NO20083186L - Krystallform av vinfluninditartrat - Google Patents

Krystallform av vinfluninditartrat

Info

Publication number: NO20083186L
Authority: NO; Norway
Prior art keywords: vinflun; inditartrate; crystal form; vinflunine; cancer
Prior art date: 2005-12-20

Application number

NO20083186A

Other languages

English (en)

Norwegian (no)

Inventor

Jean-Louis Maurel

Richard Pena

Jean-Paul Ribet

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-20

Filing date

2008-07-17

Publication date

2008-09-11

2008-07-17 Application filed by Pf Medicament filed Critical Pf Medicament

2008-09-11 Publication of NO20083186L publication Critical patent/NO20083186L/no

Links

239000013078 crystal Substances 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
NMDYYWFGPIMTKO-HBVLKOHWSA-N vinflunine Chemical compound C([C@@](C1=C(C2=CC=CC=C2N1)C1)(C2=C(OC)C=C3N(C)[C@@H]4[C@@]5(C3=C2)CCN2CC=C[C@]([C@@H]52)([C@H]([C@]4(O)C(=O)OC)OC(C)=O)CC)C(=O)OC)[C@H]2C[C@@H](C(C)(F)F)CN1C2 NMDYYWFGPIMTKO-HBVLKOHWSA-N 0.000 abstract 1
229960000922 vinflunine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyridine Compounds (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20083186A 2005-12-20 2008-07-17 Krystallform av vinfluninditartrat NO20083186L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0512942A FR2894966B1 (fr)	2005-12-20	2005-12-20	Nouvelle forme cristalline de la vinflunine
US77420106P	2006-02-17	2006-02-17
PCT/EP2006/069843 WO2007071648A1 (fr)	2005-12-20	2006-12-18	Forme cristalline de ditartrate de vinflunine

Publications (1)

Publication Number	Publication Date
NO20083186L true NO20083186L (no)	2008-09-11

Family

ID=36169082

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20083186A NO20083186L (no)	2005-12-20	2008-07-17	Krystallform av vinfluninditartrat

Country Status (20)

Country	Link
US (1)	US20090247564A1 (fr)
EP (1)	EP1971613A1 (fr)
JP (1)	JP2009519996A (fr)
KR (1)	KR101437696B1 (fr)
CN (1)	CN101331139A (fr)
AR (1)	AR058704A1 (fr)
AU (1)	AU2006328560B2 (fr)
BR (1)	BRPI0620143A2 (fr)
CA (1)	CA2633769A1 (fr)
FR (1)	FR2894966B1 (fr)
IL (1)	IL192249A0 (fr)
MA (1)	MA30164B1 (fr)
NO (1)	NO20083186L (fr)
NZ (1)	NZ569884A (fr)
RU (1)	RU2426735C2 (fr)
TN (1)	TNSN08268A1 (fr)
TW (1)	TW200733962A (fr)
UA (1)	UA91581C2 (fr)
WO (1)	WO2007071648A1 (fr)
ZA (1)	ZA200806135B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2912406B1 (fr) *	2007-02-13	2009-05-08	Pierre Fabre Medicament Sa	Sels cristalins anhydres de vinflunine, procede de preparation et utilisation en tant que medicament et moyen de purification de la vinflunine.
FR2918566B1 (fr) *	2007-07-11	2009-10-09	Pierre Fabre Medicament Sa	Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
WO2018007554A1 (fr) *	2016-07-06	2018-01-11	Pierre Fabre Medicament	Combinaison pharmaceutique comprenant la vinflunine et l'inhibiteur de pd1 et/ou de pdl1
AU2022281388A1 (en) *	2021-05-27	2023-12-07	Metro International Biotech, Llc	Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2154314A1 (en) *	1971-09-28	1973-05-11	Richter Gedeon Vegyeszet	Vinca rosea alkaloids - vinblastine, vinleurosine and vincristine selective isolation
JPS5283900A (en) *	1976-01-01	1977-07-13	Lilly Co Eli	Novel acidic and ester derivatives of vinblastine vincrystine and roylocidine
HU173379B (hu) *	1976-02-13	1979-04-28	Richter Gedeon Vegyeszet	Sposob poluchenija 4-dezacetoksi-vinblastina i kislo-additivnykh solejj
US4203898A (en) *	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
GB2089806B (en) *	1977-11-07	1982-11-24	Lilly Co Eli	4-desacetoxy-oxo-indole-dyhydroindole intermediates
FR2707988B1 (fr) *	1993-07-21	1995-10-13	Pf Medicament	Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
FR2761990B1 (fr)	1997-04-10	1999-06-25	Pf Medicament	Derives halogenes antimitotiques d'alcaloides de vinca
AR024852A1 (es) *	2000-01-12	2002-10-30	Eriochem Sa	Procedimiento para la produccion de ditartrato de 5'-nor-anhidrovinblastina a partir de especies vegetales del genero catharanthus y procedimiento a escala industrial.
US20060147518A1 (en) *	2004-12-30	2006-07-06	Pierre Fabre Medicament	Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it

