SK19242000A3 - Izolovaná molekula nukleovej kyseliny kódujúca polypeptid zúčastňujúci sa biosyntézy epotilónov, chimérický gén, rekombinantný vektor a rekombinantná hostiteľská bunka obsahujúce túto nukleovú kyselinu, spôsob prípravy epotilónu a izolovaný polypeptid obsahujúci epotilónsyntázovú doménu - Google Patents

Izolovaná molekula nukleovej kyseliny kódujúca polypeptid zúčastňujúci sa biosyntézy epotilónov, chimérický gén, rekombinantný vektor a rekombinantná hostiteľská bunka obsahujúce túto nukleovú kyselinu, spôsob prípravy epotilónu a izolovaný polypeptid obsahujúci epotilónsyntázovú doménu Download PDF

Info

Publication number: SK19242000A3
Authority: SK; Slovakia
Prior art keywords: seq; nucleotides; amino acids; nucleic acid; amino
Prior art date: 1998-06-18

Application number

SK1924-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Thomas Schupp

James Madison Ligon

Istvan Molnar

Ross Zirkle

J�Rn G�Rlach

Devon Cyr

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-18

Filing date

1999-06-16

Publication date

2001-07-10

1999-06-16 Application filed by Novartis Ag filed Critical Novartis Ag

2001-07-10 Publication of SK19242000A3 publication Critical patent/SK19242000A3/sk

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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria

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SK1924-2000A 1998-06-18 1999-06-16 Izolovaná molekula nukleovej kyseliny kódujúca polypeptid zúčastňujúci sa biosyntézy epotilónov, chimérický gén, rekombinantný vektor a rekombinantná hostiteľská bunka obsahujúce túto nukleovú kyselinu, spôsob prípravy epotilónu a izolovaný polypeptid obsahujúci epotilónsyntázovú doménu SK19242000A3 (sk)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US9950498A	1998-06-18	1998-06-18
US10163198P	1998-09-24	1998-09-24
US11890699P	1999-02-05	1999-02-05
PCT/EP1999/004171 WO1999066028A2 (en)	1998-06-18	1999-06-16	Genes for the biosynthesis of epothilones

Publications (1)

Publication Number	Publication Date
SK19242000A3 true SK19242000A3 (sk)	2001-07-10

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SK1924-2000A SK19242000A3 (sk)	1998-06-18	1999-06-16	Izolovaná molekula nukleovej kyseliny kódujúca polypeptid zúčastňujúci sa biosyntézy epotilónov, chimérický gén, rekombinantný vektor a rekombinantná hostiteľská bunka obsahujúce túto nukleovú kyselinu, spôsob prípravy epotilónu a izolovaný polypeptid obsahujúci epotilónsyntázovú doménu

Country Status (16)

Country	Link
EP (1)	EP1088078A2 (no)
JP (3)	JP2002518004A (no)
KR (1)	KR100511233B1 (no)
CN (1)	CN100374565C (no)
AU (1)	AU753567B2 (no)
BR (1)	BR9911349A (no)
CA (1)	CA2329774A1 (no)
HU (1)	HUP0102186A3 (no)
ID (1)	ID29128A (no)
IL (3)	IL139735A0 (no)
NO (2)	NO20006195L (no)
NZ (1)	NZ508326A (no)
PL (1)	PL200157B1 (no)
SK (1)	SK19242000A3 (no)
TR (1)	TR200003759T2 (no)
WO (1)	WO1999066028A2 (no)

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US6204388B1 (en)	1996-12-03	2001-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
FR2775187B1 (fr)	1998-02-25	2003-02-21	Novartis Ag	Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
DE19846493A1 (de) *	1998-10-09	2000-04-13	Biotechnolog Forschung Gmbh	DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
US6410301B1 (en)	1998-11-20	2002-06-25	Kosan Biosciences, Inc.	Myxococcus host cells for the production of epothilones
KR100851418B1 (ko) *	1998-11-20	2008-08-08	코산 바이오사이언시즈, 인코포레이티드	에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
WO2001053533A2 (en) *	2000-01-21	2001-07-26	Kosan Biosciences, Inc.	Method for cloning polyketide synthase genes
US6998256B2 (en)	2000-04-28	2006-02-14	Kosan Biosciences, Inc.	Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
DE60114865T2 (de) *	2000-04-28	2006-07-27	Kosan Biosciences, Inc., Hayward	Heterologe herstellung von polyketiden
AU2002213248A1 (en)	2000-10-13	2002-04-22	The University Of Mississipi	Synthesis of epothilones and relates analogs
US7257562B2 (en)	2000-10-13	2007-08-14	Thallion Pharmaceuticals Inc.	High throughput method for discovery of gene clusters
DK1483251T3 (da)	2002-03-12	2010-04-12	Bristol Myers Squibb Co	C3-cyano-epothilon-derivater
JP4971997B2 (ja) *	2005-01-31	2012-07-11	メルク・シャープ・エンド・ドーム・コーポレイション	プラスミドｄｎａの精製方法
AU2012211052A1 (en)	2011-01-28	2013-09-05	Amyris, Inc.	Gel-encapsulated microcolony screening
BR112013027954A2 (pt)	2011-05-13	2017-01-17	Amyris Inc	métodos e composições para detectar a produção microbiana de compostos imiscíveis em água
WO2014025941A1 (en)	2012-08-07	2014-02-13	Jiang Hanxiao	Methods for stabilizing production of acetyl-coenzyme a derived compounds
CN105189772B (zh)	2013-03-15	2019-09-13	阿迈瑞斯公司	磷酸转酮酶和磷酸转乙酰酶生产乙酰-辅酶a衍生化合物的用途
AU2013397496B2 (en)	2013-08-07	2020-03-12	Amyris, Inc.	Methods for stabilizing production of acetyl-coenzyme a derived compounds
WO2016210350A1 (en)	2015-06-25	2016-12-29	Amyris, Inc.	Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN106916834B (zh) *	2015-12-24	2022-08-05	武汉合生科技有限公司	化合物的生物合成基因簇及其应用
CN111138444B (zh) *	2020-01-08	2022-05-03	山东大学	一组埃博霉素b葡萄糖苷类化合物及其酶法制备与应用

