NO20081482L - Delta- og epsilon-krystallformer for imatinibmesylat - Google Patents

Delta- og epsilon-krystallformer for imatinibmesylat

Info

Publication number
NO20081482L
NO20081482L NO20081482A NO20081482A NO20081482L NO 20081482 L NO20081482 L NO 20081482L NO 20081482 A NO20081482 A NO 20081482A NO 20081482 A NO20081482 A NO 20081482A NO 20081482 L NO20081482 L NO 20081482L
Authority
NO
Norway
Prior art keywords
crystal forms
delta
imatinib mesylate
preparation
pharmaceutical compositions
Prior art date
Application number
NO20081482A
Other languages
English (en)
Inventor
Michael Mutz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37192362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20081482(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20081482L publication Critical patent/NO20081482L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives d- og e-krystallformer av metansulfonsyreaddisjonssaltet av 4-(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)fenyl]benzamid (forbindelsen med formel I, se nedenfor). Videre beskrives prosesser for fremstilling derav, farmasøytiske preparater inneholdende disse krystallformer, og deres anvendelse i diagnostiske metoder eller for terapeutisk behandling av varmblodige dyr, samt brukt som mellomprodukter ovenfor fremstilling av farmasøytiske preparater for anvendelse ved diagnostiske metoder eller for terapeutiske behandlinger av varmblodige dyr, særlig mennesker.
NO20081482A 2005-08-26 2008-03-26 Delta- og epsilon-krystallformer for imatinibmesylat NO20081482L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71173805P 2005-08-26 2005-08-26
US71173705P 2005-08-26 2005-08-26
US71220605P 2005-08-29 2005-08-29
PCT/EP2006/065662 WO2007023182A1 (en) 2005-08-26 2006-08-24 Delta and epsilon crystal forms of imatinib mesylate

Publications (1)

Publication Number Publication Date
NO20081482L true NO20081482L (no) 2008-05-16

Family

ID=37192362

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081482A NO20081482L (no) 2005-08-26 2008-03-26 Delta- og epsilon-krystallformer for imatinibmesylat

Country Status (16)

Country Link
US (1) US7879860B2 (no)
EP (1) EP1922314A1 (no)
JP (1) JP2009506014A (no)
KR (1) KR20080049766A (no)
CN (2) CN102002035B (no)
AR (1) AR055613A1 (no)
AU (1) AU2006283842B2 (no)
BR (1) BRPI0615383A2 (no)
CA (1) CA2620835A1 (no)
EC (1) ECSP088217A (no)
IL (1) IL189353A (no)
MX (1) MX2008002541A (no)
MY (1) MY148375A (no)
NO (1) NO20081482L (no)
UY (1) UY29766A1 (no)
WO (1) WO2007023182A1 (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130137721A (ko) * 2005-11-25 2013-12-17 노파르티스 아게 이마티니브 메실레이트의 ｆ, ｇ, ｈ, ｉ 및 ｋ 결정형
EP1919893A2 (en) 2006-04-27 2008-05-14 Sicor, Inc. Polymorphic forms of imatinib mesylate and processes for their preparation as well as of amorphous imatinib mesylate and form alpha
US8067421B2 (en) 2006-04-27 2011-11-29 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
US7977348B2 (en) 2006-04-27 2011-07-12 Sicor Inc. Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α
EP2009008A1 (en) 2006-10-26 2008-12-31 Sicor, Inc. Imatinib base, and imatinib mesylate and processes for preparation thereof
US7550591B2 (en) 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process
WO2008150481A2 (en) * 2007-05-29 2008-12-11 Sicor Inc. Processes for the preparation of crystalline form beta of imatinib mesylate
EP2081556A1 (en) * 2007-09-25 2009-07-29 Teva Pharmaceutical Industries Ltd. Stable imatinib compositions
US7947699B2 (en) 2008-01-10 2011-05-24 Actavis Group Ptc Ehf Anhydrous amorphous imatinib mesylate
US20100330130A1 (en) 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
CZ2009570A3 (cs) 2009-08-26 2011-03-09 Zentiva, K. S. Príprava, stabilizace a využití polymorfu imatinib mesylátu pro vývoj lékových forem
PL389357A1 (pl) 2009-10-22 2011-04-26 Tomasz Koźluk Sole imatinibu z pochodnymi kwasów winowych i sposób ich wytwarzania
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
CA2789989A1 (en) 2010-02-15 2011-08-18 Reliance Life Sciences Pvt. Ltd. Process for the preparation of alpha form of imatinib mesylate
PL390611A1 (pl) 2010-03-04 2011-09-12 Tomasz Koźluk Sposób otrzymywania polimorficznej formy alfa i nowa forma polimorficzna mesylanu imatinibu
EA024088B1 (ru) 2010-06-18 2016-08-31 КРКА, д.д., НОВО МЕСТО α-ФОРМА МЕЗИЛАТА ИМАТИНИБА, СПОСОБЫ ЕЕ ПОЛУЧЕНИЯ И СОДЕРЖАЩАЯ ЕЁ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ
CN102477031B (zh) 2010-11-30 2015-07-15 浙江九洲药业股份有限公司 一种甲磺酸伊马替尼α晶型的制备方法
WO2012090221A1 (en) 2010-12-29 2012-07-05 Cadila Healthcare Limited Novel salts of imatinib
PL394169A1 (pl) 2011-03-09 2012-09-10 Adamed Spółka Z Ograniczoną Odpowiedzialnością Kompozycja farmaceutyczna metanosulfonianu imatinibu do napełniania jednostkowych postaci dawkowania oraz sposób jej wytwarzania
EP2604596A1 (en) * 2011-12-16 2013-06-19 Deva Holding Anonim Sirketi Polymorphs of imatinib
JP5928159B2 (ja) * 2012-05-28 2016-06-01 ニプロ株式会社 医薬組成物
EP2864313A1 (en) 2012-06-22 2015-04-29 Basf Se Multicomponent crystals comprising imatinib mesilate and selected co-crystal formers
CN105560246B (zh) * 2012-08-04 2019-07-26 正大天晴药业集团南京顺欣制药有限公司 甲磺酸伊马替尼α结晶的制备及其药物组合物
EP2803353B1 (en) 2013-05-14 2018-05-23 Hetero Research Foundation Compositions of Imatinib
WO2017078647A1 (en) 2015-11-05 2017-05-11 Koçak Farma Ilaç Ve Kimya Sanayi Anonim Şirketi Pharmaceutical compositions of imatinib
EP3407874B1 (en) 2016-01-25 2024-05-22 KRKA, d.d., Novo mesto Fast dispersible pharmaceutical composition comprising tyrosine-kinase inhibitor
EP3539138B1 (en) 2016-11-11 2021-05-19 Curium US LLC Processes for generating germanium-68 with reduced volatiles
CN112851640B (zh) * 2019-11-28 2023-09-01 广东东阳光药业股份有限公司 嘧啶苯甲酰胺化合物的硫酸盐及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
AU2003237596A1 (en) 2003-06-02 2005-01-21 Hetero Drugs Limited Novel polymorphs of imatinib mesylate
DK1720853T3 (en) 2004-02-11 2016-03-29 Natco Pharma Ltd HIS UNKNOWN POLYMORPH FORM OF IMATINIBMYLYLATE AND PROCEDURE FOR PREPARING IT
UA84462C2 (ru) 2004-04-02 2008-10-27 Институт Фармацевтични Полиморфные модификации кислотно-аддитивных солей иматиниба с метансульфоновой кислотой
US8269003B2 (en) 2004-09-02 2012-09-18 Cipla Limited Stable crystal form of imatinib mesylate and process for the preparation thereof
WO2006048890A1 (en) 2004-11-04 2006-05-11 Sun Pharmaceutical Industries Limited Imatinib mesylate crystal form and process for preparation thereof
WO2006054314A1 (en) * 2004-11-17 2006-05-26 Natco Pharma Limited Polymorphic forms of imatinib mesylate

Also Published As

Publication number Publication date
AU2006283842B2 (en) 2011-03-17
WO2007023182A1 (en) 2007-03-01
CA2620835A1 (en) 2007-03-01
KR20080049766A (ko) 2008-06-04
CN101243066A (zh) 2008-08-13
UY29766A1 (es) 2007-03-30
IL189353A0 (en) 2008-06-05
AR055613A1 (es) 2007-08-29
CN102002035B (zh) 2013-02-27
IL189353A (en) 2014-12-31
EP1922314A1 (en) 2008-05-21
JP2009506014A (ja) 2009-02-12
CN101243066B (zh) 2012-11-14
US7879860B2 (en) 2011-02-01
CN102002035A (zh) 2011-04-06
BRPI0615383A2 (pt) 2011-05-17
US20080254116A1 (en) 2008-10-16
ECSP088217A (es) 2008-03-26
MY148375A (en) 2013-04-15
MX2008002541A (es) 2008-03-14
AU2006283842A1 (en) 2007-03-01

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