NO20083315L - 3,5-substituert piperidin-bestanddeler som renin-inhibitorer - Google Patents
3,5-substituert piperidin-bestanddeler som renin-inhibitorerInfo
- Publication number
- NO20083315L NO20083315L NO20083315A NO20083315A NO20083315L NO 20083315 L NO20083315 L NO 20083315L NO 20083315 A NO20083315 A NO 20083315A NO 20083315 A NO20083315 A NO 20083315A NO 20083315 L NO20083315 L NO 20083315L
- Authority
- NO
- Norway
- Prior art keywords
- substituted piperidine
- treatment
- compound
- renin
- constituents
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 4
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 239000000470 constituent Substances 0.000 title 1
- 239000002461 renin inhibitor Substances 0.000 title 1
- 229940086526 renin-inhibitors Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 102100028255 Renin Human genes 0.000 abstract 3
- 108090000783 Renin Proteins 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- -1 piperidine compound Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05028771 | 2005-12-30 | ||
| GB0604223A GB0604223D0 (en) | 2006-03-02 | 2006-03-02 | Organic compounds |
| GB0611390A GB0611390D0 (en) | 2006-06-08 | 2006-06-08 | Organic compounds |
| PCT/EP2006/012581 WO2007077005A1 (en) | 2005-12-30 | 2006-12-28 | 3 , 5-substitγued piperidine compounds as renin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20083315L true NO20083315L (no) | 2008-09-19 |
Family
ID=37875514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083315A NO20083315L (no) | 2005-12-30 | 2008-07-25 | 3,5-substituert piperidin-bestanddeler som renin-inhibitorer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8129411B2 (pl) |
| EP (2) | EP1968940B1 (pl) |
| JP (1) | JP5306821B2 (pl) |
| KR (1) | KR20080086921A (pl) |
| AR (1) | AR058885A1 (pl) |
| AU (1) | AU2006332124B2 (pl) |
| BR (1) | BRPI0620736A2 (pl) |
| CA (1) | CA2633624C (pl) |
| CR (1) | CR10091A (pl) |
| EC (1) | ECSP088587A (pl) |
| ES (2) | ES2430139T3 (pl) |
| IL (1) | IL192024A0 (pl) |
| MA (1) | MA30073B1 (pl) |
| NO (1) | NO20083315L (pl) |
| NZ (1) | NZ569135A (pl) |
| PE (2) | PE20071177A1 (pl) |
| PL (1) | PL2420491T3 (pl) |
| PT (1) | PT2420491E (pl) |
| TW (1) | TW200738698A (pl) |
| WO (1) | WO2007077005A1 (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0514203D0 (en) * | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| JP5306821B2 (ja) | 2005-12-30 | 2013-10-02 | ノバルティス アーゲー | レニン阻害剤としての３，５−置換ピペリジン化合物 |
| WO2008036540A2 (en) | 2006-09-20 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8129538B1 (en) | 2007-03-28 | 2012-03-06 | Takeda Pharmaceutical Company Limited | Renin inhibitors |
| NZ582098A (en) * | 2007-06-25 | 2012-03-30 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
| JP5441705B2 (ja) | 2007-10-15 | 2014-03-12 | 武田薬品工業株式会社 | アミド化合物およびその用途 |
| RU2010129690A (ru) | 2007-12-19 | 2012-01-27 | Дайниппон Сумитомо Фарма Ко., Лтд. (Jp) | Бициклические гетероциклические производные |
| CN102015682B (zh) | 2008-05-05 | 2014-07-16 | 埃科特莱茵药品有限公司 | 作为肾素抑制剂的3,4-取代的哌啶衍生物 |
| CN102123990B (zh) | 2008-06-19 | 2014-07-09 | 武田药品工业株式会社 | 杂环化合物及其用途 |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010122580A2 (en) * | 2009-04-24 | 2010-10-28 | Cadila Healthcare Limited | Novel compounds as inhibitors of renin |
