NO20083315L - 3,5-substituert piperidin-bestanddeler som renin-inhibitorer - Google Patents
3,5-substituert piperidin-bestanddeler som renin-inhibitorerInfo
- Publication number
- NO20083315L NO20083315L NO20083315A NO20083315A NO20083315L NO 20083315 L NO20083315 L NO 20083315L NO 20083315 A NO20083315 A NO 20083315A NO 20083315 A NO20083315 A NO 20083315A NO 20083315 L NO20083315 L NO 20083315L
- Authority
- NO
- Norway
- Prior art keywords
- substituted piperidine
- treatment
- compound
- renin
- constituents
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 4
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 239000000470 constituent Substances 0.000 title 1
- 239000002461 renin inhibitor Substances 0.000 title 1
- 229940086526 renin-inhibitors Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 102100028255 Renin Human genes 0.000 abstract 3
- 108090000783 Renin Proteins 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- -1 piperidine compound Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05028771 | 2005-12-30 | ||
| GB0604223A GB0604223D0 (en) | 2006-03-02 | 2006-03-02 | Organic compounds |
| GB0611390A GB0611390D0 (en) | 2006-06-08 | 2006-06-08 | Organic compounds |
| PCT/EP2006/012581 WO2007077005A1 (en) | 2005-12-30 | 2006-12-28 | 3 , 5-substitγued piperidine compounds as renin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20083315L true NO20083315L (no) | 2008-09-19 |
Family
ID=37875514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083315A NO20083315L (no) | 2005-12-30 | 2008-07-25 | 3,5-substituert piperidin-bestanddeler som renin-inhibitorer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8129411B2 (pl) |
| EP (2) | EP2420491B1 (pl) |
| JP (1) | JP5306821B2 (pl) |
| KR (1) | KR20080086921A (pl) |
| AR (1) | AR058885A1 (pl) |
| AU (1) | AU2006332124B2 (pl) |
| BR (1) | BRPI0620736A2 (pl) |
| CA (1) | CA2633624C (pl) |
| CR (1) | CR10091A (pl) |
| EC (1) | ECSP088587A (pl) |
| ES (2) | ES2476422T3 (pl) |
| IL (1) | IL192024A0 (pl) |
| MA (1) | MA30073B1 (pl) |
| NO (1) | NO20083315L (pl) |
| NZ (1) | NZ569135A (pl) |
| PE (2) | PE20110117A1 (pl) |
| PL (1) | PL2420491T3 (pl) |
| PT (1) | PT2420491E (pl) |
| TW (1) | TW200738698A (pl) |
| WO (1) | WO2007077005A1 (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| NZ569135A (en) | 2005-12-30 | 2011-08-26 | Novartis Ag | 3,5-Substituted piperidine compounds as renin inhibitors |
| ES2729424T3 (es) | 2006-09-20 | 2019-11-04 | Aerie Pharmaceuticals Inc | Inhibidores de Rho cinasa |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8129538B1 (en) | 2007-03-28 | 2012-03-06 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
| WO2009000811A1 (en) * | 2007-06-25 | 2008-12-31 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
| JP5441705B2 (ja) | 2007-10-15 | 2014-03-12 | 武田薬品工業株式会社 | アミド化合物およびその用途 |
| AU2008339351B2 (en) | 2007-12-19 | 2013-02-28 | Sumitomo Dainippon Pharma Co., Ltd. | Bicyclic heterocyclic derivative |
| NZ589019A (en) | 2008-05-05 | 2012-10-26 | Merck Frosst Canada Ltd | 3, 4 - substituted piperidine derivatives as renin inhibitors |
| JO3465B1 (ar) | 2008-06-19 | 2020-07-05 | Takeda Pharmaceuticals Co | مركب متغاير الحلقه واستخدامه |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| EP2421828A2 (en) * | 2009-04-24 | 2012-02-29 | Cadila Healthcare Limited | Piperidine derivatives as inhibitors of renin |
