NO20070557L - Ftalazinderivater som PARP-inhibitorer - Google Patents

Ftalazinderivater som PARP-inhibitorer

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Publication number
NO20070557L
NO20070557L NO20070557A NO20070557A NO20070557L NO 20070557 L NO20070557 L NO 20070557L NO 20070557 A NO20070557 A NO 20070557A NO 20070557 A NO20070557 A NO 20070557A NO 20070557 L NO20070557 L NO 20070557L
Authority
NO
Norway
Prior art keywords
parp inhibitors
phthalazine derivatives
formula
phthalazine
derivatives
Prior art date
Application number
NO20070557A
Other languages
English (en)
Inventor
Walter Boudewijn Leopo Wouters
Jacobus Alphonsus Josephus Dun
Maria Victorina Francis Somers
Ludo Edmond Josephine Kennis
Josephus Carolus Mertens
Laurence Anne Mevellec
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20070557L publication Critical patent/NO20070557L/no

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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Abstract

Den foreliggende oppfinnelse tilveiebringer forbindelser med formel (I), deres anvendelse som PARP-inhibitorer samt farmasøytiske sammensetninger omfattende forbindelsene med formel (I) hvori R\ R^ v, v, x, Y, Q og Z har deflnerte betydninger.
NO20070557A 2004-06-30 2007-01-30 Ftalazinderivater som PARP-inhibitorer NO20070557L (no)

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PCT/EP2005/053030 WO2006003147A1 (en) 2004-06-30 2005-06-28 Phthalazine derivatives as parp inhibitors

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WO2006003147A1 (en) 2006-01-12
ES2563954T3 (es) 2016-03-16
BRPI0512902A (pt) 2008-04-15
NZ551799A (en) 2009-11-27
AU2005259189B2 (en) 2011-04-21
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CN1980674B (zh) 2011-05-25
UA93351C2 (uk) 2011-02-10
AR049951A1 (es) 2006-09-20
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EP1771175A1 (en) 2007-04-11
EA200700192A1 (ru) 2007-06-29
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US7803795B2 (en) 2010-09-28
TWI376224B (en) 2012-11-11
TW200610531A (en) 2006-04-01
KR101211950B1 (ko) 2012-12-13
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EA014955B1 (ru) 2011-04-29
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