NO20084419L - Imidazopyridin-2-on derivater som inhibitorer av endoteliallipase - Google Patents

Imidazopyridin-2-on derivater som inhibitorer av endoteliallipase

Info

Publication number
NO20084419L
NO20084419L NO20084419A NO20084419A NO20084419L NO 20084419 L NO20084419 L NO 20084419L NO 20084419 A NO20084419 A NO 20084419A NO 20084419 A NO20084419 A NO 20084419A NO 20084419 L NO20084419 L NO 20084419L
Authority
NO
Norway
Prior art keywords
alkyl
cycloalkyl
aryl
bicyclic
ocoa
Prior art date
Application number
NO20084419A
Other languages
English (en)
Norwegian (no)
Inventor
Gerhard Zoller
Stefan Petry
Gunter Muller
Norbert Tennagels
Markus Follmann
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20084419L publication Critical patent/NO20084419L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20084419A 2006-03-28 2008-10-21 Imidazopyridin-2-on derivater som inhibitorer av endoteliallipase NO20084419L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006014685A DE102006014685A1 (de) 2006-03-28 2006-03-28 Imidazo-pyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholiphasen
PCT/EP2007/002637 WO2007110215A1 (en) 2006-03-28 2007-03-26 Imidazopyridin-2-one derivatives as inhibitors of endothelial lipase

Publications (1)

Publication Number Publication Date
NO20084419L true NO20084419L (no) 2008-11-26

Family

ID=38179814

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084419A NO20084419L (no) 2006-03-28 2008-10-21 Imidazopyridin-2-on derivater som inhibitorer av endoteliallipase

Country Status (14)

Country Link
US (1) US7897616B2 (de)
EP (1) EP2001878B1 (de)
JP (1) JP2009531356A (de)
KR (1) KR20080104341A (de)
CN (1) CN101405288A (de)
AT (1) ATE528307T1 (de)
AU (1) AU2007229708A1 (de)
BR (1) BRPI0709211A2 (de)
CA (1) CA2647422A1 (de)
DE (1) DE102006014685A1 (de)
MX (1) MX2008012126A (de)
NO (1) NO20084419L (de)
TW (1) TW200815434A (de)
WO (1) WO2007110215A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
US8957219B2 (en) 2008-10-17 2015-02-17 Shionogi & Co., Ltd. Acetic acid amide derivative having inhibitory activity on endothelial lipase
WO2011034741A1 (en) * 2009-09-15 2011-03-24 Merck Sharp & Dohme Corp. Imidazopyridin-2-one derivatives
MX2012004995A (es) * 2009-10-29 2012-10-03 Sirtris Pharmaceuticals Inc Piridinas biciclicas y analogos como moduladores de sirtuina.
KR20120123325A (ko) 2009-12-15 2012-11-08 시오노기세야쿠 가부시키가이샤 혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
EP2612669A4 (de) 2010-08-31 2014-05-14 Snu R&Db Foundation Verwendung der fötalen neuprogrammierung eines ppar-agonisten
US9493412B2 (en) 2011-09-27 2016-11-15 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
EP2760828B1 (de) 2011-09-27 2015-10-21 Bristol-Myers Squibb Company Als endothellipasehemmer verwendbare pyrrolinoncarboxamidverbindungen
EP2760829B1 (de) 2011-09-27 2016-05-18 Bristol-Myers Squibb Company Pyrrolinon-carboxamid-derivate als inhibitoren von endothellipase
WO2013048930A1 (en) 2011-09-30 2013-04-04 Bristol-Myers Squibb Company Pyridinedione carboxamide inhibitors of endothelial lipase
WO2013049104A1 (en) 2011-09-30 2013-04-04 Bristol-Myers Squibb Company Pyridinedione carboxamide inhibitors of endothelial lipase
EP2760840B1 (de) 2011-09-30 2015-08-12 Bristol-Myers Squibb Company Chinolinon-carboxamid-inhibitoren der endothelialen lipase
EP2844643B1 (de) 2012-04-03 2016-11-30 Bristol-Myers Squibb Company Pyrimidindioncarboxamid inhibitoren der endothelial lipase
US9394260B2 (en) 2012-04-03 2016-07-19 Bristol-Myers Squibb Company Pyrimidinone carboxamide inhibitors of endothelial lipase
US9139578B2 (en) 2012-07-09 2015-09-22 Bristol-Myers Squibb Company Amide or urea containing benzothiazole inhibitors of endothelial lipase
AR092854A1 (es) 2012-07-09 2015-05-06 Bristol Myers Squibb Co Benzotiazoles que contienen sulfonilo como inhibidores de la lipasa endotelial
WO2014015088A1 (en) 2012-07-19 2014-01-23 Bristol-Myers Squibb Company Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase
WO2014042939A1 (en) 2012-09-11 2014-03-20 Bristol-Myers Squibb Company Ketone linked benzothiazole inhibitors of endothelial lipase
US10173991B2 (en) 2014-01-07 2019-01-08 Bristol-Myers Squibb Company Sulfone amide linked benzothiazole inhibitors of endothelial lipase
US10597370B2 (en) 2016-06-06 2020-03-24 Bristol-Myers Squibb Company 2-(benzothiazol-2-yl)-2-cyano-acetamide derivatives and their use as endothelial lipase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE422799B (sv) * 1975-05-28 1982-03-29 Merck & Co Inc Analogiforfarande for framstellning av 1,3-dihydroimidazo (4,5-b)pyridin-2-oner
AU2002216314A1 (en) * 2000-10-12 2002-04-22 Scott A Henderson Heterocyclic angiogenesis inhibitors
DE102004005172A1 (de) * 2004-02-02 2005-08-18 Aventis Pharma Deutschland Gmbh Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
JP2008501027A (ja) * 2004-05-28 2008-01-17 メルク　エンド　カムパニー　インコーポレーテッド 抗糖尿病活性をもつベンゾ尿素
CA2601458C (en) * 2005-03-15 2011-04-26 Pfizer Inc. Benzimidazolone derivatives as cb2 receptor ligands
DE102005026762A1 (de) * 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen

Also Published As

Publication number Publication date
TW200815434A (en) 2008-04-01
US7897616B2 (en) 2011-03-01
EP2001878B1 (de) 2011-10-12
CN101405288A (zh) 2009-04-08
BRPI0709211A2 (pt) 2011-06-28
DE102006014685A1 (de) 2007-10-04
KR20080104341A (ko) 2008-12-02
AU2007229708A1 (en) 2007-10-04
CA2647422A1 (en) 2007-10-04
ATE528307T1 (de) 2011-10-15
US20090076068A1 (en) 2009-03-19
MX2008012126A (es) 2008-10-03
WO2007110215A1 (en) 2007-10-04
JP2009531356A (ja) 2009-09-03
EP2001878A1 (de) 2008-12-17

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