| EP3828172A1 (en) | 2009-05-01 | 2021-06-02 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| JP5331883B2 (ja) | 2009-06-24 | 2013-10-30 | 大日本住友製薬株式会社 | Ｎ−置換−環状アミノ誘導体 |
| KR20140092696A (ko) * | 2013-01-16 | 2014-07-24 | 주식회사유한양행 | 신규의 페닐에티닐 벤즈아마이드 글루코키나제 활성화제 및 그의 제조방법 |
| US20140275160A1 (en) | 2013-03-15 | 2014-09-18 | Aerie Pharmaceuticals, Inc. | Combination therapy |
| WO2015156346A1 (ja) * | 2014-04-10 | 2015-10-15 | 武田薬品工業株式会社 | 複素環化合物の製造法 |
| JP6832946B2 (ja) | 2015-11-17 | 2021-02-24 | アエリエ ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤およびその中間体の調製方法 |
| US9643927B1 (en) * | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| CN109640966A (zh) | 2016-08-31 | 2019-04-16 | 爱瑞制药公司 | 眼用组合物 |
| WO2018183911A1 (en) | 2017-03-31 | 2018-10-04 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN117986146A (zh) * | 2023-12-22 | 2024-05-07 | 河南优凯制药有限公司 | 一种枸橼酸喷托维林杂质的制备方法及其检测方法 |
| CN119059970B (zh) * | 2024-08-30 | 2026-03-24 | 上海信诺维生物医药有限公司 | 一种btk抑制剂药物中间体的制备方法 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW224941B (pl) | 1989-11-08 | 1994-06-11 | Yamanouchi Pharma Co Ltd | |
| NZ246441A (en) | 1991-12-18 | 1996-02-27 | Schering Corp | Imidazol or imidazolalkyl substituted with a 4 or 5 membered nitrogen containing heterocycle, preparation and pharmaceutical compositions thereof |
| IL111176A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them |
| PL193686B1 (pl) | 1995-09-07 | 2007-03-30 | Hoffmann La Roche | Pochodne piperydyny, środki lecznicze zawierającepochodne piperydyny, sposoby wytwarzania tych pochodnych oraz zastosowanie pochodnych |
| JP2000500502A (ja) * | 1995-11-22 | 2000-01-18 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
| CA2298813A1 (en) | 1997-08-28 | 1999-03-04 | Merck & Co., Inc. | Pyrrolidine and piperidine modulators of chemokine receptor activity |
| WO1999065867A1 (en) | 1998-06-17 | 1999-12-23 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| US6274735B1 (en) | 1998-08-10 | 2001-08-14 | Hoffmann-La Roche Inc. | Process and intermediates for preparation of substituted piperidines |
| JP2002528543A (ja) | 1998-10-30 | 2002-09-03 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害剤 |
| US6303593B1 (en) | 1999-03-02 | 2001-10-16 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
| AU3386500A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
| AU3389300A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| AU3818900A (en) | 1999-04-14 | 2000-11-02 | F. Hoffmann-La Roche Ag | Process for the preparation of substituted piperidines |
| US6376672B1 (en) | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
| US6197959B1 (en) | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| CN1481377A (zh) | 2000-03-17 | 2004-03-10 | ����˹�ж�-����˹˹����ҩƷ��˾ | 作为基质金属蛋白酶和TNF-α的抑制剂的环β-氨基酸衍生物 |
| KR100769381B1 (ko) * | 2000-04-04 | 2007-10-22 | 브랜데이스 유니버시티 | 메소 화합물을 촉매 비대칭 탈대칭화시키는 방법 |
| FR2811673B1 (fr) | 2000-07-17 | 2002-09-13 | Rhodia Chimie Sa | Utilisation de composes insatures comprenant un heterocycle comme stabilisants de polymeres halogenes |
| EP1326619A2 (en) | 2000-10-11 | 2003-07-16 | Merck & Co., Inc. | Pyrrolidine modulators of ccr5 chemokine receptor activity |
| US20060079533A1 (en) | 2001-03-23 | 2006-04-13 | Nieman James A | Methods of treating alzheimer's disease |
| AU2002256418A1 (en) | 2001-04-27 | 2002-11-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| EP1427408A4 (en) | 2001-09-17 | 2005-10-26 | Bristol Myers Squibb Co | CYCLIC HYDROXAMINE ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND / OR TNF-a-CONVERTASE (TACE TNF-a-CONVERTING ENZYM) |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| CA2483241C (en) | 2002-04-29 | 2011-05-31 | Actelion Pharmaceuticals Ltd | Novel diazabicyclononene derivatives |
| US6878722B2 (en) | 2002-05-20 | 2005-04-12 | Bristol-Myers Squibb Company | Substituted cycloalkyl P1′ hepatitis C virus inhibitors |
| AU2003259131A1 (en) | 2002-07-09 | 2004-01-23 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| US20040204455A1 (en) | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
| US20040214832A1 (en) | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
| US20060217371A1 (en) | 2003-04-28 | 2006-09-28 | Olivier Bezencon | Diazabicyclononene and tetrahydropyriddine derivatives as renin inhibitors |
| CN1972912A (zh) | 2003-04-29 | 2007-05-30 | 埃科特莱茵药品有限公司 | 新型3,4－二取代的1,2,3,6－四氢吡啶衍生物 |
| CN1780663A (zh) | 2003-04-30 | 2006-05-31 | 埃科特莱茵药品有限公司 | 作为肾素抑制剂的新型3－位具有杂原子的9－氮杂双环壬烯衍生物 |
| US20060205768A1 (en) | 2003-04-30 | 2006-09-14 | Olivier Bezencon | Tropane derivatives and their use as ace inhibitors |
| BRPI0409818A (pt) | 2003-04-30 | 2006-05-09 | Actelion Pharmaceuticals Ltd | compostos, composições farmacêuticas, método para o tratamento ou profilaxia de doenças, e, usos de compostos e de um ou mais compostos em combinação com outros compostos farmacologicamente ativos |
| MXPA05011711A (es) | 2003-05-02 | 2006-01-23 | Actelion Pharmaceuticals Ltd | Derivados de diazabiciclononeno. |
| TW200513461A (en) | 2003-10-01 | 2005-04-16 | Speedel Experimenta Ag | Organische verbindungen |
| CN1863773A (zh) | 2003-10-09 | 2006-11-15 | 埃科特莱茵药品有限公司 | 四氢吡啶衍生物 |
| BRPI0416976A (pt) | 2003-11-26 | 2007-02-21 | Novartis Ag | derivados de 4-fenilpiperidina como inibidores de renina |
| EP1689702B1 (en) | 2003-11-26 | 2013-01-30 | Novartis AG | Organic compounds |
| BRPI0506491A (pt) | 2004-01-23 | 2007-02-13 | Speedel Experimenta Ag | compostos orgánicos |
| CA2553836A1 (en) | 2004-01-23 | 2005-08-04 | Speedel Experimenta Ag | Amino alcohol derivatives and their use as renin inhibitors |
| ATE472524T1 (de) | 2004-01-23 | 2010-07-15 | Novartis Ag | Diaminoalkohole und deren verwendung als renininhibitoren |
| CN1934083A (zh) | 2004-03-19 | 2007-03-21 | 斯皮德尔实验股份公司 | 作为肾素抑制剂用于治疗高血压的5－氨基－4－羟基－7－(1h－吲哚基甲基)－8－甲基壬酰胺衍生物 |
| CA2560195A1 (en) | 2004-03-19 | 2005-09-29 | Speedel Experimenta Ag | Organic compounds |
| AR053406A1 (es) | 2004-07-09 | 2007-05-09 | Speedel Experimenta Ag | Derivados de piperidina como inhibidores de renina. composiciones farmaceuticas |
| TW200631929A (en) | 2004-12-10 | 2006-09-16 | Speedel Experimenta Ag | ω -phenyloctanamides |
| GB0428250D0 (en) | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
| GB0500784D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0504850D0 (en) | 2005-03-09 | 2005-04-13 | Novartis Ag | Organic compounds |