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JP4274583B2 (ja) *	1996-11-18	2009-06-10	ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ）	エポチロンｃ，ｄ，ｅ及びｆ、製造と薬剤

1998
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1999
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- 1999-06-16 BR BR9911349-0A patent/BR9911349A/pt not_active Application Discontinuation
- 1999-06-16 ID IDW20002594A patent/ID29128A/id unknown
- 1999-06-16 WO PCT/EP1999/004171 patent/WO1999066028A2/en not_active Ceased
- 1999-06-16 HU HU0102186A patent/HUP0102186A3/hu unknown
- 1999-06-16 TR TR2000/03759T patent/TR200003759T2/xx unknown
- 1999-06-16 JP JP2000554837A patent/JP2002518004A/ja not_active Withdrawn
- 1999-06-16 AU AU46116/99A patent/AU753567B2/en not_active Ceased
- 1999-06-16 PL PL345579A patent/PL200157B1/pl not_active IP Right Cessation
- 1999-06-16 SK SK1924-2000A patent/SK19242000A3/sk not_active Application Discontinuation
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- 1999-06-16 IL IL13973599A patent/IL139735A0/xx unknown
- 1999-06-16 EP EP99929243A patent/EP1088078A2/en not_active Withdrawn
- 1999-06-16 KR KR10-2000-7014348A patent/KR100511233B1/ko not_active Expired - Fee Related
2000
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- 2000-12-06 NO NO20006195A patent/NO20006195L/no unknown
2005
- 2005-10-20 JP JP2005305998A patent/JP2006061166A/ja active Pending
2007
- 2007-12-26 JP JP2007334606A patent/JP2008092958A/ja active Pending
2008
- 2008-03-24 IL IL190391A patent/IL190391A0/en unknown
2009
- 2009-03-09 NO NO20091055A patent/NO20091055L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2008092958A (ja)	2008-04-24
KR100511233B1 (ko)	2005-08-31
BR9911349A (pt)	2001-03-13
CA2329774A1 (en)	1999-12-23
CN100374565C (zh)	2008-03-12
NO20006195L (no)	2001-02-16
PL345579A1 (en)	2001-12-17
HUP0102186A2 (hu)	2001-10-28
WO1999066028A2 (en)	1999-12-23
CN1305530A (zh)	2001-07-25
EP1088078A2 (en)	2001-04-04
AU4611699A (en)	2000-01-05
NO20091055L (no)	2001-02-16
JP2002518004A (ja)	2002-06-25
IL139735A0 (en)	2002-02-10
NZ508326A (en)	2003-10-31
IL190391A0 (en)	2008-11-03
NO20006195D0 (no)	2000-12-06
ID29128A (id)	2001-08-02
IL139735A (en)	2009-06-15
HUP0102186A3 (en)	2005-10-28
WO1999066028A3 (en)	2000-06-29
TR200003759T2 (tr)	2001-06-21
AU753567B2 (en)	2002-10-24
KR20010052962A (ko)	2001-06-25
PL200157B1 (pl)	2008-12-31
JP2006061166A (ja)	2006-03-09

Legal Events

Date	Code	Title	Description
2012-07-03	FC9A	Refused patent application

Publication	Publication Date	Title
US6355458B1 (en)	2002-03-12	Genes for the biosynthesis of epothilones
KR100511233B1 (ko)	2005-08-31	에포틸론 생합성 유전자
AU753546B2 (en)	2002-10-24	Epothilone C, D, E and F, production process, and their use as cytostatic as well as phytosanitary agents
US7172884B2 (en)	2007-02-06	Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B
CN1298447A (zh)	2001-06-06	生产刺糖噻杀虫剂所用的生物合成基因
SK12402000A3 (sk)	2001-05-10	Spôsob fermentačnej prípravy cytostatík a ich kryštalických foriem
CN101809030A (zh)	2010-08-18	硫肽前体蛋白质、编码该蛋白质的基因及其用途
CN100374566C (zh)	2008-03-12	用于epothilone生物合成的基因
JP2023012549A (ja)	2023-01-25	改変ストレプトマイセス・フンジシディカス分離株およびその使用
KR20050050146A (ko)	2005-05-27	글리코펩티드 항생제 ａ４０９２６의 생합성을 위한 유전자및 단백질
MXPA00012342A (en)	2001-11-21	Genes for the biosynthesis of epothilones
CZ20004693A3 (cs)	2001-03-14	Izolovaná nukleová kyselina kódující polypeptid účastnící se biosyntézy epothilonu, chimérický gen, vektor a hostitelské buňky obsahující tuto nukleovou kyselinu
RU2265054C2 (ru)	2005-11-27	Рекомбинантная клетка-хозяин (варианты) и клон вас
CA2381427A1 (en)	2001-02-22	Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
RU2234532C2 (ru)	2004-08-20	Нуклеиновая кислота (варианты), ее использование для экспрессии эпотилонов, полипептид (варианты), клон бактерий е.coli
RU2773311C2 (ru)	2022-06-01	Модифицированные изоляты streptomyces fungicidicus и их применение
CN1041182A (zh)	1990-04-11	抗生素ge2270
HK1113387B (en)	2012-06-08	Microorganism producing epothilone