NO20090203L - IL-8 receptorantagonist - Google Patents

IL-8 receptorantagonist

Info

Publication number: NO20090203L
Authority: NO; Norway
Prior art keywords: receptor antagonist; compositions; useful; treatment; relates
Prior art date: 2006-06-23

Application number

NO20090203A

Other languages

English (en)

Norwegian (no)

Inventor

Christopher S Brook

Jakob Busch-Petersen

Richard M Goodman

Edward C Webb

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-23

Filing date

2009-01-13

Publication date

2009-03-20

2009-01-13 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2009-03-20 Publication of NO20090203L publication Critical patent/NO20090203L/no

Links

102000010681 interleukin-8 receptors Human genes 0.000 title 1
108010038415 interleukin-8 receptors Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
102000004890 Interleukin-8 Human genes 0.000 abstract 2
108090001007 Interleukin-8 Proteins 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 1
229940096397 interleukin-8 Drugs 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Tropical Medicine & Parasitology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hematology (AREA)
Toxicology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)

NO20090203A 2006-06-23 2009-01-13 IL-8 receptorantagonist NO20090203L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US80562606P	2006-06-23	2006-06-23
PCT/US2007/071866 WO2007150016A2 (en)	2006-06-23	2007-06-22	Il-8 receptor antagonist

Publications (1)

Publication Number	Publication Date
NO20090203L true NO20090203L (no)	2009-03-20

Family

ID=38834411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20090203A NO20090203L (no)	2006-06-23	2009-01-13	IL-8 receptorantagonist

Country Status (21)

Country	Link
US (2)	US20090170871A1 (es)
EP (2)	EP2032131A4 (es)
JP (3)	JP5711461B2 (es)
KR (1)	KR20090032097A (es)
CN (1)	CN101505595A (es)
AR (1)	AR061571A1 (es)
AU (1)	AU2007260842B2 (es)
BR (1)	BRPI0713304A2 (es)
CA (1)	CA2655468A1 (es)
CL (1)	CL2007001829A1 (es)
CR (1)	CR10535A (es)
EA (1)	EA015520B1 (es)
ES (1)	ES2437115T3 (es)
IL (1)	IL196056A0 (es)
MA (1)	MA30528B1 (es)
MX (1)	MX2009000162A (es)
NO (1)	NO20090203L (es)
NZ (1)	NZ573733A (es)
PE (1)	PE20080943A1 (es)
TW (1)	TW200817006A (es)
WO (2)	WO2007150016A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200418812A (en)	2002-10-29	2004-10-01	Smithkline Beecham Corp	IL-8 receptor antagonists
ES2892925T3 (es)	2006-03-31	2022-02-07	Chugai Pharmaceutical Co Ltd	Métodos para controlar la farmacocinética en sangre de anticuerpos
AR060562A1 (es) *	2006-04-21	2008-06-25	Smithkline Beecham Corp	Compuestos heterociclicos como antagonistas del receptor il-8. procesos de obtencion y composiciones farmaceuticas.
US8097626B2 (en) *	2006-04-21	2012-01-17	Glaxosmithkline Llc	IL-8 receptor antagonists
AR061571A1 (es) *	2006-06-23	2008-09-03	Smithkline Beecham Corp	Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un
JO2934B1 (en)	2006-06-23	2015-09-15	سميث كلاين بيتشام كوربوريشن	Prolyl hydroxylase inhibitors
CN101874042B9 (zh)	2007-09-26	2019-01-01	中外制药株式会社	利用cdr的氨基酸取代来改变抗体等电点的方法
KR102057826B1 (ko)	2008-04-11	2019-12-20	추가이 세이야쿠 가부시키가이샤	복수 분자의 항원에 반복 결합하는 항원 결합 분자
KR20130097813A (ko)	2008-04-21	2013-09-03	오토노미, 인코포레이티드	귀 질환 및 병태를 치료하기 위한 귀 조제물
US11969501B2 (en)	2008-04-21	2024-04-30	Dompé Farmaceutici S.P.A.	Auris formulations for treating otic diseases and conditions
JP5421366B2 (ja)	2008-07-21	2014-02-19	オトノミ―，インク．	制御放出性の耳の構造体調節および生来の免疫システム調節化合物および耳の障害の処置のための方法
TWI812066B (zh)	2010-11-30	2023-08-11	日商中外製藥股份有限公司	具有鈣依存性的抗原結合能力之抗體
TW202237660A (zh)	2012-08-24	2022-10-01	日商中外製藥股份有限公司	FcγRIIb特異性Fc區域變異體
EP3597747B1 (en)	2012-08-24	2023-03-15	Chugai Seiyaku Kabushiki Kaisha	Mouse fcgammarii-specific fc antibody
AU2014250434B2 (en)	2013-04-02	2019-08-08	Chugai Seiyaku Kabushiki Kaisha	Fc region variant
KR101860280B1 (ko)	2014-12-19	2018-05-21	추가이 세이야쿠 가부시키가이샤	항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
CN114773470A (zh)	2015-02-05	2022-07-22	中外制药株式会社	包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
US11359009B2 (en)	2015-12-25	2022-06-14	Chugai Seiyaku Kabushiki Kaisha	Anti-myostatin antibodies and methods of use
TWI693940B (zh) *	2016-08-05	2020-05-21	日商中外製藥股份有限公司	Ｉｌ-８相關疾病之治療用或預防用組成物
SG10201607778XA (en)	2016-09-16	2018-04-27	Chugai Pharmaceutical Co Ltd	Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
AU2017330741B2 (en)	2016-09-26	2024-07-04	Mpo, Inc.	Egg, fertilized egg, or embryo quality improving agent
CA3093729A1 (en)	2018-03-15	2019-09-19	Chugai Seiyaku Kabushiki Kaisha	Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
WO2020218465A1 (ja) *	2019-04-26	2020-10-29	中外製薬株式会社	子宮内膜症の診断方法、病態モニタリング方法及びキット
WO2023224892A1 (en) *	2022-05-20	2023-11-23	Merck Sharp & Dohme Llc	Inhibitors of msba as antibiotics, pharmaceutical compositions, and uses thereof
WO2025151629A2 (en) *	2024-01-10	2025-07-17	The Children's Medical Center Corporation	Methods and compositions for treating diseases associated with inflammation, pain and/or lesions

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1792156A (en) *	1928-01-17	1931-02-10	Gen Aniline Works Inc	5-halogen-2-amino-1-alkyloxy and 1-aralkyloxy-benzenes and intermediate products thereof and process of preparing them
US2363074A (en) *	1938-06-16	1944-11-21	Geigy Ag J R	Halogen substituted acylamino sulphonic acids of the aromatic series and their manufacture
US2407309A (en) *	1942-02-04	1946-09-10	Squibb & Sons Inc	Chemotherapeutic agents of the sulphonamide type
US2353074A (en) *	1942-07-20	1944-07-04	Pratt Read & Company	Piano action
US2795610A (en) *	1955-03-31	1957-06-11	Du Pont	Hydroxy-phenyl alkyl ureas
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
US3996253A (en) *	1966-01-11	1976-12-07	Minnesota Mining And Manufacturing Company	Process for the preparation of color images
SE370866B (es) *	1968-03-21	1974-11-04	Ciba Geigy Ag
US3647819A (en) *	1969-09-19	1972-03-07	Sterling Drug Inc	Indazolylphenylureas and indazolyl-phenylthioureas
US4048333A (en) *	1971-08-23	1977-09-13	Medizinska Akademia	Method for treating a picorna virus infection
DE2303761A1 (de) *	1973-01-26	1974-08-01	Henkel & Cie Gmbh	Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen
US4008326A (en) *	1973-12-26	1977-02-15	The Upjohn Company	Substituted ureas and thioureas and pharmaceutical compositions thereof
US3932434A (en) *	1974-08-30	1976-01-13	Eli Lilly And Company	N-2-(6-hydroxybenzothiazolyl)-N'-phenyl (or substituted phenyl) ureas
DE2928485A1 (de) *	1979-07-14	1981-01-29	Bayer Ag	Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
US4608205A (en) *	1983-03-09	1986-08-26	American Cyanamid Company	Polyanionic benzene ureas
US4591604A (en) *	1984-03-28	1986-05-27	American Cyanamid Company	Method of inhibiting the complement system by administering multisulfonated naphthalene ureas
US5215570A (en) *	1988-10-20	1993-06-01	Ciba-Geigy Corporation	Sulfamoylphenylureas
US5011937A (en) *	1988-11-14	1991-04-30	Ppg Industries, Inc.	Toluene sulfonate salts of 2-alkyl imidazolines
US5290814A (en) *	1988-11-21	1994-03-01	Burroughs Wellcome Co.	Anti-atherosclerotic diaryl compounds
US5206234A (en) *	1990-10-22	1993-04-27	Merck & Co., Inc.	Benzolactam analogs as antagonists of cck
JPH05294935A (ja) *	1991-03-15	1993-11-09	Green Cross Corp:The	アミノピリジン系化合物
HU225869B1 (en)	1992-04-02	2007-11-28	Smithkline Beecham Corp	Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them
NZ250916A (en) *	1993-02-27	1995-08-28	Nihon Nohyaku Co Ltd	N-heteroaryl-n'-phenylureas, their use as acat inhibitors
DK41193D0 (da) *	1993-04-07	1993-04-07	Neurosearch As	Ionkanalaabnere
US5312831A (en) *	1993-05-12	1994-05-17	American Cyanamid Company	Urethanes and ureas that induce cytokine production
CA2123728A1 (en) *	1993-05-21	1994-11-22	Noriyoshi Sueda	Urea derivatives and their use as acat inhibitors
US5401758A (en) *	1993-10-07	1995-03-28	Bristol-Myers Squibb Company	Pyridinyl cyanoguanidine compounds
US5441984A (en) *	1994-01-06	1995-08-15	Eli Lilly And Company	Urea, thiourea and guanidine derivatives
US5576335A (en) *	1994-02-01	1996-11-19	Nisshin Flour Milling Co., Ltd.	Urea derivatives and their use as ACAT inhibitors
DE4413265A1 (de) *	1994-04-16	1995-10-19	Basf Ag	Hydroxyphenylharnstoffe
EP0809492A4 (en) *	1995-02-17	2007-01-24	Smithkline Beecham Corp	IL-8 RECEPTOR ANTAGONISTS
US5780483A (en) *	1995-02-17	1998-07-14	Smithkline Beecham Corporation	IL-8 receptor antagonists
US6005008A (en) *	1996-02-16	1999-12-21	Smithkline Beecham Corporation	IL-8 receptor antagonists
US6262113B1 (en) *	1996-03-20	2001-07-17	Smithkline Beecham Corporation	IL-8 receptor antagonists
US6211373B1 (en) *	1996-03-20	2001-04-03	Smithkline Beecham Corporation	Phenyl urea antagonists of the IL-8 receptor