| AR053826A1 (es) | 2005-03-11 | 2007-05-23 | Speedel Experimenta Ag | Compuestos organicos |
| GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
| TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
| JP2008535825A (ja) | 2005-03-31 | 2008-09-04 | シュペーデル・エクスペリメンタ・アーゲー | レニン阻害剤としての３，４，５−置換ピペリジン |
| GB0508992D0 (en) * | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| GB0510810D0 (en) | 2005-05-26 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0511063D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| AR057816A1 (es) | 2005-09-17 | 2007-12-19 | Speedel Experimenta Ag | Compuestos organicos |
| BRPI0617166A2 (pt) | 2005-09-17 | 2011-07-12 | Speedel Experimenta Ag | derivados de 5-amino-4-hidróxi-7-(imidazo[1,2-a]piridin-6-ilmetil)-8-me til-nonamidia e compostos relacionados como inibidores de renina para o tratamento de hipertensão |
| PE20071079A1 (es) | 2005-11-15 | 2007-12-16 | Cytokinetics Inc | Compuestos de piperidina como inhibidores de la proliferacion celular |
| NZ569135A (en) | 2005-12-30 | 2011-08-26 | Novartis Ag | 3,5-Substituted piperidine compounds as renin inhibitors |
| EP1816122A3 (en) | 2006-01-19 | 2007-09-19 | Speedel Experimenta AG | 3,4,5-substituted piperidines as therapeutic compounds |
| BRPI0706778A2 (pt) | 2006-01-30 | 2011-04-05 | Speedel Experimenta Ag | processos para a preparação estéreo-seletiva de álcoois a partir de compostos alfa, beta-insaturados |
| AR061265A1 (es) | 2006-06-08 | 2008-08-13 | Speedel Experimenta Ag | Piperidinas 2,5- disustituidas |
| GB0611697D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
| GB0611696D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
| EP1908471A1 (en) | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tetrahydropyridines as renin inhibitors |
-
2006
- 2006-12-28 NZ NZ569135A patent/NZ569135A/en not_active IP Right Cessation
- 2006-12-28 ES ES06829892.6T patent/ES2476422T3/es active Active
- 2006-12-28 KR KR1020087018705A patent/KR20080086921A/ko not_active Abandoned
- 2006-12-28 AR ARP060105852A patent/AR058885A1/es not_active Application Discontinuation
- 2006-12-28 PE PE2010000928A patent/PE20110117A1/es not_active Application Discontinuation
- 2006-12-28 CA CA2633624A patent/CA2633624C/en not_active Expired - Fee Related
- 2006-12-28 PL PL11185536T patent/PL2420491T3/pl unknown
- 2006-12-28 WO PCT/EP2006/012581 patent/WO2007077005A1/en not_active Ceased
- 2006-12-28 EP EP11185536.7A patent/EP2420491B1/en active Active
- 2006-12-28 ES ES11185536T patent/ES2430139T3/es active Active
- 2006-12-28 BR BRPI0620736-7A patent/BRPI0620736A2/pt not_active IP Right Cessation
- 2006-12-28 PE PE2006001709A patent/PE20071177A1/es not_active Application Discontinuation
- 2006-12-28 AU AU2006332124A patent/AU2006332124B2/en not_active Ceased
- 2006-12-28 EP EP06829892.6A patent/EP1968940B1/en not_active Revoked
- 2006-12-28 JP JP2008547900A patent/JP5306821B2/ja not_active Expired - Fee Related
- 2006-12-28 US US12/159,749 patent/US8129411B2/en not_active Expired - Fee Related
- 2006-12-28 PT PT111855367T patent/PT2420491E/pt unknown
- 2006-12-29 TW TW095149881A patent/TW200738698A/zh unknown
-
2008
- 2008-06-10 IL IL192024A patent/IL192024A0/en unknown
- 2008-06-19 CR CR10091A patent/CR10091A/es not_active Application Discontinuation