2005
- 2005-12-20 FR FR0512942A patent/FR2894966B1/fr not_active Expired - Lifetime
2006
- 2006-12-12 TW TW095145948A patent/TW200733962A/zh unknown
- 2006-12-18 EP EP06830683A patent/EP1971613A1/fr not_active Ceased
- 2006-12-18 KR KR1020087017456A patent/KR101437696B1/ko not_active Expired - Fee Related
- 2006-12-18 NZ NZ569884A patent/NZ569884A/en not_active IP Right Cessation
- 2006-12-18 BR BRPI0620143-1A patent/BRPI0620143A2/pt not_active IP Right Cessation
- 2006-12-18 RU RU2008128317/04A patent/RU2426735C2/ru not_active IP Right Cessation
- 2006-12-18 UA UAA200809490A patent/UA91581C2/ru unknown
- 2006-12-18 US US12/086,773 patent/US20090247564A1/en not_active Abandoned
- 2006-12-18 CN CNA2006800476505A patent/CN101331139A/zh active Pending
- 2006-12-18 JP JP2008546414A patent/JP2009519996A/ja active Pending
- 2006-12-18 AU AU2006328560A patent/AU2006328560B2/en not_active Ceased
- 2006-12-18 WO PCT/EP2006/069843 patent/WO2007071648A1/fr not_active Ceased
- 2006-12-18 CA CA002633769A patent/CA2633769A1/fr not_active Abandoned
- 2006-12-20 AR ARP060105672A patent/AR058704A1/es unknown
2008
- 2008-06-17 IL IL192249A patent/IL192249A0/en unknown
- 2008-06-18 TN TNP2008000268A patent/TNSN08268A1/en unknown
- 2008-07-15 ZA ZA200806135A patent/ZA200806135B/xx unknown
- 2008-07-16 MA MA31122A patent/MA30164B1/fr unknown
- 2008-07-17 NO NO20083186A patent/NO20083186L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ569884A (en)	2011-03-31
IL192249A0 (en)	2008-12-29
CA2633769A1 (fr)	2007-06-28
BRPI0620143A2 (pt)	2011-11-01
RU2426735C2 (ru)	2011-08-20
MA30164B1 (fr)	2009-01-02
KR101437696B1 (ko)	2014-09-03
EP1971613A1 (fr)	2008-09-24
FR2894966B1 (fr)	2008-03-14
FR2894966A1 (fr)	2007-06-22
AU2006328560B2 (en)	2012-03-22
AU2006328560A1 (en)	2007-06-28
AR058704A1 (es)	2008-02-20
TNSN08268A1 (en)	2009-10-30
ZA200806135B (en)	2009-08-26
JP2009519996A (ja)	2009-05-21
US20090247564A1 (en)	2009-10-01
UA91581C2 (en)	2010-08-10
KR20080077696A (ko)	2008-08-25
WO2007071648A1 (fr)	2007-06-28
CN101331139A (zh)	2008-12-24
RU2008128317A (ru)	2010-01-27
TW200733962A (en)	2007-09-16

Legal Events

Date	Code	Title	Description
2018-04-03	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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EA200970542A1 (ru)	2009-12-30	ИНГИБИТОРЫ ДЕЙСТВИЯ Akt
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ATE484508T1 (de)	2010-10-15	Furylverbindungen
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NO20055741L (no)	2006-01-06	Nye kjemiske forbindelser
MA32183B1 (fr)	2011-04-01	Pyrimidylcyclopentanes hydroxylés utilisés comme inhibiteurs de protéine kinase akt
EA201071183A1 (ru)	2011-06-30	Безводная кристаллическая форма малеата орвепитанта
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