| EP3053913B1 (en) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| KR20120109292A (ko) | 2009-06-24 | 2012-10-08 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | Ｎ-치환-시클릭 아미노 유도체 |
| KR20140092696A (ko) * | 2013-01-16 | 2014-07-24 | 주식회사유한양행 | 신규의 페닐에티닐 벤즈아마이드 글루코키나제 활성화제 및 그의 제조방법 |
| DK3811943T3 (da) | 2013-03-15 | 2023-04-03 | Aerie Pharmaceuticals Inc | Forbindelse til anvendelse til behandling af øjenlidelser |
| WO2015156346A1 (ja) * | 2014-04-10 | 2015-10-15 | 武田薬品工業株式会社 | 複素環化合物の製造法 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| US10550087B2 (en) | 2015-11-17 | 2020-02-04 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| KR102568079B1 (ko) | 2016-08-31 | 2023-08-17 | 에어리 파마슈티컬즈, 인코포레이티드 | 안과용 조성물 |
| KR20190135027A (ko) | 2017-03-31 | 2019-12-05 | 에어리 파마슈티컬즈, 인코포레이티드 | 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물 |
| AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN117986146A (zh) * | 2023-12-22 | 2024-05-07 | 河南优凯制药有限公司 | 一种枸橼酸喷托维林杂质的制备方法及其检测方法 |
| CN119059970B (zh) * | 2024-08-30 | 2026-03-24 | 上海信诺维生物医药有限公司 | 一种btk抑制剂药物中间体的制备方法 |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW224941B (pl) | 1989-11-08 | 1994-06-11 | Yamanouchi Pharma Co Ltd | |
| MX9207393A (es) | 1991-12-18 | 1994-06-30 | Schering Corp | Imidazoil o alquilo de imidazoil susbtituido con una cadena heterociclica de cuatro o cinco miembros que contienen nitrogeno. |
| IL111176A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them |
| RU2167865C2 (ru) | 1995-09-07 | 2001-05-27 | Ф. Хоффманн-Ля Рош Аг | Производные пиперидина, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества |
| CA2238081A1 (en) | 1995-11-22 | 1997-05-29 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
| EP1009405A4 (en) | 1997-08-28 | 2001-05-09 | Merck & Co Inc | PAYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
| AU4692399A (en) | 1998-06-17 | 2000-01-05 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| US6274735B1 (en) | 1998-08-10 | 2001-08-14 | Hoffmann-La Roche Inc. | Process and intermediates for preparation of substituted piperidines |
| CA2348734A1 (en) | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Thrombin inhibitors |
| US6303593B1 (en) | 1999-03-02 | 2001-10-16 | Merck & Co., Inc. | 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity |
| AU3389300A (en) | 1999-03-02 | 2000-09-21 | Merck & Co., Inc. | Pyrrolidine modulators of chemokine receptor activity |
| WO2000051607A1 (en) | 1999-03-02 | 2000-09-08 | Merck & Co., Inc. | 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity |
| AU3818900A (en) | 1999-04-14 | 2000-11-02 | F. Hoffmann-La Roche Ag | Process for the preparation of substituted piperidines |
| US6197959B1 (en) | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| US6376672B1 (en) | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
| JP2003528072A (ja) | 2000-03-17 | 2003-09-24 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | マトリックスメタロプロテアーゼおよびＴＮＦ−αの阻害剤としての環状β−アミノ酸誘導体 |
| WO2001074741A2 (en) * | 2000-04-04 | 2001-10-11 | Brandeis University | Catalytic asymmetric desymmetrization of meso compounds |
| FR2811673B1 (fr) | 2000-07-17 | 2002-09-13 | Rhodia Chimie Sa | Utilisation de composes insatures comprenant un heterocycle comme stabilisants de polymeres halogenes |
