NO20084127L - Benzylfenylglukopyranosidderivat - Google Patents

Benzylfenylglukopyranosidderivat

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Publication number
NO20084127L
NO20084127L NO20084127A NO20084127A NO20084127L NO 20084127 L NO20084127 L NO 20084127L NO 20084127 A NO20084127 A NO 20084127A NO 20084127 A NO20084127 A NO 20084127A NO 20084127 L NO20084127 L NO 20084127L
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NO
Norway
Prior art keywords
hydrogen atom
alkyl group
hydroxy
group
atom
Prior art date
Application number
NO20084127A
Other languages
English (en)
Inventor
Jun Ohsumi
Takeshi Honda
Ryo Okuyama
Minoru Oguchi
Masao Yoshida
Tsuneaki Ogata
Manabu Abe
Kenjiro Ueda
Masanori Izumi
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of NO20084127L publication Critical patent/NO20084127L/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61P3/06—Antihyperlipidemics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

Det er beskrevet et benzylfenyl-glukopyranosidderivat som har utmerket inhibitoreffekt på human-SGLTl-og/eller -SGLT2-aktivitet. Nærmere bestemt er det beskrevet en forbindelse som har den generelle formel (I): eller et farmakologisk akseptabelt salt derav, hvor R1 er et hydrogenatom, en aminogruppe, en hydroksy-Ci-C6~alkyl-gruppe eller lignende; R2 er et hydrogenatom eller lignende; R3 er en Ci-Ce-alkylgruppe, en hydroksy-Ci-Ce-alkyl-gruppe eller lignende; R4 er et hydrogenatom, en C2-C7-acylgruppe eller lignende; R5, R6, R7 og R8 er uavhengig av hverandre et hydrogenatom, en C1-C6-alkylgruppe eller lignende (forutsatt at ikke alle av R5, R6, R7 og R8 er et hydrogenatom i et molekyl); R9 er et halogenatom; n er et tall i området fra 0 til 4; og X er CH eller N.
NO20084127A 2006-08-04 2008-09-29 Benzylfenylglukopyranosidderivat NO20084127L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006213600 2006-08-04
PCT/JP2007/065231 WO2008016132A1 (fr) 2006-08-04 2007-08-03 Dérivé du benzyl phényl glucopyranoside

Publications (1)

Publication Number Publication Date
NO20084127L true NO20084127L (no) 2009-04-30

Family

ID=38997305

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084127A NO20084127L (no) 2006-08-04 2008-09-29 Benzylfenylglukopyranosidderivat

Country Status (15)

Country Link
US (1) US20090137499A1 (no)
EP (1) EP2048150A4 (no)
JP (3) JP4249256B2 (no)
KR (1) KR20090040250A (no)
CN (1) CN101472937A (no)
AU (1) AU2007279616A1 (no)
BR (1) BRPI0708521A2 (no)
CA (1) CA2649044A1 (no)
EA (1) EA200870540A1 (no)
IL (1) IL194404A0 (no)
MX (1) MX2008012481A (no)
NO (1) NO20084127L (no)
TW (1) TW200817424A (no)
WO (1) WO2008016132A1 (no)
ZA (1) ZA200809543B (no)

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JP2009024021A (ja) 2009-02-05
KR20090040250A (ko) 2009-04-23
EP2048150A4 (en) 2011-06-29
WO2008016132A1 (fr) 2008-02-07
JPWO2008016132A1 (ja) 2009-12-24
JP4425318B2 (ja) 2010-03-03
ZA200809543B (en) 2010-03-31
JP2009108105A (ja) 2009-05-21
MX2008012481A (es) 2008-10-10
AU2007279616A1 (en) 2008-02-07
BRPI0708521A2 (pt) 2011-05-31
TW200817424A (en) 2008-04-16
JP4249256B2 (ja) 2009-04-02
US20090137499A1 (en) 2009-05-28
EP2048150A1 (en) 2009-04-15
IL194404A0 (en) 2009-08-03
CN101472937A (zh) 2009-07-01

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