NO20081111L - Nye kapslede pyrazinoylguanidin natriumkanalblokkere - Google Patents
Nye kapslede pyrazinoylguanidin natriumkanalblokkereInfo
- Publication number
- NO20081111L NO20081111L NO20081111A NO20081111A NO20081111L NO 20081111 L NO20081111 L NO 20081111L NO 20081111 A NO20081111 A NO 20081111A NO 20081111 A NO20081111 A NO 20081111A NO 20081111 L NO20081111 L NO 20081111L
- Authority
- NO
- Norway
- Prior art keywords
- sodium channel
- channel blockers
- pyrazinoylguanidine sodium
- new encapsulated
- encapsulated
- Prior art date
Links
- 239000003195 sodium channel blocking agent Substances 0.000 title abstract 3
- BGGCAGOTBOAZPU-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide;sodium Chemical compound [Na].NC(N)=NC(=O)C1=CN=CC=N1 BGGCAGOTBOAZPU-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/195,758 US7807834B2 (en) | 2005-08-03 | 2005-08-03 | Capped pyrazinoylguanidine sodium channel blockers |
| PCT/US2006/015957 WO2007018640A1 (en) | 2005-08-03 | 2006-04-27 | New capped pyrazinoylguanidine sodium channel blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20081111L true NO20081111L (no) | 2008-04-01 |
Family
ID=37718396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081111A NO20081111L (no) | 2005-08-03 | 2008-03-03 | Nye kapslede pyrazinoylguanidin natriumkanalblokkere |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US7807834B2 (da) |
| EP (1) | EP1922073B1 (da) |
| JP (2) | JP5225085B2 (da) |
| KR (1) | KR20080043773A (da) |
| AU (1) | AU2006276978B2 (da) |
| BR (1) | BRPI0614389A2 (da) |
| CA (1) | CA2617269A1 (da) |
| CY (1) | CY1114638T1 (da) |
| DK (1) | DK1922073T3 (da) |
| ES (1) | ES2430288T3 (da) |
| IL (1) | IL188941A0 (da) |
| NO (1) | NO20081111L (da) |
| PL (1) | PL1922073T3 (da) |
| PT (1) | PT1922073E (da) |
| RS (1) | RS52998B (da) |
| SI (1) | SI1922073T1 (da) |
| WO (1) | WO2007018640A1 (da) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| AU2004266704B2 (en) * | 2003-08-18 | 2012-02-23 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| JP2007502829A (ja) * | 2003-08-18 | 2007-02-15 | パリオン・サイエンシィズ・インコーポレーテッド | 環状ピラジノイルグアニジンナトリウムチャネルブロッカー |
| US7745442B2 (en) * | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| WO2006023617A2 (en) | 2004-08-18 | 2006-03-02 | Johnson Michael R | Cyclic amide & ester pyrazinoylguanidine sodium channel blockers |
| CA2575670A1 (en) * | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| US8324218B2 (en) * | 2006-06-09 | 2012-12-04 | Parion Sciences, Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity |
| PT2035004E (pt) * | 2006-06-09 | 2012-11-21 | Parion Sciences Inc | Bloqueadores dos canais de sódio de pirazinoilguanidona substituída com fenilo que possuem actividade agonista beta |
| AU2007294547A1 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
| TW200819430A (en) * | 2006-09-07 | 2008-05-01 | Michael R Johnson | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
| US20080293740A1 (en) * | 2007-04-03 | 2008-11-27 | Parion Sciences, Inc. | Method of treating acid-sensing ion channel mediated pain, cough suppression, and central nervous system disorders |
| US8288391B2 (en) * | 2007-04-03 | 2012-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use as taste modulators |
| US8551534B2 (en) | 2007-10-10 | 2013-10-08 | Parion Sciences, Inc. | Inhaled hypertonic saline delivered by a heated nasal cannula |
| WO2009139948A1 (en) * | 2008-02-26 | 2009-11-19 | Johnson Michael R | Poly aromatic sodium channel blockers |
| US20100074881A1 (en) * | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
| CA2796826A1 (en) | 2010-05-10 | 2011-11-17 | Gilead Sciences, Inc. | Bifunctional quinoline derivatives |
| UY33373A (es) | 2010-05-10 | 2011-12-30 | Gilead Sciences Inc | ?Compuestos de pirazolopiridina bifuncionales, su uso en terapia y composiciones que los comprenden?. |
| US8778383B2 (en) | 2011-06-07 | 2014-07-15 | Parion Sciences, Inc. | Methods of treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| AR086745A1 (es) * | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| HUE032851T2 (en) | 2011-06-27 | 2017-11-28 | Parion Sciences Inc | A chemically and metabolically stable dipeptide having strong sodium channel blocking activity |
| CN104170419B (zh) * | 2012-03-23 | 2018-11-02 | 日本电气株式会社 | 订户服务器、监视服务器、移动终端、与之相关的方法和计算机可读介质 |
| MX2014014648A (es) | 2012-05-29 | 2015-09-04 | Parion Sciences Inc | Aminoamidas tipo dendrimero que poseen actividad bloqueadora del canal de sodio para el tratamiento de ojo reseco y otras enfermedades mucosas. |
| SG10201708931XA (en) | 2012-12-17 | 2017-12-28 | Parion Sciences Inc | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| RU2018138195A (ru) | 2012-12-17 | 2018-12-18 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| EP3022197B1 (en) * | 2013-07-15 | 2017-09-06 | Boehringer Ingelheim International GmbH | Novel tetra- and pentasubstituted benzimidazolium compounds |
| EP3022196B1 (en) | 2013-07-15 | 2017-09-06 | Boehringer Ingelheim International GmbH | Novel benzimidazolium compounds |
| SG11201601291QA (en) | 2013-08-23 | 2016-03-30 | Parion Sciences Inc | Dithiol mucolytic agents |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
| KR20170108088A (ko) | 2015-01-30 | 2017-09-26 | 패리온 사이언스 인코퍼레이티드 | 신규 모노티올 점액용해제 |
| JP2018520986A (ja) | 2015-04-30 | 2018-08-02 | パリオン・サイエンシィズ・インコーポレーテッド | ジチオール粘液溶解剤の新規なプロドラッグ |
| GB201610854D0 (en) | 2016-06-21 | 2016-08-03 | Entpr Therapeutics Ltd | Compounds |
| GB201619694D0 (en) | 2016-11-22 | 2017-01-04 | Entpr Therapeutics Ltd | Compounds |
| GB201717051D0 (en) | 2017-10-17 | 2017-11-29 | Enterprise Therapeutics Ltd | Compounds |
| GB201808093D0 (en) | 2018-05-18 | 2018-07-04 | Enterprise Therapeutics Ltd | Compounds |
| KR102788081B1 (ko) | 2022-10-31 | 2025-03-31 | 한국과학기술연구원 | 가변 구조형 로봇 손바닥을 갖는 로봇 핸드 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894376A (en) | 1988-02-26 | 1990-01-16 | Trustees Of The University Of Pennsylvania | Methods of treating diseases characterized by hyperexcitability of neurons |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6858614B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| JP2007502829A (ja) | 2003-08-18 | 2007-02-15 | パリオン・サイエンシィズ・インコーポレーテッド | 環状ピラジノイルグアニジンナトリウムチャネルブロッカー |
| AU2004266704B2 (en) | 2003-08-18 | 2012-02-23 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| US7375107B2 (en) | 2003-08-18 | 2008-05-20 | Parion Sciences, Inc. | Alaphatic pyrazinoylguanidine sodium channel blockers |
| US20050090505A1 (en) | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US20090253714A1 (en) | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7399766B2 (en) | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| CA2575670A1 (en) | 2004-08-18 | 2006-03-02 | Michael R. Johnson | Aliphatic amide & ester pyrazinoylguanidine sodium channel blockers |
| WO2006023617A2 (en) | 2004-08-18 | 2006-03-02 | Johnson Michael R | Cyclic amide & ester pyrazinoylguanidine sodium channel blockers |
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-
2005
- 2005-08-03 US US11/195,758 patent/US7807834B2/en not_active Expired - Fee Related
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2006
- 2006-04-27 WO PCT/US2006/015957 patent/WO2007018640A1/en not_active Ceased
- 2006-04-27 KR KR1020087002867A patent/KR20080043773A/ko not_active Withdrawn
- 2006-04-27 DK DK06751598.1T patent/DK1922073T3/da active
- 2006-04-27 PT PT67515981T patent/PT1922073E/pt unknown
- 2006-04-27 EP EP06751598.1A patent/EP1922073B1/en not_active Expired - Lifetime
- 2006-04-27 BR BRPI0614389-0A patent/BRPI0614389A2/pt not_active IP Right Cessation
- 2006-04-27 RS RS20130441A patent/RS52998B/sr unknown
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- 2006-04-27 JP JP2008524957A patent/JP5225085B2/ja not_active Expired - Fee Related
- 2006-04-27 SI SI200631660T patent/SI1922073T1/sl unknown
- 2006-04-27 CA CA002617269A patent/CA2617269A1/en not_active Abandoned
- 2006-04-27 PL PL06751598T patent/PL1922073T3/pl unknown
- 2006-04-27 ES ES06751598T patent/ES2430288T3/es not_active Expired - Lifetime
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- 2008-01-22 IL IL188941A patent/IL188941A0/en unknown
- 2008-03-03 NO NO20081111A patent/NO20081111L/no not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2006276978B2 (en) | 2011-12-01 |
| SI1922073T1 (sl) | 2013-11-29 |
| EP1922073B1 (en) | 2013-07-10 |
| KR20080043773A (ko) | 2008-05-19 |
| US20120220606A1 (en) | 2012-08-30 |
| US20110003832A1 (en) | 2011-01-06 |
| US8211895B2 (en) | 2012-07-03 |
| CA2617269A1 (en) | 2007-02-15 |
| IL188941A0 (en) | 2008-04-13 |
| ES2430288T3 (es) | 2013-11-19 |
| US7807834B2 (en) | 2010-10-05 |
| CY1114638T1 (el) | 2016-10-05 |
| US8507497B2 (en) | 2013-08-13 |
| HK1112853A1 (en) | 2008-09-19 |
| AU2006276978A1 (en) | 2007-02-15 |
| JP2012211188A (ja) | 2012-11-01 |
| EP1922073A1 (en) | 2008-05-21 |
| WO2007018640A1 (en) | 2007-02-15 |
| JP2009503067A (ja) | 2009-01-29 |
| EP1922073A4 (en) | 2010-07-07 |
| JP5225085B2 (ja) | 2013-07-03 |
| BRPI0614389A2 (pt) | 2011-03-22 |
| RS52998B (sr) | 2014-02-28 |
| PL1922073T3 (pl) | 2013-12-31 |
| US20070032509A1 (en) | 2007-02-08 |
| PT1922073E (pt) | 2013-10-16 |
| DK1922073T3 (da) | 2013-10-14 |
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