NO20085265L - Nye forbindelser som har affinitet for amyloid - Google Patents

Nye forbindelser som har affinitet for amyloid

Info

Publication number
NO20085265L
NO20085265L NO20085265A NO20085265A NO20085265L NO 20085265 L NO20085265 L NO 20085265L NO 20085265 A NO20085265 A NO 20085265A NO 20085265 A NO20085265 A NO 20085265A NO 20085265 L NO20085265 L NO 20085265L
Authority
NO
Norway
Prior art keywords
carbon
amyloid
affinity
halogen substituent
salt
Prior art date
Application number
NO20085265A
Other languages
English (en)
Inventor
Daisaku Nakamura
Shinya Takasaki
Shigeyuki Tanifuji
Yuki Okumura
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of NO20085265L publication Critical patent/NO20085265L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer en forbindelse som har affinitet med amyloid, viser tilstrekkelig hurtig klaring fra normalt vev og er undertrykt når det gjelder toksisitet slik som mutagenisitet. Tilveiebrakt er en forbindelse representert ved følgende formel (1) eller et salt derav: hvori Ai, A2, A3 og A4 representerer uavhengig et karbon eller nitrogen; R1 er en halogensubstituent; R2 er en halogensubstituent; og m er et heltall på 0 til 2, forutsatt at minst én av R1 og R2 er en radioaktiv halogensubstituent, minst én av Ai, A2, A3 og A4 representer et karbon, og R1 binder til et karbon representert ved Ai, A2, A3 eller A4 så vel som et lavtoksisk, diagnostisk middel som innbefatter en forbindelse representert ved den foregående formel eller et salt derav.
NO20085265A 2006-05-19 2008-12-16 Nye forbindelser som har affinitet for amyloid NO20085265L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2006140044 2006-05-19
JP2006324701 2006-11-30
PCT/JP2007/059922 WO2007135890A1 (ja) 2006-05-19 2007-05-15 新規アミロイド親和性化合物

Publications (1)

Publication Number Publication Date
NO20085265L true NO20085265L (no) 2009-02-18

Family

ID=38723203

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20085265A NO20085265L (no) 2006-05-19 2008-12-16 Nye forbindelser som har affinitet for amyloid

Country Status (15)

Country Link
US (2) US8303935B2 (no)
EP (1) EP2019103B1 (no)
JP (1) JP5238496B2 (no)
KR (1) KR20090010987A (no)
AT (1) ATE535527T1 (no)
AU (1) AU2007252658B2 (no)
BR (1) BRPI0711818A2 (no)
CA (1) CA2653783A1 (no)
ES (1) ES2376491T3 (no)
IL (4) IL195378A0 (no)
NO (1) NO20085265L (no)
NZ (1) NZ573363A (no)
RU (1) RU2008150377A (no)
TW (1) TW200808795A (no)
WO (1) WO2007135890A1 (no)

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TW200803903A (en) * 2006-04-28 2008-01-16 Nihon Mediphysics Co Ltd Novel compound having affinity to amyloid
RU2008150377A (ru) 2006-05-19 2010-06-27 Нихон Меди-Физикс Ко., Лтд. (Jp) Новое соединение, обладающее сродством к амилоиду
CN101501033B (zh) 2006-06-21 2012-08-01 通用电气医疗有限公司 对淀粉状蛋白具有亲和性的化合物
TW200811175A (en) * 2006-06-21 2008-03-01 Nihon Mediphysics Co Ltd Novel compound with affinity with amyloid
WO2008056481A1 (en) * 2006-11-09 2008-05-15 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic imaging agent
KR20090091287A (ko) * 2006-11-17 2009-08-27 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
EP2098522B1 (en) * 2006-11-30 2011-10-19 Nihon Medi-Physics Co., Ltd. Compounds having affinity for amyloid
TWI406674B (zh) 2007-02-13 2013-09-01 日本藥學物理公司 Method for manufacturing diagnostic radiographic diagnostic agents
TW200918102A (en) * 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
AU2008314871A1 (en) * 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
CN101909658A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
WO2009057578A1 (ja) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物の使用及び製造方法
KR20100089858A (ko) * 2007-10-30 2010-08-12 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법
EP2218464A1 (en) * 2009-02-11 2010-08-18 Technische Universität München Compounds for non-invasive measurement of aggregates of amyloid peptides
WO2011108236A1 (ja) * 2010-03-01 2011-09-09 日本メジフィジックス株式会社 放射性ヨウ素標識有機化合物またはその塩
CA2836872A1 (en) * 2011-05-20 2012-11-29 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
JP5167436B2 (ja) 2011-06-24 2013-03-21 日本メジフィジックス株式会社 新規アミロイド親和性化合物
CN105229009B (zh) 2013-05-23 2017-09-29 豪夫迈·罗氏有限公司 作为成像剂的2‑苯基咪唑并[1,2‑a]嘧啶
WO2018164043A1 (ja) 2017-03-07 2018-09-13 日本メジフィジックス株式会社 放射性フッ素標識前駆体化合物及びそれを用いた放射性フッ素標識化合物の製造方法

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RU2008150377A (ru) 2006-05-19 2010-06-27 Нихон Меди-Физикс Ко., Лтд. (Jp) Новое соединение, обладающее сродством к амилоиду
CN101501033B (zh) * 2006-06-21 2012-08-01 通用电气医疗有限公司 对淀粉状蛋白具有亲和性的化合物
TW200918102A (en) 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
AU2008314871A1 (en) 2007-10-26 2009-04-30 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
WO2009057578A1 (ja) 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物の使用及び製造方法

Also Published As

Publication number Publication date
EP2019103B1 (en) 2011-11-30
IL209649A0 (en) 2011-02-28
NZ573363A (en) 2012-01-12
ATE535527T1 (de) 2011-12-15
CA2653783A1 (en) 2007-11-29
AU2007252658B2 (en) 2012-03-29
ES2376491T3 (es) 2012-03-14
IL195378A0 (en) 2011-08-01
JP5238496B2 (ja) 2013-07-17
US8506930B2 (en) 2013-08-13
EP2019103A1 (en) 2009-01-28
US20120271053A1 (en) 2012-10-25
WO2007135890A1 (ja) 2007-11-29
US8303935B2 (en) 2012-11-06
IL209651A0 (en) 2011-02-28
RU2008150377A (ru) 2010-06-27
TW200808795A (en) 2008-02-16
US20090252679A1 (en) 2009-10-08
EP2019103A4 (en) 2010-05-05
KR20090010987A (ko) 2009-01-30
AU2007252658A1 (en) 2007-11-29
BRPI0711818A2 (pt) 2011-12-13
IL209650A0 (en) 2011-02-28
JPWO2007135890A1 (ja) 2009-10-01

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