NO20074718L - BCRP/ABCG2 inhibitor - Google Patents

BCRP/ABCG2 inhibitor

Info

Publication number
NO20074718L
NO20074718L NO20074718A NO20074718A NO20074718L NO 20074718 L NO20074718 L NO 20074718L NO 20074718 A NO20074718 A NO 20074718A NO 20074718 A NO20074718 A NO 20074718A NO 20074718 L NO20074718 L NO 20074718L
Authority
NO
Norway
Prior art keywords
bcrp
inhibitor
formulas
groups represented
group selected
Prior art date
Application number
NO20074718A
Other languages
English (en)
Other versions
NO343883B1 (no
Inventor
Masato Nagaoka
Shusuke Hashimoto
Ryuta Yamazaki
Yukiko Nishiyama
Tomio Furuta
Takeshi Matsuzaki
Hiroshi Hatano
Oh Yoshida
Ritsuo Aiyama
Yoshikazu Sugimoto
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of NO20074718L publication Critical patent/NO20074718L/no
Publication of NO343883B1 publication Critical patent/NO343883B1/no

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
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    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

Det er beskrevet et brystkreftresistent protein (BCRP/ABCG2) inhibitor. En BCRP inhibitor omfattende et akrylonitrilderivat representert ved generell formel (1) eller et salt derav som aktivt ingrediens: (1) (E eller Z) hvor en av R1 og R2 representerer en cyanogruppe og den andre representerer et hydrogenatom; Ar1 representerer en gruppe valgt fra gruppene representert ved formlene (2) til (4); og Ar2 representerer en aromatisk hydrokarbongruppe som har en kondensert ring eventuelt substituert med et halogenatom eller en gruppe valgt fra gruppene representert ved formlene (5) til (15) nedenfor.
NO20074718A 2005-03-30 2007-09-17 BCRP/ABCG2 inhibitor NO343883B1 (no)

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JP2005097661 2005-03-30
PCT/JP2006/306560 WO2006106778A1 (ja) 2005-03-30 2006-03-29 Ｂｃｒｐ／ａｂｃｇ２阻害剤

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NO343883B1 NO343883B1 (no) 2019-07-01

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JP (1) JP5009151B2 (no)
KR (1) KR101424997B1 (no)
CN (1) CN101166719B (no)
AU (1) AU2006232435B8 (no)
BR (1) BRPI0609420A2 (no)
CA (1) CA2602467C (no)
EA (1) EA014555B1 (no)
IL (1) IL185996A (no)
MX (1) MX2007012177A (no)
NO (1) NO343883B1 (no)
NZ (1) NZ562143A (no)
TW (1) TWI421071B (no)
UA (1) UA105162C2 (no)
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CN101166719A (zh) 2008-04-23
KR20080006543A (ko) 2008-01-16
EP1864972A4 (en) 2009-11-11
TWI421071B (zh) 2014-01-01
MX2007012177A (es) 2007-11-21
NZ562143A (en) 2010-12-24
WO2006106778A1 (ja) 2006-10-12
AU2006232435A1 (en) 2006-10-12
TW200716089A (en) 2007-05-01
EA200702110A1 (ru) 2008-02-28
JP5009151B2 (ja) 2012-08-22
IL185996A (en) 2014-02-27
NO343883B1 (no) 2019-07-01
AU2006232435A8 (en) 2011-09-15
IL185996A0 (en) 2008-01-20
EP1864972A1 (en) 2007-12-12
US20090253656A1 (en) 2009-10-08
EA014555B1 (ru) 2010-12-30
HK1120258A1 (en) 2009-03-27
US8697742B2 (en) 2014-04-15
BRPI0609420A2 (pt) 2010-03-30
EP2332905B1 (en) 2017-03-01
EP2332905A1 (en) 2011-06-15
UA105162C2 (uk) 2014-04-25
CA2602467C (en) 2014-09-02
AU2006232435B8 (en) 2011-09-15
ZA200708786B (en) 2009-01-28
AU2006232435B2 (en) 2011-08-25
CA2602467A1 (en) 2006-10-12
JPWO2006106778A1 (ja) 2008-09-11
KR101424997B1 (ko) 2014-07-31

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