JP2000514049A (ja) *	1996-06-27	2000-10-24	スミスクライン・ビーチャム・コーポレイション	Ｉｌ―８受容体拮抗薬
CZ425698A3 (cs) *	1996-06-27	1999-06-16	Smithkline Beecham Corporation	Antagonista IL-8 receptoru
EP0932405A4 (en) *	1996-06-27	2001-10-17	Smithkline Beckman Corp	IL-8 RECEPTOR ANTAGONISTS
EP0934066A4 (en) *	1996-08-06	2001-10-17	Smithkline Beecham Corp	IL-8 RECEPTOR ANTAGONISTS
US6248785B1 (en) *	1996-08-06	2001-06-19	Smithkline Beecham Corporation	IL-8 receptor antagonists
AR008290A1 (es) *	1996-08-15	1999-12-29	Smithkline Beecham Corp	Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
US6335352B1 (en) *	1996-08-15	2002-01-01	Smithkline Beecham Corporation	IL-8 receptor antagonists
EP1019035A4 (en) *	1996-08-21	2001-10-17	Smithkline Beecham Corp	IL-8 RECEPTOR ANTAGONISTS
US6133253A (en) *	1996-12-10	2000-10-17	Abbott Laboratories	3-Pyridyl enantiomers and their use as analgesics
BR9807083A (pt) *	1997-01-23	2000-04-18	Smithkline Beckman Corp	Antagonistas ao receptor de il-8
US5929250A (en) *	1997-01-23	1999-07-27	Smithkline Beecham Corporation	IL-8 receptor antagonists
US6436927B1 (en) *	1997-02-12	2002-08-20	Smithkline Beecham Corporation	IL-8 receptor antagonists
AR015426A1 (es) *	1997-09-05	2001-05-02	Smithkline Beecham Corp	Compuestos de benzotiazol antagonistas del receptor de il-8, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento,procedimiento para su preparacion, compuestos intermediarios y procedimiento para su preparacion
AR015425A1 (es) *	1997-09-05	2001-05-02	Smithkline Beecham Corp	Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
JP2002509106A (ja) *	1998-01-20	2002-03-26	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体アンタゴニスト
ES2194547T3 (es) *	1998-09-23	2003-11-16	Tularik Inc	Arilsulfonanilida-ureas.
UY25842A1 (es) *	1998-12-16	2001-04-30	Smithkline Beecham Corp	Antagonistas de receptores de il-8
AR029637A1 (es) *	1999-05-28	2003-07-10	Smithkline Beecham Corp	Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento
US20030225125A1 (en) *	1999-06-16	2003-12-04	Smithkline Beecham Corporation	IL-8 receptor antagonists
US6372933B1 (en) *	1999-08-26	2002-04-16	Smithkline Beecham Corporation	Process for preparing certain phenyl urea compounds
US6350751B1 (en) *	1999-10-11	2002-02-26	Pfizer Inc.	Therapeutic agents
US6440993B1 (en) *	1999-10-12	2002-08-27	Smithkline Beecham Corporation	IL-8 receptor antagonists
OA11558A (en)	1999-12-08	2004-06-03	Advanced Medicine Inc	Beta 2-adrenergic receptor agonists.
AU2001241896A1 (en) *	2000-03-01	2001-09-12	Smith Kline Beecham Corporation	Il-8 receptor antagonists
JP2004504270A (ja) *	2000-03-10	2004-02-12	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体アンタゴニスト
AR030273A1 (es) *	2000-03-10	2003-08-20	Smithkline Beecham Corp	Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina
US6767922B2 (en) *	2000-03-14	2004-07-27	Smithkline Beecham Corporation	IL-8 receptor antagonists
US6664259B2 (en) *	2000-03-16	2003-12-16	Smithkline Beecham Corporation	Il-8 receptor antagonists
UY26627A1 (es) *	2000-03-24	2001-09-28	Smithkline Beecham Corp	Antagonistas de receptores de il-8
EP1274428A4 (en) *	2000-04-07	2003-05-02	Smithkline Beecham Corp	INTERLEUKIN-8 (IL-8) RECEPTOR ANTAGONISTS
US6432960B2 (en) *	2000-05-10	2002-08-13	Bristol-Myers Squibb Company	Squarate derivatives of dihydropyridine NPY antagonists
MXPA02011868A (es) *	2000-05-30	2003-04-10	Smithkline Beecham Corp	Antagonistas de receptor de interleucina 8.
US20040048897A1 (en) *	2001-01-16	2004-03-11	Mccleland Brent	Il-8 receptor antagonists
DE60230722D1 (de) *	2001-01-16	2009-02-26	Smithkline Beecham Corp	Il-8-rezeptor-antagonisten
RU2003126913A (ru) *	2001-02-02	2005-03-10	Шеринг Корпорейшн (US)	3,4-дизамещенные циклобутен-1,2-дионы, как антагонисты хемокинового рецептора схс
US20030204085A1 (en) *	2001-02-02	2003-10-30	Taveras Arthur G.	3, 4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor antagonists
GB0103630D0 (en)	2001-02-14	2001-03-28	Glaxo Group Ltd	Chemical compounds
EP1366025B1 (en)	2001-03-08	2007-06-27	Glaxo Group Limited	Agonists of beta-adrenoreceptors
JP4143413B2 (ja)	2001-03-22	2008-09-03	グラクソグループリミテッド	β２−アドレナリン受容体アゴニストとしてのホルムアニリド誘導体
CZ20032639A3 (cs) *	2001-03-30	2004-04-14	Smithkline Beecham Corporation	Způsoby přípravy sloučenin obsahujících fenol
AU2002310156A1 (en) *	2001-06-05	2002-12-16	Boehringer Ingelheim Pharmaceuticals, Inc.	1,4-disubstituted benzo-fused cycloalkyl urea compounds
US20040038854A1 (en) *	2001-07-16	2004-02-26	Dillon Susan B.	Use of il-8 receptor antagonists in the treatment of virus infections
ES2438985T3 (es)	2001-09-14	2014-01-21	Glaxo Group Limited	Formulación de inhalación que comprende derivados de fenetanolamina para el tratamiento de enfermedades respiratorias
US6653323B2 (en)	2001-11-13	2003-11-25	Theravance, Inc.	Aryl aniline β2 adrenergic receptor agonists
GB0204719D0 (en)	2002-02-28	2002-04-17	Glaxo Group Ltd	Medicinal compounds
AU2003222841A1 (en)	2002-04-25	2003-11-10	Glaxo Group Limited	Phenethanolamine derivatives
US20040029865A1 (en) *	2002-05-23	2004-02-12	Acker Brad A.	Bis-arylsulfones
GB0217225D0 (en)	2002-07-25	2002-09-04	Glaxo Group Ltd	Medicinal compounds
US20030032802A1 (en) *	2002-08-30	2003-02-13	Palovich Michael R.	IL8-receptor antagonists
US20030028042A1 (en) *	2002-08-30	2003-02-06	Palovich Michael R.	Il8-receptor antagonists
US20030065170A1 (en) *	2002-09-05	2003-04-03	Widdowson Katherine Louisa	Il-8 receptor antagonists
GB0220730D0 (en)	2002-09-06	2002-10-16	Glaxo Group Ltd	Medicinal compounds
CN100387598C (zh)	2002-09-16	2008-05-14	葛兰素集团有限公司	吡唑并[3,4-b]吡啶化合物及其作为磷酸二酯酶抑制剂的用途
GB0230045D0 (en)	2002-12-23	2003-01-29	Glaxo Group Ltd	Compounds
WO2004037807A2 (en)	2002-10-22	2004-05-06	Glaxo Group Limited	Medicinal arylethanolamine compounds
ATE390407T1 (de)	2002-10-28	2008-04-15	Glaxo Group Ltd	Phenethanolamin-derivate zur behandlung von atemwegserkrankungen
GB0225030D0 (en)	2002-10-28	2002-12-04	Glaxo Group Ltd	Medicinal compounds
TW200418812A (en) *	2002-10-29	2004-10-01	Smithkline Beecham Corp	IL-8 receptor antagonists
GB0225540D0 (en)	2002-11-01	2002-12-11	Glaxo Group Ltd	Medicinal compounds
GB0225535D0 (en)	2002-11-01	2002-12-11	Glaxo Group Ltd	Medicinal compounds
TWI328009B (en)	2003-05-21	2010-08-01	Glaxo Group Ltd	Quinoline derivatives as phosphodiesterase inhibitors
JP2006527201A (ja) *	2003-06-06	2006-11-30	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体アンタゴニスト
EA010485B1 (ru) *	2003-07-23	2008-10-30	Байер Фамэсьютиклс Копэрейшн	Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
US20070111995A1 (en)	2003-12-19	2007-05-17	Allen David G	Pyrazolo [3,4-B] pyridine Compounds and Their Use as Phosphodiesterase Inhibitors
EA200601514A1 (ru) *	2004-02-24	2007-02-27	Шеринг Акциенгезельшафт	Производные пиперазинмочевины для лечения эндометриоза
US20080275078A1 (en)	2004-03-16	2008-11-06	Glaxo Group Limited	Pyrazolo[3,4-B] Pyridine Compounds and Their Use as Pde4 Inhibitors
GB0405937D0 (en)	2004-03-16	2004-04-21	Glaxo Group Ltd	Compounds
GB0405933D0 (en)	2004-03-16	2004-04-21	Glaxo Group Ltd	Compounds
WO2006043950A1 (en) *	2004-10-20	2006-04-27	Smithkline Beecham Corporation	Il-8 receptor antagonists
AR060562A1 (es) *	2006-04-21	2008-06-25	Smithkline Beecham Corp	Compuestos heterociclicos como antagonistas del receptor il-8. procesos de obtencion y composiciones farmaceuticas.
AR061571A1 (es) *	2006-06-23	2008-09-03	Smithkline Beecham Corp	Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un

2007
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Publication number	Publication date
JP5711461B2 (ja)	2015-04-30
PE20080943A1 (es)	2008-09-27
JP2009541353A (ja)	2009-11-26
JP2009541352A (ja)	2009-11-26
EP2032131A2 (en)	2009-03-11
WO2007150016A2 (en)	2007-12-27
EA015520B1 (ru)	2011-08-30
AU2007260842B2 (en)	2012-03-15
JP2014055145A (ja)	2014-03-27
CA2655468A1 (en)	2007-12-27
ES2437115T3 (es)	2014-01-09
IL196056A0 (en)	2009-09-01
EP2034832A4 (en)	2010-12-08
EP2032131A4 (en)	2009-09-02
CL2007001829A1 (es)	2008-01-25
EP2034832B1 (en)	2013-10-02
US20090170871A1 (en)	2009-07-02
MA30528B1 (fr)	2009-06-01
TW200817006A (en)	2008-04-16
WO2007150016A3 (en)	2008-12-04
EA200970051A1 (ru)	2009-06-30
WO2007150015A3 (en)	2008-02-28
KR20090032097A (ko)	2009-03-31
US20090281110A1 (en)	2009-11-12
MX2009000162A (es)	2009-01-23
NZ573733A (en)	2011-03-31
EP2034832A2 (en)	2009-03-18
WO2007150015A2 (en)	2007-12-27
AU2007260842A1 (en)	2007-12-27
BRPI0713304A2 (pt)	2012-04-17
CN101505595A (zh)	2009-08-12
CR10535A (es)	2009-03-20
AR061571A1 (es)	2008-09-03

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Publication	Publication Date	Title
NO20090203L (no)	2009-03-20	IL-8 receptorantagonist
JO2796B1 (en)	2014-03-15	Antiallergic drugs IL-8
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WO2005000231A3 (en)	2005-05-12	Il-8 receptor antagonists
WO2001068568A3 (en)	2002-03-21	Il-8 receptor antagonists
WO2001068569A3 (en)	2002-04-18	Il-8 receptor antagonists
DE602006015686D1 (de)	2010-09-02	Als agonisten des gpr38-rezeptors geeignete biarylverbindungen
MY128154A (en)	2007-01-31	Il-8 receptor antagonists
MY143477A (en)	2011-05-31	Il-8 receptor antagonists
AP2002002606A0 (en)	2002-09-30	INTERLEUKIN 8 RECEPTOR ANTAGONISTS