- 2008-06-19 MA MA31057A patent/MA30073B1/fr unknown
- 2008-06-27 EC EC2008008587A patent/ECSP088587A/es unknown
- 2008-07-25 NO NO20083315A patent/NO20083315L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009522226A (ja) | 2009-06-11 |
| ES2430139T3 (es) | 2013-11-19 |
| TW200738698A (en) | 2007-10-16 |
| EP2420491B1 (en) | 2013-07-03 |
| ES2476422T3 (es) | 2014-07-14 |
| NZ569135A (en) | 2011-08-26 |
| EP1968940B1 (en) | 2014-04-02 |
| PE20071177A1 (es) | 2008-01-18 |
| JP5306821B2 (ja) | 2013-10-02 |
| AU2006332124B2 (en) | 2011-03-03 |
| WO2007077005A1 (en) | 2007-07-12 |
| PT2420491E (pt) | 2013-10-14 |
| EP1968940A1 (en) | 2008-09-17 |
| ECSP088587A (es) | 2008-07-30 |
| AR058885A1 (es) | 2008-02-27 |
| KR20080086921A (ko) | 2008-09-26 |
| EP2420491A1 (en) | 2012-02-22 |
| PL2420491T3 (pl) | 2013-12-31 |
| BRPI0620736A2 (pt) | 2011-12-20 |
| US20090192148A1 (en) | 2009-07-30 |
| CR10091A (es) | 2008-10-27 |
| PE20110117A1 (es) | 2011-03-07 |
| AU2006332124A1 (en) | 2007-07-12 |
| US8129411B2 (en) | 2012-03-06 |
| MA30073B1 (fr) | 2008-12-01 |
| CA2633624A1 (en) | 2007-07-12 |
| CA2633624C (en) | 2013-11-19 |
| IL192024A0 (en) | 2008-12-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW200738698A (en) | Organic compounds | |
| TW200635915A (en) | Organic compounds | |
| NO20080914L (no) | Mellomprodukt for syntetisering av farmasoytisk middel og fremgangsmate for fremstilling av dette | |
| NO20091620L (no) | Boronsyre og estere som inhibitorer av fettsyreamidhydrolaser | |
| TNSN07361A1 (en) | 3,4-substituted pyrrolidine derivatives for the treatment of hypertension | |
| NO20070566L (no) | Azin-karboksamider som antikreftmiddel | |
| EP2423207A3 (en) | 2-(cyclic amino)-pyrimidone derivatives as TPK1 inhibitors | |
| NO20073719L (no) | Kjemiske forbindelser | |
| MX2007005644A (es) | Pirazolo-pirimidinas 1,4-sustituidas como inhibidores de cinasa. | |
| NO20072784L (no) | Pyridenkarboksamidderivater for anvendelse som anticancer midler | |
| NO20071776L (no) | Kinoksaliner som B RAF inhibitorer. | |
| NO20071246L (no) | Kinazolinonderivater og deres anvendelse som B-RAF-inhibitorer. | |
| NO20054769L (no) | Substituerte fenylalkansyrer | |
| BRPI0519443A2 (pt) | composto orgÂnicos | |
| MX2007011009A (es) | Compuestos de piperidina 3,4,5-substituidos. | |
| NO20081681L (no) | N-[1,3,4]-tiadiazol-2-yl-benzensulfonamider, fremgangsmate for fremstilling derav og deres anvendelse som farmasoytika | |
| WO2006125621A8 (en) | Substituted piperidines as renin inhibitors | |
| NO20082690L (no) | Kjemiske forbindelser | |
| BG108941A (en) | Polymorph of acid 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-il]-1-piperidinyl]ethyl]-alpha, alpha-dimethyl-benzeneacetic | |
| JP5788397B2 (ja) | ケモカイン受容体活性の調節薬としてのピペリジニル誘導体のプロドラッグ | |
| WO2007006534A3 (en) | Piperidine derivatives useful in the diagnostic and therapeutic treatment of diseases depending on renin activity | |
| WO2006074924A8 (en) | 3,4,(5)-substituted tetrahvdropyridines | |
| NO20064344L (no) | Caspaseinhibitorer og anvendelser derav | |
| NO20073156L (no) | Stabilisering av radiofarmasoytiske forlopere | |
| WO2006128659A3 (en) | Piperazine derivative renin inhibitors. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |