUA, 030 |