| US7125887B2 (en) | 2000-10-11 | 2006-10-24 | Merck & Co., Inc. | Pyrrolidine modulators of CCR5 chemokine receptor activity |
| US20060079533A1 (en) | 2001-03-23 | 2006-04-13 | Nieman James A | Methods of treating alzheimer's disease |
| WO2002088101A2 (en) | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of bace |
| AU2002341715A1 (en) | 2001-09-17 | 2003-04-01 | Bristol-Myers Squibb Company | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
| WO2003031443A1 (en) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety |
| HRP20041132A2 (en) | 2002-04-29 | 2006-07-31 | Actelion Pharmaceuticals Ltd. | 7-aryl-3, 9-diazabicyclo (3.3.1) non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases |
| DE60324552D1 (en) | 2002-05-20 | 2008-12-18 | Bristol Myers Squibb Co | Substituierte cycloalkyl p1' hepatitis c virus inhibitoren |
| AU2003259131A1 (en) | 2002-07-09 | 2004-01-23 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| US20040214832A1 (en) | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
| US20040204455A1 (en) | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
| WO2004096804A1 (en) | 2003-04-28 | 2004-11-11 | Actelion Pharmaceuticals Ltd | Diazabicyclononene and tetrahydropyridine derivatives as renin inhibitors |
| CN1972912A (zh) | 2003-04-29 | 2007-05-30 | 埃科特莱茵药品有限公司 | 新型3,4－二取代的1,2,3,6－四氢吡啶衍生物 |
| US20060235044A1 (en) | 2003-04-30 | 2006-10-19 | Olivier Bezencon | Azabicyclononene derivatives |
| AU2004233575A1 (en) | 2003-04-30 | 2004-11-11 | Actelion Pharmaceuticals Ltd | 9-azabicyclo'3.3.1!non-6-ee derivatives with a heteroatom at the 3-position as renin inhibitors |
| JP2006524657A (ja) | 2003-04-30 | 2006-11-02 | アクテリオン ファマシューティカルズ リミテッド | 新規トロパン誘導体 |
| JP2006525259A (ja) | 2003-05-02 | 2006-11-09 | アクテリオン ファマシューティカルズ リミテッド | 新規ジアザビシクロノネン誘導体 |
| TW200513461A (en) | 2003-10-01 | 2005-04-16 | Speedel Experimenta Ag | Organische verbindungen |
| CN1863773A (zh) | 2003-10-09 | 2006-11-15 | 埃科特莱茵药品有限公司 | 四氢吡啶衍生物 |
| AU2004293178B8 (en) | 2003-11-26 | 2009-01-08 | Novartis Ag | Organic compounds |
| ATE440082T1 (de) * | 2003-11-26 | 2009-09-15 | Novartis Pharma Gmbh | 4-phenylpiperidinderivate als renininhibitoren |
| DE602005022060D1 (de) | 2004-01-23 | 2010-08-12 | Novartis Ag | Diaminoalkohole und deren verwendung als renininhibitoren |
| TW200529837A (en) | 2004-01-23 | 2005-09-16 | Speedel Experimenta Ag | Organic compounds |
| AR047445A1 (es) | 2004-01-23 | 2006-01-18 | Speedel Experimenta Ag | Compuestos derivados de amino alcohol con actividad inhibidora de la renina y su uso en composiciones farmaceuticas. |
| JP4927704B2 (ja) | 2004-03-19 | 2012-05-09 | シュペーデル・エクスペリメンタ・アーゲー | 有機化合物 |
| BRPI0508961A (pt) | 2004-03-19 | 2007-08-14 | Speedel Experimenta Ag | derivados de 5-amino-4-hidróxi-7-(1h-indolmetil)-8-metilnonamida como inibidores de renina para o tratamento de hipertensão |
| TW200613274A (en) | 2004-07-09 | 2006-05-01 | Speedel Experimenta Ag | Organic compounds |
| TW200631929A (en) | 2004-12-10 | 2006-09-16 | Speedel Experimenta Ag | ω -phenyloctanamides |
| GB0428250D0 (en) | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| GB0428526D0 (en) | 2004-12-30 | 2005-02-09 | Novartis Ag | Organic compounds |
| GB0500784D0 (en) | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0504850D0 (en) | 2005-03-09 | 2005-04-13 | Novartis Ag | Organic compounds |
| JP2008532983A (ja) | 2005-03-11 | 2008-08-21 | シュペーデル・エクスペリメンタ・アーゲー | レニン阻害剤として有用な複素環置換アルカンアミド |
| GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
| JP2008535825A (ja) | 2005-03-31 | 2008-09-04 | シュペーデル・エクスペリメンタ・アーゲー | レニン阻害剤としての３，４，５−置換ピペリジン |
| TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
| GB0508992D0 (en) | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| GB0510810D0 (en) | 2005-05-26 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0511063D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| PT1937248E (pt) | 2005-09-17 | 2010-07-06 | Novartis Ag | AMIDAS DE áCIDOS ALCANËICOS SUBSTITUDAS POR O-HETEROCICLOS SATURADOS |
| CN101268074B (zh) | 2005-09-17 | 2011-09-21 | 斯皮德尔实验股份公司 | 5-氨基-4-羟基-7-（咪唑并[1,2-a]吡啶-6-基甲基）-8-甲基-壬酰胺衍生物和相关用作肾素抑制剂治疗高血压的化合物 |
| PE20071079A1 (es) | 2005-11-15 | 2007-12-16 | Cytokinetics Inc | Compuestos de piperidina como inhibidores de la proliferacion celular |
| JP5306821B2 (ja) | 2005-12-30 | 2013-10-02 | ノバルティス アーゲー | レニン阻害剤としての３，５−置換ピペリジン化合物 |
| EP1816122A3 (en) | 2006-01-19 | 2007-09-19 | Speedel Experimenta AG | 3,4,5-substituted piperidines as therapeutic compounds |
| US20090088576A1 (en) | 2006-01-30 | 2009-04-02 | Peter Herold | Process for the Stereoselective Preparation of Alcohols From Alpha, Beta-Insaturated Compounds |
| JP2009539806A (ja) | 2006-06-08 | 2009-11-19 | シュペーデル・エクスペリメンタ・アーゲー | ２，５−二置換ピペリジン |
| GB0611696D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
| GB0611697D0 (en) | 2006-06-13 | 2006-07-26 | Novartis Ag | Organic compounds |
| EP1908471A1 (en) | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tetrahydropyridines as renin inhibitors |
-
2006
- 2006-12-28 JP JP2008547900A patent/JP5306821B2/ja not_active Expired - Fee Related
- 2006-12-28 EP EP06829892.6A patent/EP1968940B1/en not_active Revoked
- 2006-12-28 PE PE2006001709A patent/PE20071177A1/es not_active Application Discontinuation
- 2006-12-28 BR BRPI0620736-7A patent/BRPI0620736A2/pt not_active IP Right Cessation
- 2006-12-28 US US12/159,749 patent/US8129411B2/en not_active Expired - Fee Related
- 2006-12-28 EP EP11185536.7A patent/EP2420491B1/en active Active
- 2006-12-28 AR ARP060105852A patent/AR058885A1/es not_active Application Discontinuation
- 2006-12-28 PL PL11185536T patent/PL2420491T3/pl unknown
- 2006-12-28 NZ NZ569135A patent/NZ569135A/en not_active IP Right Cessation
- 2006-12-28 CA CA2633624A patent/CA2633624C/en not_active Expired - Fee Related
- 2006-12-28 PE PE2010000928A patent/PE20110117A1/es not_active Application Discontinuation
- 2006-12-28 AU AU2006332124A patent/AU2006332124B2/en not_active Ceased
- 2006-12-28 WO PCT/EP2006/012581 patent/WO2007077005A1/en not_active Ceased
- 2006-12-28 KR KR1020087018705A patent/KR20080086921A/ko not_active Abandoned
- 2006-12-28 ES ES11185536T patent/ES2430139T3/es active Active
- 2006-12-28 ES ES06829892.6T patent/ES2476422T3/es active Active
- 2006-12-28 PT PT111855367T patent/PT2420491E/pt unknown
- 2006-12-29 TW TW095149881A patent/TW200738698A/zh unknown
-
2008
- 2008-06-10 IL IL192024A patent/IL192024A0/en unknown
- 2008-06-19 CR CR10091A patent/CR10091A/es not_active Application Discontinuation
- 2008-06-19 MA MA31057A patent/MA30073B1/fr unknown
- 2008-06-27 EC EC2008008587A patent/ECSP088587A/es unknown
- 2008-07-25 NO NO20083315A patent/NO20083315L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2420491A1 (en) | 2012-02-22 |
| KR20080086921A (ko) | 2008-09-26 |
| PE20110117A1 (es) | 2011-03-07 |
| CR10091A (es) | 2008-10-27 |
| IL192024A0 (en) | 2008-12-29 |
| AR058885A1 (es) | 2008-02-27 |
| TW200738698A (en) | 2007-10-16 |
| BRPI0620736A2 (pt) | 2011-12-20 |
| AU2006332124A1 (en) | 2007-07-12 |
| EP2420491B1 (en) | 2013-07-03 |
| ECSP088587A (es) | 2008-07-30 |
| AU2006332124B2 (en) | 2011-03-03 |
| PT2420491E (pt) | 2013-10-14 |
| PL2420491T3 (pl) | 2013-12-31 |
| WO2007077005A1 (en) | 2007-07-12 |
| CA2633624A1 (en) | 2007-07-12 |
| US20090192148A1 (en) | 2009-07-30 |
| ES2430139T3 (es) | 2013-11-19 |
| ES2476422T3 (es) | 2014-07-14 |
| EP1968940B1 (en) | 2014-04-02 |
| CA2633624C (en) | 2013-11-19 |
| PE20071177A1 (es) | 2008-01-18 |
| JP5306821B2 (ja) | 2013-10-02 |
| JP2009522226A (ja) | 2009-06-11 |
| US8129411B2 (en) | 2012-03-06 |
| NZ569135A (en) | 2011-08-26 |
| MA30073B1 (fr) | 2008-12-01 |
| EP1968940A1 (en) | 2008-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20083315L (no) | 3,5-substituert piperidin-bestanddeler som renin-inhibitorer | |
| NO20075365L (no) | 3,4-substituerte pyrrolidinderivater for behandling av hypertensjon | |
| TW200635915A (en) | Organic compounds | |
| NO20080914L (no) | Mellomprodukt for syntetisering av farmasoytisk middel og fremgangsmate for fremstilling av dette | |
| NO20091620L (no) | Boronsyre og estere som inhibitorer av fettsyreamidhydrolaser | |
| NO20070199L (no) | Substituerte kinazoloner som anti-kreftmidler | |
| NO20082709L (no) | Kjemiske forbindelser | |
| NO20070566L (no) | Azin-karboksamider som antikreftmiddel | |
| NO20073719L (no) | Kjemiske forbindelser | |
| MX2007005644A (es) | Pirazolo-pirimidinas 1,4-sustituidas como inhibidores de cinasa. | |
| NO20091683L (no) | Kjemiske forbindelser | |
| NO20072784L (no) | Pyridenkarboksamidderivater for anvendelse som anticancer midler | |
| NO20071776L (no) | Kinoksaliner som B RAF inhibitorer. | |
| NO20071246L (no) | Kinazolinonderivater og deres anvendelse som B-RAF-inhibitorer. | |
| NO20084202L (no) | 4-anilinoquinolin-3-carboksamider som CSF-1R kinase inhibitorer | |
| NO20054769L (no) | Substituerte fenylalkansyrer | |
| WO2006072589A3 (en) | Disubstituted ureas as kinase inhibitors | |
| BRPI0519443A2 (pt) | composto orgÂnicos | |
| MX2007011009A (es) | Compuestos de piperidina 3,4,5-substituidos. | |
| NO20081681L (no) | N-[1,3,4]-tiadiazol-2-yl-benzensulfonamider, fremgangsmate for fremstilling derav og deres anvendelse som farmasoytika | |
| WO2006125621A8 (en) | Substituted piperidines as renin inhibitors | |
| NO20082690L (no) | Kjemiske forbindelser | |
| BG108941A (en) | Polymorph of acid 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-il]-1-piperidinyl]ethyl]-alpha, alpha-dimethyl-benzeneacetic | |
| JP5788397B2 (ja) | ケモカイン受容体活性の調節薬としてのピペリジニル誘導体のプロドラッグ | |
| WO2007006534A3 (en) | Piperidine derivatives useful in the diagnostic and therapeutic treatment of diseases depending on renin activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |