NO20082382L - Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri - Google Patents

Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri

Info

Publication number
NO20082382L
NO20082382L NO20082382A NO20082382A NO20082382L NO 20082382 L NO20082382 L NO 20082382L NO 20082382 A NO20082382 A NO 20082382A NO 20082382 A NO20082382 A NO 20082382A NO 20082382 L NO20082382 L NO 20082382L
Authority
NO
Norway
Prior art keywords
rapamycin
methods
crystallinity
painting
differential scanning
Prior art date
Application number
NO20082382A
Other languages
English (en)
Inventor
Subodh S Deshmukh
Mahmoud Mirmehrabi
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20082382L publication Critical patent/NO20082382L/no

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
    • G01N25/4866—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample by using a differential method

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Combustion & Propulsion (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)

Abstract

Det er beskrevet fremgangsmåter for rensing av rapamycin. Fremgangsmåter for å måle partikkelkvalitet, medianpartikkelstørrelse og krystallinitet av prøver som inneholder rapamycin eller et derivat derav er også gitt.
NO20082382A 2005-12-07 2008-05-26 Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri NO20082382L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74800505P 2005-12-07 2005-12-07
PCT/US2006/046445 WO2007067566A2 (en) 2005-12-07 2006-12-06 Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry

Publications (1)

Publication Number Publication Date
NO20082382L true NO20082382L (no) 2008-09-04

Family

ID=38117222

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082382A NO20082382L (no) 2005-12-07 2008-05-26 Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri

Country Status (17)

Country Link
US (1) US20070128731A1 (no)
EP (1) EP1957964A2 (no)
JP (1) JP2009518648A (no)
KR (1) KR20080077147A (no)
CN (1) CN101351702A (no)
AR (1) AR058283A1 (no)
AU (1) AU2006322030A1 (no)
BR (1) BRPI0619592A2 (no)
CA (1) CA2630786A1 (no)
CR (1) CR9985A (no)
EC (1) ECSP088519A (no)
IL (1) IL191545A0 (no)
NO (1) NO20082382L (no)
PE (1) PE20071000A1 (no)
RU (1) RU2008120712A (no)
TW (1) TW200736603A (no)
WO (1) WO2007067566A2 (no)

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EP2380006A4 (en) * 2009-01-21 2012-05-16 Biocon Ltd PROCESS FOR DETERMINING THE SIROLIMUS STABILITY AND METHOD FOR PRODUCING ITS STABLE FORM
FR2943539B1 (fr) 2009-03-31 2011-07-22 Ethypharm Sa Composition pharmaceutique comprenant un macrolide immunosuppresseur de la famille des limus.
WO2013022418A1 (en) * 2011-08-05 2013-02-14 Crucible Intellectual Property Llc Nondestructive method to determine crystallinity in amorphous alloy
US20150139270A1 (en) * 2012-04-23 2015-05-21 Apple Inc. Non-destructive determination of volumetric crystallinity of bulk amorphous alloy
ES2897473T3 (es) * 2013-03-15 2022-03-01 Biosensors Int Group Ltd Purificación de derivados de la rapamicina
US9439892B2 (en) 2013-05-16 2016-09-13 Surmodics, Inc. Macrolide particulates, methods for preparation, and medical devices associated therewith
CA2915704C (en) * 2013-06-12 2022-06-21 Surmodics, Inc. Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates
DE102013110294B4 (de) * 2013-09-18 2016-07-07 Innora Gmbh Limus-Depot-Formulierung auf Ballonkathetern
WO2015181826A1 (en) 2014-05-27 2015-12-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Crystalline coating and release of bioactive agents
CN105116013A (zh) * 2015-04-23 2015-12-02 山东农业大学 一种确定金属离子对蛋白酶水解大豆分离蛋白影响的方法
JP6531488B2 (ja) * 2015-05-22 2019-06-19 日産自動車株式会社 リチウムイオン二次電池の熱履歴検知方法
EP3435988B1 (en) 2016-03-31 2021-10-06 Surmodics, Inc. Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment
US11123459B2 (en) 2016-12-16 2021-09-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
US11629222B2 (en) * 2019-07-01 2023-04-18 Ethicon, Inc. Calorimetric crystallization method for evaluation of monomer purity
WO2023158308A1 (en) 2022-02-18 2023-08-24 Technische Universiteit Delft Novel method for analyzing dsc data
NL2031004B1 (en) * 2022-02-18 2023-09-05 Univ Delft Tech Novel method for analyzing DSC data
CN116794248B (zh) * 2023-04-20 2026-01-06 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所） 一种防止压片过程中堵塞机器的共处理晶体辅料评价方法
CN118706889A (zh) * 2024-05-31 2024-09-27 瀚晖制药有限公司 一种阿帕他胺固体制剂结晶度的检测方法

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JP4224115B2 (ja) * 2004-04-14 2009-02-12 ワイス ラパマイシン４２−エステル誘導体の位置特異的合成
MX2007001676A (es) * 2004-08-10 2007-04-12 Wyeth Corp Derivados de 42-ester de rapamicina con acido 2,2-bis(hidroximetil)propionico y metodos para hacer los mismos.
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Also Published As

Publication number Publication date
BRPI0619592A2 (pt) 2016-09-06
CN101351702A (zh) 2009-01-21
EP1957964A2 (en) 2008-08-20
CA2630786A1 (en) 2007-06-14
CR9985A (es) 2008-08-21
AU2006322030A1 (en) 2007-06-14
JP2009518648A (ja) 2009-05-07
ECSP088519A (es) 2008-07-30
US20070128731A1 (en) 2007-06-07
WO2007067566A3 (en) 2008-01-24
WO2007067566A2 (en) 2007-06-14
KR20080077147A (ko) 2008-08-21
TW200736603A (en) 2007-10-01
RU2008120712A (ru) 2010-01-20
IL191545A0 (en) 2008-12-29
PE20071000A1 (es) 2007-10-10
AR058283A1 (es) 2008-01-30

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