NO20082054L - Nye 2-fenylimidazo[4,5-b]pyridinderivater som inhibitorer av glykogensyntasekinase for behandling av demens og neurodegenerative forstyrrelser - Google Patents

Nye 2-fenylimidazo[4,5-b]pyridinderivater som inhibitorer av glykogensyntasekinase for behandling av demens og neurodegenerative forstyrrelser

Info

Publication number: NO20082054L
Authority: NO; Norway
Prior art keywords: treatment; phenylimidazo; dementia; inhibitors; new
Prior art date: 2005-10-03

Application number

NO20082054A

Other languages

English (en)

Norwegian (no)

Inventor

Peter Soderman

Didier Rotticci

Tobias Rein

Helena Gyback

Erwan Arzel

Per I Arvidsson

Jeremy Burrows

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-03

Filing date

2008-04-30

Publication date

2008-06-02

2008-04-30 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-06-02 Publication of NO20082054L publication Critical patent/NO20082054L/no

Links

DYKJXWALYRGLPF-UHFFFAOYSA-N 2-phenyl-1h-imidazo[4,5-b]pyridine Chemical class C1=CC=CC=C1C1=NC2=NC=CC=C2N1 DYKJXWALYRGLPF-UHFFFAOYSA-N 0.000 title 1
206010012289 Dementia Diseases 0.000 title 1
108091007911 GSKs Proteins 0.000 title 1
102000004103 Glycogen Synthase Kinases Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
208000015122 neurodegenerative disease Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 2
239000012453 solvate Substances 0.000 abstract 2
239000012458 free base Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Psychology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20082054A 2005-10-03 2008-04-30 Nye 2-fenylimidazo[4,5-b]pyridinderivater som inhibitorer av glykogensyntasekinase for behandling av demens og neurodegenerative forstyrrelser NO20082054L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0502173		2005-10-03
PCT/SE2006/001115 WO2007040439A1 (en)	2005-10-03	2006-10-02	New compounds ii

Publications (1)

Publication Number	Publication Date
NO20082054L true NO20082054L (no)	2008-06-02

Family

ID=37906402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20082054A NO20082054L (no)	2005-10-03	2008-04-30	Nye 2-fenylimidazo[4,5-b]pyridinderivater som inhibitorer av glykogensyntasekinase for behandling av demens og neurodegenerative forstyrrelser

Country Status (16)

Country	Link
US (1)	US20080255106A1 (pt)
EP (1)	EP1934217A4 (pt)
JP (1)	JP2009510162A (pt)
KR (1)	KR20080057334A (pt)
CN (1)	CN101321754A (pt)
AR (1)	AR057525A1 (pt)
AU (1)	AU2006297889A1 (pt)
BR (1)	BRPI0616663A2 (pt)
CA (1)	CA2624869A1 (pt)
IL (1)	IL189945A0 (pt)
NO (1)	NO20082054L (pt)
SA (1)	SA06270365B1 (pt)
TW (1)	TW200800984A (pt)
UY (1)	UY29823A1 (pt)
WO (1)	WO2007040439A1 (pt)
ZA (1)	ZA200802637B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR055669A1 (es) *	2005-10-03	2007-08-29	Astrazeneca Ab	Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
US20090170847A1 (en) *	2006-01-23	2009-07-02	Seung Chul Lee	Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same
RU2009135616A (ru) *	2007-03-30	2011-05-10	Астразенека Аб (Se)	НОВЫЕ АМИДАЗО[4,5-b]ПИРИДИН-7-КАРБОКСАМИДЫ 704
CN102127070A (zh) *	2010-01-15	2011-07-20	山东轩竹医药科技有限公司	吡啶并环衍生物
WO2012033149A1 (ja)	2010-09-10	2012-03-15	塩野義製薬株式会社	Ａｍｐｋ活性化作用を有するヘテロ環縮合イミダゾール誘導体
JP2017524739A (ja)	2014-07-17	2017-08-31	アンセルムＩｎｓｅｒｍ	神経筋接合部関連疾患の処置方法
WO2016207366A1 (en)	2015-06-26	2016-12-29	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of viral infections
GB201519573D0 (en)	2015-11-05	2015-12-23	King S College London	Combination
CN107151235B (zh) *	2016-03-04	2019-12-13	上海市计划生育科学研究所	噻二唑烷二酮基gsk3抑制剂在调节精子运动能力中的用途
CN110225912B (zh) *	2016-11-28	2022-10-21	百时美施贵宝公司	Gsk-3抑制剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ID24300A (id) *	1997-08-05	2000-07-13	Pfizer Prod Inc	4-AMINOPIROL(3,2-d)PIRIMIDIN SEBAGAI ANTAGONIS-ANTAGONIS RESEPTOR NEUROPEPTIDA Y
US6187777B1 (en) *	1998-02-06	2001-02-13	Amgen Inc.	Compounds and methods which modulate feeding behavior and related diseases
EP1472245A2 (en) *	2002-02-06	2004-11-03	Vertex Pharmaceuticals Incorporated	Heteroaryl compounds useful as inhibitors of gsk-3
NZ535959A (en) *	2002-03-27	2006-05-26	Altana Pharma Ag	Novel alkoxypyridine-derivatives as selective inhibitors of inducible nitric oxidase synthase NOS
SE0202462D0 (sv) *	2002-08-14	2002-08-14	Astrazeneca Ab	Novel use
JP2006515013A (ja) *	2003-01-23	2006-05-18	クリスタルジェノミクス、インコーポレイテッド	グリコーゲン合成酵素キナーゼ３β活性抑制剤、組成物及びその製造方法
EA200600607A1 (ru) *	2003-10-01	2006-10-27	Алтана Фарма Аг	Производные имидазопиридина в качестве ингибиторов индуцируемой no-синтазы
BRPI0414972A (pt) *	2003-10-01	2006-11-07	Altana Pharma Ag	derivados de imidazopiridinas como inibidores de no-sintase induzìvel
AR055669A1 (es) *	2005-10-03	2007-08-29	Astrazeneca Ab	Derivados de 3h - imidazo[4, 5 -b]piridina como inhibidores selectivos de gsk3, metodos e internediarios para su preparacion, composiciones farmaceuticas que los contienen y su uso para la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y mentales.
US20090170847A1 (en) *	2006-01-23	2009-07-02	Seung Chul Lee	Imidazopyridine Derivatives Inhibiting Protein Kinase Activity, Method for the Preparation Thereof and Pharmaceutical Composition Containing Same

2006
- 2006-09-29 UY UY29823A patent/UY29823A1/es not_active Application Discontinuation
- 2006-09-29 AR ARP060104309A patent/AR057525A1/es not_active Application Discontinuation
- 2006-10-02 JP JP2008534485A patent/JP2009510162A/ja active Pending
- 2006-10-02 EP EP06799715A patent/EP1934217A4/en not_active Withdrawn
- 2006-10-02 US US12/088,897 patent/US20080255106A1/en not_active Abandoned
- 2006-10-02 WO PCT/SE2006/001115 patent/WO2007040439A1/en not_active Ceased
- 2006-10-02 CN CNA2006800453255A patent/CN101321754A/zh active Pending
- 2006-10-02 AU AU2006297889A patent/AU2006297889A1/en not_active Abandoned
- 2006-10-02 KR KR1020087010754A patent/KR20080057334A/ko not_active Withdrawn
- 2006-10-02 CA CA002624869A patent/CA2624869A1/en not_active Abandoned
- 2006-10-02 BR BRPI0616663-6A patent/BRPI0616663A2/pt not_active IP Right Cessation
- 2006-10-03 SA SA06270365A patent/SA06270365B1/ar unknown
- 2006-10-03 TW TW095136782A patent/TW200800984A/zh unknown
2008
- 2008-03-04 IL IL189945A patent/IL189945A0/en unknown
- 2008-03-25 ZA ZA200802637A patent/ZA200802637B/xx unknown
- 2008-04-30 NO NO20082054A patent/NO20082054L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BRPI0616663A2 (pt)	2011-06-28
SA06270365B1 (ar)	2009-12-22
ZA200802637B (en)	2008-12-31
WO2007040439A1 (en)	2007-04-12
UY29823A1 (es)	2007-05-31
KR20080057334A (ko)	2008-06-24
TW200800984A (en)	2008-01-01
EP1934217A4 (en)	2010-08-04
EP1934217A1 (en)	2008-06-25
US20080255106A1 (en)	2008-10-16
AU2006297889A1 (en)	2007-04-12
CA2624869A1 (en)	2007-04-12
JP2009510162A (ja)	2009-03-12
CN101321754A (zh)	2008-12-10
AR057525A1 (es)	2007-12-05
IL189945A0 (en)	2008-08-07

Legal Events

Date	Code	Title	Description
2011-05-30	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20082065L (no)	2008-07-02	Nye imidazo[4,5-b]pyridinderivater som inhibitorer av glykogensyntasekinase 3 for anvendelse ved behandling av demens og neurodegenerative forstyrrelser
NO20082054L (no)	2008-06-02	Nye 2-fenylimidazo[4,5-b]pyridinderivater som inhibitorer av glykogensyntasekinase for behandling av demens og neurodegenerative forstyrrelser
NO20055496L (no)	2006-02-14	Pyrazolokinazolinderivater, metoder for deres fremstilling og deres anvendelse som kinaseinhibitorer
NO20075059L (no)	2007-10-08	Nye forbindelser II 2-pyridinderivater som inhibitorer av neutrofil elastase
NO20090328L (no)	2009-01-26	Nye forbindelser 385
NO20090327L (no)	2009-02-09	Nye forbindelser 384
NO20092737L (no)	2009-09-18	Substituerte pyrazolo-kinazolinderivater, fremgangsmate for deres fremstilling og deres anvendelse som kinase-inhibitorer
NO20066055L (no)	2007-01-24	Pyridinderivater
NO20071246L (no)	2007-05-24	Kinazolinonderivater og deres anvendelse som B-RAF-inhibitorer.
NO20055421L (no)	2005-12-20	Kinolinderivater som fosfodiestrase-inhibitorer
NO20071504L (no)	2007-05-25	Pyrimidinderivanter.
NO20090631L (no)	2009-03-16	Morpholin pyrimidin derivativer anvendelige i behandlingen av proliferative lidelser
NO20072259L (no)	2007-06-06	Heteroaryltiazoler og deres anvendelse som P13K-inhibitorer
NO20071245L (no)	2007-05-24	Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer.
NO20071703L (no)	2007-07-04	Kinazolinderivater
NO20074258L (no)	2007-11-27	Pyridin-2-karboksamidderivater som MGLUR5 antagonister
NO20055219L (no)	2006-01-04	Nye forbindelser
NO20074703L (no)	2007-11-14	Antibakterielle piperidinderivater
NO20085218L (no)	2009-01-12	Nye pyridinanaloger
NO20074592L (no)	2007-10-19	Acetylenyl-pyrazolo-pyrimidinderivater som mGluR2-antagonister
NO20054312L (no)	2005-11-16	HIV-replikasjonsinhiberende pyrimidiner og triaziner
NO20073791L (no)	2007-08-30	Pyrazolylaminopyridinderivater anvendbare som kinaseinhibitorer
NO20073101L (no)	2007-07-19	Nye pyridinforbindelser
NO20084129L (no)	2008-10-29	Pyridin(3,4-B)Pyrazinoner
NO20063748L (no)	2006-08-22	Kinolinderivater og anvendelse derav som mykobakterielle inhibitorer