NO20083243L - Pyrazoler for behandling av GERD og IBS - Google Patents

Pyrazoler for behandling av GERD og IBS

Info

Publication number: NO20083243L
Authority: NO; Norway
Prior art keywords: treatment; ibs; alkyl; hydrogen; compounds
Prior art date: 2005-12-23

Application number

NO20083243A

Other languages

English (en)

Norwegian (no)

Inventor

Udo Bauer

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-23

Filing date

2008-07-22

Publication date

2008-07-23

2008-07-22 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-07-23 Publication of NO20083243L publication Critical patent/NO20083243L/no

Links

208000021302 gastroesophageal reflux disease Diseases 0.000 title abstract 2
150000003217 pyrazoles Chemical class 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
208000002551 irritable bowel syndrome Diseases 0.000 abstract 2
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
206010021118 Hypotonia Diseases 0.000 abstract 1
239000000556 agonist Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000003281 allosteric effect Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000036640 muscle relaxation Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
230000001052 transient effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20083243A 2005-12-23 2008-07-22 Pyrazoler for behandling av GERD og IBS NO20083243L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0502908		2005-12-23
PCT/SE2006/001461 WO2007073297A1 (fr)	2005-12-23	2006-12-21	Pyrazoles pour le traitement du rgop et du sii

Publications (1)

Publication Number	Publication Date
NO20083243L true NO20083243L (no)	2008-07-23

Family

ID=38188928

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20083243A NO20083243L (no)	2005-12-23	2008-07-22	Pyrazoler for behandling av GERD og IBS

Country Status (12)

Country	Link
US (1)	US20090062365A1 (fr)
EP (1)	EP1966150A4 (fr)
JP (1)	JP2009521427A (fr)
KR (1)	KR20080090449A (fr)
CN (1)	CN101341128A (fr)
AU (1)	AU2006327314A1 (fr)
BR (1)	BRPI0620415A2 (fr)
CA (1)	CA2632011A1 (fr)
IL (1)	IL191765A0 (fr)
NO (1)	NO20083243L (fr)
WO (1)	WO2007073297A1 (fr)
ZA (1)	ZA200805240B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0401653D0 (sv) *	2004-06-24	2004-06-24	Astrazeneca Ab	New compounds
CA2632021A1 (fr) *	2005-12-23	2007-06-28	Astrazeneca Ab	Modulateurs des recepteurs gaba-b
KR20080091452A (ko) *	2005-12-23	2008-10-13	아스트라제네카 아베	위장 장애의 치료를 위한 이미다졸 유도체
CA2631991A1 (fr) *	2005-12-23	2007-06-28	Astrazeneca Ab	Modulateurs de gaba-b heterocycliques
WO2007073299A1 (fr) *	2005-12-23	2007-06-28	Astrazeneca Ab	Imidazoles utilisés comme modulateurs des récepteurs gaba-b
DK2903440T3 (en)	2012-10-02	2017-12-11	Bayer Cropscience Ag	THETEROCYCLIC COMPOUNDS AS PESTICIDES
TW201623257A (zh)	2014-05-09	2016-07-01	奧利安公司	藥理活性之喹唑啉二酮衍生物
GB202414199D0 (en)	2024-09-27	2024-11-13	Addex Pharmaceuticals Sa	Novel Compounds
GB202414200D0 (en)	2024-09-27	2024-11-13	Addex Pharmaceuticals Sa	Novel compounds
GB202414197D0 (en)	2024-09-27	2024-11-13	Addex Pharmaceuticals Sa	Novel compounds
GB202414193D0 (en)	2024-09-27	2024-11-13	Addex Pharmaceuticals Sa	Novel compounds
GB202414192D0 (en)	2024-09-27	2024-11-13	Addex Pharmaceuticals Sa	Novel compounds

