NO20076676L - Nye 8-sulfonyl-3-aminosubstituerte kroman- eller tetrahydronaftalenderivater som modulerer 5HT6-reseptor - Google Patents

Nye 8-sulfonyl-3-aminosubstituerte kroman- eller tetrahydronaftalenderivater som modulerer 5HT6-reseptor

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Publication number
NO20076676L
NO20076676L NO20076676A NO20076676A NO20076676L NO 20076676 L NO20076676 L NO 20076676L NO 20076676 A NO20076676 A NO 20076676A NO 20076676 A NO20076676 A NO 20076676A NO 20076676 L NO20076676 L NO 20076676L
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NO
Norway
Prior art keywords
sulfonyl
receptor
amino
new
tetrahydronaphthalene derivatives
Prior art date
Application number
NO20076676A
Other languages
English (en)
Inventor
Gunnar Nordvall
Daniel Sohn
Carl Petersson
Laszlo Rakos
Original Assignee
Astrazeneca Ab
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Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20076676L publication Critical patent/NO20076676L/no

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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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Abstract

Foreliggende oppfinnelse angår nye forbindelser med formel I, hvori R1 til R12, P, X, Q og n er som definert i formel I, eller salter, solvater eller solvaterte salter derav, fremgangsmåter for deres fremstilling og nye intermediater anvendt ved fremstilling derav, farmasøytiske formuleringer som innbefatter nevnte forbindelser og anvendelse av nevnte forbindelser ved behandling.
NO20076676A 2005-05-23 2007-12-27 Nye 8-sulfonyl-3-aminosubstituerte kroman- eller tetrahydronaftalenderivater som modulerer 5HT6-reseptor NO20076676L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0501165 2005-05-23
SE0501167 2005-05-23
PCT/SE2006/000592 WO2006126938A1 (en) 2005-05-23 2006-05-22 Novel 8-sulfonyl-3 aminosubstituted chroman or tetrahydronaphtalene derivatives modulating the 5ht6 receptor

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NO20076676L true NO20076676L (no) 2007-12-27

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NO20076676A NO20076676L (no) 2005-05-23 2007-12-27 Nye 8-sulfonyl-3-aminosubstituerte kroman- eller tetrahydronaftalenderivater som modulerer 5HT6-reseptor

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Country Link
US (1) US20090099187A1 (no)
EP (1) EP1888518A1 (no)
JP (1) JP2008545685A (no)
KR (1) KR20080012303A (no)
AR (1) AR054044A1 (no)
AU (1) AU2006250116A1 (no)
BR (1) BRPI0609800A2 (no)
CA (1) CA2609735A1 (no)
IL (1) IL187095A0 (no)
MX (1) MX2007014266A (no)
NO (1) NO20076676L (no)
TW (1) TW200716530A (no)
WO (1) WO2006126938A1 (no)

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CN101868457B (zh) 2007-09-24 2013-02-13 科门蒂斯公司 作为β-分泌酶抑制剂用于治疗的(3-羟基-4-氨基-丁-2-基)-3-(2-噻唑-2-基-吡咯烷-1-羰基)苯甲酰胺衍生物和相关化合物

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Publication number Priority date Publication date Assignee Title
AU627027B2 (en) * 1989-04-27 1992-08-13 Pharmacia & Upjohn Company Substituted 3-amino chromans
JP2785879B2 (ja) * 1989-05-31 1998-08-13 ジ・アップジョン・カンパニー 治療学的に有用な２―アミノテトラリン誘導体
IL133870A0 (en) * 1997-07-11 2001-04-30 Smithkline Beecham Plc Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation
DE10053796A1 (de) * 2000-10-30 2002-05-08 Bayer Ag Verwendung von Naphthalinsulfonamiden
EP1432696A1 (en) * 2001-10-04 2004-06-30 Wyeth Chroman derivatives as 5-hydroxytryptamine-6 ligands
ATE401072T1 (de) * 2002-02-12 2008-08-15 Organon Nv 1-arylsulfonyl-3-substituierte indol und indolinederivate verwendbar zur behandlung von erkrankungen des zentralnervensystem
CN1662521A (zh) * 2002-06-20 2005-08-31 比奥维特罗姆股份公司 可用于治疗肥胖、ii型糖尿病和cns障碍的新化合物
WO2004043369A2 (en) * 2002-11-06 2004-05-27 Smithkline Beecham Corporation Sulfonamides

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US20090099187A1 (en) 2009-04-16
AU2006250116A1 (en) 2006-11-30
WO2006126938A1 (en) 2006-11-30
MX2007014266A (es) 2008-01-22
EP1888518A1 (en) 2008-02-20
BRPI0609800A2 (pt) 2011-10-11
JP2008545685A (ja) 2008-12-18

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