NO20075312L - N-(N-sulfonylaminometyl)cyklopropankarboksamidderivater nyttige ved smertebehandling - Google Patents

N-(N-sulfonylaminometyl)cyklopropankarboksamidderivater nyttige ved smertebehandling

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Publication number
NO20075312L
NO20075312L NO20075312A NO20075312A NO20075312L NO 20075312 L NO20075312 L NO 20075312L NO 20075312 A NO20075312 A NO 20075312A NO 20075312 A NO20075312 A NO 20075312A NO 20075312 L NO20075312 L NO 20075312L
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alkyl
alkoxy
hydroxy
halo
halogen
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Takeshi Hanazawa
Misato Hirano
Tadashi Inoue
Satoshi Nagayama
Kazunari Nakao
Yuji Shishido
Hirotaka Tanaka
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Pfizer
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Abstract

Den foreliggende oppfinnelse frembringer en forbindelse av formel (I): hvori A og B uavhengig av hverandre er CR12 eller N; D og E er hver for seg uavhengig CR9 eller N; R1 representerer (C1-C6)alkyl; R2 representerer hydrogen, halogen, hydroksy, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroksy(C1-C6)alkyl, (C1-C6)alkoksy eller (C1-C6)alkoksy-( C1-C6)alkyl; R3, R4, R5, R6, R10 og R11 representerer hver for seg uavhengig hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoksy, hydroksy(C1-C6)alkyl eller (C1-C6)alkoksy-( C1-C6)alkyl; eller R3 og R4 er ført sammen med det karbonatom til hvilket de er festet for å danne en 3- til 7-leddet karbocyklisk ring eller heterocyklisk ring, hvori et eller to ikke tilstøtende karbonatomer er valgtfritt erstattet med et oksygenatom, et svovelatom eller NH; R7 og R9 representerer hver for seg uavhengig hydrogen, halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroksy(C1-C6)alkyl, (C1-C6)alkoksy, hydroksy(C1-C6)alkoksy, (C1-C6)alkoksy-( C1-C6)alky, (C1-C6)alkoksy-( C1-C6)alkoksy, (C1-C6)alkyltio, (C1-C6)alkylsulfinyl, (C1-C6)alkylsulfonyl, NH2, [(C1-C6)alkyl]NH-, [(C1-C6)alkyl]2N-, H2N-(C1-C6)alkoksy, (C1-C6)alkyl-NH-(C1-C6)alkoksy, [(C1-C6)alkyl]2N(C1-C6)alkoksy;H2N-(C1-C6)alkoksy-( C1-C6)alkyl, (C1-C6)alkyl-NH-( C1-C6)alkoksy-(C1-C6)alkyl, [(C1-C6)alkyl]2N(C1-C6)alkoksy-( C1-C6)alkyl eller 5- eller 6-leddet heterocyklisk ring som inneholder minst et nitrogen-atom; R8 representerer haogen, (C1-C6)alkyl, halo(C1-C6)alkyl, hydroksy(C1-C6)alkyl, (C1-C6)alkoksy, hydroksy(C1-C6)alkoksy, (C1-C6)alkoksy-( C1-C6)alkyl, (C1-C6)alkoksy-( C1-C6)alkoksy, halo(C1-C6)alkylsulfonyl, halo(C1-C6)alkylsulfinyl, halo(C1-C6)alkoksy, halo(C1-C6)alkyltio, [(C1-C6)alkyl]NH- eller [(C1-C6)alkyl]2N-; eller R7 og R8 er, når E er CR9, ført sammen med de karbonatomer til hvilke de er festet for å danne en 5- til 8-leddet karbocyklisk eller heterocyklisk ring, hvori et eller to ikke tilstøtende karbonatomer valgtfritt er erstattet med oksygen, svovel, N- eller NH-grupper, hvori den karbocykliske ring eller den heterocykliske ring er usubstituert eller substituert med en eller flere substituenter som hver for seg uavhengig er utvalgt fra den gruppe som består av hydroksy, (C1-C6)alkyl, (C1-C6)alkoksy og hydroksy(C1-C6)alkyl; og R12 representerer hydrogen, halogen, (C1-C6)alkyl eller hydroksy(C1-C6)alkyl; eller et farmasøytisk akseptabelt salt eller solvat derav.
NO20075312A 2005-03-17 2007-10-17 N-(N-sulfonylaminometyl)cyklopropankarboksamidderivater nyttige ved smertebehandling NO20075312L (no)

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US66337405P 2005-03-17 2005-03-17
US69980005P 2005-07-15 2005-07-15
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PCT/IB2006/000557 WO2006097817A1 (en) 2005-03-17 2006-03-07 N- (n-sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain

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US6001876A (en) 1996-07-24 1999-12-14 Warner-Lambert Company Isobutylgaba and its derivatives for the treatment of pain
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