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3876655A (en) *	1971-08-18	1975-04-08	Beecham Group Ltd	Anti-inflammatory acyl imidazoles
US3833582A (en) *	1972-08-21	1974-09-03	Pfizer	Herbicidal 1h-pyrazolo(3,4-d)pyrimidin-4-ones
US3910907A (en) *	1973-07-09	1975-10-07	Icn Pharmaceuticals	Pyrazolo(1,5-a)-1,3,5-triazines
FR2264015A1 (en) *	1974-03-13	1975-10-10	Pfizer	Pyrazolo(3,4-d)pyrimidin-4-ones - pre-and post-emergence herbicides
JPS5758670A (en) *	1980-09-25	1982-04-08	Otsuka Chem Co Ltd	1-methyl-3-(n-substituted-n-chloroacetylamino)pyrazole-4-carboxylic acid ester derivative
US4659720A (en) *	1982-12-20	1987-04-21	Merck & Co., Inc.	5-amino or substituted amino imidazoles useful to treat coccidiosis
DD240013A1 (de) *	1985-04-01	1986-10-15	Univ Halle Wittenberg	Verfahren zur herstellung von n-(1h-pyrazol-3-yl)-oxamaten
FR2663934B1 (fr) *	1990-06-27	1994-06-03	Adir	Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent.
US5214063A (en) *	1990-06-27	1993-05-25	Adir Et Compagnie	4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors
US5201938A (en) *	1991-07-19	1993-04-13	Dowelanco	N-pyrazolyl-1,2,4-triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides
DE4213750A1 (de) *	1992-04-25	1993-10-28	Basf Ag	Verfahren zur Herstellung von 3-(Hydroxyphenyl)-propionaldehyden und gegebenenfalls der Herstellung von 3-(hydroxyphenyl)-propanolen
SE9603408D0 (sv) *	1996-09-18	1996-09-18	Astra Ab	Medical use
IL132736A0 (en) *	1997-05-22	2001-03-19	Searle & Co	3(5)-Heteroaryl substituted pyrazoles as p38 kinase inhibitors
EP1019394A1 (fr) *	1997-05-22	2000-07-19	G.D. Searle & Co.	DERIVES DE PYRAZOLE COMME INHIBITEURS DE KINASE p38
US6409988B1 (en) *	1999-07-01	2002-06-25	3-Dimensional Pharmaceuticals, Inc.	Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands
WO2001007413A1 (fr) *	1999-07-22	2001-02-01	3-Dimensional Pharmaceuticals, Inc.	1-aryle-3-thioalkyle pyrazoles, leur synthese et leur utilisation comme insecticides
GB0024807D0 (en) *	2000-10-10	2000-11-22	Smithkline Beecham Plc	Novel compounds
JP2002114765A (ja) *	2000-10-11	2002-04-16	Fuji Photo Film Co Ltd	３−アミノ−４−カルボニルピラゾール化合物の製造方法
KR20040033048A (ko) *	2001-09-14	2004-04-17	미츠비시 웰파마 가부시키가이샤	티아졸리딘 유도체 및 이의 약학적 용도
WO2003035621A1 (fr) *	2001-10-22	2003-05-01	The Research Foundation Of State University Of New York	Inhibiteurs de proteines kinases et de proteines phosphatases, methodes d'identification et methodes d'utilisation associees
JP2003201271A (ja) *	2001-10-25	2003-07-18	Sankyo Co Ltd	脂質モジュレーター
US20030139427A1 (en) *	2002-08-23	2003-07-24	Osi Pharmaceuticals Inc.	Bicyclic pyrimidinyl derivatives and methods of use thereof
US7589116B2 (en) *	2003-04-03	2009-09-15	Merck & Co. Inc.	Biaryl substituted pyrazoles as sodium channel blockers
SE0401653D0 (sv) *	2004-06-24	2004-06-24	Astrazeneca Ab	New compounds
DE102005042583A1 (de) *	2005-09-08	2007-03-15	Bayer Healthcare Ag	Iminooxazolidin-Derivate und ihre Verwendung
CA2632021A1 (fr) *	2005-12-23	2007-06-28	Astrazeneca Ab	Modulateurs des recepteurs gaba-b
WO2007073299A1 (fr) *	2005-12-23	2007-06-28	Astrazeneca Ab	Imidazoles utilisés comme modulateurs des récepteurs gaba-b
CA2631991A1 (fr) *	2005-12-23	2007-06-28	Astrazeneca Ab	Modulateurs de gaba-b heterocycliques
KR20080091452A (ko) *	2005-12-23	2008-10-13	아스트라제네카 아베	위장 장애의 치료를 위한 이미다졸 유도체
CA2682301A1 (fr) *	2007-04-18	2008-10-30	Astrazeneca Ab	Composes de xanthine ayant un effet modulateur allosterique positif du recepteur gaba b
US20080262064A1 (en) *	2007-04-18	2008-10-23	Astrazeneca Ab	Novel Compounds For The Treatment Of GI Disorders 682

2006
- 2006-12-21 BR BRPI0620415-5A patent/BRPI0620415A2/pt not_active IP Right Cessation
- 2006-12-21 KR KR1020087018002A patent/KR20080090449A/ko not_active Withdrawn
- 2006-12-21 WO PCT/SE2006/001461 patent/WO2007073297A1/fr not_active Ceased
- 2006-12-21 US US12/158,203 patent/US20090062365A1/en not_active Abandoned
- 2006-12-21 AU AU2006327314A patent/AU2006327314A1/en not_active Abandoned
- 2006-12-21 EP EP06824531A patent/EP1966150A4/fr not_active Withdrawn
- 2006-12-21 CN CNA2006800483496A patent/CN101341128A/zh active Pending
- 2006-12-21 JP JP2008547164A patent/JP2009521427A/ja active Pending
- 2006-12-21 CA CA002632011A patent/CA2632011A1/fr not_active Abandoned
2008
- 2008-05-27 IL IL191765A patent/IL191765A0/en unknown
- 2008-06-17 ZA ZA200805240A patent/ZA200805240B/xx unknown
- 2008-07-22 NO NO20083243A patent/NO20083243L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ZA200805240B (en)	2009-04-29
CN101341128A (zh)	2009-01-07
AU2006327314A1 (en)	2007-06-28
CA2632011A1 (fr)	2007-06-28
US20090062365A1 (en)	2009-03-05
KR20080090449A (ko)	2008-10-08
EP1966150A1 (fr)	2008-09-10
WO2007073297A1 (fr)	2007-06-28
IL191765A0 (en)	2008-12-29
JP2009521427A (ja)	2009-06-04
BRPI0620415A2 (pt)	2011-11-08
EP1966150A4 (fr)	2011-07-20

Legal Events

Date	Code	Title	Description
2011-07-25	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20083243L (no)	2008-07-23	Pyrazoler for behandling av GERD og IBS
NO20083248L (no)	2008-07-23	Imidazoler som GABA-B reseptormodulatorer
NO20083247L (no)	2008-09-11	GABA-B reseptormodulatorer
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NO20083244L (no)	2008-09-11	Heterosykliske GABA-B modulatorer
NO20082243L (no)	2008-07-21	Fremgangsmater og forbindelser for fremstiliing av CC-1065 analoger
UA95454C2 (uk)	2011-08-10	Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
NO20073114L (no)	2007-06-18	Amidforbindelse
SMT201300085B (it)	2013-09-06	Composti di pirrolo
EA201101334A1 (ru)	2012-04-30	Новые соединения бензотиадиазепина, способ их приготовления и фармацевтические композиции, содержащие их
EP1845081A4 (fr)	2009-03-25	Composé amide
EA201170096A1 (ru)	2011-08-30	Замещенные производные пиримидона
PE20130774A1 (es)	2013-06-26	Compuestos heterociclicos activadores de ampk y metodos para emplearlos
MX2009008465A (es)	2009-08-20	Nuevas 2-aminooxazolinas como ligandos de taar1.
EA201101089A1 (ru)	2012-02-28	Производные оксадиазола в качестве агонистов рецептора s1p1
EA201071012A1 (ru)	2011-04-29	Производные азетидинов, способ их получения и применение их в терапии
NO20092770L (no)	2009-09-25	Nye aminopyrimidinderivater som PLK1-inhibitorer
NO20074763L (no)	2007-11-16	(1,5-difenyl-1H-pyrazol-3-yl)oksadiazolderivater, fremgangsmate ved fremstilling derav og anvendelse av samme i terapi
WO2010003084A3 (fr)	2010-03-25	Inhibiteurs de la phosphodiestérase 4
WO2010015355A3 (fr)	2010-12-16	Nouveaux dérivés d'acylaminobenzamide
EA200971044A1 (ru)	2010-06-30	Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
MY161403A (en)	2017-04-14	5- (phenyl/pyridinyl-ethinyl) -2-pyridine/ 2-pyrimidine-carborxamides as mglur5 modulators
MX2010009092A (es)	2011-09-21	Nuevos derivados de 3-aminoalquil-1,3-dihidro-2h-indol-2-ona, su preparacion y su aplicacion en terapeutica.
AR066710A1 (es)	2009-09-09	Derivados de espirociclopropilpiperidina