NO20075708L - Pegylert G-CSF-polypeptider og fremgangsmater for fremstilling av samme - Google Patents
Pegylert G-CSF-polypeptider og fremgangsmater for fremstilling av sammeInfo
- Publication number
- NO20075708L NO20075708L NO20075708A NO20075708A NO20075708L NO 20075708 L NO20075708 L NO 20075708L NO 20075708 A NO20075708 A NO 20075708A NO 20075708 A NO20075708 A NO 20075708A NO 20075708 L NO20075708 L NO 20075708L
- Authority
- NO
- Norway
- Prior art keywords
- pegylated
- methods
- csf polypeptides
- producing
- csf
- Prior art date
Links
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title abstract 4
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68672605P | 2005-06-01 | 2005-06-01 | |
| PCT/DK2006/000292 WO2006128460A2 (en) | 2005-06-01 | 2006-05-26 | Pegylated g-csf polypeptides and methods of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20075708L true NO20075708L (no) | 2008-02-27 |
Family
ID=37308965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20075708A NO20075708L (no) | 2005-06-01 | 2007-11-08 | Pegylert G-CSF-polypeptider og fremgangsmater for fremstilling av samme |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US7381805B2 (pt) |
| EP (1) | EP1888119B1 (pt) |
| JP (2) | JP5137821B2 (pt) |
| KR (1) | KR20080027291A (pt) |
| CN (1) | CN101193658B (pt) |
| AT (1) | ATE500847T1 (pt) |
| AU (1) | AU2006254543A1 (pt) |
| BR (1) | BRPI0611221A2 (pt) |
| CA (1) | CA2607844C (pt) |
| DE (1) | DE602006020562D1 (pt) |
| IL (1) | IL187009A0 (pt) |
| MX (1) | MX2007015156A (pt) |
| NO (1) | NO20075708L (pt) |
| RU (1) | RU2007149238A (pt) |
| WO (1) | WO2006128460A2 (pt) |
| ZA (1) | ZA200709704B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381805B2 (en) | 2005-06-01 | 2008-06-03 | Maxygen Holdings, Ltd. | Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF |
| NZ583276A (en) | 2007-08-27 | 2012-06-29 | Biogenerix Ag | Liquid formulations of granulocyte colony stimulating factor and polymer conjugates |
| AU2009293025A1 (en) * | 2008-09-19 | 2010-03-25 | Maxygen, Inc. | Method for the treatment of radiation-induced neutropenia by administration of a multi-PEGylated granulocyte colony stimulating factor (G-CSF) variant |
| US7914828B2 (en) * | 2008-10-17 | 2011-03-29 | Levine Brian M | Combination herbal product to benefit respiratory tract |
| WO2011041376A1 (en) * | 2009-09-30 | 2011-04-07 | Prolong Pharmaceuticals | Modified granulocyte colony stimulating factor (g-csf) |
| WO2011053545A1 (en) * | 2009-10-30 | 2011-05-05 | Merck Sharp & Dohme Corp. | Granulocyte-colony stimulating factor produced in glycoengineered pichia pastoris |
| TWI480288B (zh) * | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
| WO2012064845A2 (en) * | 2010-11-09 | 2012-05-18 | Nektar Therapeutics | G-csf polymer conjugates having a releasable linkage |
| WO2012158678A1 (en) | 2011-05-17 | 2012-11-22 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| CN104109199B (zh) * | 2013-04-16 | 2019-04-30 | 深圳未名新鹏生物医药有限公司 | 一种聚乙二醇单修饰的人粒细胞集落刺激因子的制备方法及其产品 |
| US20160361426A1 (en) * | 2015-06-11 | 2016-12-15 | Prolong Pharmaceuticals, LLC | Pegylated granulocyte colony stimulating factor (gcsf) |
| KR102020995B1 (ko) * | 2017-10-30 | 2019-09-16 | 한국코러스 주식회사 | 콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법 |
| US20210386680A1 (en) * | 2018-12-06 | 2021-12-16 | Board Of Regents, The University Of Texas System | Selectively cleavable therapeutic nanoparticles |
| CN114853872B (zh) * | 2022-04-27 | 2023-11-17 | 山东新时代药业有限公司 | 一种聚乙二醇修饰rhG-CSF的制备方法 |
Family Cites Families (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US588025A (en) * | 1897-08-10 | Furnace-door-operating device | ||
| AU631312B (en) | 1912-09-04 | 1913-09-16 | Aage Philip Heyman | Improvements in and relating; to milking; machines |
| WO1985000817A1 (en) | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
| JPS61227526A (ja) | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
| WO1986004605A1 (fr) | 1985-02-08 | 1986-08-14 | Chugai Seiyaku Kabushiki Kaisha | Facteur de stimulation de colonies de granulocytes humains |
| US6004548A (en) | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
| JPS63500636A (ja) | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| JPS6263335A (ja) | 1985-09-13 | 1987-03-20 | Fuji Photo Film Co Ltd | 化学反応情報の処理方法 |
| EP0220520B1 (en) | 1985-09-30 | 1991-09-18 | Chugai Seiyaku Kabushiki Kaisha | Human granulocyte colony stimulating factor |
| ES2039209T5 (es) | 1986-01-22 | 1996-07-16 | Chugai Pharmaceutical Co Ltd | Compuesto farmaceutico que promueve el restablecimiento de la capacidad hemopoyetica. |
| US4908773A (en) | 1987-04-06 | 1990-03-13 | Genex Corporation | Computer designed stabilized proteins and method for producing same |
| DK203187A (da) | 1986-04-22 | 1987-10-23 | Immunex Corp | Human g-csf proteinekspression |
| JPH01500483A (ja) | 1986-08-11 | 1989-02-23 | シタス コーポレイション | Ｇ‐ｃｓｆ及びそのミューテインの発現 |
| US4704692A (en) | 1986-09-02 | 1987-11-03 | Ladner Robert C | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| DK174044B1 (da) | 1986-12-23 | 2002-05-06 | Kyowa Hakko Kogyo Kk | Polypeptid afledt fra human granulocytkolonistimulerende faktor, og fremgangsmåde til fremstilling deraf, DNA kodende for nævnte polypeptid, rekombinant plasmid indeholdende nævnte DNA, og mikroorganismer indeholdende nævnte rekombinante plasmid....... |
| US5362853A (en) | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5214132A (en) | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5714581A (en) | 1986-12-23 | 1998-02-03 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US4853871A (en) | 1987-04-06 | 1989-08-01 | Genex Corporation | Computer-based method for designing stablized proteins |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| GB2213821B (en) | 1987-12-23 | 1992-01-02 | British Bio Technology | Synthetic human granulocyte colony stimulating factor gene |
| CA1340810C (en) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| NZ229098A (en) | 1988-05-13 | 1992-10-28 | Amgen Inc | (bg-csf) bovine granulocyte colony stimulating factor, recombinant methods and pharmaceuticals |
| ES2063783T3 (es) | 1988-06-03 | 1995-01-16 | Chugai Pharmaceutical Co Ltd | Factor de cristalino humano de estimulacion de colonias de granulocitos y procedimiento para su preparacion. |
| US5025388A (en) | 1988-08-26 | 1991-06-18 | Cramer Richard D Iii | Comparative molecular field analysis (CoMFA) |
| US5218092A (en) | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5349052A (en) | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US5104651A (en) | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
| JP2989002B2 (ja) | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
| US6166183A (en) | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5109119A (en) | 1989-06-06 | 1992-04-28 | Schering Corporation | Crystalline r-h-gm-csf and method |
| IE66494B1 (en) | 1989-09-26 | 1996-01-10 | Immunex Corp | Granulocyte-colony stimulating factor receptors |
| KR920701252A (ko) | 1989-10-10 | 1992-08-11 | 스티븐 엠. 오드레 | 과립구 군체 자극인자 및 그를 이용하여 개 및 고양이과 동물의 전염병을 치료하거나 예방하는 방법 |
| US5265030A (en) | 1990-04-24 | 1993-11-23 | Scripps Clinic And Research Foundation | System and method for determining three-dimensional structures of proteins |
| GB9107846D0 (en) | 1990-04-30 | 1991-05-29 | Ici Plc | Polypeptides |
| DE4014750A1 (de) | 1990-05-08 | 1991-11-14 | Boehringer Mannheim Gmbh | Muteine des granulozyten-stimulierenden faktors (g-csf) |
| US5399345A (en) | 1990-05-08 | 1995-03-21 | Boehringer Mannheim, Gmbh | Muteins of the granulocyte colony stimulating factor |
| JP3249147B2 (ja) | 1990-06-01 | 2002-01-21 | キリン−アムジエン・インコーポレーテツド | 生理活性蛋白含有経口製剤 |
| IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| CA2089553C (en) | 1990-08-29 | 2000-06-27 | Paul Schendel | Multidomain hematopoiesis stimulators |
| US5124297A (en) | 1990-12-07 | 1992-06-23 | Amoco Corporation | Olefin polymerization and copolymerization catalyst |
| DE4105480A1 (de) | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | Verbesserte aktivierung von rekombinanten proteinen |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5157736A (en) | 1991-04-19 | 1992-10-20 | International Business Machines Corporation | Apparatus and method for optical recognition of chemical graphics |
| ATE196548T1 (de) | 1991-05-10 | 2000-10-15 | Genentech Inc | Auswählen von agonisten und antagonisten von liganden |
| US5386507A (en) | 1991-07-18 | 1995-01-31 | Teig; Steven L. | Computer graphics system for selectively modelling molecules and investigating the chemical and physical properties thereof |
| US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| WO1993005169A1 (en) * | 1991-08-30 | 1993-03-18 | Fred Hutchinson Cancer Research Center | Hybrid cytokines |
| JP2638359B2 (ja) | 1991-11-26 | 1997-08-06 | 富士通株式会社 | 分子動力学法の拘束条件作成装置 |
| EP0955365A3 (en) | 1992-06-09 | 2000-12-20 | Chiron Corporation | Crystallization of M-CSF |
| ZA933926B (en) | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
| ATE238421T1 (de) | 1992-11-24 | 2003-05-15 | Searle & Co | Interleukin-3 (il-3)-polypeptide mith mehreren mutationen |
| US6057133A (en) | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
| US6153183A (en) | 1992-11-24 | 2000-11-28 | G. D. Searle & Company | Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production |
| US5738849A (en) | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
| US5772992A (en) | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US5424963A (en) | 1992-11-25 | 1995-06-13 | Photon Research Associates, Inc. | Molecular dynamics simulation method and apparatus |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| ATE203415T1 (de) | 1994-02-08 | 2001-08-15 | Amgen Inc | Orales verabreichungssystem von chemischmodifizierten proteinen g-csf |
| ES2312166T3 (es) | 1994-02-23 | 2009-02-16 | Kyowa Hakko Kogyo Co., Ltd | Acelerador del crecimiento plaquetario. |
| US5635599A (en) | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JPH11500308A (ja) | 1995-02-03 | 1999-01-12 | ジー．ディー．サール アンド カンパニー | 新規ｃ−ＭＰＬリガンド |
| US6017523A (en) | 1995-06-06 | 2000-01-25 | G.D. Searle & Co. | Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides |
| US6066318A (en) | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
| US6100070A (en) | 1995-10-05 | 2000-08-08 | G. D. Searle & Co. | G-CSF receptor agonists |
| AU717733B2 (en) | 1995-10-05 | 2000-03-30 | G.D. Searle & Co. | Novel G-CSF receptor agonists |
| WO1997012978A1 (en) | 1995-10-05 | 1997-04-10 | G.D. Searle & Co. | NOVEL c-mpl RECEPTOR AGONISTS |
| CN1124348C (zh) | 1995-10-05 | 2003-10-15 | G·D·瑟尔公司 | 多功能性造血受体激动剂 |
| US5969105A (en) | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
| EP0935663A2 (en) | 1996-10-25 | 1999-08-18 | G.D. SEARLE & CO. | Multi-functional chimeric hematopoietic receptor agonists |
| US6660257B1 (en) | 1996-10-25 | 2003-12-09 | Pharmacia Corporation | Circular permuteins of flt3 ligand |
| BR9808514A (pt) | 1997-04-11 | 2000-05-23 | Searle & Co | Proteìnas quiméricas do ligante flt3 |
| KR100241257B1 (ko) | 1997-05-22 | 2000-02-01 | 한승수 | 인체 과립구 콜로니 자극 인자 활성물질 및 그것의 제조방법 |
| EP0921131B1 (en) | 1997-06-06 | 2010-05-26 | Kyowa Hakko Kirin Co., Ltd. | Chemically modified polypeptides |
| DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
| US5985263A (en) | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
| US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
| WO2000018905A1 (en) | 1998-09-25 | 2000-04-06 | G.D. Searle & Co. | Method of producing permuteins by scanning permutagenesis |
| US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| CA2357811A1 (en) | 1999-01-06 | 2000-07-13 | Xencor, Inc. | Nucleic acids and proteins corresponding to mutants of g-csf with granulopoietic activity |
| CN1376164A (zh) | 1999-01-29 | 2002-10-23 | 霍夫曼-拉罗奇有限公司 | Gcsf缀合物 |
| JP2000319298A (ja) | 1999-03-04 | 2000-11-21 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | 蛋白質複合体の結晶、構造座標、及び構造座標の使用 |
| KR100356140B1 (ko) | 1999-07-08 | 2002-10-19 | 한미약품공업 주식회사 | 인간 과립구 콜로니 자극인자 변이체 및 이의 생산 방법 |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| CZ20022727A3 (cs) | 2000-01-10 | 2002-11-13 | Maxygen Holdings Ltd | Polypeptidový konjugát, způsob jeho výroby a farmaceutický prostředek |
| US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| WO2002020751A2 (en) | 2000-09-07 | 2002-03-14 | Eli Lilly And Company | Hyperglycosylated polypeptides |
| WO2002020767A2 (en) | 2000-09-08 | 2002-03-14 | Massachusetts Institute Of Technology | G-csf analog compositions and methods |
| GB0022877D0 (en) | 2000-09-18 | 2000-11-01 | Isis Innovation | Analogues |
| US20020142964A1 (en) | 2000-11-02 | 2002-10-03 | Nissen Torben Lauesgaard | Single-chain polypeptides |
| AU2002212108A1 (en) * | 2000-11-02 | 2002-05-15 | Maxygen Aps | Single-chain multimeric polypeptides |
| CN1214321C (zh) * | 2000-12-11 | 2005-08-10 | 皇家菲利浦电子有限公司 | 信号处理设备 |
| IL159524A0 (en) | 2001-07-11 | 2004-06-01 | Maxygen Holdings Ltd | G-csf conjugates |
| US7381805B2 (en) * | 2005-06-01 | 2008-06-03 | Maxygen Holdings, Ltd. | Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF |
-
2006
- 2006-05-26 US US11/420,546 patent/US7381805B2/en not_active Expired - Fee Related
- 2006-05-26 KR KR1020077030982A patent/KR20080027291A/ko not_active Abandoned
- 2006-05-26 AT AT06722962T patent/ATE500847T1/de not_active IP Right Cessation
- 2006-05-26 AU AU2006254543A patent/AU2006254543A1/en not_active Abandoned
- 2006-05-26 BR BRPI0611221-8A patent/BRPI0611221A2/pt not_active IP Right Cessation
- 2006-05-26 RU RU2007149238/13A patent/RU2007149238A/ru not_active Application Discontinuation
- 2006-05-26 WO PCT/DK2006/000292 patent/WO2006128460A2/en not_active Ceased
- 2006-05-26 EP EP06722962A patent/EP1888119B1/en not_active Not-in-force
- 2006-05-26 CA CA2607844A patent/CA2607844C/en not_active Expired - Fee Related
- 2006-05-26 CN CN2006800195588A patent/CN101193658B/zh not_active Expired - Fee Related
- 2006-05-26 JP JP2008513928A patent/JP5137821B2/ja not_active Expired - Fee Related
- 2006-05-26 DE DE602006020562T patent/DE602006020562D1/de active Active
- 2006-05-26 MX MX2007015156A patent/MX2007015156A/es unknown
- 2006-09-18 US US11/532,818 patent/US20070014763A1/en not_active Abandoned
- 2006-09-18 US US11/532,808 patent/US20070014762A1/en not_active Abandoned
-
2007
- 2007-04-30 US US11/742,551 patent/US20080167218A1/en not_active Abandoned
- 2007-04-30 US US11/742,445 patent/US7655766B2/en not_active Expired - Fee Related
- 2007-10-30 IL IL187009A patent/IL187009A0/en unknown
- 2007-11-08 NO NO20075708A patent/NO20075708L/no not_active Application Discontinuation
- 2007-11-12 ZA ZA200709704A patent/ZA200709704B/xx unknown
-
2012
- 2012-08-06 JP JP2012173959A patent/JP2013010765A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20070014763A1 (en) | 2007-01-18 |
| JP5137821B2 (ja) | 2013-02-06 |
| US20070014762A1 (en) | 2007-01-18 |
| US7655766B2 (en) | 2010-02-02 |
| AU2006254543A1 (en) | 2006-12-07 |
| WO2006128460A3 (en) | 2007-03-01 |
| US20070009478A1 (en) | 2007-01-11 |
| MX2007015156A (es) | 2008-02-15 |
| US20080090764A1 (en) | 2008-04-17 |
| JP2013010765A (ja) | 2013-01-17 |
| RU2007149238A (ru) | 2009-07-20 |
| EP1888119A2 (en) | 2008-02-20 |
| US7381805B2 (en) | 2008-06-03 |
| ATE500847T1 (de) | 2011-03-15 |
| KR20080027291A (ko) | 2008-03-26 |
| JP2008542311A (ja) | 2008-11-27 |
| US20080167218A1 (en) | 2008-07-10 |
| EP1888119B1 (en) | 2011-03-09 |
| CN101193658A (zh) | 2008-06-04 |
| CA2607844C (en) | 2012-07-10 |
| CA2607844A1 (en) | 2006-12-07 |
| DE602006020562D1 (de) | 2011-04-21 |
| IL187009A0 (en) | 2008-02-09 |
| ZA200709704B (en) | 2008-11-26 |
| CN101193658B (zh) | 2011-08-31 |
| BRPI0611221A2 (pt) | 2010-08-24 |
| WO2006128460A2 (en) | 2006-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20075708L (no) | Pegylert G-CSF-polypeptider og fremgangsmater for fremstilling av samme | |
| DK1317537T3 (da) | Sammensætninger og fremgangsmåder med G-CSF analoger | |
| IL226857A (en) | Recombinant proteins that underwent glycosylation at site n correspond to prokaryotes | |
| ATE448686T1 (de) | Actriib-fusionspolypeptide und verwendungen dafür | |
| SG131109A1 (en) | Muteins of tear lipocalin | |
| DK1638586T3 (da) | Synergistisk sammensætning til behandling af diabetes mellitus | |
| MX2009005455A (es) | (r)-n-estereoisomeros de analogos de 7,8-saturados-4,5 epoxi-morfinano. | |
| NO20082716L (no) | Sammensetninger og fremgangsmater for fremstilling av en sammensetning | |
| IN2015DN02553A (pt) | ||
| ATE540973T1 (de) | Zusammensetzungen und verfahren zur verwendung von mgd-cdf zur krankheitsbehandlung | |
| WO2006031811A3 (en) | Glycopegylated interferon alpha | |
| EP1505990A4 (en) | METHOD FOR THE TREATMENT OF HEPATITIS | |
| DE602004001727D1 (de) | Verfahren zur herstellung cyclischer peptide | |
| MXPA05014082A (es) | Acidos biariloximetilarenocarboxilicos. | |
| MX2008012748A (es) | Un proceso para la concentracion de un polipeptido. | |
| IL144830A0 (en) | Ribosomes structure and protein synthesis inhibitors | |
| ATE367167T1 (de) | Aufbereitung von aldesleukin zur pharmazeutischen verwendung | |
| MXPA06000888A (es) | Composicion, toalla limpiadora y metodo para limpiar, proteger e impartir brillo a un substrato. | |
| GB0120022D0 (en) | Conjugate | |
| WO2005040210A3 (en) | Novel cxcl8 antagonists | |
| MY141221A (en) | Casein hydrolyzate, process for producing the same, and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |