NO20076157L - Anti-TRKB monoklonale antistoffer og anvendelser derav - Google Patents
Anti-TRKB monoklonale antistoffer og anvendelser deravInfo
- Publication number
- NO20076157L NO20076157L NO20076157A NO20076157A NO20076157L NO 20076157 L NO20076157 L NO 20076157L NO 20076157 A NO20076157 A NO 20076157A NO 20076157 A NO20076157 A NO 20076157A NO 20076157 L NO20076157 L NO 20076157L
- Authority
- NO
- Norway
- Prior art keywords
- inventive
- antibodies
- trkb
- human
- monoclonal antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Mycology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68770505P | 2005-06-06 | 2005-06-06 | |
| PCT/US2006/021878 WO2006133164A2 (fr) | 2005-06-06 | 2006-06-05 | Anticorps monoclonaux anti-trkb et utilisations de ceux-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20076157L true NO20076157L (no) | 2008-02-07 |
Family
ID=37400063
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20076157A NO20076157L (no) | 2005-06-06 | 2007-11-28 | Anti-TRKB monoklonale antistoffer og anvendelser derav |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7750122B2 (fr) |
| EP (2) | EP1891114A2 (fr) |
| JP (1) | JP2008545781A (fr) |
| KR (1) | KR20080032070A (fr) |
| CN (1) | CN101273064A (fr) |
| AR (1) | AR053401A1 (fr) |
| AU (1) | AU2006255101A1 (fr) |
| BR (1) | BRPI0610938A2 (fr) |
| CA (1) | CA2610771A1 (fr) |
| EC (1) | ECSP077978A (fr) |
| GT (1) | GT200600240A (fr) |
| IL (1) | IL187710A0 (fr) |
| MX (1) | MX2007015292A (fr) |
| NI (1) | NI200700315A (fr) |
| NO (1) | NO20076157L (fr) |
| NZ (1) | NZ563941A (fr) |
| PA (1) | PA8678401A1 (fr) |
| PE (1) | PE20070183A1 (fr) |
| RU (1) | RU2007144678A (fr) |
| TW (1) | TW200722437A (fr) |
| WO (1) | WO2006133164A2 (fr) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| CA2519227C (fr) | 2003-03-19 | 2013-12-03 | Biogen Idec Ma Inc. | Proteine de liaison de recepteur de nogo |
| US8486893B2 (en) | 2004-06-24 | 2013-07-16 | Biogen Idec Ma Inc. | Treatment of conditions involving demyelination |
| HRP20131066T1 (hr) | 2005-07-08 | 2013-12-06 | Biogen Idec Ma Inc. | Sp35 antitijela i njihova upotreba |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| EP2087007A2 (fr) * | 2006-11-09 | 2009-08-12 | Irm Llc | Anticorps d'agonistes de trkb et leurs utilisations |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| WO2008078179A1 (fr) * | 2006-12-20 | 2008-07-03 | Rinat Neuroscience Corporation | Agonistes de trkb pour le traitement des troubles auto-immunitaires |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| WO2009048605A1 (fr) * | 2007-10-11 | 2009-04-16 | Biogen Idec Ma Inc. | Procédés destinés à traiter la neuropathie optique induite par la pression, à prévenir la dégénérescence neurale et à promouvoir la survie des cellules neuronales par le biais de l'administration d'antagonistes lingo-1 et d'agonistes trkb |
| EP2214706A1 (fr) * | 2007-10-23 | 2010-08-11 | Novartis AG | Utilisation d'anticorps trkb pour le traitement de troubles respiratoires |
| WO2009061500A1 (fr) * | 2007-11-08 | 2009-05-14 | Biogen Idec Ma Inc. | Utilisation des antagonistes de lingo-4 dans le traitement d'états mettant en jeu une démyélination |
| CA2729961C (fr) | 2008-07-09 | 2018-05-01 | Biogen Idec Ma Inc. | Anticorps anti-lingo, li113, li62 variant co2 |
| WO2010086828A2 (fr) * | 2009-02-02 | 2010-08-05 | Rinat Neuroscience Corporation | Anticorps monoclonaux agonistes anti-trkb |
| AU2010243551B2 (en) * | 2009-04-30 | 2015-03-26 | Ablynx Nv | Method for the production of domain antibodies |
| WO2011103667A1 (fr) * | 2010-02-26 | 2011-09-01 | 6452728 Canada Inc. | Anticorps agonistes des récepteurs trkb et leurs utilisations |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| EP3533803B1 (fr) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anticorps anti-bêta-amyloïde |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| EP2646468B1 (fr) | 2010-12-01 | 2018-07-25 | AlderBio Holdings LLC | Compositions anti-ngf et leur utilisation |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| GB2491106A (en) * | 2011-05-18 | 2012-11-28 | Univ Basel | Antibodies against tropomyosin-related kinase B receptors |
| WO2013059740A1 (fr) | 2011-10-21 | 2013-04-25 | Foundation Medicine, Inc. | Nouvelles molécules de fusion alk et ntrk1 et leurs utilisations |
| CN102645542A (zh) * | 2012-04-20 | 2012-08-22 | 苏州大学 | Bdnf酶联免疫测定试剂盒 |
| KR102142161B1 (ko) | 2012-05-14 | 2020-08-06 | 바이오젠 엠에이 인코포레이티드 | 운동 뉴런 관련 병태 치료용 lingo-2 길항제 |
| CN102901815B (zh) * | 2012-11-05 | 2014-10-22 | 武汉远征世纪制药有限公司 | 一种检测TrkB受体816/817位酪氨酸位点活性的ELISA试剂盒及其使用方法 |
| US11230589B2 (en) | 2012-11-05 | 2022-01-25 | Foundation Medicine, Inc. | Fusion molecules and uses thereof |
| EP2914621B1 (fr) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Nouvelles molécules de fusion de ntrk1 et leurs utilisations |
| CA3150658A1 (en) | 2013-01-18 | 2014-07-24 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
| ES2936810T3 (es) | 2014-05-16 | 2023-03-22 | Pfizer | Anticuerpos biespecíficos con interfaces CH1-CL de ingeniería |
| JP2018504400A (ja) | 2015-01-08 | 2018-02-15 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Lingo‐1拮抗薬及び脱髄障害の治療のための使用 |
| JP7039468B2 (ja) * | 2015-11-17 | 2022-03-22 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 神経およびその他の障害の処置のための結合アゴニスト |
| EP3452088A4 (fr) * | 2016-05-03 | 2020-04-15 | The Scripps Research Institute | Anticorps agonistes de trkb pour le traitement de troubles neurodégénératifs |
| AU2017342176A1 (en) | 2016-10-10 | 2019-05-02 | The National Institute for Biotechnology in the Negev Ltd. | Non-cytotoxic modified cells and use thereof |
| US9914781B1 (en) | 2016-11-08 | 2018-03-13 | Glaxosmithkline Intellectual Property Development Limited | Binding agonist for treatment of neurological and other disorders |
| CN110753702B (zh) * | 2017-03-15 | 2022-09-20 | 清华大学 | 抗trkb抗体 |
| US10793634B2 (en) * | 2017-06-09 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Anti-TrkB antibodies |
| US11066474B2 (en) * | 2017-11-30 | 2021-07-20 | Regeneron Pharmaceuticals, Inc. | Anti-TrkB monoclonal antibodies and methods of use |
| CN110028585A (zh) * | 2019-02-18 | 2019-07-19 | 广东三九脑科医院 | 兔抗人trk蛋白单克隆抗体制备及其免疫组化用途 |
| WO2021102276A1 (fr) | 2019-11-22 | 2021-05-27 | Ossianix, Inc. | Vnar de transfert à travers la barrière hémato-encéphalique (bbb) conjugués à des anticorps agonistes neurotrophiques pour traiter des maladies et des états neurodégénératifs |
| US12559560B2 (en) | 2020-01-30 | 2026-02-24 | Fred Hutchinson Cancer Center | Antibody-based compositions for targeting tropomyosin receptor kinase B (TrkB) isoforms |
| GB202004832D0 (en) * | 2020-04-01 | 2020-05-13 | Instituto De Medicina Molecular Faculdade De Medicina Univ De Lisboa | Therapeutic agaents, pharmaceutical compositions, and associated biomarkers |
| WO2023125485A1 (fr) * | 2021-12-28 | 2023-07-06 | 4B Technologies (Beijing) Co., Limited | Anticorps trkb et son application |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ATE158021T1 (de) | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5811396A (en) | 1991-03-14 | 1998-09-22 | The United States Of America As Represented By The Department Of Health And Human Services | TRK tyrosine kinase receptor is the physiological receptor for nerve growth factor |
| US5231001A (en) | 1991-03-14 | 1993-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Trk tyrosine kinase receptor is the physiological receptor for nerve growth factor |
| ZA922947B (en) | 1991-04-23 | 1993-01-27 | Regeneron Pharma | Assay systems for neurotrophin activity |
| EP0519596B1 (fr) | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | Procédé pour réduire l'immunogénicité des domaines variables d'anticorps |
| US5625121A (en) | 1993-09-02 | 1997-04-29 | Bristol-Myers Squibb Company | Mice deficient in nerve growth factor receptors encoded by trkB |
| US5753225A (en) | 1993-12-03 | 1998-05-19 | The Regents Of The University Of California | Antibodies that mimic actions of neurotrophins |
| US20040058416A1 (en) | 1994-03-18 | 2004-03-25 | Presta Leonard G. | Human trk receptors and neurotrophic factor inhibitors |
| US5844092A (en) | 1994-03-18 | 1998-12-01 | Genentech, Inc. | Human TRK receptors and neurotrophic factor inhibitors |
| US5877016A (en) | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
| US5601820A (en) | 1994-07-07 | 1997-02-11 | Children's Hospital Of Philadelphia | Compositions and methods of making and using human full length TRK-B |
| US5770577A (en) | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
| US5688911A (en) | 1995-05-03 | 1997-11-18 | Schneider; Rainer | Trk neurotrophin binding motifs |
| US5880153A (en) | 1995-11-13 | 1999-03-09 | Spinal Cord Society | Method for upregulation of TRKB and TRKC receptors in central nervous system neurons |
| JPH10212241A (ja) | 1996-05-27 | 1998-08-11 | Sumitomo Pharmaceut Co Ltd | Bdnfを安定に含有する製剤 |
| ZA976326B (en) | 1996-07-19 | 1998-02-03 | Amgen Inc | Analogs of cationic proteins. |
| WO2001064742A1 (fr) | 2000-02-29 | 2001-09-07 | Sumitomo Pharmaceuticals Company, Limited | Bdnf modifie |
| CA2412494C (fr) | 2000-06-22 | 2012-10-23 | Genentech, Inc. | Anticorps monoclonaux anti-trk-c agonistes |
| US7060429B2 (en) | 2001-02-22 | 2006-06-13 | University Of Maryland, Baltimore | Treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms |
| US20020169154A1 (en) | 2001-04-04 | 2002-11-14 | Cephalon, Inc. | Novel methods and compositions involving trk tyrosine kinase inhibitors and antineoplastic agents |
| US20060148749A1 (en) | 2002-02-22 | 2006-07-06 | University Of Maryland | Novel treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms |
| US20040186044A1 (en) | 2002-11-06 | 2004-09-23 | Cosgaya Jose Miguel | Modulation of myelination by interaction with P75 and TRK receptors |
-
2006
- 2006-06-05 GT GT200600240A patent/GT200600240A/es unknown
- 2006-06-05 PE PE2006000611A patent/PE20070183A1/es not_active Application Discontinuation
- 2006-06-05 AR ARP060102341A patent/AR053401A1/es not_active Application Discontinuation
- 2006-06-05 RU RU2007144678/13A patent/RU2007144678A/ru unknown
- 2006-06-05 TW TW095119800A patent/TW200722437A/zh unknown
- 2006-06-05 NZ NZ563941A patent/NZ563941A/en not_active IP Right Cessation
- 2006-06-05 CA CA002610771A patent/CA2610771A1/fr not_active Abandoned
- 2006-06-05 AU AU2006255101A patent/AU2006255101A1/en not_active Abandoned
- 2006-06-05 MX MX2007015292A patent/MX2007015292A/es active IP Right Grant
- 2006-06-05 EP EP06772254A patent/EP1891114A2/fr not_active Ceased
- 2006-06-05 BR BRPI0610938-1A patent/BRPI0610938A2/pt not_active IP Right Cessation
- 2006-06-05 JP JP2008515819A patent/JP2008545781A/ja active Pending
- 2006-06-05 WO PCT/US2006/021878 patent/WO2006133164A2/fr not_active Ceased
- 2006-06-05 PA PA20068678401A patent/PA8678401A1/es unknown
- 2006-06-05 CN CNA2006800287787A patent/CN101273064A/zh active Pending
- 2006-06-05 KR KR1020087000331A patent/KR20080032070A/ko not_active Ceased
- 2006-06-05 US US11/446,875 patent/US7750122B2/en not_active Expired - Fee Related
- 2006-06-05 EP EP10179506A patent/EP2298813A3/fr not_active Withdrawn
-
2007
- 2007-11-28 NO NO20076157A patent/NO20076157L/no not_active Application Discontinuation
- 2007-11-28 IL IL187710A patent/IL187710A0/en unknown
- 2007-12-03 EC EC2007007978A patent/ECSP077978A/es unknown
- 2007-12-03 NI NI200700315A patent/NI200700315A/es unknown
-
2010
- 2010-06-30 US US12/827,321 patent/US20110150893A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2298813A3 (fr) | 2012-03-21 |
| AU2006255101A1 (en) | 2006-12-14 |
| NI200700315A (es) | 2008-07-03 |
| IL187710A0 (en) | 2008-08-07 |
| MX2007015292A (es) | 2008-02-21 |
| EP2298813A2 (fr) | 2011-03-23 |
| CA2610771A1 (fr) | 2006-12-14 |
| WO2006133164A3 (fr) | 2007-03-15 |
| AR053401A1 (es) | 2007-05-02 |
| KR20080032070A (ko) | 2008-04-14 |
| US7750122B2 (en) | 2010-07-06 |
| RU2007144678A (ru) | 2009-07-20 |
| ECSP077978A (es) | 2008-01-23 |
| NZ563941A (en) | 2011-09-30 |
| US20070059304A1 (en) | 2007-03-15 |
| PA8678401A1 (es) | 2009-05-15 |
| EP1891114A2 (fr) | 2008-02-27 |
| PE20070183A1 (es) | 2007-02-26 |
| GT200600240A (es) | 2007-03-14 |
| CN101273064A (zh) | 2008-09-24 |
| US20110150893A1 (en) | 2011-06-23 |
| JP2008545781A (ja) | 2008-12-18 |
| BRPI0610938A2 (pt) | 2010-08-03 |
| WO2006133164A2 (fr) | 2006-12-14 |
| TW200722437A (en) | 2007-06-16 |
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| FC2A | Withdrawal, rejection or dismissal of laid open patent application |