NO20083356L - Anvendelse av 4-imidazolderivater for CNS sykdommer - Google Patents

Anvendelse av 4-imidazolderivater for CNS sykdommer

Info

Publication number: NO20083356L
Authority: NO; Norway
Prior art keywords: disorders; phenyl; lower alkyl; halogen; lower alkoxy
Prior art date: 2006-01-27

Application number

NO20083356A

Other languages

English (en)

Norwegian (no)

Inventor

Guido Galley

Katrin Groebke Zbinden

Roger Norcross

Henri Stalder

Marius Hoener

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-27

Filing date

2008-07-31

Publication date

2008-10-21

2008-07-31 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2008-10-21 Publication of NO20083356L publication Critical patent/NO20083356L/no

Links

208000015114 central nervous system disease Diseases 0.000 title 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
208000035475 disorder Diseases 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000002431 hydrogen Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
208000020925 Bipolar disease Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000020401 Depressive disease Diseases 0.000 abstract 1
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
208000032928 Dyslipidaemia Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000012902 Nervous system disease Diseases 0.000 abstract 1
208000025966 Neurological disease Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000015802 attention deficit-hyperactivity disease Diseases 0.000 abstract 1
125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
230000009045 body homeostasis Effects 0.000 abstract 1
230000036760 body temperature Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
125000000723 dihydrobenzofuranyl group Chemical group O1C(CC2=C1C=CC=C2)* 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
238000005265 energy consumption Methods 0.000 abstract 1
206010015037 epilepsy Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 hydroxy, phenyl Chemical group 0.000 abstract 1
230000007257 malfunction Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
208000030159 metabolic disease Diseases 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
201000009032 substance abuse Diseases 0.000 abstract 1
231100000736 substance abuse Toxicity 0.000 abstract 1
208000011117 substance-related disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Hematology (AREA)
Psychiatry (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20083356A 2006-01-27 2008-07-31 Anvendelse av 4-imidazolderivater for CNS sykdommer NO20083356L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06100938		2006-01-27
PCT/EP2007/050441 WO2007085556A2 (en)	2006-01-27	2007-01-17	Use of 4-imidazole derivatives for cns disorders

Publications (1)

Publication Number	Publication Date
NO20083356L true NO20083356L (no)	2008-10-21

Family

ID=38051581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20083356A NO20083356L (no)	2006-01-27	2008-07-31	Anvendelse av 4-imidazolderivater for CNS sykdommer

Country Status (18)

Country	Link
US (1)	US8158668B2 (pt)
EP (1)	EP1981880B1 (pt)
JP (1)	JP2009524616A (pt)
KR (1)	KR101079914B1 (pt)
CN (1)	CN101374832B (pt)
AR (1)	AR059206A1 (pt)
AT (1)	ATE458732T1 (pt)
AU (1)	AU2007209380B2 (pt)
BR (1)	BRPI0706759A2 (pt)
CA (1)	CA2637308C (pt)
DE (1)	DE602007004949D1 (pt)
ES (1)	ES2338716T3 (pt)
IL (1)	IL192885A0 (pt)
NO (1)	NO20083356L (pt)
RU (1)	RU2008130448A (pt)
TW (1)	TW200738645A (pt)
WO (1)	WO2007085556A2 (pt)
ZA (1)	ZA200806457B (pt)

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AU2009205539B2 (en) *	2008-01-18	2013-12-05	Allergan.Inc	Substitued-aryl-(imidazole)-methyl)-phenyl compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors
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CN102083805A (zh) *	2008-07-24	2011-06-01	弗·哈夫曼-拉罗切有限公司	4,5-二氢-唑-2-基衍生物
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UY32858A (es)	2009-08-31	2011-03-31	Abbott Healthcare Products Bv	Derivados de (tio)morfolina como moduladores de sip
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US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
TW201643169A (zh)	2010-07-09	2016-12-16	艾伯維股份有限公司	作為s1p調節劑的螺-哌啶衍生物
AR090557A1 (es)	2012-04-02	2014-11-19	Orion Corp	DERIVADOS IMIDAZOLICOS AGONISTAS ADRENERGICOS a2
JP6387360B2 (ja)	2013-03-14	2018-09-05	ノバルティスアーゲー	変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン
KR101948779B1 (ko)	2013-10-07	2019-05-21	테이코쿠 팔마 유에스에이, 인코포레이티드	덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
CA2924233C (en)	2013-10-07	2018-10-23	Teikoku Pharma Usa, Inc.	Methods and compositions for treating attention deficit hyperactivity disorder, anxiety and insomnia using dexmedetomidine transdermal compositions
CA2924236C (en)	2013-10-07	2020-01-07	Teikoku Pharma Usa, Inc.	Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine
CN103664788B (zh) *	2013-12-04	2015-11-25	湖北生物医药产业技术研究院有限公司	制备美托咪啶的方法
WO2017134053A1 (en)	2016-02-04	2017-08-10	Chiesi Farmaceutici S.P.A.	Pyrazole derivatives as phosphoinositide 3-kinases inhibitors
CN108713019B (zh)	2016-03-17	2021-06-15	豪夫迈·罗氏有限公司	具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物
CN105884691B (zh) *	2016-06-02	2017-08-25	江苏恒瑞医药股份有限公司	一种制备右美托咪定及其中间体的方法
BR112019006955A2 (pt)	2016-10-31	2019-07-02	Teikoku Pharma Usa Inc	métodos de controle da dor usando dispositivos de distribuição transdérmica de dexmedetomidina
EP3634406B1 (en) *	2017-05-12	2023-09-06	Board of Trustees of The Southern Illinois University on behalf of Southern Illinois University Edwardsville	3,4,5-trisubstituted-1,2,4-triazoles and 3,4,5-trisubstituted-3-thio-1,2,4-triazoles and uses thereof
CN107879979B (zh) *	2017-10-27	2020-08-25	广东莱佛士制药技术有限公司	一种右美托咪定的制备方法
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WO2024240240A1 (zh) *	2023-05-24	2024-11-28	江苏恩华药业股份有限公司	一种咪唑衍生物、中间体、制备方法及其应用
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2007
- 2007-01-17 RU RU2008130448/04A patent/RU2008130448A/ru not_active Application Discontinuation
- 2007-01-17 DE DE602007004949T patent/DE602007004949D1/de active Active
- 2007-01-17 BR BRPI0706759-3A patent/BRPI0706759A2/pt not_active IP Right Cessation
- 2007-01-17 AU AU2007209380A patent/AU2007209380B2/en not_active Ceased
- 2007-01-17 CN CN2007800036567A patent/CN101374832B/zh not_active Expired - Fee Related
- 2007-01-17 KR KR1020087020817A patent/KR101079914B1/ko not_active Expired - Fee Related
- 2007-01-17 AT AT07703939T patent/ATE458732T1/de active
- 2007-01-17 EP EP07703939A patent/EP1981880B1/en not_active Not-in-force
- 2007-01-17 WO PCT/EP2007/050441 patent/WO2007085556A2/en not_active Ceased
- 2007-01-17 ES ES07703939T patent/ES2338716T3/es active Active
- 2007-01-17 CA CA2637308A patent/CA2637308C/en not_active Expired - Fee Related
- 2007-01-17 JP JP2008551759A patent/JP2009524616A/ja active Pending
- 2007-01-19 US US11/655,539 patent/US8158668B2/en not_active Expired - Fee Related
- 2007-01-25 TW TW096102837A patent/TW200738645A/zh unknown
- 2007-01-26 AR ARP070100342A patent/AR059206A1/es unknown
2008
- 2008-07-17 IL IL192885A patent/IL192885A0/en unknown
- 2008-07-24 ZA ZA200806457A patent/ZA200806457B/xx unknown
- 2008-07-31 NO NO20083356A patent/NO20083356L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TW200738645A (en)	2007-10-16
CN101374832B (zh)	2013-03-06
WO2007085556A3 (en)	2007-10-04
AU2007209380A1 (en)	2007-08-02
CN101374832A (zh)	2009-02-25
ATE458732T1 (de)	2010-03-15
ZA200806457B (en)	2009-11-25
CA2637308C (en)	2014-02-25
AU2007209380B2 (en)	2011-12-08
KR101079914B1 (ko)	2011-11-04
US8158668B2 (en)	2012-04-17
RU2008130448A (ru)	2010-03-10
DE602007004949D1 (de)	2010-04-08
BRPI0706759A2 (pt)	2011-04-05
EP1981880A2 (en)	2008-10-22
US20070197622A1 (en)	2007-08-23
EP1981880B1 (en)	2010-02-24
ES2338716T3 (es)	2010-05-11
KR20080088658A (ko)	2008-10-02
CA2637308A1 (en)	2007-08-02
IL192885A0 (en)	2009-02-11
JP2009524616A (ja)	2009-07-02
WO2007085556A2 (en)	2007-08-02
AR059206A1 (es)	2008-03-19

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Date	Code	Title	Description
2011-09-05	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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