NO20091182L - 2-fenoksypyrimidinonanaloger - Google Patents

2-fenoksypyrimidinonanaloger

Info

Publication number
NO20091182L
NO20091182L NO20091182A NO20091182A NO20091182L NO 20091182 L NO20091182 L NO 20091182L NO 20091182 A NO20091182 A NO 20091182A NO 20091182 A NO20091182 A NO 20091182A NO 20091182 L NO20091182 L NO 20091182L
Authority
NO
Norway
Prior art keywords
pets
ligands
compounds
treatment
methods
Prior art date
Application number
NO20091182A
Other languages
English (en)
Inventor
Charles A Blum
Manuka Ghosh
Rajagopal Bakthavatchalam
Bertrand L Chenard
Scott Michael Capitosti
Jianjun Xu
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of NO20091182L publication Critical patent/NO20091182L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
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  • Immunology (AREA)
  • Molecular Biology (AREA)

Abstract

2-fenoksypyrimidinonanaloger er tilveiebrakt, med formelen: hvori variablene er som beskrevet heri. Slike forbindelser er ligander som kan anvendes for å modulere spesifikk reseptoraktivitet in vivo eller in vitro og er spesielt nyttige i behandlingen av tilstander forbundet med patologisk reseptoraktivering hos mennesker, kjæledyr og husdyr. Farmasøytiske sammensetninger og fremgangsmåter for anvendelse av slike forbindelser for behandling av slike lidelser er tilveiebrakt, det samme er fremgangsmåter for anvendelse av slike ligander for reseptorlokaliseringsstudier.
NO20091182A 2006-08-23 2009-03-20 2-fenoksypyrimidinonanaloger NO20091182L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82325806P 2006-08-23 2006-08-23
PCT/US2007/018654 WO2008024438A2 (en) 2006-08-23 2007-08-22 2-phenoxy pyrimidinone analogues

Publications (1)

Publication Number Publication Date
NO20091182L true NO20091182L (no) 2009-05-14

Family

ID=39107411

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091182A NO20091182L (no) 2006-08-23 2009-03-20 2-fenoksypyrimidinonanaloger

Country Status (22)

Country Link
US (2) US8003656B2 (no)
EP (1) EP2061794B1 (no)
JP (1) JP5421108B2 (no)
KR (1) KR20090043583A (no)
CN (2) CN101506210A (no)
AU (1) AU2007288203B2 (no)
BR (1) BRPI0716582A2 (no)
CA (1) CA2660957C (no)
CO (1) CO6150167A2 (no)
CR (1) CR10675A (no)
EA (1) EA200900330A1 (no)
ES (1) ES2399928T3 (no)
GT (1) GT200900040A (no)
IL (1) IL197043A0 (no)
MA (1) MA30720B1 (no)
MX (1) MX2009002066A (no)
NI (1) NI200900023A (no)
NO (1) NO20091182L (no)
SV (1) SV2009003173A (no)
TW (1) TW200825089A (no)
WO (1) WO2008024438A2 (no)
ZA (1) ZA200901163B (no)

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JP6667093B2 (ja) * 2014-08-11 2020-03-18 ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーＨｙｄｒａ Ｂｉｏｓｃｉｅｎｃｅｓ， ＬＬＣ ピリド［２，３−ｄ］ピリミジン−２，４（１Ｈ，３Ｈ）−ジオン誘導体
WO2016145045A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Compositions for use in treating glioblastoma
US10278942B2 (en) 2015-03-11 2019-05-07 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
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MX2009002066A (es) 2009-03-06
EP2061794B1 (en) 2012-12-05
WO2008024438A3 (en) 2008-11-27
GT200900040A (es) 2010-03-16
IL197043A0 (en) 2009-11-18
US8003656B2 (en) 2011-08-23
JP2010502576A (ja) 2010-01-28
ES2399928T3 (es) 2013-04-04
US20120208829A1 (en) 2012-08-16
NI200900023A (es) 2010-03-05
CO6150167A2 (es) 2010-04-20
TW200825089A (en) 2008-06-16
SV2009003173A (es) 2010-08-10
CA2660957A1 (en) 2008-02-28
ZA200901163B (en) 2010-08-25
WO2008024438A2 (en) 2008-02-28
KR20090043583A (ko) 2009-05-06
MA30720B1 (fr) 2009-09-01
JP5421108B2 (ja) 2014-02-19
EP2061794A4 (en) 2010-09-08
EP2061794A2 (en) 2009-05-27
CR10675A (es) 2009-04-17
US20090069347A1 (en) 2009-03-12
US8759361B2 (en) 2014-06-24
CN101506210A (zh) 2009-08-12
CN104292229A (zh) 2015-01-21
AU2007288203B2 (en) 2013-01-17
CA2660957C (en) 2016-10-11
BRPI0716582A2 (pt) 2013-10-08
AU2007288203A1 (en) 2008-02-28
EA200900330A1 (ru) 2009-08-28

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